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Modes of p53 regulation.

Authors: Kruse, Jan-Philipp  Gu, Wei 
Citation: Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
Pubmed: (View Article at PubMed) PMID:19450511
DOI: Full-text: DOI:10.1016/j.cell.2009.04.050

The traditional view of p53 activation includes three steps-p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated. Moreover, both genetic studies in mice and in vitro studies with purified components suggest that the classical model may not be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53.

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RGD ID: 2316155
Created: 2010-01-27
Species: All species
Last Modified: 2017-01-03
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