HEDGEHOG SIGNALING PATHWAY (PW:0000122)

View Ontology Report

Description

First discovered in Drosophila, the Hedgehog (Hh) signaling pathway is now regarded as a key regulator of mammalian embryogenesis important for processes such as cell proliferation and differentiation while in the adult it is involved in tissue repair and regeneration and the maintenance of stem cells. The three mammalian Hh genes - Dhh, Ihh and Shh, have distinct patterns of expression; only Shh is broadly expressed in many tissues. In the producing/sending cells, self-cleavage of Hh yields th

Pathway Diagram:

Ariadne Genomics Inc. Gli targets translocated Gli Gli proteins Gli modfiying kinases Ptch1 Lrp2 heparan sulfate proteoglycans secreted Hh Hh ligands palmitate GAS1 PTCH2 HHAT Btrc Gli modfiying kinases ---| Gli proteins Sufu ---| Gli proteins Smo_translocated ---| Sufu Sufu Hh ligands ---> secreted Hh Smo_translocated Smo Hh ligands ---- Lrp2 Lrp2 ---- secreted Hh Disp1 HHAT ---> Hh ligands Disp1 ---- Hh ligands secreted Hh ---| Ptch1 Gli proteins ---> translocated Gli translocated Gli ---> Gli targets Smo ---> Smo_translocated Cdon Boc PTCH2 ---| Smo Cdon --+> secreted Hh Boc ---- secreted Hh GAS1 ---- secreted Hh Btrc ---| Gli proteins secreted Hh ---| PTCH2 PTCH2 ---- secreted Hh Ptch1 ---- secreted Hh Hhip ---- secreted Hh Boc --+> secreted Hh GAS1 --+> secreted Hh Hhip ---| secreted Hh Cdon ---- secreted Hh Ptch1 ---| Smo Hhip
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:6907045
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:6907045
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:6907045
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:6907045
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:6907045
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5510025
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5510026
RGD:6907045
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:5510025
RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6484113
RGD:6907045
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:6484113
RGD:6907045
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:6484113
RGD:6907045
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:6484113
RGD:6907045
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 7 11,944,957 11,963,268 RGD:6484113
RGD:6907045
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 48,831,209 48,913,341 RGD:6484113
RGD:6907045
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
RGD:6907045
RGD:6484113
RGD:5510025
RGD:5510013
G Disp1 dispatched RND transporter family member 1 JBrowse link 13 101,451,932 101,597,570 RGD:5510026
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
RGD:6907045
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:6484113
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5510013
RGD:6907045
RGD:6484113
RGD:5510026
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:5510013
RGD:6907045
RGD:6484113
RGD:5510026
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:6484113
G Gnaz G protein subunit alpha z JBrowse link 20 14,593,072 14,644,020 RGD:6484113
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6484113
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:6484113
G Gpc1 glypican 1 JBrowse link 9 99,998,275 100,026,818 RGD:5510027
G Gpc2 glypican 2 JBrowse link 12 19,593,041 19,599,374 RGD:5510027
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:5510027
G Gpc4 glypican 4 JBrowse link X 139,354,325 139,464,876 RGD:5510027
G Gpc5 glypican 5 JBrowse link 15 100,283,131 101,776,838 RGD:5510027
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:5510026
RGD:6907045
RGD:6484113
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6484113
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6484113
G Hhat hedgehog acyltransferase JBrowse link 13 111,235,325 111,489,075 RGD:6484113
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:5510025
RGD:6907045
RGD:6484113
G Hspg2 heparan sulfate proteoglycan 2 JBrowse link 5 155,812,096 155,913,751 RGD:5510033
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:6484113
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:6484113
G Ihh Indian hedgehog JBrowse link 9 82,208,223 82,214,440 RGD:5510013
RGD:1299259
RGD:6907045
RGD:6484113
RGD:5510025
G Kif3a kinesin family member 3a JBrowse link 10 38,918,705 38,953,958 RGD:6484113
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6484113
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5510026
RGD:6907045
RGD:6484113
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:6484113
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
G Mtss1 MTSS1, I-BAR domain containing JBrowse link 7 98,820,799 98,960,878 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:6484113
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:6484113
RGD:6907045
G Rbbp4 RB binding protein 4, chromatin remodeling factor JBrowse link 5 147,499,880 147,535,240 RGD:6484113
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:6484113
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:6907045
RGD:6484113
RGD:5510025
RGD:5510013
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:6484113
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Spop speckle type BTB/POZ protein JBrowse link 10 83,231,187 83,311,987 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Stil STIL, centriolar assembly protein JBrowse link 5 133,819,302 133,851,362 RGD:6484113
G Stk36 serine/threonine kinase 36 JBrowse link 9 81,880,175 81,908,014 RGD:6484113
RGD:6907045
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:5510013
RGD:6907045
RGD:6484113
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6484113
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:6907045
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:6907045
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:6907045
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:6907045
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:6907045
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:6907045
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:6907045
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:6907045
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6907045
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:6907045
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:6907045
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:6907045
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:6907045
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:6907045
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:6907045
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:6907045
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:6907045
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:6907045
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113
G Zic2 Zic family member 2 JBrowse link 15 108,908,366 108,913,812 RGD:6907045
altered Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5491005
RGD:5490966
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:5490965
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classsecreted HhHh ligands, processed and secreted
Functional ClassGli modifying kinaseskinases, families and pathways that modify Gli
Functional Classheparan sulfate proteoglycansproteoglycans involved in in logn distance transport and regulation of Hh signaling
Gene GroupGli targetstarget genes of Gli
Functional ClassGli membersthe members of Gli family of transcription factors
Functional ClassHh ligandsthe three Hedgehog ligands

