RGD Reference Report - Transcriptional regulation by p53. - Rat Genome Database

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Transcriptional regulation by p53.

Authors: Beckerman, R  Prives, C 
Citation: Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
RGD ID: 8662965
Pubmed: PMID:20679336   (View Abstract at PubMed)
PMCID: PMC2908772   (View Article at PubMed Central)
DOI: DOI:10.1101/cshperspect.a000935   (Journal Full-text)

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal. Arguably p53's most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell's RNA polymerase II (RNAP II)-transcribed genes, and indirectly regulates thousands of others. Indeed p53 is the most well studied mammalian transcription factor. The p53 tetramer binds to its response element where it can recruit diverse transcriptional coregulators such as histone modifying enzymes, chromatin remodeling factors, subunits of the mediator complex, and components of general transcription machinery and preinitiation complex (PIC) to modulate RNAPII activity at target loci (Laptenko and Prives 2006). The p53 transcriptional program is regulated in a stimulus-specific fashion (Murray-Zmijewski et al. 2008; Vousden and Prives 2009), whereby distinct subsets of p53 target genes are induced in response to different p53-activating agents, likely allowing cells to tailor their response to different types of stress. How p53 is able to discriminate between these different loci is the subject of intense research. Here, we describe key aspects of the fundamentals of p53-mediated transcriptional regulation and target gene promoter selectivity.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Abl1  (ABL proto-oncogene 1, non-receptor tyrosine kinase)
Brca1  (BRCA1, DNA repair associated)
Crebbp  (CREB binding protein)
Kat2a  (lysine acetyltransferase 2A)
Kat2b  (lysine acetyltransferase 2B)
Kat5  (lysine acetyltransferase 5)
Muc1  (mucin 1, cell surface associated)
Pin1  (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)
Pou4f1  (POU class 4 homeobox 1)
Pou4f2  (POU class 4 homeobox 2)
Ppp1r13b  (protein phosphatase 1, regulatory subunit 13B)
Ppp1r13l  (protein phosphatase 1, regulatory subunit 13 like)
Tp53bp2  (tumor protein p53 binding protein, 2)
Ybx1  (Y box binding protein 1)
Zfp385a  (zinc finger protein 385A)
Zfp420  (zinc finger protein 420)
Znhit1  (zinc finger, HIT-type containing 1)

Genes (Mus musculus)
Abl1  (c-abl oncogene 1, non-receptor tyrosine kinase)
Brca1  (breast cancer 1, early onset)
Crebbp  (CREB binding protein)
Kat2a  (K(lysine) acetyltransferase 2A)
Kat2b  (K(lysine) acetyltransferase 2B)
Kat5  (K(lysine) acetyltransferase 5)
Muc1  (mucin 1, transmembrane)
Pin1  (peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1)
Pou4f1  (POU domain, class 4, transcription factor 1)
Pou4f2  (POU domain, class 4, transcription factor 2)
Ppp1r13b  (protein phosphatase 1, regulatory subunit 13B)
Ppp1r13l  (protein phosphatase 1, regulatory subunit 13 like)
Trp53bp2  (transformation related protein 53 binding protein 2)
Ybx1  (Y box protein 1)
Zfp385a  (zinc finger protein 385A)
Zfp420  (zinc finger protein 420)
Znhit1  (zinc finger, HIT domain containing 1)

Genes (Homo sapiens)
ABL1  (ABL proto-oncogene 1, non-receptor tyrosine kinase)
BRCA1  (BRCA1 DNA repair associated)
CREBBP  (CREB binding protein)
KAT2A  (lysine acetyltransferase 2A)
KAT2B  (lysine acetyltransferase 2B)
KAT5  (lysine acetyltransferase 5)
MUC1  (mucin 1, cell surface associated)
PIN1  (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)
POU4F1  (POU class 4 homeobox 1)
POU4F2  (POU class 4 homeobox 2)
PPP1R13B  (protein phosphatase 1 regulatory subunit 13B)
PPP1R13L  (protein phosphatase 1 regulatory subunit 13 like)
TP53BP2  (tumor protein p53 binding protein 2)
YBX1  (Y-box binding protein 1)
ZNF385A  (zinc finger protein 385A)
ZNF420  (zinc finger protein 420)
ZNHIT1  (zinc finger HIT-type containing 1)


Additional Information