NUCLEAR FACTOR, ERYTHROID 2 LIKE 2 SIGNALING PATHWAY (PW:0000369)

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Description

The nuclear factor, erythroid 2 like 2 (Nfe2l2, known as Nrf2) signaling pathway is one of the most important regulators of antioxidant and electrophilic stress responses. Upon activation, the Nrf2 transcription factor induces the expression of antioxidant, xenobiotic metabolism and cytoprotective genes and also controls the expression of genes involved in intermediary metabolism. Under unstressed conditions, Nrf2 is sequestered in the cytoplasm by the ubiquitin E3 ligase adaptor Keap1, and only

Pathway Diagram:

Elsevier Inc. Gsk3b Kelch-repeat BTB ---> CTR Neh6 Neh2 ---- Neh3 Keap1 Pten Sqstm1 mTorc1 complex electrophiles ---| Pten ROS ---| Pten electrophiles ROS Btrc environmental cues cellular stresses Nfe2l2 target genes Cul3/Rbx1 complex ---| Nfe2l2 Skp1/Cul1/Rbx1 complex ---| Nfe2l2 Cul3/Rbx1 complex ---> Nfe2l2 Keap1 ---- Nfe2l2 small MAFs mTOR signaling pathway <++> phosphatidylinositol 3-kinase-Akt signaling pathway cellular stresses --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues --+> mTOR signaling pathway Skp1/Cul1/Rbx1 complex ---> Nfe2l2 Gsk3b --+> Btrc Crebbp ROS ---| Keap1 electrophiles ---| Keap1 nuclear Nfe2l2 nuclear Nfe2l2 ---- small MAFs Neh1 Gsk3b ---> Nfe2l2 Gsk3a ---> Nfe2l2 Btrc ---- Nfe2l2 phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3a phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3a IVR Gsk3a ROS --+> nuclear Nfe2l2 electrophiles --+> nuclear Nfe2l2 nuclear Nfe2l2 ---> Nfe2l2 target genes small MAFs ---> Nfe2l2 target genes Pten --+> Gsk3b Pten ---> Gsk3b Pten --+> Gsk3a Pten ---> Gsk3a C226/C613 preferring C273/C288 preferring C434 preferring CTR Skp1/Cul1/Rbx1 complex Nfe2l2 Nfe2l2 interactors ---> Nfe2l2 Keap1 ---- Keap1 interactors Keap1 interactors ---| Keap1 mTorc1 complex ---> Sqstm1 mTorc1 complex --+> Sqstm1 Neh7 Crebbp ---- Neh5 Crebbp ---- Neh4 Neh4 Neh5 Ncoa3 ---- Neh5 Ncoa3 ---- Neh4 Nfe2l2 ---- Nfe2l2 interactors Ncoa3 Chd6 Neh3 Chd6 ---- Neh3 C151 preferring 3-box BTB Neh2 mTOR signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway Cul3/Rbx1 complex Keap1 interactors Nfe2l2 interactors
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Genes in Pathway:

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nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:11535066
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:11535066
RGD:11535070
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:11535066
G Chd6 chromodomain helicase DNA binding protein 6 JBrowse link 3 156,937,746 157,099,328 RGD:11535066
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:11535066
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:11535066
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:11535066
G Dpp3 dipeptidylpeptidase 3 JBrowse link 1 220,166,124 220,189,762 RGD:11535066
G Gadd45gip1 GADD45G interacting protein 1 JBrowse link 19 25,946,979 25,949,528 RGD:11535066
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:11535070
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:11535070
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:11535066
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:727319
RGD:11535066
RGD:6902900
