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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crebbp
Name: CREB binding protein
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crebbpdecreases expressionISOCrebbp (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of CREBBP mRNAPMID:24831965
Crebbpmultiple interactionsISOCREBBP (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [[CREBBP protein binds to CDKN1A promoter] which results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [CREBBP protein binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [CREBBP protein results in increased expression of VCP mRNA]PMID:18822310
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