HEDGEHOG SIGNALING PATHWAY (PW:0000122)

View Ontology Report

Description

First discovered in Drosophila, the Hedgehog (Hh) signaling pathway is now regarded as a key regulator of mammalian embryogenesis important for processes such as cell proliferation and differentiation while in the adult it is involved in tissue repair and regeneration and the maintenance of stem cells. The three mammalian Hh genes - Dhh, Ihh and Shh, have distinct patterns of expression; only Shh is broadly expressed in many tissues. In the producing/sending cells, self-cleavage of Hh yields th

Pathway Diagram:

Ariadne Genomics Inc. Gli targets translocated Gli Gli proteins Gli modfiying kinases Ptch1 Lrp2 heparan sulfate proteoglycans secreted Hh Hh ligands palmitate GAS1 PTCH2 HHAT Btrc Gli modfiying kinases ---| Gli proteins Sufu ---| Gli proteins Smo_translocated ---| Sufu Sufu Hh ligands ---> secreted Hh Smo_translocated Smo Hh ligands ---- Lrp2 Lrp2 ---- secreted Hh Disp1 HHAT ---> Hh ligands Disp1 ---- Hh ligands secreted Hh ---| Ptch1 Gli proteins ---> translocated Gli translocated Gli ---> Gli targets Smo ---> Smo_translocated Cdon Boc PTCH2 ---| Smo Cdon --+> secreted Hh Boc ---- secreted Hh GAS1 ---- secreted Hh Btrc ---| Gli proteins secreted Hh ---| PTCH2 PTCH2 ---- secreted Hh Ptch1 ---- secreted Hh Hhip ---- secreted Hh Boc --+> secreted Hh GAS1 --+> secreted Hh Hhip ---| secreted Hh Cdon ---- secreted Hh Ptch1 ---| Smo Hhip
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Genes in Pathway:

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Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:6907045
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:6907045
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:6907045
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:6907045
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:6907045
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5510025
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5510026
RGD:6907045
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:5510025
RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6484113
RGD:6907045
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:6484113
RGD:6907045
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:6484113
RGD:6907045
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:6484113
RGD:6907045
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 7 11,944,957 11,963,268 RGD:6484113
RGD:6907045
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 48,831,209 48,913,341 RGD:6484113
RGD:6907045
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
RGD:6907045
RGD:6484113
RGD:5510025
RGD:5510013
G Disp1 dispatched RND transporter family member 1 JBrowse link 13 101,451,932 101,597,570 RGD:5510026
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
RGD:6907045
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:6484113
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5510013
RGD:6907045
RGD:6484113
RGD:5510026
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:5510013
RGD:6907045
RGD:6484113
RGD:5510026
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:6484113
G Gnaz G protein subunit alpha z JBrowse link 20 14,593,072 14,644,020 RGD:6484113
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6484113
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:6484113
G Gpc1 glypican 1 JBrowse link 9 99,998,275 100,026,818 RGD:5510027
G Gpc2 glypican 2 JBrowse link 12 19,593,041 19,599,374 RGD:5510027
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:5510027
G Gpc4 glypican 4 JBrowse link X 139,354,325 139,464,876 RGD:5510027
G Gpc5 glypican 5 JBrowse link 15 100,283,131 101,776,838 RGD:5510027
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:5510026
RGD:6907045
RGD:6484113
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6484113
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6484113
G Hhat hedgehog acyltransferase JBrowse link 13 111,235,325 111,489,075 RGD:6484113
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:5510025
RGD:6907045
RGD:6484113
G Hspg2 heparan sulfate proteoglycan 2 JBrowse link 5 155,812,096 155,913,751 RGD:5510033
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:6484113
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:6484113
G Ihh Indian hedgehog JBrowse link 9 82,208,223 82,214,440 RGD:5510013
RGD:1299259
RGD:6907045
RGD:6484113
RGD:5510025
G Kif3a kinesin family member 3a JBrowse link 10 38,918,705 38,953,958 RGD:6484113
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6484113
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5510026
RGD:6907045
RGD:6484113
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:6484113
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
G Mtss1 MTSS1, I-BAR domain containing JBrowse link 7 98,820,799 98,960,878 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:6484113