RGD:11530066
G Maff MAF bZIP transcription factor F JBrowse link 7 120,580,743 120,592,095 RGD:11535066
G Mafg MAF bZIP transcription factor G JBrowse link 10 109,802,877 109,811,476 RGD:11535066
G Mafk MAF bZIP transcription factor K JBrowse link 12 16,923,989 16,934,706 RGD:11535066
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:11535066
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11530066
RGD:11535070
RGD:11535066
G Palb2 partner and localizer of BRCA2 JBrowse link 1 192,064,586 192,088,547 RGD:11535066
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase JBrowse link 12 52,467,417 52,474,533 RGD:11535066
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:11535070
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:11535066
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:11535066
G Siah2 siah E3 ubiquitin protein ligase 2 JBrowse link 2 148,874,151 148,891,900 RGD:11535066
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:11535066
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:11535066

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGsk3b
acoustic neuromaCdkn1a
acute kidney failureGsk3b , Nfe2l2
Acute Lung InjuryNfe2l2
acute lymphocytic leukemiaPten
acute myeloid leukemiaCrebbp
adenocarcinomaNcoa3 , Pten
adenoid cystic carcinomaBrca1 , Crebbp , Pten
adenosine deaminase deficiencyBrca1
Alcoholic Liver DiseasesKeap1
allergic contact dermatitisNfe2l2
Alzheimer's diseaseCrebbp , Gsk3a , Gsk3b , Ikbkb , Nfe2l2
amyotrophic lateral sclerosisGsk3a , Gsk3b , Keap1 , Nfe2l2 , Sqstm1
amyotrophic lateral sclerosis type 1Crebbp
Angelman syndromeRnf4
angiomyolipomaPten
anisometropiaPten
Arsenic PoisoningCdkn1a
asthmaNfe2l2 , Pten
astrocytomaNcoa3
AtaxiaPten
atrial fibrillationCdkn1a
attention deficit hyperactivity disorderCrebbp
autistic disorderCrebbp , Pten
autosomal dominant polycystic kidney diseaseCdkn1a
autosomal dominant pseudohypoaldosteronism type 1Cul3
autosomal recessive limb-girdle muscular dystrophy type 2ABrca1
Bannayan-Riley-Ruvalcaba syndromePten
Barrett's esophagusCdkn1a
basal cell carcinomaPalb2
biliary atresiaPten
bipolar disorderGsk3a , Gsk3b
bladder urothelial carcinomaCrebbp
Bone NeoplasmsNcoa3
Bowen's DiseaseCdkn1a
brain diseasePten
Brain InjuriesCdkn1a , Gsk3b , Nfe2l2
Brain NeoplasmsPten
breast cancerBrca1 , Palb2 , Pten
Breast Cancer, FamilialBrca1 , Palb2
breast carcinomaBrca1 , Palb2
breast ductal carcinomaBrca1
Breast NeoplasmsBrca1 , Cdkn1a , Ikbkb , Ncoa3 , Palb2 , Pten
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca1
BurnsGsk3b
CarcinogenesisNfe2l2
carcinomaBrca1 , Cdkn1a , Pten
CardiomegalyGsk3b , Pten
cataractNfe2l2 , Pten
Cell Transformation, NeoplasticBrca1 , Pten
central nervous system diseaseCrebbp
cerebral cavernous malformationPten
Cerebral HemorrhageSqstm1
cervix uteri carcinoma in situBrca1 , Cdkn1a , Pten
Chemical and Drug Induced Liver InjuryKeap1 , Nfe2l2
cholangiocarcinomaPten
cholestasisNfe2l2
cholesteatoma of middle earCdkn1a
Cholesteatoma, CongenitalCdkn1a
Choroidal NeovascularizationIkbkb
Chromosome BreakageBrca1 , Nfe2l2
chronic kidney diseaseNfe2l2
chronic obstructive pulmonary diseaseNfe2l2
Cognition DisordersGsk3b
colitisIkbkb
Colonic NeoplasmsBrca1 , Cdkn1a , Gsk3b , Ikbkb , Pten
colorectal adenocarcinomaCdkn1a , Gsk3b
colorectal cancerNfe2l2
