RGD Reference Report - The nucleolus-guardian of cellular homeostasis and genome integrity. - Rat Genome Database

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The nucleolus-guardian of cellular homeostasis and genome integrity.

Authors: Grummt, I 
Citation: Grummt I Chromosoma. 2013 Dec;122(6):487-97.
RGD ID: 9588250
Pubmed: PMID:24022641   (View Abstract at PubMed)
DOI: DOI:10.1007/s00412-013-0430-0   (Journal Full-text)

All organisms sense and respond to conditions that stress their homeostasis by downregulating the synthesis of rRNA and ribosome biogenesis, thus designating the nucleolus as the central hub in coordinating the cellular stress response. One of the most intriguing roles of the nucleolus, long regarded as a mere ribosome-producing factory, is its participation in monitoring cellular stress signals and transmitting them to the RNA polymerase I (Pol I) transcription machinery. As rRNA synthesis is a most energy-consuming process, switching off transcription of rRNA genes is an effective way of saving the energy required to maintain cellular homeostasis during acute stress. The Pol I transcription machinery is the key convergence point that collects and integrates a vast array of information from cellular signaling cascades to regulate ribosome production which, in turn, guides cell growth and proliferation. This review focuses on the mechanisms that link cell physiology to rDNA silencing, a prerequisite for nucleolar integrity and cell survival.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Crebbp  (CREB binding protein)
Sirt1  (sirtuin 1)
Sirt7  (sirtuin 7)

Genes (Mus musculus)
Crebbp  (CREB binding protein)
Sirt1  (sirtuin 1)
Sirt7  (sirtuin 7)

Genes (Homo sapiens)
CREBBP  (CREB binding protein)
SIRT1  (sirtuin 1)
SIRT7  (sirtuin 7)


Additional Information