HUNTINGTON DISEASE PATHWAY (PW:0000017)

View Ontology Report

Description

Huntington disease (HD) is an autosomal dominant neurodegenerative condition manifested in movement, cognitive and psychiatric symptoms. HD is associated with the abnormal expansion of a trinucleotide (CAG) repeat in the huntingtin (HTT) gene translating into an expanded stretch of glutamine residues (polyQ), conferring aberrant conformational propensities. Between 9 to 35 repeats are normally found in the wild-type protein/non-HD population. Mutant HTT proteins (mHTT) have over 36 repeats; havi

Pathway Diagram:

Elsevier Inc. potential HD lncRNA ---> Huntington Disease QUIN ---> Huntington Disease potential HD lncRNA upregulated miRNA upregulated miRNA ---> downregulated target translation downregulated target translation downregulated miRNA ---> upregulated target translation downregulated miRNA upregulated target translation potential HD miRNA ex-Grin2b loss of projecting cortical neurons potential HD miRNA ---> Huntington Disease loss of striatal SPNs Huntington Disease QUIN Grin2b D2 SPNs D1 SPNs brain-derived neurotrophic factor signaling pathway Dnm1l KYNA 3-HANA 3-HK kynurenine metabolic pathway microglia astrocyte neuroinflammatory responses --+> microglia HTT interacting proteins shorter, toxic fragments cell homeostasis transcription vesicular trafficking Rest ---| BDNF transcription Rest Htt ---> cell homeostasis Rasd2 interacting proteins Htt DNA modification pathway dorsal striatal SPNs neurons mHtt Casp6 1-586 fragment NMDAR-mediated excitotoxicity Ntrk2 mHtt ---- Rasd2 neuroinflammatory responses polyQ RNA polymerase II transcription pathway histone modification pathway electron transport chain pathway autophagy pathway Htt ---> transcription Htt ---> mitochondria function Htt ---> vesicular trafficking mHtt ---| BDNF transcription Bdnf BDNF transcription Bdnf ---- Ntrk2 BDNF transport aa1-17 mitochondria function Casp6 ---> PRD mitochondria dynamics pathway mHtt ---| Rasd2 Rasd2 ---- Rasd2 interacting proteins brain-derived neurotrophic factor signaling pathway ---> D1 SPNs Rasd2 brain-derived neurotrophic factor signaling pathway --+> D2 SPNs mHtt ---| electron transport chain pathway mHtt ---| autophagy pathway Crebbp brain-derived neurotrophic factor signaling pathway ---> dorsal striatal SPNs neurons mHtt ---| mitochondria dynamics pathway Htt ---- HTT interacting proteins HTT interacting proteins ---- mHtt Rasd2 ---> mHtt Htt ---| Rest mHtt ---| brain-derived neurotrophic factor signaling pathway mHtt ---| BDNF transport Htt --+> BDNF transport Crebbp ---> histone modification pathway Crebbp ---> RNA polymerase II transcription pathway Crebbp ---> DNA modification pathway mHtt ---| Crebbp Crebbp ---- mHtt Dnm1l ---- mHtt aa69-3144, HEAT repeat domains, PEST domains in disordered regions polyQ ---> Htt polyQ ---> mHtt mHtt ---> ex-Grin2b mHtt ---> Huntington Disease PRD
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Genes in Pathway:

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Huntington disease pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap2a1 adaptor-related protein complex 2, alpha 1 subunit JBrowse link 1 100,896,582 100,926,443 RGD:6907045
G Ap2a2 adaptor-related protein complex 2, alpha 2 subunit JBrowse link 1 214,534,217 214,607,497 RGD:6907045
G Ap2b1 adaptor-related protein complex 2, beta 1 subunit JBrowse link 10 70,516,462 70,621,973 RGD:6907045
G Ap2m1 adaptor-related protein complex 2, mu 1 subunit JBrowse link 11 84,041,184 84,047,542 RGD:6907045
G Ap2s1 adaptor-related protein complex 2, sigma 1 subunit JBrowse link 1 78,671,238 78,682,847 RGD:6907045
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:6907045
G Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 JBrowse link 17 72,209,321 72,231,562 RGD:6907045
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6907045
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6907045
G Atp5f1d ATP synthase F1 subunit delta JBrowse link 7 12,426,807 12,432,120 RGD:6907045
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:6907045