Colorectal NeoplasmsCrebbp , Nfe2l2 , Pten
congenital myasthenic syndrome 10Brca1
congenital myasthenic syndrome 4CPten
congestive heart failureGsk3b , Nfe2l2
Cowden diseasePten
Craniofacial AbnormalitiesPten
Cutaneous Malignant Melanoma, Susceptibility To, 1Pten
dermatitisIkbkb
developmental coordination disorderPten
Developmental DisabilitiesPten
diabetes mellitusPten
Diabetic CardiomyopathiesNfe2l2
Diabetic NephropathiesCdkn1a , Keap1 , Nfe2l2 , Pten
diabetic retinopathyKeap1 , Nfe2l2
dilated cardiomyopathyGsk3a
disease of cellular proliferationBrca1 , Pten
Disease ProgressionKeap1 , Pten
Drug-Related Side Effects and Adverse ReactionsNfe2l2
ductal carcinoma in situCdkn1a
dysgerminomaBrca1
dysplastic nevus syndromePten
EmphysemaNfe2l2
end stage renal failureKeap1
endometrial cancerPten
endometrial carcinomaGsk3b , Pten
Endometrial HyperplasiaPten
Endometrial NeoplasmsCdkn1a , Gsk3b , Nfe2l2 , Pten
Endometrioid CarcinomasPten
EndotoxemiaKeap1
esophageal atresia/tracheoesophageal fistulaPalb2
Esophageal NeoplasmsCdkn1a
esophagus squamous cell carcinomaCdkn1a , Crebbp , Nfe2l2
Experimental ArthritisGsk3b , Ikbkb
Experimental Autoimmune EncephalomyelitisNfe2l2
Experimental ColitisNfe2l2
Experimental Diabetes MellitusCdkn1a , Gsk3a , Ikbkb , Nfe2l2
Experimental Liver CirrhosisCdkn1a , Nfe2l2
facioscapulohumeral muscular dystrophyCdkn1a
familial meningiomaPten
Familial Paget's Disease of BoneSqstm1
Fanconi anemiaBrca1 , Palb2
Fanconi anemia complementation group ABrca1
Fanconi anemia complementation group NPalb2
fatty liver diseaseKeap1 , Nfe2l2 , Pten
fetal alcohol spectrum disorderPten
Fetal Growth RetardationNfe2l2
follicular lymphomaCrebbp
Follicular Thyroid CancerPten
follicular thyroid carcinomaPten
FTDALS1Sqstm1
FTDALS3Sqstm1
Fuchs' endothelial dystrophyCdkn1a
Gallbladder NeoplasmsKeap1
gastric adenocarcinomaCrebbp , Pten
Gastrointestinal DiseasesKeap1 , Nfe2l2
Gastrointestinal NeoplasmsPten
genetic diseaseCrebbp , Cul3 , Pten
glaucomaCrebbp
glioblastoma multiformeCrebbp , Pten
growth hormone secreting pituitary adenomaCdkn1a
head and neck squamous cell carcinomaCrebbp , Nfe2l2 , Pten
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a
hemangiomaPten
HepatitisKeap1
Hepatitis B, ChronicKeap1
hepatocellular adenomaPten
hepatocellular carcinomaCdkn1a , Crebbp , Nfe2l2 , Pten
HepatomegalyPten
hereditary breast ovarian cancer syndromeBrca1 , Palb2
Hereditary Neoplastic SyndromesBrca1 , Palb2 , Pten , Skp1
Hirschsprung Disease 1Crebbp
human immunodeficiency virus infectious diseaseCdkn1a
Huntington's diseaseCrebbp , Nfe2l2
Hyperbilirubinemia, NeonatalIkbkb
hyperglycemiaNfe2l2
hyperinsulinismPten
HyperoxiaCdkn1a
HyperplasiaBrca1 , Cdkn1a , Ikbkb , Nfe2l2
hypertensionBrca1 , Gsk3b , Ikbkb , Nfe2l2 , Pten , Sqstm1
HypertrophyCdkn1a , Pten
Hypertrophy, Left VentricularGsk3a , Pten
HypovolemiaCdkn1a
idiopathic interstitial pneumoniaKeap1
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIANfe2l2
in situ carcinomaPten
inflammatory bowel diseaseIkbkb
Insulin ResistanceIkbkb , Pten
intellectual disabilityPten
Intestinal NeoplasmsCdkn1a , Gsk3b
intestinal pseudo-obstructionPten
intrahepatic cholestasisMafg
invasive ductal carcinomaBrca1
inverted papillomaCdkn1a
juvenile rheumatoid arthritisMaff
Keratoconus 1Skp1
keratosisKeap1 , Nfe2l2
kidney diseaseCdkn1a , Nfe2l2