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the Hedgehog signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1 , Gnai2
acute myeloid leukemia pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
adenosine signaling pathwayAkt1 , Gnb1 , Pik3ca , Prkacb
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayCrebbp , Pias1 , Pik3ca , Pik3r1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1
altered Hedgehog signaling pathwayBoc , Dhh , Gli1 , Gli3 , Lrp2 , Ptch1 , Shh , Smo
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Wnt signaling, canonical pathwayWnt9a
Alzheimer disease pathwayGsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
androgen signaling pathwayCrebbp
angiotensin II signaling pathway via AT1 receptorArrb2 , Grk2
angiotensin II signaling pathway via AT2 receptorGnai2 , Gnai3
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
basal cell carcinoma pathwayBmp2 , Bmp4 , Gli1 , Gli2 , Gli3 , Gsk3b , Hhip , Ptch1 , Shh , Smo , Stk36 , Sufu , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayPrkaca
bladder cancer pathwayMap2k1
Bone morphogenetic proteins signaling pathwayBmp2 , Bmp4 , Bmp6 , Bmp7 , Gsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium signaling pathway via the calcium-sensing receptorArrb2 , Grk2
calcium/calcium-mediated signaling pathwayPrkaca , Prkacb , Prkx
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCrebbp , Gsk3b , Hdac1 , Hdac2 , Tgfb2
ceramide signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd , Tgfb2
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2 , Rbbp4 , Rbbp7
chemokine mediated signaling pathwayAkt1 , Arrb2 , Gnai1 , Gnai2 , Gnai3 , Gnb1 , Gng2 , Grk2 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx
chronic myeloid leukemia pathwayAkt1 , Hdac1 , Hdac2 , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
colorectal cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
CRM1 export pathwayXpo1
cytokine mediated signaling pathwayTgfb2
dilated cardiomyopathy pathwayPrkaca , Prkacb , Prkx , Tgfb2
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
DNA modification pathwaySin3a
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayCsnk1a1 , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsArrb2 , Gnb1 , Grk2 , Prkacb
dopamine signaling pathway via D2 family of receptorsArrb2 , Gnai2 , Gnao1 , Grk2
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Arrb2 , Gnai2 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkcd
endocytosis pathwayArrb2 , Grk2 , Tgfb2
endometrial cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
endothelin signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Map2k1 , Prkcd
Entamoeba histolyca infection pathwayPik3ca , Pik3r1 , Prkaca , Prkacb , Prkx , Tgfb2
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
epinephrine signaling pathway via adrenergic receptor betaArrb2 , Grk2
erythropoietin signaling pathwayPik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
Fc gamma receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
fibroblast growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayPrkaca
follicle-stimulating hormone signaling pathwayGnb1 , Prkacb
forkhead class A signaling pathwayAkt1 , Crebbp , Foxa2 , Shh
fosphenytoin pharmacodynamics pathwayPrkaca
G protein mediated signaling pathwayGnao1
G protein mediated signaling pathway via Galpha12/Galpha13 familyGnb1
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai2 , Gnai3 , Gnao1
G protein mediated signaling pathway via Galphas familyGrk2
glioma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
glutamate signaling pathwayGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkacb , Prkx
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayBmp4 , Gpc1 , Gpc2 , Gpc3 , Ptch1 , Shh , Tgfb2
gonadotropin-releasing hormone signaling pathwayMap2k1 , Prkaca , Prkacb , Prkcd , Prkx
granulocyte-macrophage colony-stimulating factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
Hedgehog signaling pathwayAkt1 , Arrb2 , Bmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Boc , Btrc , Cdon , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Dhh , Disp1 , Fbxw11 , Foxa2 , Gli1 , Gli2 , Gli3 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gnb1 , Gng2 , Gpc1 , Gpc2 , Gpc3 , Gpc4 , Gpc5 , Grk2 , Gsk3b , Hdac1 , Hdac2 , Hhat , Hhip , Hspg2 , Ift172 , Ift88 , Ihh , Kif3a , Lgals3 , Lrp2 , Lrpap1 , Map2k1 , Mtss1 , Pias1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx , Ptch1 , Pthlh , Rab23 , Rbbp4 , Rbbp7 , Shh , Sin3a , Smo , Spop , Sspo , Stil , Stk36 , Sufu , Tgfb2 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b , Xpo1 , Zic2
hepatitis C virus infection pathwayAkt1 , Gsk3b , Pias1 , Pik3ca , Pik3r1
histamine signaling pathway, immunologicalGnb1 , Prkacb
histone modification pathwayCrebbp , Hdac1 , Hdac2 , Rbbp4 , Rbbp7
Huntington disease pathwayCrebbp , Hdac1 , Hdac2 , Sin3a