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:6484113
RGD:6907045
G Rbbp4 RB binding protein 4, chromatin remodeling factor JBrowse link 5 147,499,880 147,535,240 RGD:6484113
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:6484113
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:6907045
RGD:6484113
RGD:5510025
RGD:5510013
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:6484113
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355
RGD:6907045
RGD:6484113
RGD:5510026
RGD:5510013
G Spop speckle type BTB/POZ protein JBrowse link 10 83,231,187 83,311,987 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Stil STIL, centriolar assembly protein JBrowse link 5 133,819,302 133,851,362 RGD:6484113
G Stk36 serine/threonine kinase 36 JBrowse link 9 81,880,175 81,908,014 RGD:6484113
RGD:6907045
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:5510013
RGD:6907045
RGD:6484113
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6484113
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:6907045
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:6907045
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:6907045
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:6907045
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:6907045
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:6907045
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:6907045
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:6907045
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6907045
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:6907045
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:6907045
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:6907045
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:6907045
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:6907045
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:6907045
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:6907045
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:6907045
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:6907045
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113
G Zic2 Zic family member 2 JBrowse link 15 108,908,366 108,913,812 RGD:6907045
altered Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5491005
RGD:5490966
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:5490965
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classsecreted HhHh ligands, processed and secreted
Functional ClassGli modifying kinaseskinases, families and pathways that modify Gli
Functional Classheparan sulfate proteoglycansproteoglycans involved in in logn distance transport and regulation of Hh signaling
Gene GroupGli targetstarget genes of Gli
Functional ClassGli membersthe members of Gli family of transcription factors
Functional ClassHh ligandsthe three Hedgehog ligands

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Hedgehog signaling pathway
Disease TermsGene Symbols
46 XX gonadal dysgenesisWnt4
46 XY gonadal dysgenesisDhh
46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and LungsWnt4
46,XY Gonadal Dysgenesis, Complete or Partial, DHH-RelatedDhh
46,XY Partial Gonadal Dysgenesis, with Minifascicular NeuropathyDhh
Aberrant Crypt FociGsk3b , Tgfb2
Abnormalities, Drug-InducedWnt11
Abortion, SpontaneousLgals3 , Pthlh
Absence of Tibia with PolydactylyShh
achondroplasiaPthlh
Acrocallosal Syndrome, Schinzel TypeShh
acrocapitofemoral dysplasiaIhh
Acrocephalopolysyndactyly Type IIRab23
ACTH-secreting pituitary adenomaBmp4 , Gnai2
acute kidney failureGsk3b , Hdac2 , Lgals3 , Lrp2 , Wnt4
acute kidney tubular necrosisBmp7
acute lymphocytic leukemiaGnb1
acute myeloid leukemiaCrebbp
acute promyelocytic leukemiaAkt1 , Gli1 , Gli2 , Smo
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaPik3ca
adenoid cystic carcinomaCrebbp , Pik3ca , Wnt5b
adrenal carcinomaPik3ca
Adrenal Cortex NeoplasmsGnai2
adrenal cortical adenomaPrkaca
Adrenal Gland NeoplasmsPrkaca
adrenocortical carcinomaPik3ca
adult T-cell leukemiaBmp6 , Csnk1a1
advanced sleep phase syndrome 1Csnk1d
advanced sleep phase syndrome 2Csnk1d
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Agenesis of Corpus CallosumSin3a
Al Awadi SyndromeWnt7a
Albright's hereditary osteodystrophyPthlh
AlbuminuriaGpc5 , Lrp2
alcohol use disorderHdac2
alcoholic pancreatitisPthlh
allergic contact dermatitisBmp6 , Grk2
alopecia areataHdac1 , Hdac2
Alzheimer's diseaseAkt1 , Bmp4 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Gsk3b , Hdac2 , Lrpap1 , Pik3r1
ameloblastomaSmo
amnestic disorderGnai1 , Gnai3
amphetamine abuseAkt1 , Arrb2
amyotrophic lateral sclerosisAkt1 , Gsk3b
amyotrophic lateral sclerosis type 1Crebbp , Wnt7a
anemiaBmp6
Animal Disease ModelsAkt1 , Gli2 , Wnt11
annular pancreasIhh
anodontiaGli3
Anorectal MalformationsBmp4 , Gli2 , Gli3 , Shh
ANTERIOR SEGMENT DYSGENESIS 6Ptch1
anxiety disorderGnb1 , Hdac2
aortic aneurysmTgfb2
aortic valve insufficiencyTgfb2
aortic valve stenosisLgals3
Aortic Valve, Calcification ofAkt1
Arsenic PoisoningPias1
Arteriovenous FistulaArrb2
arteriovenous malformations of the brainGli2
asphyxiating thoracic dystrophyIft172
asphyxiating thoracic dystrophy 1Ift88
asthmaHdac2 , Kif3a , Lgals3
astrocytomaAkt1
atherosclerosisAkt1
atrial fibrillationWnt8a
atrial heart septal defectBmp4
atrioventricular blockGnai2
atrioventricular septal defectBmp4 , Ift172 , Shh
attention deficit hyperactivity disorderCrebbp , Csnk1d , Lgals3
Auriculo-Condylar SyndromeGnai3
autism spectrum disorderIhh , Shh , Sin3a
autistic disorderCrebbp , Wnt2
Autoimmune DiseasesTgfb2
autoimmune lymphoproliferative syndrome type 3Prkcd
autoimmune thyroiditisLrp2
autosomal dominant non-syndromic intellectual disability 42Gnb1
autosomal dominant polycystic kidney diseaseLrp2
autosomal dominant Robinow syndrome 1Wnt5a
autosomal recessive polycystic kidney diseaseAkt1 , Ift88 , Pik3ca
Axenfeld-Rieger syndromePtch1
Axenfeld-Rieger syndrome type 3Bmp4
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeGli1
Barrett's esophagusBmp4
basal cell carcinomaGli2 , Hhip , Pik3ca , Ptch1 , Shh , Smo , Sufu
biliary atresiaGli2 , Shh
biliary tract neoplasmPrkacb
bipolar disorderAkt1 , Gsk3b
bladder exstrophyWnt10a , Wnt11 , Wnt3 , Wnt6 , Wnt7a
bladder urothelial carcinomaAkt1 , Crebbp , Map2k1 , Pik3ca
body dysmorphic disorderHdac2
bone development diseaseKif3a , Tgfb2
bone diseaseBmp2
Bone FracturesBmp2 , Bmp7
bone resorption diseaseBmp7 , Pthlh
brachydactylyIhh
brachydactyly type A1Ihh , Shh
brachydactyly type A2Bmp2
brachydactyly type E2Pthlh
BradycardiaGnai2
Brain InjuriesAkt1 , Bmp6 , Gsk3b , Pias1
brain ischemiaAkt1 , Bmp6 , Lgals3 , Map2k1 , Prkaca , Prkacb , Prkcd
Brain NeoplasmsPik3ca , Pik3r1 , Ptch1 , Smo
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Pik3ca , Wnt1 , Xpo1
Breast NeoplasmsAkt1 , Bmp2 , Bmp4 , Bmp6 , Bmp7 , Gnai2 , Hdac1 , Map2k1 , Pik3ca , Pik3r1 , Pthlh , Wnt10b , Wnt2 , Wnt7b , Wnt9a , Xpo1
bronchitisHdac2
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaPik3r1
BurnsGrk2 , Gsk3b , Prkcd
CachexiaPthlh
CAKUTBmp4 , Bmp7
CAKUT2Bmp4
calcinosisBmp4
cannabis abuseAkt1
carcinomaGnai2 , Pik3r1
cardiac arrestAkt1
Cardiac ArrhythmiasGnai2
cardiofaciocutaneous syndromeMap2k1
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bmp4 , Grk2 , Gsk3b , Hdac2 , Prkcd
cardiomyopathyAkt1 , Grk2
Cardiovascular AbnormalitiesMap2k1
cardiovascular system diseaseGrk2
carotid artery diseaseHspg2
Carpenter syndromeRab23
cartilage diseaseBmp4
cataractMap2k1
Cell Transformation, NeoplasticLgals3 , Wnt5a
central nervous system diseaseCrebbp
cervix uteri carcinoma in situHdac1 , Hdac2
CHARGE syndromeBmp4
Chemical and Drug Induced Liver InjuryLgals3
Childhood SchizophreniaHspg2
cholangiocarcinomaPrkaca , Prkacb
cholangitisTgfb2
chondrodysplasia-pseudohermaphroditism syndromeHhat
chondromaIhh , Smo
Choroidal NeovascularizationBmp4
Choroidal Neovascularization, ExperimentalSmo
chromosome 15q24 deletion syndromeSin3a
chronic kidney diseaseShh
chronic lymphocytic leukemiaXpo1
Chronic Lymphocytic Leukemia, B-CellXpo1
chronic myeloid leukemiaAkt1
chronic obstructive pulmonary diseaseHdac2 , Hhip
cleft lipBmp4 , Ptch1
cleft palateGli3 , Gnb1 , Ptch1 , Shh , Tgfb2
clubfootGli3
Cognition DisordersGsk3b , Hdac2 , Zic2
colitisBmp6
colon cancerAkt1 , Pik3ca
colon carcinomaAkt1 , Pik3ca , Tgfb2
Colonic NeoplasmsGsk3b , Hdac1 , Hdac2 , Pik3ca , Pik3r1
Colonic PolypsHdac2
colorectal adenocarcinomaGsk3b
colorectal cancerAkt1 , Pik3ca , Tgfb2
Colorectal NeoplasmsAkt1 , Bmp4 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2 , Xpo1
complex cortical dysplasia with other brain malformationsPik3ca
Congenital AbnormalitiesGrk2
congenital diaphragmatic herniaBmp4 , Foxa2 , Gli3 , Lrp2
Congenital Foot DeformitiesPthlh
Congenital Hand DeformitiesPthlh
congenital heart diseasePtch1 , Tgfb2
Congenital Limb DeformitiesBmp4 , Shh , Tgfb2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congestive heart failureGrk2 , Gsk3b , Lgals3 , Prkaca
coronary artery diseaseAkt1
cortical blindnessGnb1
Costello syndromeMap2k1
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
Cranial Nerve InjuriesBmp4
Craniofacial AbnormalitiesCsnk1a1 , Gpc4 , Hspg2 , Kif3a , Lrp2 , Ptch1 , Sin3a , Tgfb2
craniosynostosisBmp2
Craniosynostosis 7Bmp2
Cronkhite-Canada syndromeGli3
Crossed Polydactyly, Type IGli3
Culler-Jones SyndromeGli2
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Lrp2 , Map2k1 , Pik3ca , Rab23 , Sufu
CyanosisTgfb2
dementiaLrpap1
demyelinating diseaseHdac1 , Ptch1 , Shh
Developmental DisabilitiesGnb1 , Lrp2
dextro-looped transposition of the great arteries 1Hspg2
Diabetic NephropathiesBmp7 , Hdac2
diabetic neuropathyHhip , Tgfb2
diffuse large B-cell lymphomaGli1 , Pik3ca
dilated cardiomyopathyDhh
disease of cellular proliferationMap2k1 , Pik3ca , Pik3r1
Disease ProgressionPik3ca
Donnai-Barrow syndromeLrp2
DwarfismSin3a , Wnt4
dysostosisKif3a
dystoniaGnb1
early infantile epileptic encephalopathyGnao1
Early Infantile Epileptic Encephalopathy, 17Gnao1
EctromeliaWnt3
EdemaPthlh
Embryo LossGrk2
end stage renal failureLrp2
endodermal sinus tumorWnt2b
endometrial cancerPik3r1
endometrial carcinomaGsk3b , Pik3ca , Pik3r1
Endometrial NeoplasmsGsk3b , Hdac1 , Hdac2 , Pik3ca , Spop , Wnt2 , Wnt3 , Wnt4 , Wnt5a
Endometrioid CarcinomasAkt1 , Bmp4
endometriosisBmp7 , Hdac1 , Hdac2 , Ihh , Tgfb2
enophthalmosGli2
epidermal nevusPik3ca
epilepsyAkt1 , Bmp4 , Gli2 , Gnb1
epilepsy with generalized tonic-clonic seizuresGnb1
esophageal atresia/tracheoesophageal fistulaGli2 , Gli3 , Shh
esophageal carcinomaPik3ca
Esophageal NeoplasmsLgals3 , Pik3ca
esophagitisBmp4
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaBmp6 , Crebbp
exostosisGli2
Experimental ArthritisAkt1 , Arrb2 , Gli1 , Grk2 , Gsk3b , Lgals3 , Ptch1 , Shh , Smo
Experimental Autoimmune EncephalomyelitisGli1 , Shh , Tgfb2
Experimental Diabetes MellitusAkt1 , Foxa2 , Hdac1 , Hdac2 , Hspg2 , Lgals3 , Lrp2 , Pik3r1 , Prkcd , Tgfb2
Experimental Liver CirrhosisArrb2 , Bmp4 , Bmp7 , Foxa2 , Gnai2 , Grk2 , Lgals3 , Prkcd
Eye AbnormalitiesShh , Tgfb2
Facial AsymmetryPik3ca
Facial Dysmorphism with Multiple MalformationsGli2 , Shh
Failure to ThriveGnb1 , Wnt2b
familial adenomatous polyposisAkt1 , Hdac2 , Ihh
familial meningiomaSufu
Familial SchizencephalyShh
Fanconi anemiaPtch1
Fanconi syndromeLrp2
fatty liver diseaseLgals3 , Prkcd
Female InfertilitySmo
Female Urogenital DiseasesWnt4 , Wnt5a , Wnt7a
Femoral FracturesBmp4 , Bmp7
Fetal Growth RetardationBmp4 , Hdac1 , Hdac2 , Sin3a
FibroadenomaWnt2 , Wnt4
fibrodysplasia ossificans progressivaBmp4
FibrosisAkt1 , Lgals3
Fluoride PoisoningGli1 , Shh , Smo
Focal Cortical Dysplasia of TaylorBmp4
focal segmental glomerulosclerosisPias1 , Shh
follicular lymphomaCrebbp
Fractures, CartilageBmp4
Fuhrmann syndromeWnt7a
fundus dystrophyLrp2
gastric adenocarcinomaAkt1 , Crebbp , Map2k1 , Pik3ca
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorBoc , Cdon , Disp1 , Gli1 , Gli2 , Gli3 , Hhat , Hhip , Ift172 , Ift88 , Ihh , Kif3a , Ptch1 , Rab23 , Smo , Stk36 , Sufu
genetic diseaseBmp7 , Cdon , Crebbp , Gli2 , Gnao1 , Gnb1 , Gpc4 , Hdac1 , Hdac2 , Hhat , Ift172 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Ptch1 , Pthlh , Rab23 , Shh , Sin3a , Stil , Tgfb2 , Wnt10a
Gitelman syndromeDhh
glaucomaCrebbp , Tgfb2
glioblastoma multiformeAkt1 , Crebbp , Pik3ca , Pik3r1
GliosisBmp4 , Bmp7
granulosa cell tumorBmp4 , Gnai2
Granulosa Cell Tumor of the OvaryGnai2
Greig cephalopolysyndactyly syndromeGli3
Growth DisordersPik3ca , Pthlh
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsPik3ca
head and neck squamous cell carcinomaAkt1 , Crebbp , Map2k1 , Pik3ca
Hearing LossBmp4
Hearing Loss, Cisplatin-InducedGsk3b
heart diseaseHdac1
HemimegalencephalyPik3ca
hemochromatosisBmp2 , Bmp6
hemochromatosis type 1Bmp2
hepatocellular carcinomaAkt1 , Crebbp , Gli1 , Gpc3 , Hdac2 , Hhip , Pik3ca , Shh
Hereditary Eye DiseasesLrp2
Hereditary Neoplastic SyndromesCsnk1a1 , Csnk1g3 , Kif3a , Pik3ca , Ptch1 , Sufu , Wnt8a
Hernias, Diaphragmatic, CongenitalBmp4 , Wnt11
High MyopiaLrp2
Hirschsprung Disease 1Crebbp , Gli3 , Ihh , Ptch1 , Tgfb2
Hirschsprung's diseaseIhh , Shh , Tgfb2 , Wnt8b
holoprosencephalyBoc , Cdon , Disp1 , Gli2 , Ptch1 , Shh , Sufu , Zic2
holoprosencephaly 1Boc , Cdon , Disp1 , Gli2 , Ptch1 , Shh
Holoprosencephaly 10Gli2
holoprosencephaly 11Cdon
holoprosencephaly 3Shh
holoprosencephaly 5Zic2
holoprosencephaly 7Ptch1
holoprosencephaly 9Gli2
Holt-Oram syndromeTgfb2
human immunodeficiency virus infectious diseasePtch1
Huntington's diseaseCrebbp , Hdac1 , Ift88 , Sin3a
hydrocephalusSin3a , Stk36
HyperalgesiaGrk2 , Pthlh , Sin3a
hypercalcemiaPthlh
hyperglycemiaGrk2 , Hspg2 , Ptch1
hyperinsulinismFoxa2 , Prkcd
HyperoxiaBmp4
Hyperoxic Lung InjuryPtch1 , Shh
HyperplasiaAkt1 , Pik3ca
hypertensionAkt1 , Arrb2 , Gnai2 , Gnai3 , Grk2 , Gsk3b , Hspg2 , Lgals3 , Lrp2 , Pik3r1 , Prkcd
hypertrophic cardiomyopathyPrkaca
Hypertrophy, Left VentricularGrk2 , Prkcd
Hypertrophy, Right VentricularAkt1 , Hdac1 , Prkcd
Hypoglossal Nerve InjuriesPrkaca , Prkacb
hypoglycemiaPik3r1
HypopigmentationGli3
hypospadiasGli3
Hypothalamic HamartomasGli3
hypothyroidismGnb1 , Shh , Wnt3a
Hypoxia-Ischemia, BrainBmp4
idiopathic pulmonary fibrosisWnt5a
IgA glomerulonephritisShh
Immunodeficiency 36Pik3r1
impotenceAkt1
in situ carcinomaAkt1
inclusion body myositisCsnk1a1
InflammationAkt1
inflammatory bowel disease 12Gnai2
Insulin ResistanceGrk2 , Pik3r1 , Prkcd
intellectual disabilityGli2 , Gnb1 , Sin3a
intermediate coronary syndromeAkt1
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsGsk3b , Map2k1 , Prkcd
invasive ductal carcinomaAkt1 , Csnk1e
Jaw AbnormalitiesSmo
Joubert syndromeIft172
Joubert syndrome 1Ift172
Joubert syndrome 32Sufu
juvenile rheumatoid arthritisMtss1
keratoconusBmp4
kidney diseaseBmp7 , Lrp2 , Wnt4
Kidney NeoplasmsAkt1
Kidney Reperfusion InjuryLgals3 , Shh
Language Development DisordersHdac2
leiomyomaWnt5b , Wnt7a
Limb IschemiaGrk2
liver cancerAkt1 , Crebbp , Pik3ca
liver cirrhosisHdac2 , Hhip , Lgals3
liver neoplasmIft88
Liver Neoplasms, ExperimentalArrb2 , Map2k1
Loeys-Dietz syndromeTgfb2
Loeys-Dietz Syndrome 4Tgfb2
lung adenocarcinomaAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1
lung cancerPik3ca
lung diseaseFoxa2 , Pthlh
Lung NeoplasmsAkt1 , Pik3ca , Wnt5a
lung small cell carcinomaAkt1 , Crebbp , Pik3ca
lung squamous cell carcinomaAkt1 , Crebbp , Pik3ca
Lymphatic MetastasisPik3ca
macular degenerationBmp4
malignant gliomaLgals3 , Pik3ca
malignant mesotheliomaTgfb2 , Wnt3
Mammary Neoplasms, AnimalGnai2 , Pik3r1 , Wnt1 , Wnt3 , Wnt6
Mammary Neoplasms, ExperimentalAkt1 , Gnai2 , Pik3r1 , Wnt1 , Wnt2 , Wnt3 , Wnt3a , Wnt5b , Wnt6 , Wnt7a , Wnt7b
Mandibular FracturesIhh
mantle cell lymphomaGsk3b , Wnt10a , Wnt3
Maxillary NeoplasmsSmo
medulloblastomaCrebbp , Pik3ca , Ptch1 , Smo , Sufu
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
MegalencephalyGli3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
Meier-Gorlin syndromeBmp5
melanomaAkt1 , Bmp4 , Crebbp , Hdac2 , Lgals3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Rab23 , Sufu
membranous glomerulonephritisLrp2 , Lrpap1 , Shh
Memory DisordersHdac2
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Smo
mental depressionGnb1 , Gsk3b
MesotheliomaGpc3
Metabolic Bone DiseasesLrp2
Metabolic SyndromeLrpap1
microcephalyGli2 , Sin3a , Stil
Microcephaly, Primary Autosomal Recessive, 7Stil
microphthalmiaBmp4 , Gli2
Microphthalmia, Isolated, with Coloboma 5Shh
Microphthalmia, Syndromic 1Gli2 , Ift172 , Ptch1 , Wnt7a
Microphthalmia, Syndromic 6Bmp4
Microsatellite InstabilityHdac2
middle cerebral artery infarctionShh , Smo
Mouth NeoplasmsPik3ca
Mullerian Aplasia and HyperandrogenismWnt4
Multicystic Dysplastic KidneyBmp4
Multiple AbnormalitiesCrebbp , Gnao1 , Gnb1 , Gsk3b , Hdac1 , Wnt10a
Multiple Hamartoma SyndromePik3ca
multiple myelomaPik3ca , Pthlh
multiple sclerosisGli1 , Hdac1 , Shh
Muscle HypotoniaGnb1 , Hdac2
Muscle SpasticityCrebbp
muscular atrophyAkt1 , Gsk3b
muscular diseasePrkcd
Musculoskeletal AbnormalitiesTgfb2
myelodysplastic syndromeCrebbp , Gnb1
myeloid leukemiaHdac2
myocardial infarctionAkt1 , Gsk3b , Lrpap1 , Shh , Tgfb2
Myocardial IschemiaPrkcd
Myocardial Reperfusion InjuryAkt1 , Arrb2 , Grk2 , Gsk3b , Prkcd , Shh
myopiaBmp2 , Lrpap1
Myopia 23, Autosomal RecessiveLrpap1
myositis ossificansBmp4
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaPik3ca
NecrosisLgals3
Nematode InfectionsPik3r1
NeointimaLgals3
Neoplasm MetastasisBmp6 , Bmp7 , Lgals3 , Pik3ca
Neoplasm Recurrence, LocalGnai2 , Wnt10b
nephritisLgals3
nephroblastomaBmp7 , Gpc3 , Gpc4
nephrosisLrp2
nephrotic syndromeGpc5
neural tube defectGli3 , Zic2
neuroblastomaPik3ca
NEURODEVELOPMENTAL DISORDER WITH INVOLUNTARY MOVEMENTSGnao1
neuroendocrine tumorPthlh
neuronal ceroid lipofuscinosis 6Gsk3b
nevoid basal cell carcinoma syndromeGli1 , Gli2 , Ptch1 , Shh , Smo , Sufu
non-Hodgkin lymphomaMap2k1 , Mtss1 , Pik3ca
non-small cell lung carcinomaAkt1 , Map2k1 , Pik3ca , Pthlh
Noonan syndromeMap2k1
Noonan syndrome 1Map2k1
obesityAkt1 , Foxa2 , Pik3r1 , Prkcd , Wnt10b , Wnt3a
ocular hypertensionBmp4 , Gli1 , Shh , Smo
Odontoonychodermal DysplasiaWnt10a
Oral Lichen PlanusBmp4
orofacial cleftBmp4
Orofacial Cleft 11Bmp4
ossification of the posterior longitudinal ligament of spineBmp4
osteoarthritisBmp2 , Bmp4 , Bmp6 , Bmp7 , Ihh
Osteoarthritis, ExperimentalBmp4 , Lrpap1
osteochondrodysplasiaHspg2 , Tgfb2
osteogenesis imperfecta type 15Wnt1
OsteolysisPthlh
osteoporosisBmp2 , Wnt1
osteosarcomaAkt1
otosclerosisBmp2 , Bmp4
ovarian cancerAkt1 , Pik3ca
ovarian cystIhh
Ovarian NeoplasmsAkt1 , Bmp7 , Gsk3b , Hdac1 , Hdac2 , Map2k1 , Pik3ca , Pik3r1 , Wnt7a
ovarian serous cystadenocarcinomaPik3ca
ovary epithelial cancerWnt4
PainAkt1
Pallister-Hall syndromeGli3
palmoplantar keratosisWnt10a
pancreatic adenocarcinomaPik3ca
pancreatic cancerAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Ptch1 , Pthlh , Shh , Smo , Wnt9a
pancreatic ductal carcinomaHdac1 , Smo
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaHdac1
pancreatitisSmo
Pancreatitis, Acute NecrotizingPthlh
Pancreatitis, ChronicPthlh
Pancreatitis, Experimental, Chronic Gli1 , Ptch1 , Smo
paraplegiaAkt1
Parkinson's diseaseAkt1 , Grk2 , Gsk3b
Parkinsonian DisordersPrkcd , Shh
pathologic nystagmusGnb1
Patterson Stevenson SyndromeShh
penile neoplasmPik3ca
peptic esophagitisBmp4
peripheral artery diseaseBmp2 , Bmp8a
Peripheral Nerve InjuriesHhip , Shh
peripheral nervous system diseaseGli1
peritonitisGsk3b
Persistent CloacaShh
Peters anomalyPtch1
Peyronie's diseaseHdac2
physical disorderBmp4
piebaldismGli3
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
pituitary-dependent Cushing's diseaseGnai2
plasmacytomaPik3ca
pleomorphic xanthoastrocytomaGli3 , Gnai1 , Gpc2 , Smo , Wnt16 , Wnt2
Pneumococcal MeningitisLgals3
PoisoningGsk3b
polycystic kidney disease 1Kif3a
polydactylyGli3 , Ift88 , Kif3a , Shh
Polydactyly, PostaxialGli3
Polydactyly, Preaxial 4Gli3
Polydactyly, Preaxial IIShh
portal hypertensionArrb2 , Grk2 , Pik3r1 , Prkcd
pre-malignant neoplasmAkt1 , Ift88
precursor lymphoblastic lymphoma/leukemiaCrebbp , Gnb1 , Hdac1 , Hdac2
primary biliary cirrhosisHhip
Primary Hyperoxaluria Type 1Gpc1
primary pigmented nodular adrenocortical diseasePrkaca
primary progressive multiple sclerosisShh
primary pulmonary hypertensionHdac1
Primitive Neuroectodermal TumorsPtch1 , Smo
Progressive Osseous HeteroplasiaBmp4
prolactinomaBmp4 , Lrp2
prostate adenocarcinomaAkt1 , Map2k1 , Pik3ca , Spop , Xpo1
prostate cancerGli1 , Lrpap1 , Pik3ca , Pik3r1 , Spop , Sufu
prostate carcinoma in situHdac1
Prostatic NeoplasmsAkt1 , Bmp2 , Bmp4 , Bmp6 , Bmp7 , Crebbp , Gsk3b , Hdac1 , Hdac2 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Prkacb , Pthlh , Spop , Wnt10b , Wnt11 , Wnt2 , Wnt4 , Xpo1 , Zic2
Proteus syndromeAkt1
PruritusGrk2
psoriatic arthritisBmp4
PTEN hamartoma tumor syndromePik3ca
pulmonary emphysemaHdac2 , Hhip
pulmonary fibrosisBmp7
pulmonary hypertensionHdac1 , Hdac2
pyelonephritisBmp7
RASopathiesMap2k1
rectal neoplasmPik3ca
renal carcinomaPik3ca
renal cell carcinomaAkt1 , Bmp4 , Bmp6 , Bmp7 , Map2k1 , Pik3ca , Pik3r1 , Wnt11
renal fibrosisArrb2 , Bmp6
Reperfusion InjuryAkt1 , Bmp6 , Gnai2 , Gnai3 , Pik3r1 , Wnt3a
Respiratory System AbnormalitiesTgfb2
restrictive cardiomyopathyPrkcd
Retina Reperfusion InjuryHdac2
retinitis pigmentosa 71Ift172
retinopathy of prematurityIhh
rhabdomyosarcomaPtch1
rheumatoid arthritisBmp4 , Bmp6 , Grk2
Robinow syndromeWnt5a
Rubinstein-Taybi syndromeCrebbp
Salivary Gland NeoplasmsWnt5b
sarcomaPik3ca
Schistosomiasis MansoniIhh
SchizencephalyShh
schizophreniaAkt1 , Gnaz , Gsk3b , Xpo1 , Zic2
Schopf-Schulz-Passarge SyndromeWnt10a
Schwartz-Jampel syndrome 1Hspg2
scoliosisCrebbp
seborrheic keratosisPik3ca
secondary Parkinson diseaseShh
Selective Tooth Agenesis 4Wnt10a
Selective Tooth Agenesis 8Wnt10b
sensorineural hearing lossLrp2
SepsisGrk2 , Gsk3b
Septic PeritonitisPik3r1
septooptic dysplasiaCdon
Sezary's diseaseCrebbp
SHORT STATURE, FACIAL DYSMORPHISM, AND SKELETAL ANOMALIES WITH OR WITHOUT CARDIAC ANOMALIESBmp2
SHORT SyndromePik3r1
short-rib thoracic dysplasia 10 with or without polydactylyIft172
Silverman-Handmaker type dyssegmental dysplasiaHspg2
Simpson-Golabi-Behmel syndromeGpc3 , Gpc4
Single Upper Central IncisorShh
skin diseasePias1
Skin NeoplasmsAkt1 , Gli2 , Ptch1 , Smo
Skull FracturesBmp4
Smith-Magenis syndromeCsnk1d , Spop , Wnt3 , Wnt9b
spina bifidaCrebbp , Gli1 , Gli2 , Ptch1
Spinal Cord InjuriesAkt1 , Bmp2 , Bmp4 , Shh , Tgfb2
split hand-foot malformation 6Wnt10b
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaAkt1 , Crebbp , Hdac1 , Hdac2 , Pik3ca
status epilepticusGsk3b
stomach cancerPik3ca
Stomach NeoplasmsBmp2 , Bmp7 , Gli3 , Hdac2 , Lgals3 , Mtss1 , Pik3ca
strabismusBmp4 , Gnb1
StrokeAkt1 , Bmp4 , Hdac1 , Hdac2 , Pik3ca , Prkcd , Wnt2b
Subarachnoid HemorrhageGli1 , Ptch1 , Shh
substance-induced psychosisAkt1
Superior Vena Cava SyndromePthlh
syndactylyGli3
Syndactyly, Type IIhh
Syndactyly, Type IVShh
T-Cell LymphomaAkt1
Tachycardia, VentricularGnai2
tauopathyGsk3b , Hdac1
temporal lobe epilepsyHdac2 , Shh
teratomaWnt2b
tethered spinal cord syndromeCrebbp
Tetra-Amelia Autosomal RecessiveWnt3
thanatophoric dysplasiaHspg2
ThecomaGnai2
thoracic aortic aneurysmTgfb2
Thumb DeformityCrebbp
Thyroid NeoplasmsAkt1 , Pik3ca
Tibial FracturesBmp2 , Bmp4 , Bmp6 , Bmp7
tooth agenesisBmp2 , Bmp4 , Wnt10a
toxic encephalopathyPrkcd
Tracheoesophageal FistulaBmp4
transient cerebral ischemiaSin3a
transitional cell carcinomaAkt1 , Crebbp , Map2k1 , Pik3ca
Transplant RejectionArrb2
TremorGli2
Tremor Hereditary Essential, 1Gli2
tuberous sclerosisBmp4
type 1 diabetes mellitusHdac1 , Hdac2 , Lgals3
type 2 diabetes mellitusAkt1 , Arrb2 , Foxa2 , Gsk3b , Hdac1 , Hdac2 , Pik3r1
uremiaBmp2
ureteral obstructionAkt1 , Shh , Tgfb2
urinary bladder cancerAkt1 , Crebbp , Gli1 , Wnt7b
urinary system diseaseBmp4
Urogenital AbnormalitiesTgfb2 , Wnt4
Urogenital NeoplasmsWnt7a
Urologic NeoplasmsWnt2
Usher syndromeTgfb2
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Crebbp , Hdac1 , Hdac2 , Pik3ca , Wnt2 , Wnt5a
Uterine LeiomyomaPtch1
Uterine NeoplasmsMap2k1 , Pik3ca , Pik3r1 , Spop , Xpo1
VACTERL associationIft172 , Shh
vascular diseaseLgals3
Vascular MalformationsPik3ca
Vascular System InjuriesGrk2
Ventilator-Induced Lung InjuryAkt1
Ventricular Tachycardia, FamilialGnai2
visual epilepsyGli2 , Gnai1 , Gnb1 , Hdac2 , Pik3ca , Prkcd , Smo , Wnt2
Vitamin A DeficiencyBmp4
Vitamin D DeficiencyLrp2
vitiligoPik3r1
Wallerian DegenerationTgfb2
Weight GainPik3ca
Winter Shortland Temple SyndromeSmo
withdrawal disorderGnai1 , Gnao1
Wounds and InjuriesTgfb2
Pathway Annotations Associated with Genes in the Hedgehog signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1 , Gnai2
acute myeloid leukemia pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
adenosine signaling pathwayAkt1 , Gnb1 , Pik3ca , Prkacb
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayCrebbp , Pias1 , Pik3ca , Pik3r1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1
altered Hedgehog signaling pathwayBoc , Dhh , Gli1 , Gli3 , Lrp2 , Ptch1 , Shh , Smo
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Wnt signaling, canonical pathwayWnt9a
Alzheimer's disease pathwayGsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
androgen signaling pathwayCrebbp
angiotensin II signaling pathway via AT1 receptorArrb2 , Grk2
angiotensin II signaling pathway via AT2 receptorGnai2 , Gnai3
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
basal cell carcinoma pathwayBmp2 , Bmp4 , Gli1 , Gli2 , Gli3 , Gsk3b , Hhip , Ptch1 , Shh , Smo , Stk36 , Sufu , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayPrkaca
Bone morphogenetic proteins signaling pathwayBmp2 , Bmp4 , Bmp6 , Bmp7 , Gsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium signaling pathway via the calcium-sensing receptorArrb2 , Grk2
calcium/calcium-mediated signaling pathwayPrkaca , Prkacb , Prkx
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCrebbp , Gsk3b , Hdac1 , Hdac2 , Tgfb2
ceramide signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd , Tgfb2
Chagas disease pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2 , Rbbp4 , Rbbp7
chemokine mediated signaling pathwayAkt1 , Arrb2 , Gnai1 , Gnai2 , Gnai3 , Gnb1 , Gng2 , Grk2 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx
chronic myeloid leukemia pathwayAkt1 , Hdac1 , Hdac2 , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
colorectal cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
CRM1 export pathwayXpo1
cytokine mediated signaling pathwayTgfb2
dilated cardiomyopathy pathwayPrkaca , Prkacb , Prkx , Tgfb2
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
DNA modification pathwaySin3a
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayCsnk1a1 , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsArrb2 , Gnb1 , Grk2 , Prkacb
dopamine signaling pathway via D2 family of receptorsArrb2 , Gnai2 , Gnao1 , Grk2
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Arrb2 , Gnai2 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkcd
endocytosis pathwayArrb2 , Grk2 , Tgfb2
endometrial cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
endothelin signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Map2k1 , Prkcd
Entamoebiasis pathwayPik3ca , Pik3r1 , Prkaca , Prkacb , Prkx , Tgfb2
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
epinephrine signaling pathway via adrenergic receptor betaArrb2 , Grk2
erythropoietin signaling pathwayPik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
Fc gamma receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
fibroblast growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayPrkaca
follicle-stimulating hormone signaling pathwayGnb1 , Prkacb
forkhead class A signaling pathwayAkt1 , Crebbp , Foxa2 , Shh
fosphenytoin pharmacodynamics pathwayPrkaca
G protein mediated signaling pathwayGnao1 , Grk2
G protein mediated signaling pathway via Galpha12/Galpha13 familyGnb1
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai2 , Gnai3 , Gnao1
G protein mediated signaling pathway via Galphas familyGrk2
glioma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
glutamate signaling pathwayGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkacb , Prkx
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayBmp4 , Gpc1 , Gpc2 , Gpc3 , Ptch1 , Shh , Tgfb2
gonadotropin-releasing hormone signaling pathwayMap2k1 , Prkaca , Prkacb , Prkcd , Prkx
granulocyte-macrophage colony-stimulating factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
Hedgehog signaling pathwayAkt1 , Arrb2 , Bmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Boc , Btrc , Cdon , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Dhh , Disp1 , Fbxw11 , Foxa2 , Gli1 , Gli2 , Gli3 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gnb1 , Gng2 , Gpc1 , Gpc2 , Gpc3 , Gpc4 , Gpc5 , Grk2 , Gsk3b , Hdac1 , Hdac2 , Hhat , Hhip , Hspg2 , Ift172 , Ift88 , Ihh , Kif3a , Lgals3 , Lrp2 , Lrpap1 , Map2k1 , Mtss1 , Pias1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx , Ptch1 , Pthlh , Rab23 , Rbbp4 , Rbbp7 , Shh , Sin3a , Smo , Spop , Sspo , Stil , Stk36 , Sufu , Tgfb2 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b , Xpo1 , Zic2
hepatitis C pathwayAkt1 , Gsk3b , Pias1 , Pik3ca , Pik3r1
histamine signaling pathway, immunologicalGnb1 , Prkacb
histone modification pathwayCrebbp , Hdac1 , Hdac2 , Rbbp4 , Rbbp7
Huntington's disease pathwayCrebbp , Hdac1 , Hdac2 , Sin3a
hypertrophic cardiomyopathy pathwayTgfb2
hypoxia inducible factor pathwayAkt1 , Crebbp
ibutilide pharmacodynamics pathwayPrkaca
influenza A pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Gsk3b , Kif3a
insulin signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
insulin-like growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1 , Prkcd
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayMap2k1 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayHdac1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
interleukin-4 signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
ISWI family mediated chromatin remodeling pathwayRbbp4 , Rbbp7
Jak-Stat signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmaniasis pathwayTgfb2
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gsk3b , Map2k1
long term potentiationCrebbp , Map2k1 , Prkaca , Prkacb , Prkx
luteinizing hormone signaling pathwayGnb1 , Prkacb
malaria pathwayTgfb2
maturity-onset diabetes of the young pathwayFoxa2
measles pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
melanocortin system pathwayGnb1 , Prkacb
melanoma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitogen activated protein kinase signaling pathwayAkt1 , Arrb2 , Map2k1 , Prkaca , Prkacb , Prkx , Tgfb2
mTOR signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
neurotrophic factor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkcd
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
non-small cell lung carcinoma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
Notch signaling pathwayCrebbp , Hdac1 , Hdac2 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Crebbp , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCdon
p53 signaling pathwayAkt1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Gsk3b , Hdac1 , Prkcd
pancreatic cancer pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
parathyroid hormone signaling pathwayArrb2 , Grk2
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
phosphoinositide metabolic pathwayPik3ca , Pik3r1
pindolol pharmacodynamics pathwayPrkaca
platelet-derived growth factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkcd
prion disease pathwayMap2k1 , Prkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostaglandin D2 signaling pathwayGnb1 , Prkacb
prostaglandin I2 signaling pathwayGnb1 , Prkacb
prostate cancer pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1
protein kinase A (PKA) signaling pathwayPrkaca , Prkacb
protein kinase C (PKC) signaling pathwayPrkcd
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Lrpap1 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
rheumatoid arthritis pathwayTgfb2
ribosome biogenesis pathwayCsnk1d , Csnk1e , Xpo1
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayXpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
serotonin signaling pathway via receptors engaging G alphas protein familyGnb1 , Prkacb
small cell lung carcinoma pathwayAkt1 , Pias1 , Pik3ca , Pik3r1
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz
syndecan signaling pathwayPrkaca , Prkcd
T cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1 , Prkcd
the Wnt/calcium signaling pathwayWnt11
thyroid cancer pathwayMap2k1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
toxoplasmosis pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
Trail mediated signaling pathwayPik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Crebbp , Tgfb2
transforming growth factor-beta superfamily mediated signaling pathwayBmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Crebbp , Tgfb2
tuberculosis pathwayAkt1 , Crebbp , Tgfb2
type 2 diabetes mellitus pathwayPik3ca , Pik3r1 , Prkcd
type II interferon signaling pathwayAkt1 , Crebbp , Map2k1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
ubiquitin/proteasome degradation pathwayBtrc , Fbxw11 , Pias1
urinary bladder cancer pathwayMap2k1
vascular endothelial growth factor signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkcd
vasopressin signaling pathway via receptor type 2Gnb1 , Prkaca , Prkacb , Prkx
verapamil pharmacodynamics pathwayPrkaca
visual phototransduction pathwayArrb2 , Gnb1
Wnt signaling pathwayBtrc , Crebbp , Csnk1a1 , Csnk1e , Fbxw11 , Gsk3b , Prkaca , Prkacb , Prkx , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, canonical pathwayBtrc , Crebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, non-canonical pathwayArrb2 , Csnk1a1 , Wnt5a , Wnt7a
Wnt signaling, the planar cell polarity pathwayWnt7b
Phenotype Annotations Associated with Genes in the Hedgehog signaling pathway

References Associated with the Hedgehog signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: