HUNTINGTON DISEASE PATHWAY (PW:0000017)

View Ontology Report

Description

Huntington disease (HD) is an autosomal dominant neurodegenerative condition manifested in movement, cognitive and psychiatric symptoms. HD is associated with the abnormal expansion of a trinucleotide (CAG) repeat in the huntingtin (HTT) gene translating into an expanded stretch of glutamine residues (polyQ), conferring aberrant conformational propensities. Between 9 to 35 repeats are normally found in the wild-type protein/non-HD population. Mutant HTT proteins (mHTT) have over 36 repeats; havi

Pathway Diagram:

Elsevier Inc. potential HD lncRNA ---> Huntington Disease QUIN ---> Huntington Disease potential HD lncRNA upregulated miRNA upregulated miRNA ---> downregulated target translation downregulated target translation downregulated miRNA ---> upregulated target translation downregulated miRNA upregulated target translation potential HD miRNA ex-Grin2b loss of projecting cortical neurons potential HD miRNA ---> Huntington Disease loss of striatal SPNs Huntington Disease QUIN Grin2b D2 SPNs D1 SPNs brain-derived neurotrophic factor signaling pathway Dnm1l KYNA 3-HANA 3-HK kynurenine metabolic pathway microglia astrocyte neuroinflammatory responses --+> microglia HTT interacting proteins shorter, toxic fragments cell homeostasis transcription vesicular trafficking Rest ---| BDNF transcription Rest Htt ---> cell homeostasis Rasd2 interacting proteins Htt DNA modification pathway dorsal striatal SPNs neurons mHtt Casp6 1-586 fragment NMDAR-mediated excitotoxicity Ntrk2 mHtt ---- Rasd2 neuroinflammatory responses polyQ RNA polymerase II transcription pathway histone modification pathway electron transport chain pathway autophagy pathway Htt ---> transcription Htt ---> mitochondria function Htt ---> vesicular trafficking mHtt ---| BDNF transcription Bdnf BDNF transcription Bdnf ---- Ntrk2 BDNF transport aa1-17 mitochondria function Casp6 ---> PRD mitochondria dynamics pathway mHtt ---| Rasd2 Rasd2 ---- Rasd2 interacting proteins brain-derived neurotrophic factor signaling pathway ---> D1 SPNs Rasd2 brain-derived neurotrophic factor signaling pathway --+> D2 SPNs mHtt ---| electron transport chain pathway mHtt ---| autophagy pathway Crebbp brain-derived neurotrophic factor signaling pathway ---> dorsal striatal SPNs neurons mHtt ---| mitochondria dynamics pathway Htt ---- HTT interacting proteins HTT interacting proteins ---- mHtt Rasd2 ---> mHtt Htt ---| Rest mHtt ---| brain-derived neurotrophic factor signaling pathway mHtt ---| BDNF transport Htt --+> BDNF transport Crebbp ---> histone modification pathway Crebbp ---> RNA polymerase II transcription pathway Crebbp ---> DNA modification pathway mHtt ---| Crebbp Crebbp ---- mHtt Dnm1l ---- mHtt aa69-3144, HEAT repeat domains, PEST domains in disordered regions polyQ ---> Htt polyQ ---> mHtt mHtt ---> ex-Grin2b mHtt ---> Huntington Disease PRD
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Genes in Pathway:

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Huntington's disease pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 JBrowse link 1 100,896,582 100,926,443 RGD:6907045
G Ap2a2 adaptor related protein complex 2 subunit alpha 2 JBrowse link 1 214,534,217 214,607,497 RGD:6907045
G Ap2b1 adaptor related protein complex 2 subunit beta 1 JBrowse link 10 70,516,462 70,621,973 RGD:6907045
G Ap2m1 adaptor related protein complex 2 subunit mu 1 JBrowse link 11 84,041,184 84,047,542 RGD:6907045
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 JBrowse link 1 78,671,238 78,682,847 RGD:6907045
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6907045
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6907045
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6907045
G Atp5f1c ATP synthase F1 subunit gamma JBrowse link 17 72,209,321 72,231,562 RGD:6907045
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:6907045
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:6907045
G Atp5hl1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 JBrowse link 16 51,816,495 51,817,031 RGD:6907045
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:6907045
G Atp5mc2 ATP synthase membrane subunit c locus 2 JBrowse link 7 144,264,207 144,272,578 RGD:6907045
G Atp5mc3 ATP synthase membrane subunit c locus 3 JBrowse link 3 60,811,218 60,813,903 RGD:6907045
G Atp5pb ATP synthase peripheral stalk-membrane subunit b JBrowse link 2 208,566,385 208,577,147 RGD:6907045
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:6907045
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:6907045
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6907045
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Clta clathrin, light chain A JBrowse link 5 59,490,689 59,509,139 RGD:6907045
G Cltb clathrin, light chain B JBrowse link 17 10,537,348 10,554,999 RGD:6907045
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:6907045
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6907045
G Cox4i2 cytochrome c oxidase subunit 4i2 JBrowse link 3 148,234,546 148,245,424 RGD:6907045
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 8 62,298,358 62,309,765 RGD:6907045
G Cox5b cytochrome c oxidase subunit 5B JBrowse link 9 43,259,706 43,262,039 RGD:6907045
G Cox6a1 cytochrome c oxidase subunit 6A1 JBrowse link 12 47,024,442 47,027,495 RGD:6907045
G Cox6a2 cytochrome c oxidase subunit 6A2 JBrowse link 1 199,624,037 199,626,255 RGD:6907045
G Cox6b1 cytochrome c oxidase subunit 6B1 JBrowse link 1 89,075,987 89,084,834 RGD:6907045
G Cox6b2 cytochrome c oxidase subunit 6B2 JBrowse link 1 72,661,099 72,662,436 RGD:6907045
G Cox6c cytochrome c oxidase subunit 6C JBrowse link 7 74,723,177 74,735,650 RGD:6907045
G Cox7a2 cytochrome c oxidase subunit 7A2 JBrowse link 8 87,209,529 87,213,627 RGD:6907045
G Cox7a2l cytochrome c oxidase subunit 7A2 like JBrowse link 6 6,695,807 6,709,790 RGD:6907045
G Cox7a2l2 cytochrome c oxidase subunit VIIa polypeptide 2-like 2 JBrowse link 14 52,661,933 52,662,375 RGD:6907045
G Cox7b cytochrome c oxidase subunit 7B JBrowse link X 77,065,427 77,071,676 RGD:6907045
G Cox7c cytochrome c oxidase subunit 7C JBrowse link 2 14,699,878 14,701,903 RGD:6907045
G Cox8a cytochrome c oxidase subunit 8A JBrowse link 1 222,466,575 222,468,896 RGD:6907045
G Cox8b cytochrome c oxidase, subunit VIIIb JBrowse link 1 213,648,787 213,650,247 RGD:6907045
G Cox8c cytochrome c oxidase subunit 8C JBrowse link 6 126,766,967 126,768,290 RGD:6907045
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6907045
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:6907045
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:6907045
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:6907045
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Cyc1 cytochrome c-1 JBrowse link 7 117,409,576 117,411,953 RGD:6907045
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:6907045
G Dctn2 dynactin subunit 2 JBrowse link 7 70,555,953 70,571,433 RGD:6907045
G Dctn4 dynactin subunit 4 JBrowse link 18 55,797,188 55,824,195 RGD:6907045
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:6907045
G Dnah1 dynein, axonemal, heavy chain 1 JBrowse link 16 7,345,131 7,407,009 RGD:6907045
G Dnah2 dynein, axonemal, heavy chain 2 JBrowse link 10 56,029,022 56,154,602 RGD:6907045
G Dnah3 dynein, axonemal, heavy chain 3 JBrowse link 1 189,708,985 189,865,431 RGD:6907045
G Dnai1 dynein, axonemal, intermediate chain 1 JBrowse link 5 57,947,796 58,017,985 RGD:6907045
G Dnai2 dynein, axonemal, intermediate chain 2 JBrowse link 10 103,266,343 103,301,521 RGD:6907045
G Dnal1 dynein, axonemal, light chain 1 JBrowse link 6 107,596,785 107,623,869 RGD:6907045
G Dnal4 dynein, axonemal, light chain 4 JBrowse link 7 120,987,438 121,000,272 RGD:6907045
G Dnali1 dynein, axonemal, light intermediate chain 1 JBrowse link 5 143,053,365 143,062,203 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6907045
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6907045
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6907045
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6907045
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:6907045
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:6907045
G Hap1 huntingtin-associated protein 1 JBrowse link 10 88,257,975 88,266,210 RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6907045
G Hdac1l histone deacetylase 1-like JBrowse link 9 84,893,145 84,894,599 RGD:6907045
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6907045
G Hip1 huntingtin interacting protein 1 JBrowse link 12 24,180,795 24,315,373 RGD:6907045
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:6907045
RGD:11062153
RGD:11062152
G Ift57 intraflagellar transport 57 JBrowse link 11 53,664,638 53,731,779 RGD:6907045
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6907045
G Mir132 microRNA 132 JBrowse link 10 62,014,995 62,015,095 RGD:11041745
G Mir22 microRNA 22 JBrowse link 10 62,299,592 62,299,686 RGD:11041745
G Mir222 microRNA 222 JBrowse link X 3,683,919 3,684,021 RGD:11041745
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 JBrowse link X 123,803,109 123,806,760 RGD:6907045
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 9 99,617,051 99,651,827 RGD:6907045
G Ndufa10l1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 JBrowse link 6 62,796,951 62,798,384 RGD:6907045
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 JBrowse link 9 10,334,104 10,338,163 RGD:6907045
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 JBrowse link 7 35,125,516 35,163,182 RGD:6907045
G Ndufa13-ps1 NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 JBrowse link 7 36,826,357 36,826,837 RGD:6907045
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 18 29,585,671 29,587,760 RGD:6907045
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 JBrowse link 1 64,172,462 64,175,174 RGD:6907045
G Ndufa4 NDUFA4, mitochondrial complex associated JBrowse link 4 38,233,680 38,240,848 RGD:6907045
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 JBrowse link 4 51,590,413 51,598,771 RGD:6907045
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 JBrowse link 7 123,583,062 123,586,919 RGD:6907045
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 JBrowse link 7 18,683,553 18,696,332 RGD:6907045
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 JBrowse link 3 15,362,888 15,379,386 RGD:6907045
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 JBrowse link 4 159,371,263 159,399,636 RGD:6907045
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 JBrowse link 1 192,044,209 192,057,644 RGD:6907045
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link 10 14,090,128 14,092,289 RGD:6907045
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 JBrowse link X 1,787,266 1,789,524 RGD:6907045
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 JBrowse link 4 67,378,188 67,385,267 RGD:6907045
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 JBrowse link 9 65,478,496 65,488,708 RGD:6907045
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 JBrowse link 11 65,960,277 65,966,899 RGD:6907045
G Ndufb4l1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1 JBrowse link 14 7,949,217 7,949,662 RGD:6907045
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 JBrowse link 2 119,139,717 119,153,753 RGD:6907045
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 JBrowse link 5 56,567,109 56,576,676 RGD:6907045
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 JBrowse link 19 24,701,067 24,705,405 RGD:6907045
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6907045
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 JBrowse link 7 98,813,062 98,819,408 RGD:6907045
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:6907045
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 9 69,919,863 69,953,182 RGD:6907045
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:6907045
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 3 79,721,686 79,728,863 RGD:6907045
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 JBrowse link 2 46,372,488 46,476,162 RGD:6907045
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 JBrowse link 5 141,390,577 141,405,507 RGD:6907045
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 2 26,471,173 26,471,587 RGD:6907045
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:6907045
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 JBrowse link 1 219,141,289 219,144,610 RGD:6907045
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 1 219,254,293 219,259,328 RGD:6907045
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 JBrowse link 9 113,875,718 113,900,169 RGD:6907045
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 JBrowse link 20 10,265,826 10,275,298 RGD:6907045
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6907045
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6907045
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6907045
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:6907045
G Polr2b RNA polymerase II subunit B JBrowse link 14 33,070,104 33,107,792 RGD:6907045
G Polr2c RNA polymerase II subunit C JBrowse link 19 10,575,060 10,581,842 RGD:6907045
G Polr2d RNA polymerase II subunit D JBrowse link 18 24,570,762 24,577,894 RGD:6907045
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:6907045
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:6907045
G Polr2g RNA polymerase II subunit G JBrowse link 1 224,991,250 224,998,355 RGD:6907045
G Polr2h RNA polymerase II subunit H JBrowse link 11 83,877,760 83,882,208 RGD:6907045
G Polr2i RNA polymerase II subunit I JBrowse link 1 88,686,812 88,688,249 RGD:6907045
G Polr2j RNA polymerase II subunit J JBrowse link 12 23,587,222 23,592,774 RGD:6907045
G Polr2l RNA polymerase II subunit L JBrowse link 1 214,451,966 214,453,974 RGD:6907045
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6907045
G Ppid peptidylprolyl isomerase D JBrowse link 2 178,354,830 178,366,843 RGD:6907045
G Ppidl1 peptidylprolyl isomerase D-like 1 JBrowse link 9 121,456,762 121,458,035 RGD:6907045
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:6907045
G RGD1559629 similar to H+ ATP synthase JBrowse link 6 69,950,129 69,951,013 RGD:6907045
G RGD1559781 similar to Dynein, axonemal, light chain 4 JBrowse link 20 23,146,842 23,148,234 RGD:6907045
G RGD1560088 similar to NADH:ubiquinone oxidoreductase B15 subunit JBrowse link 1 90,729,267 90,729,711 RGD:6907045
G RGD1565904 similar to polymerase (RNA) II (DNA directed) polypeptide H JBrowse link 18 1,410,974 1,412,769 RGD:6907045
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6907045
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6907045
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:6907045
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6907045
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:6907045
G Slc25a31 solute carrier family 25 member 31 JBrowse link 2 127,538,323 127,554,276 RGD:6907045
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:6907045
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6907045
G Slc25a6 solute carrier family 25 member 6 JBrowse link 18 70,959,872 70,961,040 RGD:6907045
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6907045
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6907045
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6907045
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:6907045
G Tbpl1 TATA-box binding protein like 1 JBrowse link 1 23,977,154 24,002,512 RGD:6907045
G Tbpl2 TATA box binding protein-like 2 JBrowse link 3 1,095,883 1,116,677 RGD:6907045
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6907045
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
G Tug1 taurine up-regulated 1 JBrowse link 14 83,878,757 83,885,791 RGD:11073597
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6907045
G Uqcrb ubiquinol-cytochrome c reductase binding protein JBrowse link 7 71,264,501 71,269,869 RGD:6907045
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 8 117,679,328 117,691,073 RGD:6907045
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 JBrowse link 1 190,555,177 190,585,741 RGD:6907045
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 JBrowse link 17 35,677,984 35,682,262 RGD:6907045
G Uqcrh ubiquinol-cytochrome c reductase hinge protein JBrowse link 5 134,919,040 134,927,235 RGD:6907045
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII JBrowse link 10 38,779,132 38,782,489 RGD:6907045
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6907045
G Vdac2 voltage-dependent anion channel 2 JBrowse link 15 2,634,622 2,648,548 RGD:6907045
G Vdac3 voltage-dependent anion channel 3 JBrowse link 16 74,292,466 74,308,910 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Molecule3-HANA3-Hydroxyanthranilic acid
Small Molecule3-HK3-Hydroxykynurenine
Small MoleculeQUINQuinolinic acid
Small MoleculeKYNAQynurenic acid

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Huntington disease pathway
Disease TermsGene Symbols
abdominal aortic aneurysmSod2
abdominal obesity-metabolic syndromePparg , Ppargc1a
acoustic neuromaBdnf
Acute Coronary SyndromeSod2
acute kidney failureAtp5f1b , Bax , Hdac2 , Pparg , Ppargc1a , Sod1 , Tp53
acute kidney tubular necrosisSod2
Acute Lung InjuryBax , Pparg
acute myeloid leukemiaCrebbp , Gpx1 , Plcb1 , Sod2 , Tp53
acute T cell leukemiaBax
adenocarcinomaCasp8 , Pparg , Sod2 , Tp53
adenoid cystic carcinomaCrebbp , Ep300 , Tp53
adenomaTp53
adrenal carcinomaTp53
Adrenal Gland NeoplasmsTp53
Adrenal InsufficiencyBax
adrenocortical carcinomaTp53
adrenoleukodystrophySod2
adult respiratory distress syndromeSod2
adult T-cell leukemiaTp53
Agenesis of Corpus CallosumNdufs1 , Sin3a
AlbuminuriaGnaq , Ppargc1a , Sod2
alcohol use disorderGrin1 , Grin2b , Hdac2
alcoholic cardiomyopathyPparg , Slc25a4
Alcoholic Fatty LiverSod1 , Sod2
alcoholic liver cirrhosisSod2
Alcoholic Liver DiseasesSod1
allergic contact dermatitisCasp8
alopeciaBdnf
alopecia areataHdac1 , Hdac2
alpha thalassemiaGpx1
Alzheimer's diseaseAtp5f1a , Atp5pf , Bax , Bdnf , Casp3 , Crebbp , Ep300 , Hdac2 , Itpr1 , Plcb1 , Pparg , Ppargc1a , Slc25a4 , Sod1 , Sod2 , Tbp , Tfam , Tp53 , Ucp1
amblyopiaPpargc1a
amnestic disorderBdnf
amphetamine abuseBdnf
amyotrophic lateral sclerosisBax , Casp3 , Casp9 , Dctn1 , Ppargc1a , Sod1 , Sod2 , Tfam , Tp53
amyotrophic lateral sclerosis type 1Crebbp , Dctn1 , Sod1 , Sod2
Anaplastic Thyroid CarcinomaSod2 , Tp53
anemiaGpx1 , Sod2
angiosarcomaTp53
Animal Disease ModelsGrin1 , Sod1 , Tfam , Tp53
AnorexiaGpx1
anti-basement membrane glomerulonephritisBax
antiphospholipid syndromePparg
anxiety disorderHdac2 , Htt
Aortic CalcificationSod1 , Sod2
aortic diseaseSod1 , Sod2
Arsenic PoisoningNdufb8 , Sod2 , Tp53
arteriosclerosisGpx1 , Ndufs6 , Pparg
asphyxia neonatorumSod1 , Sod2
asthmaBdnf , Hdac2 , Itpr1 , Sod1 , Sod2
astigmatismGrin2b
astrocytomaTp53
AtaxiaBdnf , Grin2b , Itpr1
atherosclerosisPparg , Sod1 , Sod2
atopic dermatitisBdnf , Casp8
atrial fibrillationSod1
attention deficit hyperactivity disorderBdnf , Crebbp , Grin2b , Grm1 , Grm5
Auriculo-Condylar SyndromePlcb4
Auriculocondylar Syndrome 2Plcb4
autism spectrum disorderBdnf , Dlg4 , Grin2b , Sin3a
autistic disorderBdnf , Crebbp , Dlg4 , Gpx1 , Grin2b
Autoimmune DiseasesCasp8 , Sod2
autoimmune lymphoproliferative syndromeCasp8
autoimmune lymphoproliferative syndrome type 2BCasp8
autosomal dominant mental retardation 56Cltc
autosomal dominant non-syndromic intellectual disability 6Grin2b
autosomal dominant non-syndromic intellectual disability 8Grin1
autosomal dominant polycystic kidney diseasePparg
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive spinocerebellar ataxia 13Grm1
bacterial infectious diseaseCasp3 , Casp8 , Casp9
bacterial meningitisBdnf
Balkan nephropathyTp53
Barrett's esophagusPparg
basal cell carcinomaTp53
Behcet's diseaseSod1
benign epilepsy with centrotemporal spikesGrin1 , Plcb1
bipolar disorderBdnf , Grin2b , Ndufs7 , Ndufv2
bladder neck obstructionSod2
bladder urothelial carcinomaCrebbp , Ep300 , Tp53
blood coagulation diseaseGnaq
body dysmorphic disorderHdac2
Body Mass Index Quantitative Trait Locus 10Pparg
Body Mass Index Quantitative Trait Locus 11Pparg
Body Mass Index Quantitative Trait Locus 12Pparg
Body Mass Index Quantitative Trait Locus 14Pparg
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 18Pparg
Body Mass Index Quantitative Trait Locus 4Pparg
Body Mass Index Quantitative Trait Locus 7Pparg
Body Mass Index Quantitative Trait Locus 8Pparg
Body Mass Index Quantitative Trait Locus 9Pparg
Body WeightBdnf
bone development diseaseTp53
Bone Marrow NeoplasmsTp53
Bowen's DiseaseNrf1 , Ppargc1a , Tfam
Brain Diseases, Metabolic, InbornNdufs4
Brain HypoxiaEp300 , Itpr1
Brain InjuriesApaf1 , Bax , Bdnf , Casp3 , Casp8 , Gpx1 , Mir132 , Ppargc1a , Sod1 , Sod2
brain ischemiaApaf1 , Bbc3 , Bdnf , Casp3 , Casp9 , Creb1 , Cycs , Gpx1 , Nrf1 , Ppid , Sod1 , Sod2 , Tp53
Brain NeoplasmsSod2 , Tgm2 , Tp53
breast adenocarcinomaTp53
breast cancerCasp8 , Sod2 , Tp53
Breast Cancer, FamilialTp53
Breast NeoplasmsBax , Casp3 , Casp8 , Casp9 , Ep300 , Gpx1 , Hdac1 , Mir132 , Mir222 , Ndufs3 , Sod2 , Tgm2 , Tp53
bronchiolo-alveolar adenocarcinomaTp53
bronchitisHdac2
bulimia nervosaBdnf
Burkitt lymphomaBbc3
BurnsBax , Casp3 , Vdac2
CachexiaTfam
Cadmium PoisoningGpx1 , Htt
calcinosisCasp3 , Gpx1
Canavan diseaseSod2
Capillary Malformations, CongenitalGnaq
Carcinoid TumorMir222
Carcinoid Tumors, IntestinalSdhd
carcinomaSod2 , Tp53
cardiac arrestEp300 , Itpr1 , Sod1
Cardiac ArrhythmiasSod2
Cardiogenic ShockSod2
CardiomegalyCox5b , Ep300 , Gnaq , Hdac2 , Ppargc1a , Slc25a4 , Sod2
cardiomyopathyEp300 , Ndufs2 , Ndufv2 , Ppargc1a , Sod1 , Sod2 , Tp53
Cardiomyopathy, Hypertrophic, FamilialDlg4
Cardiovascular AbnormalitiesGpx1
cardiovascular system diseaseGpx1 , Pparg , Ppargc1a
Carney TriadSdha , Sdhb , Sdhc
Carney-Stratakis SyndromeSdhb , Sdhc , Sdhd
carotid artery diseasePparg , Sod2 , Tp53
Carotid Artery InjuriesPparg , Ppargc1a , Sp1
Carotid Body TumorSdhd
Carotid Intimal Medial Thickness 1Pparg
carotid stenosisGpx1
cataractGpx1 , Sod1 , Tp53
Cecal NeoplasmsTp53
celiac diseaseTgm2
Cell Transformation, NeoplasticSod1 , Sod2 , Sp1 , Tp53
central nervous system diseaseCrebbp , Sod2
Central Nervous System InfectionsSod2
Central Nervous System NeoplasmsTp53
Cerebral HemorrhageBax , Bdnf , Casp3 , Casp8
Cerebral Visual Impairment and Intellectual DisabilityDlg4
cervical cancerTp53
cervix carcinomaTp53
cervix uteri carcinoma in situHdac1 , Hdac2
Charcot-Marie-Tooth diseaseDctn1 , Dctn2 , Sdhc
Charcot-Marie-Tooth disease intermediate typeSdhc
Charcot-Marie-Tooth disease recessive intermediate DCox6a1
Charcot-Marie-Tooth disease type 1Sdhc
Charcot-Marie-Tooth disease type 1BSdhc
Charcot-Marie-Tooth disease type 4ESdhc
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBax , Casp8 , Itpr1 , Mir132 , Mir22 , Mir222 , Ndufs3 , Polr2g , Sod1 , Sod2
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneCycs
cholangiocarcinomaCycs , Tp53
cholesteatoma of middle earTp53
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Choroidal NeovascularizationSod1
chromosome 15q24 deletion syndromeSin3a
Chromosome 17 DeletionTp53
Chronic Allograft NephropathyPparg
chronic kidney diseaseGpx1 , Ppargc1a
chronic lymphocytic leukemiaTp53
Chronic Lymphocytic Leukemia, B-CellTp53
chronic myeloid leukemiaGpx1
chronic obstructive pulmonary diseaseHdac2 , Ppargc1a , Tp53
Chronic PainBdnf
chronic progressive external ophthalmoplegiaSlc25a4 , Sod1 , Sod2
chronic ulcer of skinPlcb3
Chronobiology DisordersPparg
Ciliary Motility DisordersDnai1 , Dnai2 , Dnal1 , Ndufv3
clear cell adenocarcinomaTp53
clear cell renal cell carcinomaEp300
Cocaine-Related DisordersBdnf , Creb1 , Grin1 , Grm5
Cognition DisordersBdnf , Hdac2
cognitive disorderPparg
colitisBdnf , Ppargc1a
colon cancerPparg , Tp53
colon carcinomaBax , Ep300 , Pparg , Tp53
Colonic NeoplasmsBax , Casp3 , Hdac1 , Hdac2 , Plcb1 , Pparg , Sod2 , Tp53
Colonic PolypsHdac2
color blindnessBdnf
colorectal adenocarcinomaTp53
colorectal cancerEp300 , Pparg , Tp53
Colorectal NeoplasmsBax , Casp8 , Casp9 , Crebbp , Ep300 , Pparg , Sod2 , Tp53
combined oxidative phosphorylation deficiencyAtp5f1a
Combined Oxidative Phosphorylation Deficiency 11Tp53
Combined Oxidative Phosphorylation Deficiency 22Atp5f1a
Combined Oxidative Phosphorylation Deficiency 8Sdhd
congenital central hypoventilation syndromeBdnf
congenital generalized lipodystrophy type 2Pparg
congenital heart diseaseGnaq
congenital hypothyroidismPpargc1a
congenital muscular dystrophySdhc
congestive heart failureBax , Ep300 , Gnaq , Pparg , Ppargc1a , Sod1 , Sod2 , Tp53 , Ucp1
contact dermatitisCasp8 , Sod1
Copper-Overload CirrhosisCasp3
corneal neovascularizationPparg
coronary artery diseaseGpx1 , Pparg , Sod1
coronary restenosisTp53
Cowden diseaseSdhb , Sdhd
Cowden-Like SyndromeSdhb , Sdhd
Craniofacial AbnormalitiesApaf1 , Ep300 , Gnaq , Sin3a , Tp53
Crohn's diseaseGpx1 , Pparg
cryptorchidismCasp3
Currarino TriadAp2m1 , Ndufb5 , Polr2h
cutaneous leishmaniasisSod1
Cutaneous Malignant Melanoma, Susceptibility To, 1Gnaq , Grin2b , Tp53
cutaneous T cell lymphomaBax , Mir22 , Tp53
cystic fibrosisDctn4 , Ndufs1
Cystic Leukoencephalopathy without MegalencephalyNdufa2
cystitisBdnf , Sod1 , Sod2
cytochrome-c oxidase deficiency diseaseCox6b1 , Cox8a
Danon diseaseNdufa1
DeafnessBdnf
DehydrationHap1
dementiaBax
Dementia, Multi-InfarctBax
demyelinating diseaseHdac1 , Tp53
Deoxyguanosine Kinase DeficiencyTfam
Developmental DisabilitiesEp300
diabetes mellitusItpr1 , Pparg , Sod1
diabetic angiopathyCasp3 , Gpx1 , Sod1
Diabetic CardiomyopathiesSlc25a4
diabetic encephalopathyPparg
Diabetic NephropathiesBdnf , Casp3 , Creb1 , Ep300 , Gpx1 , Hdac2 , Pparg , Ppargc1a , Sod1 , Sod2 , Tp53 , Ucp1 , Vdac1 , Vdac2
diabetic neuropathyBdnf , Casp3 , Grm5
diabetic retinopathyBdnf , Casp3 , Casp9 , Ep300 , Pparg , Ppargc1a , Sod1
Diamond-Blackfan anemiaDnah2 , Tp53
diffuse large B-cell lymphomaCltc , Sod2 , Tp53
dilated cardiomyopathyBax , Creb1 , Gnaq , Gpx1 , Itpr1 , Ppargc1a , Sdha , Slc25a4 , Sod2 , Ucp1
dilated cardiomyopathy 1GGSdha
dilated cardiomyopathy 1HSlc25a4
disease of cellular proliferationSod2 , Tp53
disease of metabolismPparg
Disease ProgressionNdufa2 , Ndufs1 , Ndufv1 , Sod2
Diseases of the AgedPpargc1a
Distal Hereditary Motor Neuropathy, Type IDctn1
Down syndromeSod1
Drug EruptionsBdnf
Drug-induced NeutropeniaSod2 , Tp53
Drug-Related Side Effects and Adverse ReactionsSod1 , Tp53
dry eye syndromeSod1
ductal carcinoma in situTp53
DwarfismSin3a
dyskeratosis congenitaTp53
DyslipidemiasPparg
dystoniaDctn1
Early Infantile Epileptic Encephalopathy 1Plcb1
Early Infantile Epileptic Encephalopathy, 12Plcb1
Early Infantile Epileptic Encephalopathy, 27Grin2b
EdemaCasp3 , Casp8 , Casp9
egg allergyGrin2b
EmphysemaTp53
end stage renal failurePparg
endogenous depressionHap1
endometrial cancerTp53
Endometrial NeoplasmsEp300 , Hdac1 , Hdac2 , Tp53
endometriosisBax , Hdac1 , Hdac2
EndotoxemiaAtp5f1a , Bax , Casp3 , Ep300 , Pparg , Sod2
epilepsyBdnf , Gpx1 , Grin2b , Grm1 , Itpr1 , Vdac1 , Vdac2
epilepsy with generalized tonic-clonic seizuresBdnf
EPILEPSY, FOCAL, WITH SPEECH DISORDER AND WITH OR WITHOUT MENTAL RETARDATIONGrin2b
esophageal cancerTp53
esophageal carcinomaEp300 , Tp53
Esophageal NeoplasmsBax , Bbc3 , Casp8 , Ep300 , Sod2 , Tgm2 , Tp53
Esophageal StenosisSod2
esophagitisSod2
esophagus adenocarcinomaTp53
esophagus squamous cell carcinomaCrebbp , Ep300 , Sod2 , Tp53
exfoliation syndromeSod2
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial HyperostosisCox4i2
Experimental ArthritisBax
Experimental Autoimmune EncephalomyelitisBdnf , Casp3 , Casp8 , Casp9
Experimental Autoimmune MyocarditisPparg
Experimental Diabetes MellitusBax , Bdnf , Casp3 , Casp8 , Casp9 , Ep300 , Gpx1 , Grin2b , Hdac1 , Hdac2 , Ndufs2 , Ndufs3 , Plcb3 , Pparg , Ppargc1a , Sod1 , Sod2 , Tp53 , Vdac1
Experimental Liver CirrhosisApaf1 , Hip1 , Pparg , Slc25a4
Experimental NeoplasmsTp53
Extra-Adrenal ParagangliomaSdhd
extrinsic allergic alveolitisSod2
Eye AbnormalitiesApaf1
Eye BurnsPparg
Eye InjuriesPparg
Facial Nerve InjuriesNdufa5
facioscapulohumeral muscular dystrophySlc25a4
familial adenomatous polyposisHdac2 , Sod2
familial combined hyperlipidemiaPparg
familial hypocalciuric hypercalcemia 3Ap2s1
familial partial lipodystrophyPparg
Farber lipogranulomatosisSod2
fatty liver diseaseCreb1 , Cycs , Gpx1 , Pparg , Ppargc1a , Sod1 , Sod2
Female InfertilityTp53
fetal alcohol spectrum disorderGrin2b
Fetal Growth RetardationBax , Casp3 , Grin2b , Hdac1 , Hdac2 , Pparg , Ppargc1a , Sin3a , Sod1
FeverSod2
fibromaGrm1
Fibromatosis, Gingival, 1Rest
FibrosisPparg , Sod2
focal epilepsyBdnf
focal segmental glomerulosclerosisGnaq
follicular lymphomaCrebbp
Follicular Thyroid CancerPparg
fragile X syndromeGrm1
fragile X-associated tremor/ataxia syndromeSod1
Frontotemporal Lobar DegenerationBdnf
Gait Disorders, NeurologicSod1
Gallbladder NeoplasmsTp53
gastric adenocarcinomaCrebbp , Tp53
Gastrointestinal HemorrhageBax
gastrointestinal stromal tumorSdhb , Sdhc
Gaucher's diseaseTp53
Generalized EpilepsyGrin2b
genetic diseaseApaf1 , Bdnf , Cltc , Crebbp , Ep300 , Grin1 , Grin2b , Hdac1 , Hdac2 , Htt , Itpr1 , Ndufa1 , Ndufa10 , Ndufb3 , Ndufs3 , Ndufv1 , Plcb4 , Polr2f , Rest , Sin3a , Slc25a4
gestational diabetesGpx1 , Sod2
Gillespie SyndromeItpr1
gingival fibromatosis 5Rest
glaucomaBax , Bdnf , Crebbp
glioblastoma multiformeCrebbp , Pparg , Tgm2 , Tp53
GliosisBdnf
glomerulonephritisEp300 , Pparg
glomerulosclerosisPparg
glucose intolerancePpargc1a
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due toGpx1
grade III astrocytomaTp53
Graft vs Host DiseaseTp53
Granuloma, Respiratory TractSod2
Graves OphthalmopathyPparg
Graves' diseaseTp53
guanidinoacetate methyltransferase deficiencyNdufs7
hairy cell leukemiaGpx1
Head and Neck NeoplasmsGpx1 , Tp53
head and neck squamous cell carcinomaCasp8 , Crebbp , Ep300 , Mir222 , Sod2 , Tp53
Hearing LossBdnf , Sod1
Hearing Loss, Noise-InducedBdnf , Sod1 , Sod2
heart diseaseAtp5pf , Bax , Casp9 , Ep300 , Hdac1 , Ppargc1a
heart valve diseaseCasp3
HemimegalencephalyGrin1
HemolysisGpx1 , Sod1
hemolytic anemiaSod2
Hepatitis, ChronicCasp3 , Gpx1 , Sod1
hepatoblastomaTp53
hepatocellular carcinomaAtp5pd , Casp8 , Crebbp , Ep300 , Hdac2 , Pparg , Sod2 , Tp53
hepatorenal syndromeSod1
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeTp53
Hereditary Neoplastic SyndromesDctn4 , Ndufa2 , Sdha , Sdhb , Sdhc , Sdhd , Tp53 , Uqcrq , Vdac1
Hereditary Paraganglioma-Pheochromocytoma SyndromesSdhb , Sdhc , Sdhd
hereditary spastic paraplegia 11Tp53
Hernias, Diaphragmatic, CongenitalEp300 , Sod1 , Sod2
heroin dependenceBdnf
Hirschsprung Disease 1Crebbp , Polr2f
HirsutismEp300
Histiocytoma, Angiomatoid FibrousCreb1
holoprosencephalyCreb1
human immunodeficiency virus infectious diseaseBax
Huntington's diseaseBax , Bdnf , Casp3 , Casp8 , Casp9 , Creb1 , Crebbp , Cycs , Dlg4 , Ep300 , Gpx1 , Grin2b , Grm5 , Hap1 , Hdac1 , Htt , Ift57 , Itpr1 , Mir132 , Mir22 , Mir222 , Nrf1 , Plcb3 , Polr2a , Ppargc1a , Sin3a , Sod2 , Tbp , Tfam , Tug1 , Ucp1
hydrocephalusSin3a
HyperalgesiaBdnf , Dlg4 , Ep300 , Grin1 , Grin2b , Sin3a
hyperandrogenismPparg
hyperglycemiaCasp8 , Gpx1 , Ppargc1a , Sod1 , Sp1
hyperhomocysteinemiaGpx1 , Sod2
hyperinsulinismGpx1
HyperoxiaBdnf , Sod2
Hyperphosphatasia with Mental Retardation Syndrome 2Dnai1
HyperplasiaBax
hypertensionBax , Casp3 , Cox5b , Ep300 , Gpx1 , Pparg , Sod1 , Sod2 , Tgm2 , Tp53 , Ucp1
hypertensive encephalopathyBdnf
hyperthyroidismGpx1 , Ppargc1a , Sod1 , Sod2
hypertrophic cardiomyopathyCasp3 , Ndufs1 , Ndufs2 , Slc25a4 , Tp53
hypertrophic cardiomyopathy 1Slc25a4
Hypertrophy, Left VentricularPparg , Ppargc1a , Slc25a4 , Tgm2
Hypertrophy, Right VentricularHdac1 , Nrf1 , Ppargc1a
hypoglycemiaCreb1 , Grin2b , Sod2
Hypopharyngeal NeoplasmsSod2
HypotensionGrin2b , Sod1
HypothermiaSod1
hypothyroidismBdnf , Gpx1 , Sod1
HypoventilationDctn1
HypoxiaAtp5f1b , Bdnf , Casp3 , Grin2b , Sod1 , Sod2
Hypoxia-Ischemia, BrainBax , Casp3 , Grin1 , Grin2b , Tfam
impotenceBax , Casp3
inclusion body myositisSod2
infantile histiocytoid cardiomyopathyNdufb11
InfarctionPolr2a
infectious mononucleosisSod2
InflammationBdnf , Mir22 , Pparg , Sod1 , Tfam
inherited metabolic disorderNdufs1 , Ndufs2 , Uqcrb
Insulin ResistancePparg , Ppargc1a , Sod2 , Ucp1
intellectual disabilityBdnf , Ep300 , Grin1 , Grin2b , Sin3a
intermediate coronary syndromeBdnf
intermittent claudicationBax , Bbc3 , Casp3
interstitial lung diseaseBdnf , Sod2
Intervertebral Disc DisplacementBdnf
intestinal diseaseBax , Casp3 , Sod2
Intestinal NeoplasmsBax
invasive ductal carcinomaSod2
iron deficiency anemiaGpx1 , Sod1
Iron OverloadGpx1
irritable bowel syndromeBdnf
ischemiaBax , Cycs , Pparg , Sod1 , Sod2 , Tp53
Joint InstabilityGrin2b
Kabuki Syndrome 2Mir222
Kaposi's sarcomaTp53
Kartagener syndromeDnah1 , Dnai1 , Dnai2 , Dnal1
Kashin-Beck DiseaseBax
Kearns-Sayre syndromePpargc1a , Tfam
keratoconusBdnf
keratosisTp53
Keshan diseaseGpx1
Kidney CalculiSod1
kidney diseaseSod2
kidney failurePparg , Ppargc1a
Kidney NeoplasmsPpargc1a , Sod2
Kidney Reperfusion InjuryBax , Casp3 , Ep300 , Ppargc1a
Kuhnt-Junius degenerationSod2
Language Development DisordersGrin2b , Hdac2
late onset Parkinson's diseaseTbp
Lead Poisoning, Nervous SystemEp300
Leber hereditary optic neuropathyNdufs2 , Sod2 , Tp53
Leigh diseaseNdufa10 , Ndufa12 , Ndufa2 , Ndufa9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Sdha , Sod2
Leigh Syndrome Due To Mitochondrial Complex I DeficiencyNdufa10 , Ndufa12 , Ndufa2 , Ndufa9 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8
Leigh Syndrome due to Mitochondrial Complex II DeficiencySdha
leiomyomaBax
leukemiaGpx1 , Tp53
LeukoencephalopathiesBdnf
leukostasisPparg
Lewy body dementiaSod2
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni Syndrome 3Tp53
Li-Fraumeni-Like SyndromeTp53
LINEAR SKIN DEFECTS WITH MULTIPLE CONGENITAL ANOMALIES 2Cox7b
LINEAR SKIN DEFECTS WITH MULTIPLE CONGENITAL ANOMALIES 3Ndufb11
Lip NeoplasmsTp53
lipid storage diseasePparg
lipodystrophyPparg
Lipoyltransferase 1 DeficiencyTp53
liver cancerCasp8 , Crebbp , Tp53
liver cirrhosisHdac2
liver diseaseSod1
Liver InjuryGpx1
liver neoplasmPparg , Tp53
Liver Neoplasms, ExperimentalBbc3 , Tp53
Liver Reperfusion InjuryBax , Casp8 , Sod1
long QT syndromePlcb4
LOPES-MACIEL-RODAN SYNDROMEHtt
low tension glaucomaBdnf , Sod1 , Tp53
lung adenocarcinomaAtp5pd , Crebbp , Ep300 , Sod2 , Tp53
lung cancerCasp8
lung diseaseSod2
Lung NeoplasmsCasp8 , Cltb , Gpx1 , Mir222 , Sod2 , Tp53
Lung Reperfusion InjuryBax , Casp3
lung small cell carcinomaCrebbp , Ep300 , Tp53
lung squamous cell carcinomaCrebbp , Ep300 , Tp53
Lymphatic MetastasisCasp9 , Pparg , Sod2 , Tp53
lymphomaTp53
macular degenerationBax , Ppargc1a , Sod1 , Sod2
major depressive disorderBdnf , Sod2
male infertilityBax , Sod2 , Tp53
malignant fibroxanthomaPpargc1a
malignant gliomaPparg , Sod1 , Tp53
malignant mesotheliomaSod2 , Tp53
Mammary Neoplasms, AnimalSod1
Mammary Neoplasms, ExperimentalApaf1 , Bax , Casp3 , Casp8 , Casp9 , Sod2 , Tp53
Manganese PoisoningHtt
Marfan syndromeSod1 , Sod2
marginal zone B-cell lymphomaTp53
maturity-onset diabetes of the youngTgm2
medulloblastomaCrebbp , Ep300 , Tp53
Megakaryoblastic Leukemia of Down SyndromeTp53
megakaryocytic leukemiaTp53
melanomaCasp8 , Crebbp , Ep300 , Gnaq , Grin2b , Hdac2 , Plcb4 , Pparg , Ppargc1a , Sdhd , Sod2 , Tp53
MELAS syndromeNdufs1 , Sod1 , Sod2
membranoproliferative glomerulonephritisEp300
Memory DisordersCreb1 , Hdac2
mental depressionBax , Bdnf , Gpx1 , Sod1
Mercury PoisoningGpx1
Merkel cell carcinomaSdhd
MesotheliomaSod2 , Tp53
Metabolic SyndromeBdnf , Pparg , Ppargc1a
methylmalonic acidemiaCycs , Sod2
microcephalyEp300 , Sin3a
MicrognathismEp300
Microsatellite InstabilityBax , Hdac2
Microvascular Complications of Diabetes, Susceptibility to, 3Sod2
Microvascular Complications of Diabetes, Susceptibility to, 4Sod2
Microvascular Complications of Diabetes, Susceptibility to, 6Sod2
Microvascular Complications of Diabetes, Susceptibility to, 7Sod2
middle cerebral artery infarctionAp2b1 , Bax , Bdnf , Casp3 , Sod1 , Sod2
Mirror Movements 3Dnal4
mitochondrial complex I deficiencyNdufa1 , Ndufa10 , Ndufa11 , Ndufa2 , Ndufb11 , Ndufb3 , Ndufb9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2
mitochondrial complex II deficiencySdha , Sdhd
mitochondrial complex III deficiencyUqcrb , Uqcrq
mitochondrial complex III deficiency nuclear type 1Cyc1 , Uqcrb , Uqcrc2 , Uqcrq
mitochondrial complex III deficiency nuclear type 3Uqcrb
mitochondrial complex III deficiency nuclear type 4Uqcrq
mitochondrial complex III deficiency nuclear type 5Uqcrc2
mitochondrial complex III deficiency nuclear type 6Cyc1
mitochondrial complex V (ATP synthase) deficiency nuclear type 3Atp5f1d , Atp5f1e
mitochondrial complex V (ATP synthase) deficiency nuclear type 4Atp5f1a
mitochondrial DNA depletion syndrome 12Slc25a4
MITOCHONDRIAL DNA DEPLETION SYNDROME 12A (CARDIOMYOPATHIC TYPE), AUTOSOMAL DOMINANTSlc25a4
MITOCHONDRIAL DNA DEPLETION SYNDROME 12B (CARDIOMYOPATHIC TYPE), AUTOSOMAL RECESSIVESlc25a4
Mitochondrial DNA Depletion Syndrome 15 (Hepatocerebral Type)Tfam
mitochondrial encephalomyopathyNdufs2 , Ndufv2
mitochondrial metabolism diseaseAtp5f1d , Slc25a4 , Sod2 , Uqcrfs1
mitochondrial myopathySlc25a4 , Vdac1
Mobius syndromePlcb2
mood disorderDctn1
morbid obesityBdnf , Pparg
morphine dependenceBax , Creb1
motor neuron diseaseSod1
Mouth NeoplasmsSod2 , Tp53 , Vdac2
movement diseaseHtt , Itpr1
Multiple AbnormalitiesCltc , Crebbp , Ep300 , Grin1 , Grin2b , Hdac1 , Itpr1 , Ndufa1
multiple chemical sensitivitySod2
multiple myelomaGpx1 , Sod2 , Tp53
Multiple Organ FailureTfam
multiple sclerosisBdnf , Hdac1 , Ndufs2
Muscle HypotoniaEp300 , Hdac2
Muscle SpasticityCrebbp
muscular atrophyApaf1 , Sod1
muscular diseaseSdha
muscular dystrophySdhc
Muscular Dystrophy, AnimalPpargc1a
Mycoplasma InfectionsCasp3
mycosis fungoidesSod2
myelodysplastic syndromeCrebbp , Plcb1 , Tp53
myelofibrosisTp53
myeloid leukemiaHdac2
myeloid neoplasmGpx1
myelomeningoceleSod1 , Sod2
myocardial infarctionBax , Casp3 , Creb1 , Gpx1 , Plcb1 , Plcb3 , Ppargc1a , Sod1 , Sod2 , Tp53 , Vdac1 , Vdac2
Myocardial IschemiaBax , Cox5b , Sod2 , Uqcrfs1
Myocardial Reperfusion InjuryBax , Casp3 , Casp8 , Casp9 , Pparg , Ppargc1a , Slc25a4 , Sod1 , Sod2 , Tp53 , Vdac1
myopiaEp300 , Slc25a4
Nasal PolypsBdnf , Sod1 , Sod2
Nasopharyngeal NeoplasmsTp53
nasopharynx carcinomaSod2 , Tp53
NecrosisSod1 , Sod2
Neoplasm InvasivenessSod2 , Sp1
Neoplasm MetastasisBax , Casp3 , Mir222 , Sod2 , Sp1 , Tp53
Neoplasm Recurrence, LocalCreb3l4
Neoplasms, Bone TissueGrm1
nephroblastomaRest , Tp53
nephronophthisis-like nephropathy 1Ep300
nephrosisGpx1 , Sod1
nephrotic syndromePpargc1a , Sod2
Nerve DegenerationBax , Bdnf , Casp3 , Pparg , Sod1 , Sod2
Nerve InjuriesBdnf
Nerve Sheath NeoplasmsTp53
nervous system diseaseBdnf , Casp3 , Casp9 , Sod1 , Tp53
NeuralgiaGrm5
neuroblastomaTp53
neurodegenerative diseaseDctn1 , Itpr1 , Sod2
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, AUTOSOMAL RECESSIVEGrin1
Neurodevelopmental DisordersDlg4 , Grin2b , Itpr1
neuronal ceroid lipofuscinosisSod2
neuronal ceroid lipofuscinosis 1Ppargc1a , Tfam
Neuronopathy, Distal Hereditary Motor, Type ViibDctn1
Neuropathy, PainfulEp300
Nevi Flammei, Familial MultipleGnaq
newborn respiratory distress syndromeSod1
Niemann-Pick disease type AItpr1
non-Hodgkin lymphomaGpx1 , Tp53
non-small cell lung carcinomaCasp3 , Casp8 , Casp9 , Sod2 , Tp53
nonalcoholic fatty liver diseaseAtp5f1b , Gpx1 , Ppargc1a , Sod2
Noonan syndromeApaf1
Nose NeoplasmsTp53
nutrition diseaseHap1
nutritional deficiency diseaseSod1
obesityBdnf , Cox7c , Cox8b , Cycs , Ep300 , Gpx1 , Pparg , Ppargc1a , Sod1 , Sod2 , Tfam , Ucp1 , Uqcrc2
obsessive-compulsive disorderBdnf , Htt
obstructive sleep apneaBdnf
ocular hypertensionSod1
ocular melanomaGnaq
Odontogenic MyxomaTp53
optic atrophyNdufs3
Optic Nerve InjuriesBax , Bdnf , Ep300
optic neuritisSod2
Oral Lichen PlanusTp53
oral mucosa leukoplakiaTp53
oral submucous fibrosisTp53
OROFACIODIGITAL SYNDROME XVIIIIft57
Oropharyngeal NeoplasmsTp53
osteoarthritisBax , Ndufs8 , Ndufv1 , Pparg , Sdha , Sod2 , Tgm2 , Vdac2
Osteoarthritis, KneeBax
osteopetrosisNdufs8
osteoporosisBax , Gpx1 , Sod2
osteosarcomaTp53
ovarian cancerTp53
Ovarian NeoplasmsHdac1 , Hdac2 , Sod1 , Sod2 , Tp53
ovarian serous cystadenocarcinomaTp53
ovary epithelial cancerTp53
Oxygen-Induced RetinopathyPparg , Sod1
PainBdnf , Grin1 , Plcb1 , Pparg
Pain, ReferredBdnf
pancreatic adenocarcinomaTp53
pancreatic cancerApaf1 , Casp8 , Casp9 , Cycs , Pparg , Sod1 , Sod2 , Tp53
pancreatic carcinomaSod2 , Tp53
pancreatic ductal carcinomaHdac1 , Pparg
Pancreatic Intraepithelial NeoplasiaHdac1
pancreatitisCasp3 , Mir22 , Pparg
Pancreatitis, Acute NecrotizingCasp3
papillomaSod2
Papillomavirus InfectionsCasp8
paragangliomaSdha , Sdhb , Sdhc , Sdhd
Paragangliomas 3Sdhc
Paragangliomas 4Sdhb
Paragangliomas 5Sdha
Paragangliomas with Sensorineural Hearing LossSdhd
paranasal sinus neoplasmTp53
Parasitic Liver DiseasesTp53
Parkinson's diseaseApaf1 , Bdnf , Casp3 , Casp9 , Dlg4 , Gpx1 , Htt , Mir132 , Mir22 , Ndufb8 , Ndufs1 , Ndufs4 , Ndufv2 , Ppargc1a , Sdha , Sod1 , Sod2 , Tbp , Tfam , Vdac1
Parkinson's Disease, MitochondrialNdufv2
Parkinsonian DisordersApaf1 , Bdnf , Casp3 , Casp9 , Dctn1 , Ppargc1a , Tfam , Vdac1
PCWH syndromePolr2f
Pediatric Adrenocortical CarcinomaTp53
penile neoplasmTp53
Perennial Allergic RhinitisPparg
perinatal necrotizing enterocolitisSod2
Peripheral Nerve InjuriesBdnf
peripheral nervous system diseaseCasp9 , Sod2
Perry syndromeDctn1
Peutz-Jeghers syndromePolr2e
Peyronie's diseaseHdac2
phaeochromocytomaSdha , Sdhb , Sdhc , Sdhd
phenylketonuriaGrin2b
Phyllodes TumorTp53
Pick's diseaseCreb1
pituitary-dependent Cushing's diseasePparg
placental insufficiencyGrin1 , Grin2b , Ppargc1a
Plaque, AmyloidBdnf
Plaque, AtheroscleroticSp1
plasmacytomaTp53
pleomorphic xanthoastrocytomaCreb3l2 , Cycs , Hip1 , Ndufa5 , Ndufb2 , Nrf1 , Polr2j
Polycystic Kidney DiseasesSod1
polycystic ovary syndromeBax , Dlg4
polyneuropathySod2
PolyploidyTp53
Port-Wine StainGnaq
post-traumatic stress disorderBax , Bdnf
pre-eclampsiaPparg
pre-malignant neoplasmAtp5f1b , Sod2 , Tp53
precursor B lymphoblastic lymphoma/leukemiaTp53
precursor lymphoblastic lymphoma/leukemiaCasp8 , Crebbp , Gpx1 , Hdac1 , Hdac2 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaBax
prediabetes syndromePpargc1a , Ucp1
Premature AgingBax , Tp53
Premature BirthSod2
PresbycusisBdnf , Sod1 , Sod2
primary biliary cirrhosisPpargc1a , Sod2
primary ciliary dyskinesiaDnai1 , Dnai2 , Dnal1 , Ndufv3
primary ciliary dyskinesia 1Dnai1
primary ciliary dyskinesia 16Dnal1
primary ciliary dyskinesia 37Dnah1
primary ciliary dyskinesia 9Dnai2
Primary Hyperoxaluria Type 1Ndufa10
primary immunodeficiency diseaseCasp8
primary open angle glaucomaBdnf , Sod2 , Tp53
primary pulmonary hypertensionHdac1 , Pparg
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 2Slc25a4
progressive myoclonus epilepsyNdufv3
progressive supranuclear palsySod1
proliferative diabetic retinopathyPparg
proliferative vitreoretinopathyBdnf
prostate adenocarcinomaCreb3l4 , Tp53
prostate cancerDnah3 , Grin1 , Hip1 , Plcb4 , Tp53 , Vdac1
prostate carcinoma in situCreb3l4 , Hdac1
Prostatic NeoplasmsBax , Casp3 , Casp9 , Creb3l4 , Crebbp , Ep300 , Hdac1 , Hdac2 , Hip1 , Itpr1 , Sod2 , Tp53
Protein DeficiencySod1
protein-energy malnutritionCox4i1
proteinuriaSod1
Pseudomonas InfectionsDctn4
pseudoxanthoma elasticumGpx1 , Sod2
psoriasisPparg , Sod2 , Tp53
Psychomotor DisordersVdac1
psychotic disorderBdnf , Grin1
pterygiumTp53
pulmonary emphysemaHdac2 , Ppargc1a
pulmonary fibrosisBdnf , Sod1
pulmonary hypertensionHdac1 , Hdac2 , Sod2 , Tp53
pulmonary sarcoidosisBdnf
Radiation InjuriesBdnf , Sod2
Radiation Injuries, ExperimentalSod1 , Sod2
reactive arthritisSod2
renal artery obstructionSod1
renal carcinomaSdhb , Tp53
renal cell carcinomaApaf1 , Casp3 , Sdhb , Sdhd , Sod2 , Tgm2 , Tp53
renal fibrosisPpargc1a , Sod2
Reperfusion InjuryApaf1 , Bax , Bdnf , Casp3 , Casp8 , Casp9 , Ep300 , Gpx1 , Grin2b , Itpr1 , Pparg , Sod1 , Sod2 , Tfam , Tp53
Respiration DisordersBdnf
Respiratory Tract InfectionsBdnf
ReticulocytosisGpx1 , Sod2
Retina Reperfusion InjuryBax , Bdnf , Hdac2 , Sod2
retinal degenerationBax , Bdnf , Sod1
retinal detachmentApaf1 , Casp3 , Casp9
retinal diseaseCasp3
Retinal NeovascularizationSod1
retinitis pigmentosaGrin2b , Sod1 , Sod2
retinopathy of prematuritySod1
RetrognathiaEp300
rhabdomyosarcomaTp53
rheumatoid arthritisSod2
rhinitisBdnf
Rubinstein-Taybi syndromeCrebbp , Ep300
salivary gland diseaseCasp3
sarcoidosisSod2
sarcomaTp53
Sarcoma Family Syndrome of Li and FraumeniTp53
SarcopeniaBax , Ppargc1a
Schistosomiasis MansoniSod1
schizophreniaBdnf , Creb1 , Grin1 , Grin2b , Ndufv2 , Plcb1 , Ppargc1a , Tbp , Tp53 , Uqcrc2
sciatic neuropathyBdnf , Creb1 , Ppargc1a , Sod1
scoliosisCrebbp
scrapieSod1
Seasonal Allergic RhinitisBdnf
secondary Parkinson diseaseTfam
Sengers syndromeSod2
senile cataractGpx1
sensorineural hearing lossBdnf , Sod2
SepsisCasp3 , Casp8 , Ep300 , Ppargc1a , Sod1 , Sod2
serous cystadenocarcinomaTp53
Sezary's diseaseCrebbp , Tp53
Shock, HemorrhagicTfam
sickle cell anemiaGpx1
sideroblastic anemiaSod2
Sjogren's syndromeBdnf
Skin AbnormalitiesApaf1 , Sod2
skin diseaseNdufb8 , Sod2
skin melanomaGrm1
Skin NeoplasmsCasp8 , Sod2 , Sp1 , Tp53
sleep apneaTbp
Sleep DeprivationBdnf , Grin2b
Sleep Initiation and Maintenance DisordersPpargc1a
small cell carcinomaTp53
Smith-Magenis syndromeAp2b1 , Atp5mc1 , Atp5pd , Cltc , Dnai2 , Hap1
Spermatogenic Failure 18Dnah1
spina bifidaCrebbp
Spinal Cord InjuriesBdnf , Casp3 , Ppargc1a , Sod1 , Tbp , Tp53
Spinal Cord Reperfusion InjuryBdnf
spinocerebellar ataxia 44Grm1
spinocerebellar ataxia type 15Itpr1
spinocerebellar ataxia type 17Atp5f1b , Tbp
spinocerebellar ataxia type 29Itpr1
Spinocerebellar AtaxiasGrm1 , Itpr1 , Tbp
Sporadic Papillary Renal Cell CarcinomaTp53
squamous cell carcinomaCrebbp , Ep300 , Gpx1 , Hdac1 , Hdac2 , Sod2 , Tp53 , Vdac2
status epilepticusBax , Bdnf , Casp3 , Casp8 , Grm1 , Grm5 , Sod2 , Tfam
Stevens-Johnson syndromeEp300
Stomach NeoplasmsBdnf , Casp8 , Hdac2 , Ndufa2 , Ndufs1 , Ndufv1 , Pparg , Sod2 , Tp53
StrokeCasp3 , Hdac1 , Hdac2 , Ndufc2 , Sod1
Sturge-Weber SyndromeGnaq
Subarachnoid HemorrhageCasp3
substance-induced psychosisSod2
substance-related disorderGrm5
synucleinopathyDctn1 , Dctn2
systemic lupus erythematosusEp300 , Pparg , Sod2
systemic sclerodermaBdnf
T-Cell LymphomaEp300 , Pparg , Tp53
Takotsubo CardiomyopathyPpargc1a
Tardive DyskinesiaSod2
tauopathyHdac1
temporal lobe epilepsyDlg4 , Grin2b , Grm1 , Grm5 , Hdac2 , Vdac2
teratomaBax
tethered spinal cord syndromeCrebbp
thrombocytopeniaCycs
Thrombocytopenia 4Cycs
Thumb DeformityCrebbp , Ep300
thymomaTp53
Thymus NeoplasmsTp53
Thyroid NeoplasmsPparg , Sod2 , Tp53
thyroiditisBax
TinnitusBdnf
Tobacco Addiction, Susceptibility ToBdnf
Tobacco Use DisorderBdnf
Tongue NeoplasmsMir222 , Sod2 , Tp53
tongue squamous cell carcinomaTp53
toxic encephalopathyCasp3
toxoplasmosisBax
transient cerebral ischemiaBax , Bbc3 , Casp3 , Casp9 , Creb1 , Cycs , Ep300 , Htt , Pparg , Sin3a , Sod1 , Sod2
transitional cell carcinomaApaf1 , Casp3 , Crebbp , Ep300 , Gpx1 , Tp53
Trauma, Nervous SystemGrin2b
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaGrin1
Tumor Predisposition SyndromeSdha , Sdhb , Sdhc , Sdhd , Tp53
Turner syndromeSod1 , Sod2
type 1 diabetes mellitusCasp3 , Casp8 , Casp9 , Hdac1 , Hdac2 , Ppargc1a , Sod1 , Sod2 , Tbp
type 2 diabetes mellitusBax , Bdnf , Casp3 , Casp8 , Casp9 , Ep300 , Gpx1 , Hdac1 , Hdac2 , Mir222 , Pparg , Ppargc1a , Sod1 , Sod2 , Ucp1
ulcerative colitisCasp3 , Gpx1
Ureteral CalculiSod1
urinary bladder cancerAtp5f1d , Bax , Casp3 , Casp9 , Crebbp , Ep300 , Gpx1 , Pparg , Sod2 , Tp53
Urogenital NeoplasmsTp53
Urologic NeoplasmsTp53
urticariaBdnf , Sod2
uterine carcinosarcomaTp53
Uterine Cervical NeoplasmsBax , Casp3 , Casp8 , Crebbp , Ep300 , Hdac1 , Hdac2 , Ndufs6 , Tp53
Uterine NeoplasmsTp53
uveal melanomaGnaq , Grm1 , Plcb4
uveitisSod2
varicoceleCasp9
vascular dementiaBdnf , Gpx1 , Tp53
vascular diseaseSod2
Venous ThrombosisGpx1
Ventricular Dysfunction, LeftSod2 , Vdac1
ventricular septal defectDnal1
very long chain acyl-CoA dehydrogenase deficiencyDlg4
visceral heterotaxyDnai1
Visceral PainBdnf
visual epilepsyApaf1 , Bdnf , Grin2b , Hdac2 , Rest , Sod2 , Vdac1 , Vdac2
vitiligoSod2
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsTp53
Waardenburg syndrome type 2APolr2f
Waardenburg syndrome type 2EPolr2f
Waardenburg syndrome type 4CPolr2f
Waardenburg's syndromePolr2f
Weight GainNdufb9
Weight LossSod1
West syndromePlcb1
Williams-Beuren syndromeDlg4
WILMS TUMOR 6Rest
Wilson diseaseNdufb7
withdrawal disorderBdnf , Creb1
xeroderma pigmentosumTp53
Pathway Annotations Associated with Genes in the Huntington disease pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayItpr1 , Plcb1
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGnaq
acetylsalicylic acid pharmacodynamics pathwayGpx1
adenosine signaling pathwayCreb1
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayItpr1 , Plcb1
aldosterone signaling pathwayCrebbp , Ppargc1a
alfentanil pharmacodynamics pathwayGrin1
altered citric acid cycle pathwaySdhb , Sdhd
altered p53 signaling pathwayTp53
Alzheimer's disease pathwayApaf1 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Casp3 , Casp8 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Gnaq , Grin1 , Grin2b , Itpr1 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
amiodarone pharmacodynamics pathwayItpr1 , Plcb1
amlodipine pharmacodynamics pathwayItpr1 , Plcb1
amyotrophic lateral sclerosis pathwayApaf1 , Bax , Casp3 , Casp9 , Cycs , Cyct , Gpx1 , Grin1 , Grin2b , Sod1 , Tp53
androgen signaling pathwayCrebbp , Ep300
angiotensin II signaling pathway via AT1 receptorGnaq
antigen processing and presentation pathwayCreb1
antipyrine drug pathwayGpx1
apoptotic cell death pathwayApaf1 , Bax , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Tp53
arachidonic acid metabolic pathwayGpx1
Arf family mediated signaling pathwayAp2a1 , Ap2m1 , Clta , Cltb
atenolol pharmacodynamics pathwayItpr1 , Plcb1
basal cell carcinoma pathwayTp53
betaxolol pharmacodynamics pathwayItpr1 , Plcb1
bisoprolol pharmacodynamics pathwayItpr1 , Plcb1
brain-derived neurotrophic factor signaling pathwayBdnf
bupivacaine pharmacodynamics pathwayGrin1
bupranolol drug pathwayItpr1 , Plcb1
bupranolol pharmacodynamics pathwayItpr1 , Plcb1
buprenorphine pharmacodynamics pathwayGrin1
calcium transport pathwayItpr1
calcium/calcium-mediated signaling pathwayGnaq , Grin1 , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppid , Ppidl1 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Vdac1 , Vdac2 , Vdac3
calcium/calmodulin dependent kinase 2 signaling pathwayGrin1 , Grin2b
cardiolipin metabolic pathwayCycs
carvedilol pharmacodynamics pathwayItpr1 , Plcb1
celecoxib pharmacodynamics pathwayGpx1
cell cycle pathway, mitoticCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2 , Tp53
ceramide signaling pathwayBax , Casp8 , Casp9 , Cycs , Tp53
Chagas disease pathwayCasp8 , Gnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2
chemokine mediated signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
chloroprocaine pharmacodynamics pathwayGrin1
chronic myeloid leukemia pathwayHdac1 , Hdac1l , Hdac2 , Tp53
cisplatin drug pathwayTbp
citalopram pharmacodynamics pathwayGrin1
citric acid cycle pathwaySdha , Sdhb , Sdhc , Sdhd
clathrin-dependent synaptic vesicle endocytosisAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Clta , Cltb , Cltc
cocaine pharmacodynamics pathwayGrin1
codeine and morphine pharmacodynamics pathwayGrin1
colorectal cancer pathwayBax , Casp3 , Casp9 , Cycs , Cyct , Tp53
cortisol signaling pathwayCrebbp , Ep300
desipramine pharmacodynamics pathwayGrin1
diclofenac pharmacodynamics pathwayGpx1
diflunisal pharmacodynamics pathwayGpx1
diltiazem pharmacodynamics pathwayItpr1 , Plcb1
diphenoxylate pharmacodynamics pathwayGrin1
disopyramide pharmacodynamics pathwayItpr1 , Plcb1
DNA modification pathwayPparg , Sin3a
dobutamine pharmacodynamics pathwayItpr1 , Plcb1
doxorubicin pharmacokinetics pathwayNdufs2 , Ndufs3 , Ndufs7
eicosanoid signaling pathwayGnaq , Plcb2 , Tgm2
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPparg , Ucp1
electron transport chain pathwayAtp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5mc2 , Atp5pb , Cycs , Ndufa1 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a4 , Uqcrc1 , Uqcrh
endocytosis pathwayAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Clta , Cltb , Cltc
endometrial cancer pathwayCasp9 , Tp53
endoplasmic reticulum stress - the unfolded protein response pathwayCreb3l1 , Creb3l2 , Creb3l3 , Creb3l4
Endoplasmic Reticulum-associated degradation pathwayBax
endothelin signaling pathwayGnaq , Plcb1 , Plcb2 , Plcb3
Entamoebiasis pathwayCasp3 , Gnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
escitalopram pharmacodynamics pathwayGrin1
esmolol pharmacodynamics pathwayItpr1 , Plcb1
estrogen signaling pathwayCrebbp , Ep300 , Ppid
ethylmorphine pharmacodynamics pathwayGrin1
etodolac pharmacodynamics pathwayGpx1
excitatory synaptic transmission pathwayGrin1 , Grin2b
extrinsic apoptotic pathwayCasp3 , Casp8
FasL mediated signaling pathwayCasp3 , Casp8 , Cltc
fenoprofen pharmacodynamics pathwayGpx1
fentanyl pharmacodynamics pathwayGrin1
flecainde pharmacodynamics pathwayItpr1 , Plcb1
fluoxetine pharmacodynamics pathwayGrin1
flurbiprofen pharmacodynamics pathwayGpx1
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAtp5pf , Creb1 , Crebbp , Ep300 , Ndufv3 , Sod1 , Sp1
fosphenytoin pharmacodynamics pathwayItpr1 , Plcb1
fumaric aciduria pathwaySdha , Sdhb , Sdhc , Sdhd
G protein mediated signaling pathway via Galphaq familyGnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
glioma pathwayTp53
glutamate signaling pathwayDlg4 , Gnaq , Grin1 , Grin2b , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
glutathione metabolic pathwayGpx1
glutathione synthase deficiency pathwayGpx1
glutathionuria disease pathwayGpx1
gonadotropin-releasing hormone signaling pathwayGnaq , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Sin3a
hepatitis C pathwayTp53
heroin pharmacodynamics pathwayGrin1
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300 , Hdac1 , Hdac2
Huntington's disease pathwayAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Apaf1 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Bax , Bbc3 , Bdnf , Casp3 , Casp8 , Casp9 , Clta , Cltb , Cltc , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Cyc1 , Cycs , Cyct , Dctn1 , Dctn2 , Dctn4 , Dlg4 , Dnah1 , Dnah2 , Dnah3 , Dnai1 , Dnai2 , Dnal1 , Dnal4 , Dnali1 , Ep300 , Gnaq , Gpx1 , Grin1 , Grin2b , Grm1 , Grm5 , Hap1 , Hdac1 , Hdac1l , Hdac2 , Hip1 , Htt , Ift57 , Itpr1 , Mir132 , Mir22 , Mir222 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Nrf1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Polr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , Pparg , Ppargc1a , Ppid , Ppidl1 , Rest , RGD1559629 , RGD1559781 , RGD1560088 , RGD1565904 , Sdha , Sdhb , Sdhc , Sdhd , Sin3a , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Sod1 , Sod2 , Sp1 , Tbp , Tbpl1 , Tbpl2 , Tfam , Tgm2 , Tp53 , Tug1 , Ucp1 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3
hydrocodone pharmacodynamics pathwayGrin1
hydromorphone pharmacodynamics pathwayGrin1
hypertension pathwaySod1 , Sod2
hypoxia inducible factor pathwayCreb1 , Crebbp , Ep300 , Sp1
ibuprofen pharmacodynamics pathwayGpx1
ibutilide pharmacodynamics pathwayItpr1 , Plcb1
imipramine pharmacodynamics pathwayGrin1
indometacin pharmacodynamics pathwayGpx1
indometacin pharmacodynamics pathwayGpx1
influenza A pathwayCasp9 , Crebbp , Cycs , Cyct , Ep300 , Vdac1
inositol phosphate metabolic pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
insulin signaling pathwayPpargc1a
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwaySp1
intrinsic apoptotic pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp9 , Cycs
isoprenaline pharmacodynamics pathwayItpr1 , Plcb1
isradipine pharmacodynamics pathwayItpr1 , Plcb1
Jak-Stat signaling pathwayCrebbp , Ep300
ketoprofen pharmacodynamics pathwayGpx1
ketorolac pharmacodynamics pathwayGpx1
leukotriene C4 synthase deficiency pathwayGpx1
levacetylmethadol pharmacodynamics pathwayGrin1
levobunolol pharmacodynamics pathwayItpr1 , Plcb1
levobupivacaine phgarmacodynamics pathwayGrin1
levorphanol pharmacodynamics pathwayGrin1
lidocaine pharmacodynamics pathwayGrin1 , Itpr1 , Plcb1
long term depressionGnaq , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
long term potentiationCrebbp , Ep300 , Gnaq , Grin1 , Grin2b , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
lornoxicam pharmacodynamics pathwayGpx1
luteinizing hormone signaling pathwayCreb1
magnesium salicylate pharmacodynamics pathwayGpx1
measles pathwayBbc3 , Tp53
mefenamic acid pharmacodynamics pathwayGpx1
melanoma pathwayTp53
meloxicam pharmacodynamics pathwayGpx1
mepivacaine pharmacodynamics pathwayGrin1
methadone pharmacodynamics pathwayGrin1
methadone pharmacokinetics pathwayGrin1
metoprolol pharmacodynamics pathwayItpr1 , Plcb1
mexiletine pharmacodynamics pathwayItpr1 , Plcb1
mitochondria transport pathwayDctn1 , Dctn2 , Dctn4
mitochondrial complex II deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
mitogen activated protein kinase signaling pathwayBdnf , Casp3 , Tp53
mTOR signaling pathwayCycs , Ppargc1a
myocarditis pathwayCasp3 , Casp8 , Casp9 , Cycs , Cyct
N-cadherin signaling pathwayDctn1
nabumetone pharmacodynamics pathwayGpx1
nadolol pharmacodynamics pathwayItpr1 , Plcb1
nalbuphine pharmacodynamics pathwayGrin1
naloxone pharmacodynamics pathwayGrin1
naltrexone pharmacodynamics pathwayGrin1
naproxen pharmacodynamics pathwayGpx1
nebivolol pharmacodynamics pathwayItpr1 , Plcb1
neurotrophic factor signaling pathwayBax , Bdnf , Tp53
nicotine pharmacodynamics pathwayGrin1
nifedipine pharmacodynamics pathwayItpr1 , Plcb1
nimodipine pharmacodynamics pathwayItpr1 , Plcb1
nisoldipine pharmacodynamics pathwayItpr1 , Plcb1
nitrendipine pharmacodynamics pathwayItpr1 , Plcb1
NOD-like receptor signaling pathwayCasp8
non-small cell lung carcinoma pathwayCasp9 , Tp53
Notch signaling pathwayCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxidative phosphorylation pathwayAtp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
oxybuprocaine pharmacodynamics pathwayGrin1
oxycodone pharmacodynamics pathwayGrin1
oxymorphone pharmacodynamics pathwayGrin1
oxytocin signaling pathwayGnaq
p53 signaling pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Hdac1 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayCasp9 , Tp53
paracetamol drug pathwayGpx1
Parkinson's disease pathwayApaf1 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5f1e , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Casp3 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Mir132 , Mir22 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Ppid , Ppidl1 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3
penbutolol pharmacodynamics pathwayItpr1 , Plcb1
pentazocine pharmacodynamics pathwayGrin1
phenytoin pharmacodynamics pathwayItpr1 , Plcb1
phosphatidylinositol 3-kinase signaling pathwayItpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
phosphatidylinositol 3-kinase-Akt signaling pathwayCasp9
phosphoinositide metabolic pathwayPlcb1
pindolol pharmacodynamics pathwayItpr1 , Plcb1
piroxicam pharmacodynamics pathwayGpx1
prilocaine pharmacodynamics pathwayGrin1
prion disease pathwayBax , Sod1
procainamide pharmacodynamics pathwayItpr1 , Plcb1
procaine pharmacodynamics pathwayGrin1
propranolol pharmacodynamics pathwayItpr1 , Plcb1
prostate cancer pathwayCasp9 , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Ep300 , Tp53
protein kinase C (PKC) signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
purine metabolic pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , RGD1565904
pyrimidine metabolic pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , RGD1565904
pyruvate dehydrogenase E2 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
pyruvate dehydrogenase E3 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
quinidine pharmacodynamics pathwayItpr1 , Plcb1
Reelin signaling pathwayGrin2b
remifentanil pharmacodynamics pathwayGrin1
renal cell carcinoma pathwayCrebbp , Ep300 , Sdhb , Sdhd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
RNA polymerase I transcription pathwayCrebbp , Polr2e , Polr2f , Tbp
RNA polymerase II transcription initiation pathwayTbp
RNA polymerase II transcription pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2j
RNA polymerase III transcription pathwayPolr2e , Polr2f , Tbp
ropivacaine pharmacodynamics pathwayGrin1
salicylic acid pharmacodynamics pathwayGpx1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1
sleeping sickness pathwayGnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
small cell lung carcinoma pathwayApaf1 , Casp9 , Cycs , Cyct , Tp53
sodium salicylate pharmacodynamics pathwayGpx1
sotalol pharmacodynamics pathwayItpr1 , Plcb1
sphingosine 1-phosphate signaling pathwayGnaq , Plcb2
sulindac pharmacodynamics pathwayGpx1
syndecan signaling pathwayBax , Casp3
systemic lupus erythematosus pathwayGrin2b
tenoxicam pharmacodynamics pathwayGpx1
thyroid cancer pathwayPparg , Tp53
tiaprofenic acid pharmacodynamics pathwayGpx1
timolol pharmacodynamics pathwayItpr1 , Plcb1
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Tp53
Toll-like receptor signaling pathwayCasp8
tolmetin pharmacodynamics pathwayGpx1
toxoplasmosis pathwayCasp3 , Casp8 , Casp9 , Cycs , Cyct
Trail mediated signaling pathwayCasp3 , Casp8
tramadol pharmacodynamics pathwayGrin1
transforming growth factor-beta Smad dependent signaling pathwayCreb1 , Crebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Sp1
tuberculosis pathwayApaf1 , Bax , Casp3 , Casp8 , Casp9 , Creb1 , Crebbp , Cycs , Cyct , Ep300
tumor necrosis factor mediated signaling pathwayCasp8
type II interferon signaling pathwayCrebbp , Ep300
urinary bladder cancer pathwayTp53
valdecoxib pharmacodynamics pathwayGpx1
vascular endothelial growth factor signaling pathwayCasp9
vasopressin signaling pathwayGnaq
vasopressin signaling pathway via receptor type 1Gnaq
vasopressin signaling pathway via receptor type 2Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Dctn1 , Dctn2 , Dctn4
verapamil pharmacodynamics pathwayItpr1 , Plcb1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayCrebbp , Ep300 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Tp53
Wnt signaling, canonical pathwayCrebbp
Wnt signaling, non-canonical pathwayPparg
Phenotype Annotations Associated with Genes in the Huntington disease pathway

References Associated with the Huntington disease pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: