Crebbp (CREB binding protein) - Rat Genome Database

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Gene: Crebbp (CREB binding protein) Rattus norvegicus
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Symbol: Crebbp
Name: CREB binding protein
RGD ID: 2401
Description: Enables several functions, including SMAD binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including behavioral response to cocaine; long-term memory; and positive regulation of cell adhesion molecule production. Located in nuclear body. Part of transcription regulator complex. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CBP; Creb binding protein (CBP); CREB-binding protein; histone lysine acetyltransferase CREBBP; protein-lysine acetyltransferase CREBBP; RSTS; RTS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD  
Candidate Gene For: Alc5 Alc9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,842,307 - 11,968,266 (+)NCBIGRCr8
mRatBN7.21011,335,551 - 11,461,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,335,953 - 11,461,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,043,424 - 16,169,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,532,272 - 15,658,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,201,637 - 11,327,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO,ISS)
adenoid cystic carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
atrial heart septal defect  (ISO)
Au-Kline Syndrome  (ISO)
autism spectrum disorder  (ISS)
Colorectal Neoplasms  (ISO)
Developmental Disabilities  (ISO)
diffuse large B-cell lymphoma  (ISO)
epilepsy  (ISO)
esophagus squamous cell carcinoma  (ISO)
follicular lymphoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO)
Huntington's disease  (ISO)
idiopathic generalized epilepsy  (ISO)
intellectual disability  (ISO)
Kohlschutter-Tonz syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
Menke-Hennekam Syndrome  (ISO)
Menke-Hennekam Syndrome 1  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISS)
Myocardial Reperfusion Injury  (IEP)
Nervous System Malformations  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
Rubinstein-Taybi syndrome  (ISO,ISS)
scoliosis  (ISO)
Sezary's disease  (ISO)
short-rib thoracic dysplasia 9 with or without polydactyly  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
teratoma  (ISO)
Thumb Deformity  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
androst-4-ene-3,17-dione  (ISO)
aripiprazole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aurantio-obtusin  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butanal  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin a  (ISO)
camptothecin  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chaetocin  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
curcumin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproterone acetate  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
enzalutamide  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
gentamycin  (EXP)
hydrogen peroxide  (EXP)
ibrutinib  (ISO)
inulin  (ISO)
irinotecan  (ISO)
KT 5823  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
o-anisidine  (ISO)
okadaic acid  (ISO)
oleic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (EXP)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to cocaine  (IMP)
canonical NF-kappaB signal transduction  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to nutrient levels  (IEA,ISO)
cellular response to UV  (IEA,ISO,ISS)
cellular response to virus  (ISO)
chromatin remodeling  (IEA)
face morphogenesis  (ISO)
germ-line stem cell population maintenance  (ISO)
long-term memory  (IMP)
negative regulation of interferon-beta production  (ISO)
negative regulation of transcription by RNA polymerase I  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of viral process  (ISO)
non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell adhesion molecule production  (IMP)
positive regulation of dendritic spine development  (IMP)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of double-strand break repair via homologous recombination  (IEA,ISO,ISS)
positive regulation of G1/S transition of mitotic cell cycle  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IMP)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
protein destabilization  (IEA,ISO,ISS)
protein modification process  (IDA)
regulation of DNA-templated transcription  (IDA,ISO)
response to interleukin-1  (IEP)
response to ischemia  (IEP)
rhythmic process  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. FISH studies in 45 patients with Rubinstein-Taybi syndrome: deletions associated with polysplenia, hypoplastic left heart and death in infancy. Bartsch O, etal., Eur J Hum Genet. 1999 Oct-Nov;7(7):748-56.
2. DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Bartsch O, etal., Hum Genet. 2005 Sep;117(5):485-93. Epub 2005 Jul 14.
3. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
4. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Caccamo A, etal., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22687-92. doi: 10.1073/pnas.1012851108. Epub 2010 Dec 13.
5. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
6. Down-regulation of CREB-binding protein expression blocks thrombin-mediated endothelial activation by inhibiting acetylation of NF-kappaB. Chen J, etal., Int J Cardiol. 2012 Jan 26;154(2):147-52. doi: 10.1016/j.ijcard.2010.09.003. Epub 2010 Oct 5.
7. Dysregulation of CREB binding protein triggers thrombin-induced proliferation of vascular smooth muscle cells. Chen J, etal., Mol Cell Biochem. 2008 Aug;315(1-2):123-30. Epub 2008 May 23.
8. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
9. Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats. Chung YH, etal., Brain Res 2002 Nov 29;956(2):312-8.
10. Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Cong SY, etal., Mol Cell Neurosci. 2005 Dec;30(4):560-71.
11. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
12. Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. Dohda T, etal., J Biochem (Tokyo). 2004 Sep;136(3):313-9.
13. Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. Dohda T, etal., J Biochem. 2004 Sep;136(3):313-9.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. Giampa C, etal., Eur J Neurosci. 2009 Mar;29(5):902-10. doi: 10.1111/j.1460-9568.2009.06649.x.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. Gordon MD and Nusse R, J Biol Chem. 2006 Aug 11;281(32):22429-33. Epub 2006 Jun 22.
18. The nucleolus-guardian of cellular homeostasis and genome integrity. Grummt I Chromosoma. 2013 Dec;122(6):487-97.
19. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. Gusterson RJ, etal., J Biol Chem 2003 Feb 28;278(9):6838-47. Epub 2002 Dec 10.
20. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
21. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
22. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. Klevytska AM, etal., J Neuropathol Exp Neurol. 2010 Apr;69(4):396-404. doi: 10.1097/NEN.0b013e3181d6c436.
25. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
26. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Kung AL, etal., Genes Dev 2000 Feb 1;14(3):272-7.
27. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
28. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
29. Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. Ma QL, etal., J Neurochem. 2007 Nov;103(4):1594-607. Epub 2007 Aug 30.
30. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Malinowska-Ozdowy K, etal., Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.
31. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Mochizuki K, etal., Gene 2002 May 29;291(1-2):271-7.
34. Nuclear receptor coactivators modulate hormone-dependent gene expression in brain and female reproductive behavior in rats. Molenda HA, etal., Endocrinology 2002 Feb;143(2):436-44.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Nucifora FC, etal., Science. 2001 Mar 23;291(5512):2423-8.
37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
38. Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13). Panagopoulos I, etal., Genes Chromosomes Cancer 2003 Jan;36(1):90-8.
39. In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Pasheva E, etal., Biochemistry 2004 Mar 16;43(10):2935-40.
40. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies. Pradhan A and Liu Y, Neurosci Lett. 2004 Nov 11;370(2-3):191-5.
44. Cocaine self-administration in rats lacking a functional trpc4 gene. Rasmus KC, etal., F1000Res. 2013 Apr 17;2:110. doi: 10.12688/f1000research.2-110.v1. eCollection 2013.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
49. CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene. Sadeghi H, etal., Mol Biol Rep. 2021 Mar;48(3):2117-2122. doi: 10.1007/s11033-021-06215-1. Epub 2021 Feb 24.
50. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Saifudeen Z, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F899-909. Epub 2005 Jan 4.
51. The bromodomain: From epigenome reader to druggable target. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
52. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
53. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Sugawara A, etal., Hypertens Res 2003 Aug;26(8):623-8.
54. Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain. Sun H, etal., Sci Adv. 2020 Mar 18;6(12):eaay6687. doi: 10.1126/sciadv.aay6687. eCollection 2020 Mar.
55. Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP. Tang C, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):213-22. Epub 2005 Apr 25.
56. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
57. MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats. Yang J, etal., Mol Biol Rep. 2014 Jan;41(1):555-61. doi: 10.1007/s11033-013-2891-x. Epub 2013 Dec 12.
58. TOX3 regulates calcium-dependent transcription in neurons. Yuan SH, etal., Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2909-14. doi: 10.1073/pnas.0805555106. Epub 2009 Feb 5.
59. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Zhang H, etal., Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.
60. Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats. Zhang JJ, etal., Neuroscience 2003;117(3):707-13.
Additional References at PubMed
PMID:3410843   PMID:7913207   PMID:8621548   PMID:8684459   PMID:9194565   PMID:9413984   PMID:9679056   PMID:9742083   PMID:9973256   PMID:10075717   PMID:10733899   PMID:10893273  
PMID:11115394   PMID:11278547   PMID:11583620   PMID:11742995   PMID:11823864   PMID:11867645   PMID:11963968   PMID:12169688   PMID:12435739   PMID:12456660   PMID:12464179   PMID:12496368  
PMID:12586840   PMID:12929931   PMID:14519686   PMID:14563703   PMID:14594809   PMID:14645221   PMID:14681880   PMID:14716005   PMID:15187136   PMID:15273251   PMID:15464984   PMID:15509593  
PMID:15607978   PMID:15631885   PMID:15681609   PMID:15703171   PMID:15722556   PMID:15748849   PMID:15832170   PMID:15833741   PMID:15882794   PMID:15929978   PMID:15994095   PMID:16012757  
PMID:16043122   PMID:16135789   PMID:16145670   PMID:16205321   PMID:16207717   PMID:16246306   PMID:16426870   PMID:16427017   PMID:16452470   PMID:16461377   PMID:16581185   PMID:16606840  
PMID:16769066   PMID:16873684   PMID:16904066   PMID:17120015   PMID:17337597   PMID:17475479   PMID:17936260   PMID:18086876   PMID:18395914   PMID:19406844   PMID:19587222   PMID:19596989  
PMID:19729597   PMID:19822209   PMID:20021662   PMID:20094059   PMID:20157765   PMID:20452968   PMID:20718713   PMID:21072211   PMID:21367864   PMID:21402781   PMID:21539536   PMID:21670961  
PMID:22488213   PMID:22523253   PMID:22780989   PMID:22884549   PMID:22977234   PMID:23129231   PMID:24207024   PMID:24939902   PMID:25059824   PMID:25514493   PMID:27010597   PMID:27363274  
PMID:28222740   PMID:28790157   PMID:30540930   PMID:31272713   PMID:31949036   PMID:37566526   PMID:37874694  


Genomics

Comparative Map Data
Crebbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,842,307 - 11,968,266 (+)NCBIGRCr8
mRatBN7.21011,335,551 - 11,461,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,335,953 - 11,461,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,043,424 - 16,169,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,532,272 - 15,658,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,201,637 - 11,327,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
CREBBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,725,054 - 3,880,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,725,054 - 3,880,713 (-)EnsemblGRCh38hg38GRCh38
GRCh37163,775,055 - 3,930,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,715,056 - 3,870,122 (-)NCBINCBI36Build 36hg18NCBI36
Build 34163,716,569 - 3,870,712NCBI
Celera163,981,749 - 4,136,789 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,743,994 - 3,898,607 (-)NCBIHuRef
CHM1_1163,775,055 - 3,930,225 (-)NCBICHM1_1
T2T-CHM13v2.0163,752,324 - 3,907,918 (-)NCBIT2T-CHM13v2.0
Crebbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,899,198 - 4,031,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,899,192 - 4,031,861 (-)EnsemblGRCm39 Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,081,328 - 4,213,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBIMGSCv36mm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.4NCBI
Crebbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544213,559,496 - 13,692,004 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544213,559,496 - 13,691,913 (+)NCBIChiLan1.0ChiLan1.0
CREBBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,251,350 - 4,405,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,033,402 - 8,189,001 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,645,445 - 2,800,975 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,820,507 - 3,974,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,820,519 - 3,974,206 (-)Ensemblpanpan1.1panPan2
CREBBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,410,201 - 37,536,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,409,930 - 37,534,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,739,122 - 38,865,694 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,623,705 - 37,751,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,649,589 - 37,750,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,408,543 - 37,535,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,301,774 - 37,428,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,712,371 - 37,838,937 (+)NCBIUU_Cfam_GSD_1.0
Crebbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,046,214 - 106,180,473 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694553,753 - 663,617 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936694552,447 - 663,237 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREBBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,388,547 - 38,530,224 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,388,366 - 38,530,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2339,768,553 - 39,798,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREBBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,415,548 - 3,570,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,415,412 - 3,540,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606827,238,466 - 27,395,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crebbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,517,966 - 1,655,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,516,481 - 1,655,364 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crebbp
375 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000007079
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat

Markers in Region
RH130099  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,461,668 - 11,461,855 (+)MAPPERmRatBN7.2
Rnor_6.01011,720,820 - 11,721,006NCBIRnor6.0
Rnor_5.01010,475,287 - 10,475,473UniSTSRnor5.0
RGSC_v3.41011,725,312 - 11,725,498UniSTSRGSC3.4
Celera1010,418,234 - 10,418,420UniSTS
Cytogenetic Map10q12UniSTS
AW558298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,461,429 - 11,461,517 (+)MAPPERmRatBN7.2
Rnor_6.01011,720,581 - 11,720,668NCBIRnor6.0
Rnor_5.01010,475,048 - 10,475,135UniSTSRnor5.0
RGSC_v3.41011,725,073 - 11,725,160UniSTSRGSC3.4
Celera1010,417,995 - 10,418,082UniSTS
Cytogenetic Map10q12UniSTS
WI-22537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,461,570 - 11,461,852 (+)MAPPERmRatBN7.2
Rnor_6.01011,720,722 - 11,721,003NCBIRnor6.0
Rnor_5.01010,475,189 - 10,475,470UniSTSRnor5.0
RGSC_v3.41011,725,214 - 11,725,495UniSTSRGSC3.4
Celera1010,418,136 - 10,418,417UniSTS
Cytogenetic Map10q12UniSTS
RH137561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,452,815 - 11,452,979 (+)MAPPERmRatBN7.2
Rnor_6.01011,711,971 - 11,712,134NCBIRnor6.0
Rnor_5.01010,466,438 - 10,466,601UniSTSRnor5.0
RGSC_v3.41011,716,463 - 11,716,626UniSTSRGSC3.4
Celera1010,409,385 - 10,409,548UniSTS
Cytogenetic Map10q12UniSTS


Related Rat Strains
The following Strains have been annotated to Crebbp
SD    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 28 12 19 12 7 7 74 29 38 11 7
Low 15 29 29 29 1 4 6 3 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000007079   ⟹   ENSRNOP00000007079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1011,335,953 - 11,461,888 (+)Ensembl
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117260   ⟹   ENSRNOP00000080986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1011,335,953 - 11,461,888 (+)Ensembl
RefSeq Acc Id: NM_133381   ⟹   NP_596872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,842,340 - 11,968,266 (+)NCBI
mRatBN7.21011,335,953 - 11,461,888 (+)NCBI
Rnor_6.01011,595,044 - 11,721,039 (+)NCBI
Rnor_5.01010,349,914 - 10,475,506 (+)NCBI
RGSC_v3.41011,598,680 - 11,724,122 (+)RGD
Celera1010,292,190 - 10,418,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086667   ⟹   XP_038942595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,842,307 - 11,968,266 (+)NCBI
mRatBN7.21011,335,552 - 11,459,262 (+)NCBI
RefSeq Acc Id: XM_039086668   ⟹   XP_038942596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,842,307 - 11,968,266 (+)NCBI
mRatBN7.21011,335,551 - 11,459,262 (+)NCBI
RefSeq Acc Id: XM_039086669   ⟹   XP_038942597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,842,307 - 11,968,266 (+)NCBI
mRatBN7.21011,335,551 - 11,459,263 (+)NCBI
RefSeq Acc Id: XM_039086670   ⟹   XP_038942598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,842,307 - 11,968,266 (+)NCBI
mRatBN7.21011,335,552 - 11,459,262 (+)NCBI
RefSeq Acc Id: NP_596872   ⟸   NM_133381
- UniProtKB: Q6JHU9 (UniProtKB/Swiss-Prot),   F1M9G7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007079   ⟸   ENSRNOT00000007079
RefSeq Acc Id: XP_038942597   ⟸   XM_039086669
- Peptide Label: isoform X3
- UniProtKB: Q6JHU9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942596   ⟸   XM_039086668
- Peptide Label: isoform X2
- UniProtKB: Q6JHU9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942595   ⟸   XM_039086667
- Peptide Label: isoform X1
- UniProtKB: Q6JHU9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038942598   ⟸   XM_039086670
- Peptide Label: isoform X4
- UniProtKB: Q6JHU9 (UniProtKB/Swiss-Prot),   A0A8I5ZRH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080986   ⟸   ENSRNOT00000117260
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6JHU9-F1-model_v2 AlphaFold Q6JHU9 1-2442 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2401 AgrOrtholog
BioCyc Gene G2FUF-26002 BioCyc
Ensembl Genes ENSRNOG00000005330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007079 ENTREZGENE
  ENSRNOT00000007079.6 UniProtKB/TrEMBL
  ENSRNOT00000117260.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.246.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1020.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.10.110.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_AcTrfase_Rtt109/CBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING_CBP-p300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING_CBP-p300_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54244 UniProtKB/TrEMBL
NCBI Gene 54244 ENTREZGENE
PANTHER CREB-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13808 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bromodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Creb_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF902 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAT_KAT11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CREBBP RGD
PhenoGen Crebbp PhenoGen
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005330 RatGTEx
SMART BROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAT11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_TAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47040 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57933 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRH6 ENTREZGENE, UniProtKB/TrEMBL
  CBP_RAT UniProtKB/Swiss-Prot
  F1M9G7 ENTREZGENE, UniProtKB/TrEMBL
  Q6JHU9 ENTREZGENE
  Q812C1_RAT UniProtKB/TrEMBL
  Q812C2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Crebbp  CREB binding protein    Creb binding protein (CBP)  Name updated 625702 APPROVED
2002-06-10 Crebbp  Creb binding protein (CBP)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in Rubenstein-Taybi syndrome 70390
gene_expression expressed in brain 70390
gene_expression expression decreases in the cerebral cortex and hippocampus of aged rats 1298795
gene_function nuclear receptor coactivator 70390
gene_process increases estrogen receptor transcriptional activity and regulates hormone-dependent female sexual behavior 70390
gene_process may have a role in long-term memory 1298598