G Atp5h ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d JBrowse link 10 103,967,340 103,972,552 RGD:6907045
G Atp5hl1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 JBrowse link 16 51,816,495 51,817,031 RGD:6907045
G Atp5mc1 ATP synthase membrane subunit c locus 1 JBrowse link 10 83,895,941 83,898,640 RGD:6907045
G Atp5mc2 ATP synthase membrane subunit c locus 2 JBrowse link 7 144,264,207 144,272,578 RGD:6907045
G Atp5mc3 ATP synthase membrane subunit c locus 3 JBrowse link 3 60,811,218 60,813,903 RGD:6907045
G Atp5pb ATP synthase peripheral stalk-membrane subunit b JBrowse link 2 208,566,385 208,577,147 RGD:6907045
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:6907045
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:6907045
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6907045
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:6907045
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6907045
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Clta clathrin, light chain A JBrowse link 5 59,490,689 59,509,139 RGD:6907045
G Cltb clathrin, light chain B JBrowse link 17 10,537,348 10,554,999 RGD:6907045
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:6907045
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6907045
G Cox4i2 cytochrome c oxidase subunit 4i2 JBrowse link 3 148,234,546 148,245,424 RGD:6907045
G Cox5a cytochrome c oxidase subunit 5A JBrowse link 8 62,298,358 62,309,765 RGD:6907045
G Cox5b cytochrome c oxidase subunit 5B JBrowse link 9 43,259,706 43,262,039 RGD:6907045
G Cox6a1 cytochrome c oxidase subunit 6A1 JBrowse link 12 47,024,442 47,027,495 RGD:6907045
G Cox6a2 cytochrome c oxidase subunit 6A2 JBrowse link 1 199,624,037 199,626,255 RGD:6907045
G Cox6b1 cytochrome c oxidase subunit 6B1 JBrowse link 1 89,075,987 89,084,834 RGD:6907045
G Cox6b2 cytochrome c oxidase subunit 6B2 JBrowse link 1 72,661,099 72,662,436 RGD:6907045
G Cox6c cytochrome c oxidase subunit 6C JBrowse link 7 74,723,177 74,735,650 RGD:6907045
G Cox7a2 cytochrome c oxidase subunit 7A2 JBrowse link 8 87,209,529 87,213,627 RGD:6907045
G Cox7a2l cytochrome c oxidase subunit 7A2 like JBrowse link 6 6,695,807 6,709,790 RGD:6907045
G Cox7a2l2 cytochrome c oxidase subunit VIIa polypeptide 2-like 2 JBrowse link 14 52,661,933 52,662,375 RGD:6907045
G Cox7b cytochrome c oxidase subunit 7B JBrowse link X 77,065,427 77,071,676 RGD:6907045
G Cox7c cytochrome c oxidase subunit 7C JBrowse link 2 14,699,878 14,701,903 RGD:6907045
G Cox8a cytochrome c oxidase subunit 8A JBrowse link 1 222,466,575 222,468,896 RGD:6907045
G Cox8b cytochrome c oxidase, subunit VIIIb JBrowse link 1 213,648,787 213,650,247 RGD:6907045
G Cox8c cytochrome c oxidase subunit 8C JBrowse link 6 126,766,967 126,768,290 RGD:6907045
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6907045
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:6907045
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:6907045
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:6907045
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Cyc1 cytochrome c-1 JBrowse link 7 117,409,576 117,411,953 RGD:6907045
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6907045
G Cyct cytochrome c, testis JBrowse link 3 63,204,779 63,211,847 RGD:6907045
G Dctn1 dynactin subunit 1 JBrowse link 4 114,876,770 114,896,567 RGD:6907045
G Dctn2 dynactin subunit 2 JBrowse link 7 70,555,953 70,571,433 RGD:6907045
G Dctn4 dynactin subunit 4 JBrowse link 18 55,797,188 55,824,195 RGD:6907045
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:6907045
G Dnah1 dynein, axonemal, heavy chain 1 JBrowse link 16 7,345,131 7,407,009 RGD:6907045
G Dnah2 dynein, axonemal, heavy chain 2 JBrowse link 10 56,029,022 56,154,602 RGD:6907045
G Dnah3 dynein, axonemal, heavy chain 3 JBrowse link 1 189,708,985 189,865,431 RGD:6907045
G Dnai1 dynein, axonemal, intermediate chain 1 JBrowse link 5 57,947,796 58,017,985 RGD:6907045
G Dnai2 dynein, axonemal, intermediate chain 2 JBrowse link 10 103,266,343 103,301,521 RGD:6907045
G Dnal1 dynein, axonemal, light chain 1 JBrowse link 6 107,596,785 107,623,869 RGD:6907045
G Dnal4 dynein, axonemal, light chain 4 JBrowse link 7 120,987,438 121,000,272 RGD:6907045
G Dnali1 dynein, axonemal, light intermediate chain 1 JBrowse link 5 143,053,365 143,062,203 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6907045
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:6907045
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6907045
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6907045
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:6907045
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:6907045
G Hap1 huntingtin-associated protein 1 JBrowse link 10 88,257,975 88,266,210 RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6907045
G Hdac1l histone deacetylase 1-like JBrowse link 9 84,893,145 84,894,599 RGD:6907045
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6907045
G Hip1 huntingtin interacting protein 1 JBrowse link 12 24,180,795 24,315,373 RGD:6907045
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:6907045
RGD:11062153
RGD:11062152
G Ift57 intraflagellar transport 57 JBrowse link 11 53,664,638 53,731,779 RGD:6907045
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6907045
G Mir132 microRNA 132 JBrowse link 10 62,014,995 62,015,095 RGD:11041745
G Mir22 microRNA 22 JBrowse link 10 62,299,592 62,299,686 RGD:11041745
G Mir222 microRNA 222 JBrowse link X 3,683,919 3,684,021 RGD:11041745
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 JBrowse link X 123,803,109 123,806,760 RGD:6907045
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 9 99,617,051 99,651,827 RGD:6907045
G Ndufa10l1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 JBrowse link 6 62,796,951 62,798,384 RGD:6907045
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 JBrowse link 9 10,334,104 10,338,163 RGD:6907045
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 JBrowse link 7 35,125,516 35,163,182 RGD:6907045
G Ndufa13-ps1 NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 JBrowse link 7 36,826,357 36,826,837 RGD:6907045
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 18 29,585,671 29,587,760 RGD:6907045
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 JBrowse link 1 64,172,462 64,175,174 RGD:6907045
G Ndufa4 NDUFA4, mitochondrial complex associated JBrowse link 4 38,233,680 38,240,848 RGD:6907045
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 JBrowse link 4 51,590,413 51,598,771 RGD:6907045
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 JBrowse link 7 123,583,062 123,586,919 RGD:6907045
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 JBrowse link 7 18,683,553 18,696,332 RGD:6907045
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 JBrowse link 3 15,362,888 15,379,386 RGD:6907045
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 JBrowse link 4 159,371,263 159,399,636 RGD:6907045
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 JBrowse link 1 192,044,209 192,057,644 RGD:6907045
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link 10 14,090,128 14,092,289 RGD:6907045
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 JBrowse link X 1,787,266 1,789,524 RGD:6907045
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 JBrowse link 4 67,378,188 67,385,267 RGD:6907045
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 JBrowse link 9 65,478,496 65,488,708 RGD:6907045
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 JBrowse link 11 65,960,277 65,966,899 RGD:6907045
G Ndufb4l1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1 JBrowse link 14 7,949,217 7,949,662 RGD:6907045
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 JBrowse link 2 119,139,717 119,153,753 RGD:6907045
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 JBrowse link 5 56,567,109 56,576,676 RGD:6907045
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 JBrowse link 19 24,701,067 24,705,405 RGD:6907045
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6907045
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 JBrowse link 7 98,813,062 98,819,408 RGD:6907045
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:6907045