hypertrophic cardiomyopathy pathwayTgfb2
hypoxia inducible factor pathwayAkt1 , Crebbp
ibutilide pharmacodynamics pathwayPrkaca
influenza A virus infection pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Gsk3b , Kif3a
insulin signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
insulin-like growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1 , Prkcd
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayMap2k1 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayHdac1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
interleukin-4 signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
ISWI family mediated chromatin remodeling pathwayRbbp4 , Rbbp7
Jak-Stat signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmania infection pathwayTgfb2
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gsk3b , Map2k1
long term potentiationCrebbp , Map2k1 , Prkaca , Prkacb , Prkx
luteinizing hormone signaling pathwayGnb1 , Prkacb
maturity onset diabetes of the young pathwayFoxa2
measles infection pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
melanocortin system pathwayGnb1 , Prkacb
melanoma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitogen activated protein kinase signaling pathwayAkt1 , Arrb2 , Map2k1 , Prkaca , Prkacb , Prkx , Tgfb2
mTOR signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
Mycobacterium tuberculosis infection pathwayAkt1 , Crebbp , Tgfb2
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
neurotrophic factor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkcd
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
non-small cell lung cancer pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
Notch signaling pathwayCrebbp , Hdac1 , Hdac2 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Crebbp , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCdon
p53 signaling pathwayAkt1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Gsk3b , Hdac1 , Prkcd
pancreatic cancer pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
parathyroid hormone signaling pathwayArrb2 , Grk2
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
phosphoinositide metabolic pathwayPik3ca , Pik3r1
pindolol pharmacodynamics pathwayPrkaca
Plasmodium infection pathwayTgfb2
platelet-derived growth factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkcd
prion diseases pathwayMap2k1 , Prkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostaglandin D2 signaling pathwayGnb1 , Prkacb
prostaglandin I2 signaling pathwayGnb1 , Prkacb
prostate cancer pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1
protein kinase A (PKA) signaling pathwayPrkaca , Prkacb
protein kinase C (PKC) signaling pathwayPrkcd
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Lrpap1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
rheumatoid arthritis disease pathwayTgfb2
ribosome biogenesis pathwayCsnk1d , Csnk1e , Xpo1
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayXpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
serotonin signaling pathway via receptors engaging G alphas protein familyGnb1 , Prkacb
small cell lung cancer pathwayAkt1 , Pias1 , Pik3ca , Pik3r1
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz
syndecan signaling pathwayPrkaca , Prkcd
T cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1 , Prkcd
the Wnt/calcium signaling pathwayWnt11
thyroid cancer pathwayMap2k1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
Toxoplasma gondii infection pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
Trail mediated signaling pathwayPik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Crebbp , Tgfb2
transforming growth factor-beta superfamily mediated signaling pathwayBmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Crebbp , Tgfb2
Trypanosoma cruzi infection pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
type 2 diabetes mellitus pathwayPik3ca , Pik3r1 , Prkcd
type II interferon signaling pathwayAkt1 , Crebbp , Map2k1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
ubiquitin/proteasome degradation pathwayBtrc , Fbxw11 , Pias1
vascular endothelial growth factor signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkcd
vasopressin signaling pathway via receptor type 2Gnb1 , Prkaca , Prkacb , Prkx
verapamil pharmacodynamics pathwayPrkaca
visual phototransduction pathwayArrb2 , Gnb1
Wnt signaling pathwayBtrc , Crebbp , Csnk1a1 , Csnk1e , Fbxw11 , Gsk3b , Prkaca , Prkacb , Prkx , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, canonical pathwayBtrc , Crebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, non-canonical pathwayArrb2 , Csnk1a1 , Wnt5a , Wnt7a
Wnt signaling, the planar cell polarity pathwayWnt7b
Phenotype Annotations Associated with Genes in the Hedgehog signaling pathway

References Associated with the Hedgehog signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: