Crebbp (CREB binding protein) - Rat Genome Database

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Gene: Crebbp (CREB binding protein) Rattus norvegicus
Analyze
Symbol: Crebbp
Name: CREB binding protein
RGD ID: 2401
Description: Exhibits several functions, including SMAD binding activity; activating transcription factor binding activity; and peroxisome proliferator activated receptor binding activity. Contributes to DNA-binding transcription factor activity. Involved in several processes, including positive regulation of G1/S transition of mitotic cell cycle; positive regulation of NIK/NF-kappaB signaling; and positive regulation of cell adhesion molecule production. Localizes to nuclear body and transcription regulator complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CBP; Creb binding protein (CBP); CREB-binding protein; histone lysine acetyltransferase CREBBP; protein-lysine acetyltransferase CREBBP; RSTS; RTS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21011,335,551 - 11,461,888 (+)NCBI
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
androst-4-ene-3,17-dione  (ISO)
aripiprazole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butanal  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
calyculin a  (ISO)
camptothecin  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chaetocin  (EXP)
chloroprene  (EXP)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
curcumin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproterone acetate  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
ibrutinib  (ISO)
irinotecan  (ISO)
KT 5823  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP)
mifepristone  (ISO)
Mitotane  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
o-anisidine  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Bartsch O, etal., Eur J Hum Genet. 1999 Oct-Nov;7(7):748-56.
2. Bartsch O, etal., Hum Genet. 2005 Sep;117(5):485-93. Epub 2005 Jul 14.
3. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
4. Caccamo A, etal., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22687-92. doi: 10.1073/pnas.1012851108. Epub 2010 Dec 13.
5. Chen J, etal., Int J Cardiol. 2012 Jan 26;154(2):147-52. doi: 10.1016/j.ijcard.2010.09.003. Epub 2010 Oct 5.
6. Chen J, etal., Mol Cell Biochem. 2008 Aug;315(1-2):123-30. Epub 2008 May 23.
7. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
8. Chung YH, etal., Brain Res 2002 Nov 29;956(2):312-8.
9. Cong SY, etal., Mol Cell Neurosci. 2005 Dec;30(4):560-71.
10. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
11. Dohda T, etal., J Biochem (Tokyo). 2004 Sep;136(3):313-9.
12. Dohda T, etal., J Biochem. 2004 Sep;136(3):313-9.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Giampa C, etal., Eur J Neurosci. 2009 Mar;29(5):902-10. doi: 10.1111/j.1460-9568.2009.06649.x.
15. GOA data from the GO Consortium
16. Gordon MD and Nusse R, J Biol Chem. 2006 Aug 11;281(32):22429-33. Epub 2006 Jun 22.
17. Grummt I Chromosoma. 2013 Dec;122(6):487-97.
18. Gusterson RJ, etal., J Biol Chem 2003 Feb 28;278(9):6838-47. Epub 2002 Dec 10.
19. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
20. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
21. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
22. KEGG
23. Klevytska AM, etal., J Neuropathol Exp Neurol. 2010 Apr;69(4):396-404. doi: 10.1097/NEN.0b013e3181d6c436.
24. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
25. Kung AL, etal., Genes Dev 2000 Feb 1;14(3):272-7.
26. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
27. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
28. Ma QL, etal., J Neurochem. 2007 Nov;103(4):1594-607. Epub 2007 Aug 30.
29. Malinowska-Ozdowy K, etal., Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.
30. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
31. MGD data from the GO Consortium
32. Mochizuki K, etal., Gene 2002 May 29;291(1-2):271-7.
33. Molenda HA, etal., Endocrinology 2002 Feb;143(2):436-44.
34. NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Nucifora FC, etal., Science. 2001 Mar 23;291(5512):2423-8.
36. OMIM Disease Annotation Pipeline
37. Panagopoulos I, etal., Genes Chromosomes Cancer 2003 Jan;36(1):90-8.
38. Pasheva E, etal., Biochemistry 2004 Mar 16;43(10):2935-40.
39. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
40. Pipeline to import KEGG annotations from KEGG into RGD
41. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. Pradhan A and Liu Y, Neurosci Lett. 2004 Nov 11;370(2-3):191-5.
43. RGD automated data pipeline
44. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. RGD automated import pipeline for gene-chemical interactions
46. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
47. Saifudeen Z, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F899-909. Epub 2005 Jan 4.
48. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
49. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
50. Sugawara A, etal., Hypertens Res 2003 Aug;26(8):623-8.
51. Tang C, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):213-22. Epub 2005 Apr 25.
52. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
53. Yuan SH, etal., Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2909-14. doi: 10.1073/pnas.0805555106. Epub 2009 Feb 5.
54. Zhang JJ, etal., Neuroscience 2003;117(3):707-13.
Additional References at PubMed
PMID:3410843   PMID:7913207   PMID:8621548   PMID:8684459   PMID:9194565   PMID:9413984   PMID:9679056   PMID:9742083   PMID:9973256   PMID:10075717   PMID:10733899   PMID:10893273  
PMID:11115394   PMID:11278547   PMID:11583620   PMID:11742995   PMID:11823864   PMID:11867645   PMID:11963968   PMID:12169688   PMID:12435739   PMID:12456660   PMID:12464179   PMID:12496368  
PMID:12586840   PMID:12929931   PMID:14519686   PMID:14563703   PMID:14594809   PMID:14645221   PMID:14681880   PMID:14716005   PMID:15187136   PMID:15273251   PMID:15464984   PMID:15509593  
PMID:15607978   PMID:15631885   PMID:15681609   PMID:15703171   PMID:15722556   PMID:15748849   PMID:15832170   PMID:15833741   PMID:15882794   PMID:15929978   PMID:15994095   PMID:16012757  
PMID:16043122   PMID:16135789   PMID:16145670   PMID:16205321   PMID:16207717   PMID:16246306   PMID:16426870   PMID:16427017   PMID:16452470   PMID:16461377   PMID:16581185   PMID:16606840  
PMID:16769066   PMID:16873684   PMID:16904066   PMID:17120015   PMID:17337597   PMID:17475479   PMID:17936260   PMID:18086876   PMID:18395914   PMID:19406844   PMID:19587222   PMID:19596989  
PMID:19729597   PMID:19822209   PMID:20021662   PMID:20094059   PMID:20157765   PMID:20452968   PMID:20718713   PMID:21072211   PMID:21367864   PMID:21402781   PMID:21539536   PMID:21670961  
PMID:22488213   PMID:22523253   PMID:22780989   PMID:22884549   PMID:22977234   PMID:23129231   PMID:24207024   PMID:24338162   PMID:24939902   PMID:25059824   PMID:25514493   PMID:27010597  
PMID:27363274   PMID:28222740   PMID:28790157   PMID:30540930   PMID:31272713  


Genomics

Candidate Gene Status
Crebbp is a candidate Gene for QTL Alc5
Crebbp is a candidate Gene for QTL Alc9
Comparative Map Data
Crebbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21011,335,551 - 11,461,888 (+)NCBI
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
CREBBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl163,725,054 - 3,880,726 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl163,725,054 - 3,880,713 (-)EnsemblGRCh38hg38GRCh38
GRCh38163,725,054 - 3,880,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37163,775,055 - 3,930,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,715,056 - 3,870,122 (-)NCBINCBI36hg18NCBI36
Build 34163,716,569 - 3,870,712NCBI
Celera163,981,749 - 4,136,789 (-)NCBI
Cytogenetic Map16p13.3NCBI
HuRef163,743,994 - 3,898,607 (-)NCBIHuRef
CHM1_1163,775,055 - 3,930,225 (-)NCBICHM1_1
Crebbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,899,198 - 4,031,864 (-)NCBIGRCm39mm39
GRCm39 Ensembl163,899,192 - 4,031,861 (-)Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,081,328 - 4,213,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBImm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.4NCBI
Crebbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544213,559,496 - 13,692,004 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544213,559,496 - 13,691,913 (+)NCBIChiLan1.0ChiLan1.0
CREBBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1163,820,507 - 3,974,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,820,519 - 3,974,206 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0162,645,445 - 2,800,975 (-)NCBIMhudiblu_PPA_v0panPan3
CREBBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,410,201 - 37,536,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,409,930 - 37,534,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,739,122 - 38,865,694 (+)NCBI
ROS_Cfam_1.0637,623,705 - 37,751,833 (+)NCBI
UMICH_Zoey_3.1637,408,543 - 37,535,100 (+)NCBI
UNSW_CanFamBas_1.0637,301,774 - 37,428,236 (+)NCBI
UU_Cfam_GSD_1.0637,712,371 - 37,838,937 (+)NCBI
LOC101957668
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,046,214 - 106,180,473 (-)NCBI
SpeTri2.0NW_004936694552,447 - 663,237 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREBBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,388,547 - 38,530,230 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,388,366 - 38,530,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2339,768,553 - 39,798,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231770
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,415,548 - 3,570,030 (-)NCBI
ChlSab1.1 Ensembl53,415,412 - 3,540,943 (-)Ensembl
Crebbp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248241,516,481 - 1,655,364 (-)NCBI

Position Markers
RH130099  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01011,720,820 - 11,721,006NCBIRnor6.0
Rnor_5.01010,475,287 - 10,475,473UniSTSRnor5.0
RGSC_v3.41011,725,312 - 11,725,498UniSTSRGSC3.4
Celera1010,418,234 - 10,418,420UniSTS
Cytogenetic Map10q12UniSTS
AW558298  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01011,720,581 - 11,720,668NCBIRnor6.0
Rnor_5.01010,475,048 - 10,475,135UniSTSRnor5.0
RGSC_v3.41011,725,073 - 11,725,160UniSTSRGSC3.4
Celera1010,417,995 - 10,418,082UniSTS
Cytogenetic Map10q12UniSTS
WI-22537  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01011,720,722 - 11,721,003NCBIRnor6.0
Rnor_5.01010,475,189 - 10,475,470UniSTSRnor5.0
RGSC_v3.41011,725,214 - 11,725,495UniSTSRGSC3.4
Celera1010,418,136 - 10,418,417UniSTS
Cytogenetic Map10q12UniSTS
RH137561  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01011,711,971 - 11,712,134NCBIRnor6.0
Rnor_5.01010,466,438 - 10,466,601UniSTSRnor5.0
RGSC_v3.41011,716,463 - 11,716,626UniSTSRGSC3.4
Celera1010,409,385 - 10,409,548UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat


Related Rat Strains
The following Strains have been annotated to Crebbp
SD

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000007079
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 28 12 19 12 7 7 74 29 38 11 7
Low 15 29 29 29 1 4 6 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007079   ⟹   ENSRNOP00000007079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)Ensembl
RefSeq Acc Id: NM_133381   ⟹   NP_596872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,335,953 - 11,461,888 (+)NCBI
Rnor_6.01011,595,044 - 11,721,039 (+)NCBI
Rnor_5.01010,349,914 - 10,475,506 (+)NCBI
RGSC_v3.41011,598,680 - 11,724,122 (+)RGD
Celera1010,292,190 - 10,418,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597482   ⟹   XP_017452971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,594,914 - 11,718,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597483   ⟹   XP_017452972
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,590,994 - 11,721,039 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086667   ⟹   XP_038942595
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,335,552 - 11,459,262 (+)NCBI
RefSeq Acc Id: XM_039086668   ⟹   XP_038942596
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,335,551 - 11,459,262 (+)NCBI
RefSeq Acc Id: XM_039086669   ⟹   XP_038942597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,335,551 - 11,459,263 (+)NCBI
RefSeq Acc Id: XM_039086670   ⟹   XP_038942598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21011,335,552 - 11,459,262 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_596872   ⟸   NM_133381
- UniProtKB: F1M9G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452972   ⟸   XM_017597483
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452971   ⟸   XM_017597482
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000007079   ⟸   ENSRNOT00000007079
RefSeq Acc Id: XP_038942597   ⟸   XM_039086669
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942596   ⟸   XM_039086668
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942595   ⟸   XM_039086667
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942598   ⟸   XM_039086670
- Peptide Label: isoform X4
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 10471400 10471401 C A snv BDIX/NemOda (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2401 AgrOrtholog
Ensembl Genes ENSRNOG00000005330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007079 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007079 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.1630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.246.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1020.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.10.110.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_AcTrfase_Rtt109/CBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING_CBP-p300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING_CBP-p300_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54244 UniProtKB/TrEMBL
NCBI Gene 54244 ENTREZGENE
Pfam Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Creb_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF902 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAT_KAT11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CREBBP RGD
PhenoGen Crebbp PhenoGen
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAT11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57933 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CBP_RAT UniProtKB/Swiss-Prot
  F1M9G7 ENTREZGENE, UniProtKB/TrEMBL
  Q6JHU9 ENTREZGENE
  Q812C1_RAT UniProtKB/TrEMBL
  Q812C2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Crebbp  CREB binding protein    Creb binding protein (CBP)  Name updated 625702 APPROVED
2002-06-10 Crebbp  Creb binding protein (CBP)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in Rubenstein-Taybi syndrome 70390
gene_expression expressed in brain 70390
gene_expression expression decreases in the cerebral cortex and hippocampus of aged rats 1298795
gene_function nuclear receptor coactivator 70390
gene_process increases estrogen receptor transcriptional activity and regulates hormone-dependent female sexual behavior 70390
gene_process may have a role in long-term memory 1298598