Crebbp (CREB binding protein) - Rat Genome Database

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Gene: Crebbp (CREB binding protein) Mus musculus
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Symbol: Crebbp
Name: CREB binding protein
RGD ID: 619553
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including embryo ectoderm; eye; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW558298; CB; CBP; CBP/p300; CREB-binding protein; histone lysine acetyltransferase CREBBP; KAT; KAT3A; p300/CBP; protein-lysine acetyltransferase CREBBP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,899,198 - 4,031,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,899,192 - 4,031,861 (-)EnsemblGRCm39 Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,081,328 - 4,213,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBIMGSCv36mm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (IAGP,ISO)
adenoid cystic carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (IDA,IEP)
amyotrophic lateral sclerosis type 1  (ISO)
Au-Kline Syndrome  (ISO)
autism spectrum disorder  (IAGP)
Developmental Disabilities  (ISO)
diffuse large B-cell lymphoma  (ISO)
epilepsy  (ISO)
esophagus squamous cell carcinoma  (ISO)
follicular lymphoma  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung Disease 1  (ISO)
Hirschsprung's disease  (ISO)
Huntington's disease  (IEP,IMP)
Idiopathic Generalized Epilepsy  (ISO)
intellectual disability  (ISO)
Kohlschutter-Tonz syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Reperfusion Injury  (IMP)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
Menke-Hennekam Syndrome  (ISO)
Menke-Hennekam Syndrome 1  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (IAGP)
Myocardial Reperfusion Injury  (ISO)
Nervous System Malformations  (ISO)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
Rubinstein-Taybi syndrome  (IAGP,ISO)
scoliosis  (ISO)
Sezary's disease  (ISO)
short-rib thoracic dysplasia 9 with or without polydactyly  (ISO)
squamous cell carcinoma  (ISO)
teratoma  (ISO)
Thumb Deformity  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-tert-butylhydroquinone  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP)
androst-4-ene-3,17-dione  (ISO)
aripiprazole  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aurantio-obtusin  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bucladesine  (EXP,ISO)
butanal  (ISO)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (EXP)
calyculin A  (ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chaetocin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
curcumin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenthion  (EXP)
fenvalerate  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (ISO)
inulin  (EXP)
irinotecan  (ISO)
KT 5823  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
o-anisidine  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (EXP)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to cocaine  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to hepatocyte growth factor stimulus  (IDA)
cellular response to nutrient levels  (ISO)
cellular response to UV  (ISO,ISS)
cellular response to virus  (IMP)
chromatin remodeling  (IEA)
face morphogenesis  (IMP)
germ-line stem cell population maintenance  (IMP)
long-term memory  (ISO)
N-terminal peptidyl-lysine acetylation  (ISO,ISS)
negative regulation of interferon-beta production  (IMP)
negative regulation of transcription by RNA polymerase I  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of viral process  (IMP)
positive regulation of cell adhesion molecule production  (ISO)
positive regulation of CREB transcription factor activity  (IDA)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA-binding transcription factor activity  (TAS)
positive regulation of DNA-templated transcription  (IDA,ISO,ISS)
positive regulation of double-strand break repair via homologous recombination  (ISO,ISS)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IGI)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IGI,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
protein acetylation  (ISO)
protein destabilization  (ISO,ISS)
protein modification process  (ISO)
regulation of DNA-templated transcription  (IDA,IMP,ISO)
response to interleukin-1  (ISO)
response to ischemia  (ISO)
rhythmic process  (IEA)

Cellular Component

Molecular Function
acetyltransferase activity  (ISO,ISS)
cAMP response element binding protein binding  (IPI)
chromatin binding  (IDA,ISO)
chromatin DNA binding  (IBA)
damaged DNA binding  (ISO,ISS)
disordered domain specific binding  (IPI)
DNA binding  (IDA)
DNA-binding transcription factor binding  (ISO,ISS)
histone acetyltransferase activity  (IBA,IDA,ISO,ISS,TAS)
histone H2AK5 acetyltransferase activity  (IEA)
histone H2AK9 acetyltransferase activity  (IEA)
histone H2BK12 acetyltransferase activity  (IEA)
histone H2BK5 acetyltransferase activity  (IEA)
histone H3K122 acetyltransferase activity  (IEA)
histone H3K14 acetyltransferase activity  (IEA)
histone H3K18 acetyltransferase activity  (ISO,ISS)
histone H3K23 acetyltransferase activity  (IEA)
histone H3K27 acetyltransferase activity  (ISO,ISS)
histone H3K36 acetyltransferase activity  (IEA)
histone H3K4 acetyltransferase activity  (IEA)
histone H3K56 acetyltransferase activity  (IEA)
histone H3K9 acetyltransferase activity  (IEA)
histone H4K12 acetyltransferase activity  (IEA)
histone H4K16 acetyltransferase activity  (IEA)
histone H4K5 acetyltransferase activity  (IEA)
histone H4K8 acetyltransferase activity  (IEA)
molecular adaptor activity  (EXP)
MRF binding  (ISO,ISS)
p53 binding  (ISO)
peptide lactyltransferase (CoA-dependent) activity  (ISO,ISS)
peroxisome proliferator activated receptor binding  (ISO)
protein binding  (IPI,ISO)
protein domain specific binding  (IPI)
protein-containing complex binding  (ISO)
protein-lysine-acetyltransferase activity  (ISO,TAS)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI,ISO)
SMAD binding  (ISO)
TFIIB-class transcription factor binding  (IPI)
transcription coactivator activity  (IBA,IDA,ISO,ISS,TAS)
transcription coactivator binding  (ISO)
transcription corepressor activity  (ISO)
zinc ion binding  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal lung interstitium morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal occipital bone morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular endothelial cell development  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal vertebrae morphology  (IAGP)
absent organized vascular network  (IAGP)
absent pre-B cells  (IAGP)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
atrial septal defect  (IAGP)
broad nasal bridge  (IAGP)
cardiovascular system phenotype  (IAGP)
cleft secondary palate  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased angiogenesis  (IAGP)
decreased anxiety-related response  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucagon level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased fat cell size  (IAGP)
decreased grip strength  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased triglyceride level  (IAGP)
decreased vascular endothelial cell number  (IAGP)
decreased vertical activity  (IAGP)
decreased white adipose tissue amount  (IAGP)
delayed bone ossification  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged spleen  (IAGP)
exencephaly  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of vascular branching  (IAGP)
flattened snout  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired hematopoiesis  (IAGP)
impaired long-term object recognition memory  (IAGP)
improved glucose tolerance  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased bone marrow cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased granulocyte number  (IAGP)
increased grooming behavior  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased insulin sensitivity  (IAGP)
increased leukemia incidence  (IAGP)
increased liver glycogen level  (IAGP)
increased locomotor activity  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased oxygen consumption  (IAGP)
increased post-tetanic potentiation  (IAGP)
increased response to leptin  (IAGP)
increased stereotypic behavior  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased vertical activity  (IAGP)
insulin resistance  (IAGP)
intracranial hemorrhage  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
maxilla hypoplasia  (IAGP)
nasal bone hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
open neural tube  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
scoliosis  (IAGP)
seizures  (IAGP)
short maxilla  (IAGP)
short nasal bone  (IAGP)
short premaxilla  (IAGP)
short snout  (IAGP)
small lung  (IAGP)
small thymus  (IAGP)
split xiphoid process  (IAGP)
supernumerary teeth  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
wide frontal bone  (IAGP)
xiphoid process foramen  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Aizawa H, etal., Science 2004 Jan 9;303(5655):197-202.
2. FISH studies in 45 patients with Rubinstein-Taybi syndrome: deletions associated with polysplenia, hypoplastic left heart and death in infancy. Bartsch O, etal., Eur J Hum Genet. 1999 Oct-Nov;7(7):748-56.
3. DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Bartsch O, etal., Hum Genet. 2005 Sep;117(5):485-93. Epub 2005 Jul 14.
4. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
5. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Caccamo A, etal., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22687-92. doi: 10.1073/pnas.1012851108. Epub 2010 Dec 13.
6. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
7. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
8. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
9. Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. Giampa C, etal., Eur J Neurosci. 2009 Mar;29(5):902-10. doi: 10.1111/j.1460-9568.2009.06649.x.
10. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. Gordon MD and Nusse R, J Biol Chem. 2006 Aug 11;281(32):22429-33. Epub 2006 Jun 22.
11. The nucleolus-guardian of cellular homeostasis and genome integrity. Grummt I Chromosoma. 2013 Dec;122(6):487-97.
12. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. Gusterson RJ, etal., J Biol Chem 2003 Feb 28;278(9):6838-47. Epub 2002 Dec 10.
13. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
14. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
15. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
16. Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. Klevytska AM, etal., J Neuropathol Exp Neurol. 2010 Apr;69(4):396-404. doi: 10.1097/NEN.0b013e3181d6c436.
17. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
18. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Kung AL, etal., Genes Dev 2000 Feb 1;14(3):272-7.
19. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
20. Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. Ma QL, etal., J Neurochem. 2007 Nov;103(4):1594-607. Epub 2007 Aug 30.
21. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Malinowska-Ozdowy K, etal., Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.
22. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
23. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Nucifora FC, etal., Science. 2001 Mar 23;291(5512):2423-8.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13). Panagopoulos I, etal., Genes Chromosomes Cancer 2003 Jan;36(1):90-8.
29. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
36. CREB-binding protein (CREBBP) and preeclampsia: a new promising target gene. Sadeghi H, etal., Mol Biol Rep. 2021 Mar;48(3):2117-2122. doi: 10.1007/s11033-021-06215-1. Epub 2021 Feb 24.
37. The bromodomain: From epigenome reader to druggable target. Sanchez R, etal., Biochim Biophys Acta. 2014 Aug;1839(8):676-685. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28.
38. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
39. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
40. MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats. Yang J, etal., Mol Biol Rep. 2014 Jan;41(1):555-61. doi: 10.1007/s11033-013-2891-x. Epub 2013 Dec 12.
41. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Yao TP, etal., Cell 1998 May 1;93(3):361-72.
42. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Zhang H, etal., Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.
Additional References at PubMed
PMID:3410843   PMID:7606928   PMID:7913207   PMID:8413673   PMID:8552098   PMID:8616895   PMID:9192892   PMID:9194565   PMID:9223672   PMID:9294190   PMID:9413984   PMID:9556555  
PMID:9659901   PMID:9742083   PMID:9858769   PMID:9949198   PMID:9973256   PMID:10050886   PMID:10075717   PMID:10215616   PMID:10216070   PMID:10349636   PMID:10610021   PMID:10610177  
PMID:10722728   PMID:10733899   PMID:10748221   PMID:10823891   PMID:10906457   PMID:10922068   PMID:11042159   PMID:11076796   PMID:11076861   PMID:11106745   PMID:11115394   PMID:11217851  
PMID:11438528   PMID:11471062   PMID:11564891   PMID:11583620   PMID:11689662   PMID:11701890   PMID:11799127   PMID:11818964   PMID:11823864   PMID:11850820   PMID:11864601   PMID:11864910  
PMID:11867645   PMID:11884404   PMID:11931765   PMID:11943779   PMID:11959977   PMID:11963968   PMID:12015147   PMID:12165570   PMID:12372411   PMID:12384703   PMID:12397173   PMID:12407098  
PMID:12408825   PMID:12464179   PMID:12466851   PMID:12477932   PMID:12496368   PMID:12504852   PMID:12520002   PMID:12527917   PMID:12586840   PMID:12617806   PMID:12770687   PMID:12789342  
PMID:12840167   PMID:12857787   PMID:12930888   PMID:14517255   PMID:14517256   PMID:14519686   PMID:14560007   PMID:14594809   PMID:14610273   PMID:14612417   PMID:14648603   PMID:14722092  
PMID:14742445   PMID:14759370   PMID:14980219   PMID:14998493   PMID:15019774   PMID:15143155   PMID:15146178   PMID:15150259   PMID:15161102   PMID:15187136   PMID:15207239   PMID:15304484  
PMID:15308626   PMID:15340071   PMID:15452871   PMID:15464984   PMID:15507449   PMID:15509593   PMID:15542861   PMID:15550512   PMID:15572674   PMID:15572696   PMID:15607978   PMID:15618518  
PMID:15641773   PMID:15647252   PMID:15681609   PMID:15735738   PMID:15741177   PMID:15750622   PMID:15752756   PMID:15832170   PMID:15860545   PMID:16012757   PMID:16026544   PMID:16098148  
PMID:16141072   PMID:16141073   PMID:16145670   PMID:16166631   PMID:16204234   PMID:16237459   PMID:16253272   PMID:16332960   PMID:16380431   PMID:16424387   PMID:16427017   PMID:16428436  
PMID:16452649   PMID:16540468   PMID:16596650   PMID:16606840   PMID:16611827   PMID:16678094   PMID:16704373   PMID:16707491   PMID:16766198   PMID:16768624   PMID:16785536   PMID:16799563  
PMID:16801560   PMID:16817232   PMID:16908541   PMID:16920712   PMID:16969114   PMID:16980541   PMID:17043108   PMID:17053159   PMID:17054391   PMID:17177285   PMID:17332504   PMID:17372190  
PMID:17467007   PMID:17525731   PMID:17543037   PMID:17599912   PMID:17656371   PMID:17707229   PMID:17923090   PMID:17936260   PMID:17967808   PMID:18022353   PMID:18241125   PMID:18246306  
PMID:18263767   PMID:18287559   PMID:18295234   PMID:18319327   PMID:18329113   PMID:18330926   PMID:18458062   PMID:18469200   PMID:18485870   PMID:18509338   PMID:18519545   PMID:18544709  
PMID:18552833   PMID:19057620   PMID:19100722   PMID:19220000   PMID:19252086   PMID:19272189   PMID:19357310   PMID:19416967   PMID:19433445   PMID:19450513   PMID:19470462   PMID:19524524  
PMID:19598128   PMID:19651603   PMID:19729597   PMID:19738286   PMID:19786557   PMID:19822209   PMID:19822904   PMID:19922678   PMID:19924292   PMID:20152182   PMID:20211142   PMID:20466049  
PMID:20508149   PMID:20516639   PMID:20534573   PMID:20616042   PMID:20660310   PMID:20859256   PMID:20881124   PMID:20930143   PMID:20961098   PMID:20969867   PMID:21072211   PMID:21098220  
PMID:21140220   PMID:21164521   PMID:21224411   PMID:21228185   PMID:21267068   PMID:21289174   PMID:21390126   PMID:21402781   PMID:21451036   PMID:21459086   PMID:21508930   PMID:21549327  
PMID:21555743   PMID:21558372   PMID:21751375   PMID:21766169   PMID:21774670   PMID:21803292   PMID:21847097   PMID:21873635   PMID:21901164   PMID:22006020   PMID:22049069   PMID:22114264  
PMID:22116937   PMID:22179676   PMID:22198154   PMID:22207202   PMID:22292123   PMID:22364282   PMID:22387215   PMID:22431394   PMID:22467641   PMID:22508984   PMID:22523253   PMID:22649236  
PMID:22658979   PMID:22770240   PMID:22780989   PMID:22807441   PMID:22815486   PMID:22884877   PMID:22890843   PMID:22977234   PMID:22982455   PMID:22988430   PMID:23235480   PMID:23273993  
PMID:23308088   PMID:23321477   PMID:23373423   PMID:23441852   PMID:23532979   PMID:23768074   PMID:23783631   PMID:23831576   PMID:23868976   PMID:23922782   PMID:24019758   PMID:24038357  
PMID:24089570   PMID:24247009   PMID:24265455   PMID:24340053   PMID:24491799   PMID:24522976   PMID:24586743   PMID:24639469   PMID:24648406   PMID:24748101   PMID:24753318   PMID:24792116  
PMID:24825348   PMID:24853677   PMID:24878634   PMID:24880616   PMID:24946904   PMID:24952961   PMID:25071087   PMID:25154413   PMID:25314079   PMID:25500291   PMID:25706271   PMID:25885346  
PMID:25888034   PMID:25941038   PMID:25961797   PMID:26113042   PMID:26164627   PMID:26180185   PMID:26258652   PMID:26496610   PMID:26633036   PMID:26708506   PMID:26730956   PMID:26755589  
PMID:26870802   PMID:26921097   PMID:26976603   PMID:27311442   PMID:27427906   PMID:27477692   PMID:27618724   PMID:27667451   PMID:27721240   PMID:27832201   PMID:27881875   PMID:27999180  
PMID:28069569   PMID:28086087   PMID:28288979   PMID:28291835   PMID:28398509   PMID:28562591   PMID:28611184   PMID:28630323   PMID:28675294   PMID:28752224   PMID:28825697   PMID:28831000  
PMID:29145650   PMID:29173896   PMID:29184203   PMID:29217654   PMID:29551561   PMID:29967375   PMID:30181244   PMID:30186101   PMID:30334186   PMID:30526058   PMID:30573679   PMID:30850733  
PMID:30888860   PMID:30953353   PMID:30971452   PMID:30980515   PMID:31091449   PMID:31138536   PMID:31286141   PMID:31499338   PMID:31519498   PMID:31570593   PMID:31600191   PMID:31806049  
PMID:31898871   PMID:31899788   PMID:32267917   PMID:32325033   PMID:32444594   PMID:32576962   PMID:32690000   PMID:32877653   PMID:32968282   PMID:33022214   PMID:33121486   PMID:33603756  
PMID:33718883   PMID:33765415   PMID:34023501   PMID:34101965   PMID:34161765   PMID:34321999   PMID:34424532   PMID:34463256   PMID:34637754   PMID:34813504   PMID:34905914   PMID:35017472  
PMID:35339471   PMID:35502657   PMID:35855613   PMID:36109165   PMID:36215692   PMID:36385105   PMID:36403758   PMID:36629882   PMID:37770430   PMID:37850815   PMID:38570506   PMID:39140972  


Genomics

Comparative Map Data
Crebbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,899,198 - 4,031,864 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,899,192 - 4,031,861 (-)EnsemblGRCm39 Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,081,328 - 4,213,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBIMGSCv36mm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.4NCBI
CREBBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,725,054 - 3,880,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,725,054 - 3,880,713 (-)EnsemblGRCh38hg38GRCh38
GRCh37163,775,055 - 3,930,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,715,056 - 3,870,122 (-)NCBINCBI36Build 36hg18NCBI36
Build 34163,716,569 - 3,870,712NCBI
Celera163,981,749 - 4,136,789 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,743,994 - 3,898,607 (-)NCBIHuRef
CHM1_1163,775,055 - 3,930,225 (-)NCBICHM1_1
T2T-CHM13v2.0163,752,324 - 3,907,918 (-)NCBIT2T-CHM13v2.0
Crebbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,842,307 - 11,968,266 (+)NCBIGRCr8
mRatBN7.21011,335,551 - 11,461,888 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,335,953 - 11,461,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,043,424 - 16,169,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,532,272 - 15,658,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,201,637 - 11,327,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,590,994 - 11,721,039 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,595,044 - 11,721,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,349,914 - 10,475,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,598,680 - 11,724,122 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,598,679 - 11,724,107 (+)NCBI
Celera1010,292,190 - 10,418,453 (+)NCBICelera
Cytogenetic Map10q12NCBI
Crebbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544213,559,496 - 13,692,004 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544213,559,496 - 13,691,913 (+)NCBIChiLan1.0ChiLan1.0
CREBBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,251,350 - 4,405,330 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,033,402 - 8,189,001 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,645,445 - 2,800,975 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,820,507 - 3,974,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,820,519 - 3,974,206 (-)Ensemblpanpan1.1panPan2
CREBBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,410,201 - 37,536,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,409,930 - 37,534,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,739,122 - 38,865,694 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,623,705 - 37,751,833 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,649,589 - 37,750,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,408,543 - 37,535,100 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,301,774 - 37,428,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,712,371 - 37,838,937 (+)NCBIUU_Cfam_GSD_1.0
Crebbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,046,214 - 106,180,473 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694553,753 - 663,617 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936694552,447 - 663,237 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREBBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,388,547 - 38,530,224 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,388,366 - 38,530,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2339,768,553 - 39,798,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREBBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,415,548 - 3,570,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,415,412 - 3,540,943 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606827,238,466 - 27,395,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crebbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,517,966 - 1,655,329 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,516,481 - 1,655,364 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crebbp
3276 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSMUST00000023165
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse

Markers in Region
AW558298  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38164,081,696 - 4,081,783UniSTSGRCm38
MGSCv37164,081,696 - 4,081,783UniSTSGRCm37
Celera164,714,013 - 4,714,100UniSTS
Cytogenetic Map16A1UniSTS
Whitehead/MRC_RH1610.87UniSTS
RH137561  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38164,091,795 - 4,091,958UniSTSGRCm38
MGSCv37164,091,795 - 4,091,958UniSTSGRCm37
Celera164,724,113 - 4,724,276UniSTS
Cytogenetic Map16A1UniSTS
Crebbp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A1UniSTS
cM Map16 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY079443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY079444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU705617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01026247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S66385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000023165   ⟹   ENSMUSP00000023165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,899,192 - 4,031,861 (-)Ensembl
GRCm38.p6 Ensembl164,081,328 - 4,213,997 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191387
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,904,474 - 3,907,607 (-)Ensembl
GRCm38.p6 Ensembl164,086,610 - 4,089,743 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205344   ⟹   ENSMUSP00000146029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,909,703 - 3,946,485 (-)Ensembl
GRCm38.p6 Ensembl164,091,839 - 4,128,621 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205685   ⟹   ENSMUSP00000146076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,936,897 - 3,944,466 (-)Ensembl
GRCm38.p6 Ensembl164,119,033 - 4,126,602 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205765   ⟹   ENSMUSP00000146330
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,901,565 - 4,031,277 (-)Ensembl
GRCm38.p6 Ensembl164,083,701 - 4,213,413 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,905,665 - 3,906,459 (-)Ensembl
GRCm38.p6 Ensembl164,087,801 - 4,088,595 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206098   ⟹   ENSMUSP00000145825
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,910,054 - 3,913,990 (-)Ensembl
GRCm38.p6 Ensembl164,092,190 - 4,096,126 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206464   ⟹   ENSMUSP00000145798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl163,906,244 - 3,912,508 (-)Ensembl
GRCm38.p6 Ensembl164,088,380 - 4,094,644 (-)Ensembl
RefSeq Acc Id: NM_001025432   ⟹   NP_001020603
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39163,901,912 - 4,031,268 (-)NCBI
GRCm38164,084,048 - 4,213,404 (-)NCBI
MGSCv37164,084,048 - 4,213,404 (-)RGD
Celera164,716,365 - 4,845,799 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521751   ⟹   XP_006521814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39163,899,198 - 4,031,864 (-)NCBI
GRCm38164,081,334 - 4,213,450 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521752   ⟹   XP_006521815
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39163,899,198 - 4,031,863 (-)NCBI
GRCm38164,081,334 - 4,213,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521753   ⟹   XP_006521816
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39163,899,198 - 4,031,864 (-)NCBI
GRCm38164,081,334 - 4,213,957 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521754   ⟹   XP_006521817
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39163,899,198 - 4,031,864 (-)NCBI
GRCm38164,081,334 - 4,213,957 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001020603   ⟸   NM_001025432
- UniProtKB: P45481 (UniProtKB/Swiss-Prot),   E9QPH4 (UniProtKB/Swiss-Prot),   F8VPR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521817   ⟸   XM_006521754
- Peptide Label: isoform X4
- UniProtKB: P45481 (UniProtKB/Swiss-Prot),   E9QPH4 (UniProtKB/Swiss-Prot),   A0A0U1RQB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521816   ⟸   XM_006521753
- Peptide Label: isoform X3
- UniProtKB: P45481 (UniProtKB/Swiss-Prot),   E9QPH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521815   ⟸   XM_006521752
- Peptide Label: isoform X2
- UniProtKB: P45481 (UniProtKB/Swiss-Prot),   E9QPH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521814   ⟸   XM_006521751
- Peptide Label: isoform X1
- UniProtKB: P45481 (UniProtKB/Swiss-Prot),   E9QPH4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000145825   ⟸   ENSMUST00000206098
Ensembl Acc Id: ENSMUSP00000145798   ⟸   ENSMUST00000206464
Ensembl Acc Id: ENSMUSP00000146330   ⟸   ENSMUST00000205765
Ensembl Acc Id: ENSMUSP00000146029   ⟸   ENSMUST00000205344
Ensembl Acc Id: ENSMUSP00000146076   ⟸   ENSMUST00000205685
Ensembl Acc Id: ENSMUSP00000023165   ⟸   ENSMUST00000023165
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45481-F1-model_v2 AlphaFold P45481 1-2441 view protein structure

Promoters
RGD ID:6826937
Promoter ID:MM_KWN:19958
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:UC007XZM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36164,119,956 - 4,120,692 (-)MPROMDB
RGD ID:6826936
Promoter ID:MM_KWN:19959
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4
Transcripts:ENSMUST00000080297,   NM_001025432
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36164,213,106 - 4,214,357 (-)MPROMDB
RGD ID:8685320
Promoter ID:EPDNEW_M20691
Type:multiple initiation site
Name:Crebbp_1
Description:Mus musculus CREB binding protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38164,213,374 - 4,213,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098280 AgrOrtholog
Ensembl Genes ENSMUSG00000022521 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000023165 ENTREZGENE
  ENSMUST00000205765 ENTREZGENE
Gene3D-CATH 1.10.1630.10 UniProtKB/Swiss-Prot
  1.10.246.20 UniProtKB/Swiss-Prot
  1.20.1020.10 UniProtKB/Swiss-Prot
  1.20.920.10 UniProtKB/Swiss-Prot
  2.10.110.40 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.30.60.90 UniProtKB/Swiss-Prot
InterPro Bromodomain UniProtKB/Swiss-Prot
  Bromodomain-like_sf UniProtKB/Swiss-Prot
  Bromodomain_CS UniProtKB/Swiss-Prot
  CBP_P300_HAT UniProtKB/Swiss-Prot
  Histone_AcTrfase_Rtt109/CBP UniProtKB/Swiss-Prot
  KIX_dom UniProtKB/Swiss-Prot
  KIX_dom_sf UniProtKB/Swiss-Prot
  Nuc_rcpt_coact UniProtKB/Swiss-Prot
  Nuc_rcpt_coact_CREBbp UniProtKB/Swiss-Prot
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/Swiss-Prot
  RING_CBP-p300 UniProtKB/Swiss-Prot
  RING_CBP-p300_sf UniProtKB/Swiss-Prot
  TAZ_dom_sf UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_TAZ UniProtKB/Swiss-Prot
  Znf_ZZ UniProtKB/Swiss-Prot
  Znf_ZZ_sf UniProtKB/Swiss-Prot
MGD MGI:1098280 ENTREZGENE
NCBI Gene 12914 ENTREZGENE
PANTHER CREB-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR13808 UniProtKB/Swiss-Prot
Pfam Bromodomain UniProtKB/Swiss-Prot
  Creb_binding UniProtKB/Swiss-Prot
  DUF902 UniProtKB/Swiss-Prot
  HAT_KAT11 UniProtKB/Swiss-Prot
  KIX UniProtKB/Swiss-Prot
  PF00569 UniProtKB/Swiss-Prot
  zf-TAZ UniProtKB/Swiss-Prot
PharmGKB CREBBP RGD
PhenoGen Crebbp PhenoGen
PRINTS BROMODOMAIN UniProtKB/Swiss-Prot
PROSITE BROMODOMAIN_1 UniProtKB/Swiss-Prot
  BROMODOMAIN_2 UniProtKB/Swiss-Prot
  CBP_P300_HAT UniProtKB/Swiss-Prot
  KIX UniProtKB/Swiss-Prot
  ZF_TAZ UniProtKB/Swiss-Prot
  ZF_ZZ_1 UniProtKB/Swiss-Prot
  ZF_ZZ_2 UniProtKB/Swiss-Prot
SMART BROMO UniProtKB/Swiss-Prot
  KAT11 UniProtKB/Swiss-Prot
  ZnF_TAZ UniProtKB/Swiss-Prot
  ZnF_ZZ UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF47040 UniProtKB/Swiss-Prot
  SSF47370 UniProtKB/Swiss-Prot
  SSF57933 UniProtKB/Swiss-Prot
  SSF69125 UniProtKB/Swiss-Prot
UniProt A0A0U1RP23_MOUSE UniProtKB/TrEMBL
  A0A0U1RP46_MOUSE UniProtKB/TrEMBL
  A0A0U1RPL2_MOUSE UniProtKB/TrEMBL
  A0A0U1RPQ3_MOUSE UniProtKB/TrEMBL
  A0A0U1RQB6 ENTREZGENE, UniProtKB/TrEMBL
  CBP_MOUSE UniProtKB/Swiss-Prot
  E9QPH4 ENTREZGENE
  F8VPR5 ENTREZGENE, UniProtKB/TrEMBL
  P45481 ENTREZGENE
  Q3V351_MOUSE UniProtKB/TrEMBL
  Q6GQV9_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QPH4 UniProtKB/Swiss-Prot