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 9 69,919,863 69,953,182 RGD:6907045
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:6907045
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 3 79,721,686 79,728,863 RGD:6907045
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 JBrowse link 2 46,372,488 46,476,162 RGD:6907045
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 JBrowse link 5 141,390,577 141,405,507 RGD:6907045
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 2 26,471,173 26,471,587 RGD:6907045
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:6907045
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 JBrowse link 1 219,141,289 219,144,610 RGD:6907045
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 1 219,254,293 219,259,328 RGD:6907045
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 JBrowse link 9 113,875,718 113,900,169 RGD:6907045
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 JBrowse link 20 10,265,826 10,275,298 RGD:6907045
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6907045
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6907045
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6907045
G Polr2a RNA polymerase II subunit A JBrowse link 10 56,339,277 56,364,888 RGD:6907045
G Polr2b RNA polymerase II subunit B JBrowse link 14 33,070,104 33,107,792 RGD:6907045
G Polr2c RNA polymerase II subunit C JBrowse link 19 10,575,060 10,581,842 RGD:6907045
G Polr2d RNA polymerase II subunit D JBrowse link 18 24,570,762 24,577,894 RGD:6907045
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:6907045
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:6907045
G Polr2g RNA polymerase II subunit G JBrowse link 1 224,991,250 224,998,355 RGD:6907045
G Polr2h RNA polymerase II subunit H JBrowse link 11 83,877,760 83,882,208 RGD:6907045
G Polr2i RNA polymerase II subunit I JBrowse link 1 88,686,812 88,688,249 RGD:6907045
G Polr2j RNA polymerase II subunit J JBrowse link 12 23,587,222 23,592,774 RGD:6907045
G Polr2l RNA polymerase II subunit L JBrowse link 1 214,451,966 214,453,974 RGD:6907045
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6907045
G Ppid peptidylprolyl isomerase D JBrowse link 2 178,354,830 178,366,843 RGD:6907045
G Ppidl1 peptidylprolyl isomerase D-like 1 JBrowse link 9 121,456,762 121,458,035 RGD:6907045
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:6907045
G RGD1559629 similar to H+ ATP synthase JBrowse link 6 69,950,129 69,951,013 RGD:6907045
G RGD1559781 similar to Dynein, axonemal, light chain 4 JBrowse link 20 23,146,842 23,148,234 RGD:6907045
G RGD1560088 similar to NADH:ubiquinone oxidoreductase B15 subunit JBrowse link 1 90,729,267 90,729,711 RGD:6907045
G RGD1565904 similar to polymerase (RNA) II (DNA directed) polypeptide H JBrowse link 18 1,410,974 1,412,769 RGD:6907045
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6907045
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6907045
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:6907045
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6907045
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:6907045
G Slc25a31 solute carrier family 25 member 31 JBrowse link 2 127,538,323 127,554,276 RGD:6907045
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:6907045
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6907045
G Slc25a6 solute carrier family 25 member 6 JBrowse link 18 70,959,872 70,961,040 RGD:6907045
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6907045
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6907045
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6907045
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:6907045
G Tbpl1 TATA-box binding protein like 1 JBrowse link 1 23,977,154 24,002,512 RGD:6907045
G Tbpl2 TATA box binding protein-like 2 JBrowse link 3 1,095,883 1,116,677 RGD:6907045
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:6907045
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6907045
G Tug1 taurine up-regulated 1 (non-protein coding) JBrowse link 14 83,878,757 83,885,791 RGD:11073597
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6907045
G Uqcrb ubiquinol-cytochrome c reductase binding protein JBrowse link 7 71,264,501 71,269,869 RGD:6907045
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 8 117,679,328 117,691,073 RGD:6907045
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 JBrowse link 1 190,555,177 190,585,741 RGD:6907045
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 JBrowse link 17 35,677,984 35,682,262 RGD:6907045
G Uqcrh ubiquinol-cytochrome c reductase hinge protein JBrowse link 5 134,919,040 134,927,235 RGD:6907045
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII JBrowse link 10 38,779,132 38,782,489 RGD:6907045
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6907045
G Vdac2 voltage-dependent anion channel 2 JBrowse link 15 2,634,622 2,648,548 RGD:6907045
G Vdac3 voltage-dependent anion channel 3 JBrowse link 16 74,292,466 74,308,910 RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small Molecule3-HANA3-Hydroxyanthranilic acid
Small Molecule3-HK3-Hydroxykynurenine
Small MoleculeQUINQuinolinic acid
Small MoleculeKYNAQynurenic acid

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Huntington disease pathway
Disease TermsGene Symbols
Colitis, UlcerativeTp53
Pathway Annotations Associated with Genes in the Huntington disease pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayItpr1 , Plcb1
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGnaq
acetylsalicylic acid pharmacodynamics pathwayGpx1
adenosine signaling pathwayCreb1
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayItpr1 , Plcb1
aldosterone signaling pathwayCrebbp , Ppargc1a
alfentanil pharmacodynamics pathwayGrin1
altered citric acid cycle pathwaySdhb , Sdhd
altered p53 signaling pathwayTp53
Alzheimer disease pathwayApaf1 , Atp5c1 , Atp5f1a , Atp5f1b , Atp5f1d , Atp5f1e , Atp5h , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pf , Atp5po , Casp3 , Casp8 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Gnaq , Grin1 , Grin2b , Itpr1 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
amiodarone pharmacodynamics pathwayItpr1 , Plcb1
amlodipine pharmacodynamics pathwayItpr1 , Plcb1
amyotrophic lateral sclerosis disease pathwayApaf1 , Bax , Casp3 , Casp9 , Cycs , Cyct , Gpx1 , Grin1 , Grin2b , Sod1 , Tp53
androgen signaling pathwayCrebbp , Ep300
angiotensin II signaling pathway via AT1 receptorGnaq
antigen processing and presentation pathwayCreb1
antipyrine drug pathwayGpx1
apoptotic cell death pathwayApaf1 , Bax , Casp3 , Casp8 , Casp9 , Cycs , Cyct , Tp53
arachidonic acid metabolic pathwayGpx1
Arf family mediated signaling pathwayAp2a1 , Ap2m1 , Clta , Cltb
atenolol pharmacodynamics pathwayItpr1 , Plcb1
basal cell carcinoma pathwayTp53
betaxolol pharmacodynamics pathwayItpr1 , Plcb1
bisoprolol pharmacodynamics pathwayItpr1 , Plcb1
bladder cancer pathwayTp53
brain-derived neurotrophic factor signaling pathwayBdnf
bupivacaine pharmacodynamics pathwayGrin1
bupranolol drug pathwayItpr1 , Plcb1
bupranolol pharmacodynamics pathwayItpr1 , Plcb1
buprenorphine pharmacodynamics pathwayGrin1
calcium transport pathwayItpr1
calcium/calcium-mediated signaling pathwayGnaq , Grin1 , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppid , Ppidl1 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Vdac1 , Vdac2 , Vdac3
calcium/calmodulin dependent kinase 2 signaling pathwayGrin1 , Grin2b
cardiolipin metabolic pathwayCycs
carvedilol pharmacodynamics pathwayItpr1 , Plcb1
celecoxib pharmacodynamics pathwayGpx1
cell cycle pathway, mitoticCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2 , Tp53
ceramide signaling pathwayBax , Casp8 , Casp9 , Cycs , Tp53
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2
chemokine mediated signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
chloroprocaine pharmacodynamics pathwayGrin1
chronic myeloid leukemia pathwayHdac1 , Hdac1l , Hdac2 , Tp53
cisplatin drug pathwayTbp
citalopram pharmacodynamics pathwayGrin1
citric acid cycle pathwaySdha , Sdhb , Sdhc , Sdhd
clathrin-dependent synaptic vesicle endocytosisAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Clta , Cltb , Cltc
