RGD Reference Report - Physical and functional HAT/HDAC interplay regulates protein acetylation balance. - Rat Genome Database

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Physical and functional HAT/HDAC interplay regulates protein acetylation balance.

Authors: Peserico, A  Simone, C 
Citation: Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
RGD ID: 9104959
Pubmed: PMID:21151613   (View Abstract at PubMed)
PMCID: PMC2997516   (View Article at PubMed Central)
DOI: DOI:10.1155/2011/371832   (Journal Full-text)

The balance between protein acetylation and deacetylation controls several physiological and pathological cellular processes, and the enzymes involved in the maintenance of this equilibrium-acetyltransferases (HATs) and deacetylases (HDACs)-have been widely studied. Presently, the evidences obtained in this field suggest that the dynamic acetylation equilibrium is mostly maintained through the physical and functional interplay between HAT and HDAC activities. This model overcomes the classical vision in which the epigenetic marks of acetylation have only an activating function whereas deacetylation marks have a repressing activity. Given the existence of several players involved in the preservation of this equilibrium, the identification of these complex networks of interacting proteins will likely foster our understanding of how cells regulate intracellular processes and respond to the extracellular environment and will offer the rationale for new therapeutic approaches based on epigenetic drugs in human diseases.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
histone modification pathway   TAS 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959; 9104959 RGD 
histone modification pathway   ISOCREBBP (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOEP300 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHAT1 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC1 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC10 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC11 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC2 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOClpb (Mus musculus)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC4 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC5 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC6 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC7 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOHDAC8 (Homo sapiens)9104959 RGD 
histone modification pathway   ISOHDAC9 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT2A (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT2B (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT5 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT6A (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT6B (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT7 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOKAT8 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT1 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT2 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT3 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT4 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT5 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT6 (Homo sapiens)9104959; 9104959 RGD 
histone modification pathway   ISOSIRT7 (Homo sapiens)9104959; 9104959 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Crebbp  (CREB binding protein)
Ep300  (E1A binding protein p300)
Hat1  (histone acetyltransferase 1)
Hdac1  (histone deacetylase 1)
Hdac10  (histone deacetylase 10)
Hdac11  (histone deacetylase 11)
Hdac2  (histone deacetylase 2)
Hdac3  (histone deacetylase 3)
Hdac4  (histone deacetylase 4)
Hdac5  (histone deacetylase 5)
Hdac6  (histone deacetylase 6)
Hdac7  (histone deacetylase 7)
Hdac9  (histone deacetylase 9)
Kat2a  (lysine acetyltransferase 2A)
Kat2b  (lysine acetyltransferase 2B)
Kat5  (lysine acetyltransferase 5)
Kat6a  (lysine acetyltransferase 6A)
Kat6b  (lysine acetyltransferase 6B)
Kat7  (lysine acetyltransferase 7)
Kat8  (lysine acetyltransferase 8)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)
Sirt3  (sirtuin 3)
Sirt4  (sirtuin 4)
Sirt5  (sirtuin 5)
Sirt6  (sirtuin 6)
Sirt7  (sirtuin 7)

Genes (Mus musculus)
Crebbp  (CREB binding protein)
Ep300  (E1A binding protein p300)
Hat1  (histone aminotransferase 1)
Hdac1  (histone deacetylase 1)
Hdac10  (histone deacetylase 10)
Hdac11  (histone deacetylase 11)
Hdac2  (histone deacetylase 2)
Hdac3  (histone deacetylase 3)
Hdac4  (histone deacetylase 4)
Hdac5  (histone deacetylase 5)
Hdac6  (histone deacetylase 6)
Hdac7  (histone deacetylase 7)
Hdac8  (histone deacetylase 8)
Hdac9  (histone deacetylase 9)
Kat2a  (K(lysine) acetyltransferase 2A)
Kat2b  (K(lysine) acetyltransferase 2B)
Kat5  (K(lysine) acetyltransferase 5)
Kat6a  (K(lysine) acetyltransferase 6A)
Kat6b  (K(lysine) acetyltransferase 6B)
Kat7  (K(lysine) acetyltransferase 7)
Kat8  (K(lysine) acetyltransferase 8)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)
Sirt3  (sirtuin 3)
Sirt4  (sirtuin 4)
Sirt5  (sirtuin 5)
Sirt6  (sirtuin 6)
Sirt7  (sirtuin 7)

Genes (Homo sapiens)
CREBBP  (CREB binding protein)
EP300  (E1A binding protein p300)
HAT1  (histone acetyltransferase 1)
HDAC1  (histone deacetylase 1)
HDAC10  (histone deacetylase 10)
HDAC11  (histone deacetylase 11)
HDAC2  (histone deacetylase 2)
HDAC3  (histone deacetylase 3)
HDAC4  (histone deacetylase 4)
HDAC5  (histone deacetylase 5)
HDAC6  (histone deacetylase 6)
HDAC7  (histone deacetylase 7)
HDAC8  (histone deacetylase 8)
HDAC9  (histone deacetylase 9)
KAT2A  (lysine acetyltransferase 2A)
KAT2B  (lysine acetyltransferase 2B)
KAT5  (lysine acetyltransferase 5)
KAT6A  (lysine acetyltransferase 6A)
KAT6B  (lysine acetyltransferase 6B)
KAT7  (lysine acetyltransferase 7)
KAT8  (lysine acetyltransferase 8)
SIRT1  (sirtuin 1)
SIRT2  (sirtuin 2)
SIRT3  (sirtuin 3)
SIRT4  (sirtuin 4)
SIRT5  (sirtuin 5)
SIRT6  (sirtuin 6)
SIRT7  (sirtuin 7)


Additional Information