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Gene: Crebbp (CREB binding protein) Rattus norvegicus
Symbol: Crebbp
Name: CREB binding protein
Description: Exhibits several functions, including activating transcription factor binding activity; histone acetyltransferase activity; and peroxisome proliferator activated receptor binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including positive regulation of G1/S transition of mitotic cell cycle; positive regulation of NIK/NF-kappaB signaling; and positive regulation of cell adhesion molecule production. Localizes to nuclear body and transcription factor complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CBP; Creb binding protein (CBP); CREB-binding protein; histone lysine acetyltransferase CREBBP; protein-lysine acetyltransferase CREBBP; RSTS; RTS
Homo sapiens (human) : CREBBP (CREB binding protein)  HGNC  Alliance
Mus musculus (house mouse) : Crebbp (CREB binding protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crebbp (CREB binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CREBBP (CREB binding protein)
Canis lupus familiaris (dog) : CREBBP (CREB binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crebbp (CREB binding protein)
Sus scrofa (pig) : CREBBP (CREB binding protein)
Chlorocebus sabaeus (African green monkey) : CREBBP (CREB binding protein)
Heterocephalus glaber (naked mole-rat) : Crebbp (CREB binding protein)
more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Crebbp
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2401
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.