Kidney Reperfusion InjuryIkbkb
Language Development DisordersPten
Laryngeal NeoplasmsCdkn1a
leiomyomaPten
lens diseaseSiah2
LEOPARD syndromePten
leukemiaNcoa3 , Pten
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
lipomaPten
lipomatosisPten
liver cancerCrebbp
liver cirrhosisNfe2l2
liver neoplasmCdkn1a , Nfe2l2
Liver Neoplasms, ExperimentalCdkn1a
Liver Reperfusion InjuryNfe2l2
localized sclerodermaCdkn1a
long QT syndromePten
lung adenocarcinomaCrebbp , Nfe2l2
lung diseaseNfe2l2
Lung NeoplasmsCdkn1a , Pten
lung small cell carcinomaCrebbp , Pten
lung squamous cell carcinomaCrebbp , Nfe2l2 , Pten
Lymphatic MetastasisCdkn1a , Pten
lymphomaPten
macrocephaly-autism syndromePten
macular degenerationCdkn1a , Nfe2l2 , Sqstm1
Malformations of Cortical Development, Group IIPten
malignant gliomaPten
malignant mesotheliomaCdkn1a
Mammary Neoplasms, AnimalBrca1 , Cdkn1a
Mammary Neoplasms, ExperimentalBrca1 , Nfe2l2 , Pten
mantle cell lymphomaGsk3b
maxillary sinus neoplasmCdkn1a
medulloblastomaCrebbp
megakaryocytic leukemiaPten
MegalencephalyPten
melanomaCdkn1a , Crebbp , Cul3 , Pten
Melanoma, ExperimentalIkbkb
meningiomaPten
mental depressionGsk3a , Gsk3b
Micronuclei, Chromosome-DefectiveNfe2l2
middle cerebral artery infarctionIkbkb , Nfe2l2
mouth diseaseBrca1
Mouth NeoplasmsPten
Multiple AbnormalitiesCrebbp , Gsk3b , Pten
Multiple Hamartoma SyndromePten
Muscle SpasticityCrebbp
muscular atrophyGsk3b , Ikbkb
muscular dystrophyPten
Muscular Dystrophy-Dystroglycanopathy (congenital with brain and eye anomalies), Type A, 11Brca1
myelodysplastic syndromeCrebbp
myocardial infarctionGsk3b , Nfe2l2
Myocardial Reperfusion InjuryGsk3b , Nfe2l2 , Pten
nasopharynx carcinomaPten
NecrosisNfe2l2
Neoplasm InvasivenessPten
Neoplasm MetastasisCdkn1a , Pten
nephronophthisis-like nephropathy 1Rbx1
Nephropathy, Chronic TubulointerstitialNfe2l2
Nerve Sheath NeoplasmsPten
neuroblastomaChd6
Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy, Childhood-OnsetSqstm1
Neurodevelopmental DisordersCul3 , Pten
neuronal ceroid lipofuscinosis 6Gsk3b
non-small cell lung carcinomaKeap1 , Ncoa3 , Nfe2l2 , Pten
Nonaka MyopathySqstm1
nonalcoholic fatty liver diseaseNfe2l2
obesityIkbkb , Ncoa3
ocular hypertensionCdkn1a
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a
osteochondrodysplasiaPten
ovarian cancerBrca1 , Palb2
Ovarian NeoplasmsBrca1 , Cdkn1a , Gsk3b , Palb2 , Pten
Paget's disease of boneSqstm1
pancreatic cancerBrca1 , Palb2 , Pten
pancreatic carcinomaCdkn1a
pancreatic ductal carcinomaCdkn1a , Nfe2l2
pancreatitisIkbkb
Pancreatitis, Experimental, Acute Cdkn1a
papillomaCdkn1a
Parkinson's diseaseGsk3b
Parkinsonian DisordersGsk3a
Pena Shokeir Syndrome, Type 1Pten
peripheral nervous system neoplasmPten
peritonitisGsk3b
persistent fetal circulation syndromePten
Phyllodes TumorCdkn1a
Pituitary NeoplasmsCdkn1a
pleurisyNfe2l2
pneumoniaIkbkb
PoisoningGsk3b
polydactylyPten
Porokeratosis Punctata Palmaris et PlantarisBrca1
portal hypertensionPten
precursor lymphoblastic lymphoma/leukemiaCrebbp
Premature AgingBrca1 , Cdkn1a , Nfe2l2
premature ovarian failureNfe2l2
primary biliary cirrhosisCdkn1a
primary open angle glaucomaCdkn1a
prostate adenocarcinomaIkbkb , Pten
prostate cancerBrca1 , Ikbkb , Pten
Prostate Cancer, SomaticPten
prostate carcinoma in situPten
prostatic hypertrophyPten
Prostatic NeoplasmsBrca1 , Cdkn1a , Chd6 , Crebbp , Cul3 , Gsk3b , Keap1 , Ncoa3 , Nfe2l2 , Palb2 , Pten
Proteus syndromePten
pseudohypoaldosteronismCul3
Pseudohypoaldosteronism, Type IIECul3
psoriasisCdkn1a , Ikbkb
PTEN hamartoma tumor syndromePten
pulmonary emphysemaKeap1 , Nfe2l2
pulmonary fibrosisNfe2l2
pulmonary hypertensionCdkn1a
punctate palmoplantar keratoderma type IIBrca1
renal carcinomaPten
renal cell carcinomaKeap1 , Nfe2l2 , Pten
renal hypertensionCdkn1a
Reperfusion InjuryCdkn1a , Keap1 , Pten
retinitis pigmentosaPten
rhabdomyosarcomaBrca1
Rubinstein-Taybi syndromeCrebbp
Salivary Gland NeoplasmsCdkn1a
sarcoidosisCdkn1a
SarcopeniaCdkn1a
schizophreniaGsk3a , Gsk3b
scoliosisCrebbp
sebaceous gland neoplasmCdkn1a
SepsisCdkn1a , Gsk3b , Keap1
serous cystadenocarcinomaCdkn1a
Sezary's diseaseCrebbp , Pten
Sinonasal NeoplasmsCdkn1a
skin diseasePten
skin melanomaPten
Skin NeoplasmsCdkn1a , Nfe2l2
Smith-Magenis syndromeBrca1 , Mafg
spina bifidaCrebbp
Spinal Cord InjuriesNfe2l2
squamous cell carcinomaCdkn1a , Crebbp , Ncoa3 , Nfe2l2
status epilepticusGsk3b
Stevens-Johnson syndromeCul1 , Rbx1
stomach diseasePten
Stomach NeoplasmsCdkn1a
Subarachnoid HemorrhageNfe2l2
substance-related disorderPten
SunburnNfe2l2
systemic lupus erythematosusCdkn1a
T-Cell LymphomaCdkn1a
tauopathyGsk3b
Testicular NeoplasmsRnf4
tethered spinal cord syndromeCrebbp
Thumb DeformityCrebbp
Thyroid NeoplasmsCdkn1a , Pten
Tongue NeoplasmsCdkn1a
tongue squamous cell carcinomaCdkn1a
toxic encephalopathyNfe2l2
transient cerebral ischemiaIkbkb , Keap1 , Pten
transitional cell carcinomaCdkn1a , Chd6 , Crebbp , Nfe2l2 , Pten
Transplant RejectionIkbkb
Triple Negative Breast NeoplasmsPalb2
Tumor Predisposition SyndromeBrca1 , Palb2 , Pten
type 2 diabetes mellitusGadd45gip1 , Gsk3b , Ikbkb , Nfe2l2
ulcerative colitisCdkn1a
ureteral obstructionKeap1
urinary bladder cancerBrca1 , Cdkn1a , Chd6 , Crebbp , Pten
uterine carcinosarcomaPten
Uterine Cervical NeoplasmsBrca1 , Cdkn1a , Crebbp , Nfe2l2 , Pten
Uterine NeoplasmsNfe2l2 , Pten
VACTERL associationPten
VACTERL/VATER Association with HydrocephalusPten
Vascular System InjuriesNfe2l2
visual epilepsyNfe2l2 , Pten
vitiligoNfe2l2
Pathway Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayIkbkb
adenosine signaling pathwayIkbkb
aldosterone signaling pathwayCrebbp
altered phosphatidylinositol 3-kinase signaling pathwayPten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPten
Alzheimer's disease pathwayGsk3b
androgen signaling pathwayCrebbp , Ncoa3
apoptotic cell death pathwayIkbkb
ataxia telangiectasia-mutated (ATM) signaling pathwayBrca1 , Rnf4
B cell receptor signaling pathwayGsk3b , Ikbkb
basal cell carcinoma pathwayGsk3b
Bone morphogenetic proteins signaling pathwayGsk3b
cell cycle pathway, mitoticCdkn1a , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
ceramide signaling pathwayIkbkb
Chagas disease pathwayIkbkb
chemokine mediated signaling pathwayGsk3a , Gsk3b , Ikbkb
chronic myeloid leukemia pathwayCdkn1a , Ikbkb
colorectal cancer pathwayGsk3b
cortisol signaling pathwayCrebbp , Ncoa3
endometrial cancer pathwayGsk3b , Pten
Endoplasmic Reticulum-associated degradation pathwayCul1 , Nfe2l2 , Rbx1 , Skp1
epidermal growth factor/neuregulin signaling pathwayCdkn1a , Gsk3b
estrogen signaling pathwayCrebbp , Ncoa3 , Siah2