cocaine pharmacodynamics pathwayGrin1
codeine and morphine pharmacodynamics pathwayGrin1
colorectal cancer pathwayBax , Casp3 , Casp9 , Cycs , Cyct , Tp53
cortisol signaling pathwayCrebbp , Ep300
desipramine pharmacodynamics pathwayGrin1
diclofenac pharmacodynamics pathwayGpx1
diflunisal pharmacodynamics pathwayGpx1
diltiazem pharmacodynamics pathwayItpr1 , Plcb1
diphenoxylate pharmacodynamics pathwayGrin1
disopyramide pharmacodynamics pathwayItpr1 , Plcb1
DNA modification pathwayPparg , Sin3a
dobutamine pharmacodynamics pathwayItpr1 , Plcb1
doxorubicin pharmacokinetics pathwayNdufs2 , Ndufs3 , Ndufs7
eicosanoid signaling pathwayGnaq , Plcb2 , Tgm2
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPparg , Ucp1
electron transport chain pathwayAtp5c1 , Atp5f1a , Atp5f1b , Atp5f1d , Atp5f1e , Atp5mc2 , Atp5pb , Cycs , Ndufa1 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a4 , Uqcrc1 , Uqcrh
endocytosis pathwayAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Clta , Cltb , Cltc
endometrial cancer pathwayCasp9 , Tp53
endoplasmic reticulum stress - the unfolded protein response pathwayCreb3l1 , Creb3l2 , Creb3l3 , Creb3l4
Endoplasmic Reticulum-associated degradation pathwayBax
endothelin signaling pathwayGnaq , Plcb1 , Plcb2 , Plcb3
Entamoeba histolyca infection pathwayCasp3 , Gnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
escitalopram pharmacodynamics pathwayGrin1
esmolol pharmacodynamics pathwayItpr1 , Plcb1
estrogen signaling pathwayCrebbp , Ep300 , Ppid
ethylmorphine pharmacodynamics pathwayGrin1
etodolac pharmacodynamics pathwayGpx1
excitatory synaptic transmission pathwayGrin1 , Grin2b
extrinsic apoptotic pathwayCasp3 , Casp8
FasL mediated signaling pathwayCasp3 , Casp8 , Cltc
fenoprofen pharmacodynamics pathwayGpx1
fentanyl pharmacodynamics pathwayGrin1
flecainde pharmacodynamics pathwayItpr1 , Plcb1
fluoxetine pharmacodynamics pathwayGrin1
flurbiprofen pharmacodynamics pathwayGpx1
follicle-stimulating hormone signaling pathwayCreb1
forkhead class A signaling pathwayAtp5pf , Creb1 , Crebbp , Ep300 , Ndufv3 , Sod1 , Sp1
fosphenytoin pharmacodynamics pathwayItpr1 , Plcb1
fumaric aciduria disease pathwaySdha , Sdhb , Sdhc , Sdhd
G protein mediated signaling pathway via Galphaq familyGnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
glioma pathwayTp53
glutamate signaling pathwayDlg4 , Gnaq , Grin1 , Grin2b , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
glutathione metabolic pathwayGpx1
glutathione synthase deficiency pathwayGpx1
glutathionuria disease pathwayGpx1
gonadotropin-releasing hormone signaling pathwayGnaq , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
Hedgehog signaling pathwayCrebbp , Hdac1 , Hdac2 , Sin3a
hepatitis C virus infection pathwayTp53
heroin pharmacodynamics pathwayGrin1
histamine signaling pathway, immunologicalCreb1
histone modification pathwayCrebbp , Ep300 , Hdac1 , Hdac2
Huntington disease pathwayAp2a1 , Ap2a2 , Ap2b1 , Ap2m1 , Ap2s1 , Apaf1 , Atp5c1 , Atp5f1a , Atp5f1b , Atp5f1d , Atp5f1e , Atp5h , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pf , Atp5po , Bax , Bbc3 , Bdnf , Casp3 , Casp8 , Casp9 , Clta , Cltb , Cltc , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Cyc1 , Cycs , Cyct , Dctn1 , Dctn2 , Dctn4 , Dlg4 , Dnah1 , Dnah2 , Dnah3 , Dnai1 , Dnai2 , Dnal1 , Dnal4 , Dnali1 , Ep300 , Gnaq , Gpx1 , Grin1 , Grin2b , Grm1 , Grm5 , Hap1 , Hdac1 , Hdac1l , Hdac2 , Hip1 , Htt , Ift57 , Itpr1 , Mir132 , Mir22 , Mir222 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Nrf1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Polr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , Pparg , Ppargc1a , Ppid , Ppidl1 , Rest , RGD1559629 , RGD1559781 , RGD1560088 , RGD1565904 , Sdha , Sdhb , Sdhc , Sdhd , Sin3a , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Sod1 , Sod2 , Sp1 , Tbp , Tbpl1 , Tbpl2 , Tfam , Tgm2 , Tp53 , Tug1 , Ucp1 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3
hydrocodone pharmacodynamics pathwayGrin1
hydromorphone pharmacodynamics pathwayGrin1
hypertension pathwaySod1 , Sod2
hypoxia inducible factor pathwayCreb1 , Crebbp , Ep300 , Sp1
ibuprofen pharmacodynamics pathwayGpx1
ibutilide pharmacodynamics pathwayItpr1 , Plcb1
imipramine pharmacodynamics pathwayGrin1
indometacin pharmacodynamics pathwayGpx1
indometacin pharmacodynamics pathwayGpx1
influenza A virus infection pathwayCasp9 , Crebbp , Cycs , Cyct , Ep300 , Vdac1
inositol phosphate metabolic pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
insulin signaling pathwayPpargc1a
interleukin-3 signaling pathwayHdac1
interleukin-4 signaling pathwaySp1
intrinsic apoptotic pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp9 , Cycs
isoprenaline pharmacodynamics pathwayItpr1 , Plcb1
isradipine pharmacodynamics pathwayItpr1 , Plcb1
Jak-Stat signaling pathwayCrebbp , Ep300
ketoprofen pharmacodynamics pathwayGpx1
ketorolac pharmacodynamics pathwayGpx1
leukotriene C4 synthase deficiency pathwayGpx1
levacetylmethadol pharmacodynamics pathwayGrin1
levobunolol pharmacodynamics pathwayItpr1 , Plcb1
levobupivacaine phgarmacodynamics pathwayGrin1
levorphanol pharmacodynamics pathwayGrin1
lidocaine pharmacodynamics pathwayGrin1 , Itpr1 , Plcb1
long term depressionGnaq , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
long term potentiationCrebbp , Ep300 , Gnaq , Grin1 , Grin2b , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
lornoxicam pharmacodynamics pathwayGpx1
luteinizing hormone signaling pathwayCreb1
magnesium salicylate pharmacodynamics pathwayGpx1
measles infection pathwayBbc3 , Tp53
mefenamic acid pharmacodynamics pathwayGpx1
melanoma pathwayTp53
meloxicam pharmacodynamics pathwayGpx1
mepivacaine pharmacodynamics pathwayGrin1
methadone pharmacodynamics pathwayGrin1
methadone pharmacokinetics pathwayGrin1
metoprolol pharmacodynamics pathwayItpr1 , Plcb1
mexiletine pharmacodynamics pathwayItpr1 , Plcb1
mitochondria transport pathwayDctn1 , Dctn2 , Dctn4
mitochondrial complex II deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
mitogen activated protein kinase signaling pathwayBdnf , Casp3 , Tp53
mTOR signaling pathwayCycs , Ppargc1a
Mycobacterium tuberculosis infection pathwayApaf1 , Bax , Casp3 , Casp8 , Casp9 , Creb1 , Crebbp , Cycs , Cyct , Ep300
myocarditis pathwayCasp3 , Casp8 , Casp9 , Cycs , Cyct
N-cadherin signaling pathwayDctn1
nabumetone pharmacodynamics pathwayGpx1
nadolol pharmacodynamics pathwayItpr1 , Plcb1
nalbuphine pharmacodynamics pathwayGrin1
naloxone pharmacodynamics pathwayGrin1
naltrexone pharmacodynamics pathwayGrin1
naproxen pharmacodynamics pathwayGpx1
nebivolol pharmacodynamics pathwayItpr1 , Plcb1
neurotrophic factor signaling pathwayBax , Bdnf , Tp53
nicotine pharmacodynamics pathwayGrin1
nifedipine pharmacodynamics pathwayItpr1 , Plcb1
nimodipine pharmacodynamics pathwayItpr1 , Plcb1
nisoldipine pharmacodynamics pathwayItpr1 , Plcb1
nitrendipine pharmacodynamics pathwayItpr1 , Plcb1
NOD-like receptor signaling pathwayCasp8
non-small cell lung cancer pathwayCasp9 , Tp53
Notch signaling pathwayCrebbp , Ep300 , Hdac1 , Hdac1l , Hdac2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxidative phosphorylation pathwayAtp5c1 , Atp5f1a , Atp5f1b , Atp5f1d , Atp5f1e , Atp5h , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pf , Atp5po , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
oxybuprocaine pharmacodynamics pathwayGrin1
oxycodone pharmacodynamics pathwayGrin1
oxymorphone pharmacodynamics pathwayGrin1
oxytocin signaling pathwayGnaq
p53 signaling pathwayApaf1 , Bax , Bbc3 , Casp3 , Casp8 , Casp9 , Crebbp , Cycs , Cyct , Ep300 , Hdac1 , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayCasp9 , Tp53
paracetamol drug pathwayGpx1
Parkinson disease pathwayApaf1 , Atp5c1 , Atp5f1a , Atp5f1b , Atp5f1d , Atp5f1e , Atp5h , Atp5hl1 , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pf , Atp5po , Casp3 , Casp9 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox7a2l , Cox7a2l2 , Cox7b , Cox7c , Cox8a , Cox8b , Cox8c , Cyc1 , Cycs , Cyct , Mir132 , Mir22 , Ndufa1 , Ndufa10 , Ndufa10l1 , Ndufa11 , Ndufa12 , Ndufa13-ps1 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb4l1 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufc2 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs6 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Ppid , Ppidl1 , RGD1559629 , RGD1560088 , Sdha , Sdhb , Sdhc , Sdhd , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq , Vdac1 , Vdac2 , Vdac3
penbutolol pharmacodynamics pathwayItpr1 , Plcb1
pentazocine pharmacodynamics pathwayGrin1
phenytoin pharmacodynamics pathwayItpr1 , Plcb1
phosphatidylinositol 3-kinase signaling pathwayItpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4
phosphatidylinositol 3-kinase-Akt signaling pathwayCasp9
phosphoinositide metabolic pathwayPlcb1
pindolol pharmacodynamics pathwayItpr1 , Plcb1
piroxicam pharmacodynamics pathwayGpx1
prilocaine pharmacodynamics pathwayGrin1
prion diseases pathwayBax , Sod1
procainamide pharmacodynamics pathwayItpr1 , Plcb1
procaine pharmacodynamics pathwayGrin1
propranolol pharmacodynamics pathwayItpr1 , Plcb1
prostate cancer pathwayCasp9 , Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Crebbp , Ep300 , Tp53
protein kinase C (PKC) signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4
purine metabolic pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , RGD1565904
pyrimidine metabolic pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2h , Polr2i , Polr2j , Polr2l , RGD1565904
pyruvate dehydrogenase E2 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
pyruvate dehydrogenase E3 deficiency pathwaySdha , Sdhb , Sdhc , Sdhd
quinidine pharmacodynamics pathwayItpr1 , Plcb1
Reelin signaling pathwayGrin2b
remifentanil pharmacodynamics pathwayGrin1
renal cell cancer pathwayCrebbp , Ep300 , Sdhb , Sdhd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8
RNA polymerase I transcription pathwayCrebbp , Polr2e , Polr2f , Tbp
RNA polymerase II transcription initiation pathwayTbp
RNA polymerase II transcription pathwayPolr2a , Polr2b , Polr2c , Polr2d , Polr2e , Polr2f , Polr2g , Polr2j
RNA polymerase III transcription pathwayPolr2e , Polr2f , Tbp
ropivacaine pharmacodynamics pathwayGrin1
salicylic acid pharmacodynamics pathwayGpx1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1
small cell lung cancer pathwayApaf1 , Casp9 , Cycs , Cyct , Tp53
sodium salicylate pharmacodynamics pathwayGpx1
sotalol pharmacodynamics pathwayItpr1 , Plcb1
sphingosine 1-phosphate signaling pathwayGnaq , Plcb2
sulindac pharmacodynamics pathwayGpx1
syndecan signaling pathwayBax , Casp3
systemic lupus erythematosus pathwayGrin2b
tenoxicam pharmacodynamics pathwayGpx1
thyroid cancer pathwayPparg , Tp53
tiaprofenic acid pharmacodynamics pathwayGpx1
timolol pharmacodynamics pathwayItpr1 , Plcb1
titanium dioxide nanoparticle response pathwayBax , Casp3 , Casp8 , Tp53
Toll-like receptor signaling pathwayCasp8
tolmetin pharmacodynamics pathwayGpx1
Toxoplasma gondii infection pathwayCasp3 , Casp8 , Casp9 , Cycs , Cyct
Trail mediated signaling pathwayCasp3 , Casp8
tramadol pharmacodynamics pathwayGrin1
transforming growth factor-beta Smad dependent signaling pathwayCreb1 , Crebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Sp1
Trypanosoma brucei infection pathwayGnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
Trypanosoma cruzi infection pathwayCasp8 , Gnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4
tumor necrosis factor mediated signaling pathwayCasp8
type II interferon signaling pathwayCrebbp , Ep300
valdecoxib pharmacodynamics pathwayGpx1
vascular endothelial growth factor signaling pathwayCasp9
vasopressin signaling pathwayGnaq
vasopressin signaling pathway via receptor type 1Gnaq
vasopressin signaling pathway via receptor type 2Creb1 , Creb3l1 , Creb3l2 , Creb3l3 , Creb3l4 , Dctn1 , Dctn2 , Dctn4
verapamil pharmacodynamics pathwayItpr1 , Plcb1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayCrebbp , Ep300 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Tp53
Wnt signaling, canonical pathwayCrebbp
Wnt signaling, non-canonical pathwayPparg
Phenotype Annotations Associated with Genes in the Huntington disease pathway

References Associated with the Huntington disease pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: