RGD Reference Report - Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. - Rat Genome Database

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Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.

Authors: Chmelar, R  Buchanan, G  Need, EF  Tilley, W  Greenberg, NM 
Citation: Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
RGD ID: 2326123
Pubmed: PMID:17163421   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.22365   (Journal Full-text)

The androgen receptor signaling axis plays an essential role in the development, function and homeostasis of male urogenital structures including the prostate gland although the mechanism by which the AR axis contributes to the initiation, progression and metastatic spread of prostate cancer remains somewhat enigmatic. A number of molecular events have been proposed to act at the level of the AR and associated coregulators to influence the natural history of prostate cancer including deregulated expression, somatic mutation, and post-translational modification. The purpose of this article is to review the evidence for deregulated expression and function of the AR and associated coactivators and corepressors and how such events might contribute to the progression of prostate cancer by controlling the selection and expression of AR targets.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CARM1Humanandrogen signaling pathway   TAS  RGD 
CREBBPHumanandrogen signaling pathway   TAS  RGD 
Carm1Ratandrogen signaling pathway   ISOCARM1 (Homo sapiens) RGD 
Carm1Mouseandrogen signaling pathway   ISOCARM1 (Homo sapiens) RGD 
CrebbpRatandrogen signaling pathway   ISOCREBBP (Homo sapiens) RGD 
CrebbpMouseandrogen signaling pathway   ISOCREBBP (Homo sapiens) RGD 
EP300Humanandrogen signaling pathway   TAS  RGD 
Ep300Ratandrogen signaling pathway   ISOEP300 (Homo sapiens) RGD 
Ep300Mouseandrogen signaling pathway   ISOEP300 (Homo sapiens) RGD 
NCOA1Humanandrogen signaling pathway   TAS  RGD 
NCOA2Humanandrogen signaling pathway   TAS  RGD 
NCOA3Humanandrogen signaling pathway   TAS  RGD 
NCOR1Humanandrogen signaling pathway   TAS  RGD 
NCOR2Humanandrogen signaling pathway   TAS  RGD 
Ncoa1Ratandrogen signaling pathway   ISONCOA1 (Homo sapiens) RGD 
Ncoa1Mouseandrogen signaling pathway   ISONCOA1 (Homo sapiens) RGD 
Ncoa2Ratandrogen signaling pathway   ISONCOA2 (Homo sapiens) RGD 
Ncoa2Mouseandrogen signaling pathway   ISONCOA2 (Homo sapiens) RGD 
Ncoa3Ratandrogen signaling pathway   ISONCOA3 (Homo sapiens) RGD 
Ncoa3Mouseandrogen signaling pathway   ISONCOA3 (Homo sapiens) RGD 
Ncor1Ratandrogen signaling pathway   ISONCOR1 (Homo sapiens) RGD 
Ncor1Mouseandrogen signaling pathway   ISONCOR1 (Homo sapiens) RGD 
Ncor2Ratandrogen signaling pathway   ISONCOR2 (Homo sapiens) RGD 
Ncor2Mouseandrogen signaling pathway   ISONCOR2 (Homo sapiens) RGD 
PRMT1Humanandrogen signaling pathway   TAS  RGD 
Prmt1Ratandrogen signaling pathway   ISOPRMT1 (Homo sapiens) RGD 
Prmt1Mouseandrogen signaling pathway   ISOPRMT1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Carm1  (coactivator-associated arginine methyltransferase 1)
Crebbp  (CREB binding protein)
Ep300  (E1A binding protein p300)
Ncoa1  (nuclear receptor coactivator 1)
Ncoa2  (nuclear receptor coactivator 2)
Ncoa3  (nuclear receptor coactivator 3)
Ncor1  (nuclear receptor co-repressor 1)
Ncor2  (nuclear receptor co-repressor 2)
Prmt1  (protein arginine methyltransferase 1)

Genes (Mus musculus)
Carm1  (coactivator-associated arginine methyltransferase 1)
Crebbp  (CREB binding protein)
Ep300  (E1A binding protein p300)
Ncoa1  (nuclear receptor coactivator 1)
Ncoa2  (nuclear receptor coactivator 2)
Ncoa3  (nuclear receptor coactivator 3)
Ncor1  (nuclear receptor co-repressor 1)
Ncor2  (nuclear receptor co-repressor 2)
Prmt1  (protein arginine N-methyltransferase 1)

Genes (Homo sapiens)
CARM1  (coactivator associated arginine methyltransferase 1)
CREBBP  (CREB binding protein)
EP300  (E1A binding protein p300)
NCOA1  (nuclear receptor coactivator 1)
NCOA2  (nuclear receptor coactivator 2)
NCOA3  (nuclear receptor coactivator 3)
NCOR1  (nuclear receptor corepressor 1)
NCOR2  (nuclear receptor corepressor 2)
PRMT1  (protein arginine methyltransferase 1)


Additional Information