FasL mediated signaling pathwayIkbkb
forkhead class A signaling pathwayBrca1 , Crebbp , Ncoa3
G1/S transition pathwayCdkn1a
glioma pathwayCdkn1a , Pten
glycogen biosynthetic pathwayGsk3a , Gsk3b
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb
Hedgehog signaling pathwayBtrc , Crebbp , Gsk3b
hepatitis C pathwayCdkn1a , Gsk3b , Ikbkb
histone modification pathwayCrebbp
homologous recombination pathway of double-strand break repairBrca1
Huntington's disease pathwayCrebbp
hypoxia inducible factor pathwayCrebbp , Rbx1
influenza A pathwayCrebbp , Gsk3b , Ikbkb
inositol phosphate metabolic pathwayPten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayGsk3b
insulin signaling pathwayGsk3b , Ikbkb
interleukin-1 signaling pathwayIkbkb , Sqstm1
Jak-Stat signaling pathwayCrebbp
long term depressionGsk3b
long term potentiationCrebbp
measles pathwayGsk3b
melanoma pathwayCdkn1a , Pten
mitochondrial autophagy pathwayPgam5 , Sqstm1
mitogen activated protein kinase signaling pathwayIkbkb
mTOR signaling pathwayIkbkb
neddylation pathwayCul1 , Cul3 , Rbx1
neurotrophic factor signaling pathwayGsk3b , Ikbkb
NOD-like receptor signaling pathwayIkbkb
non-small cell lung carcinoma pathwayPten
Notch signaling pathwayCdkn1a , Crebbp , Cul1 , Skp1
nuclear factor kappa B signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nuclear factor, erythroid 2 like 2 signaling pathwayBrca1 , Btrc , Cdkn1a , Chd6 , Crebbp , Cul1 , Cul3 , Dpp3 , Gadd45gip1 , Gsk3a , Gsk3b , Ikbkb , Keap1 , Maff , Mafg , Mafk , Ncoa3 , Nfe2l2 , Palb2 , Pgam5 , Pten , Rbx1 , Rnf4 , Siah2 , Skp1 , Sqstm1
nucleotide excision repair pathwayRbx1
p53 signaling pathwayBrca1 , Cdkn1a , Crebbp , Gsk3b , Pten
pancreatic cancer pathwayIkbkb , Pten
phosphatidylinositol 3-kinase class I signaling pathwayPten
phosphatidylinositol 3-kinase signaling pathwayPten
phosphatidylinositol 3-kinase-Akt signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
phosphoinositide metabolic pathwayPten
platelet-derived growth factor signaling pathwayPten
prostate cancer pathwayCdkn1a , Crebbp , Gsk3b , Ikbkb , Pten
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Cul3 , Rbx1
Reelin signaling pathwayGsk3b
renal cell carcinoma pathwayCrebbp , Rbx1
retinoic acid signaling pathwayNcoa3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb
RNA polymerase I transcription pathwayCrebbp
small cell lung carcinoma pathwayIkbkb , Pten
T cell receptor signaling pathwayGsk3b , Ikbkb
tamoxifen pharmacodynamics pathwayNcoa3
Toll-like receptor signaling pathwayIkbkb
toxoplasmosis pathwayIkbkb
Trail mediated signaling pathwayIkbkb
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Cul1 , Rbx1 , Skp1
tuberculosis pathwayCrebbp
tumor necrosis factor mediated signaling pathwayIkbkb , Sqstm1
type 2 diabetes mellitus pathwayIkbkb
type II interferon signaling pathwayCrebbp
ubiquitin/proteasome degradation pathwayBrca1 , Btrc , Cul1 , Cul3 , Keap1 , Rbx1 , Skp1
urinary bladder cancer pathwayCdkn1a
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayBtrc , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc , Crebbp , Cul3 , Gsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway

References Associated with the nuclear factor, erythroid 2 like 2 signaling pathway:

Ontology Path Diagram:

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