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The nuclear factor, erythroid 2 like 2 (Nfe2l2, known as Nrf2) signaling pathway is one of the most important regulators of antioxidant and electrophilic stress responses. Upon activation, the Nrf2 transcription factor induces the expression of antioxidant, xenobiotic metabolism and cytoprotective genes and also controls the expression of genes involved in intermediary metabolism. Under unstressed conditions, Nrf2 is sequestered in the cytoplasm by the ubiquitin E3 ligase adaptor Keap1, and only

Pathway Diagram:

Elsevier Inc. Gsk3b Kelch-repeat BTB ---> CTR Neh6 Neh2 ---- Neh3 Keap1 Pten Sqstm1 mTorc1 complex electrophiles ---| Pten ROS ---| Pten electrophiles ROS Btrc environmental cues cellular stresses Nfe2l2 target genes Cul3/Rbx1 complex ---| Nfe2l2 Skp1/Cul1/Rbx1 complex ---| Nfe2l2 Cul3/Rbx1 complex ---> Nfe2l2 Keap1 ---- Nfe2l2 small MAFs mTOR signaling pathway <++> phosphatidylinositol 3-kinase-Akt signaling pathway cellular stresses --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues --+> mTOR signaling pathway Skp1/Cul1/Rbx1 complex ---> Nfe2l2 Gsk3b --+> Btrc Crebbp ROS ---| Keap1 electrophiles ---| Keap1 nuclear Nfe2l2 nuclear Nfe2l2 ---- small MAFs Neh1 Gsk3b ---> Nfe2l2 Gsk3a ---> Nfe2l2 Btrc ---- Nfe2l2 phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3b phosphatidylinositol 3-kinase-Akt signaling pathway ---| Gsk3a phosphatidylinositol 3-kinase-Akt signaling pathway ---> Gsk3a IVR Gsk3a ROS --+> nuclear Nfe2l2 electrophiles --+> nuclear Nfe2l2 nuclear Nfe2l2 ---> Nfe2l2 target genes small MAFs ---> Nfe2l2 target genes Pten --+> Gsk3b Pten ---> Gsk3b Pten --+> Gsk3a Pten ---> Gsk3a C226/C613 preferring C273/C288 preferring C434 preferring CTR Skp1/Cul1/Rbx1 complex Nfe2l2 Nfe2l2 interactors ---> Nfe2l2 Keap1 ---- Keap1 interactors Keap1 interactors ---| Keap1 mTorc1 complex ---> Sqstm1 mTorc1 complex --+> Sqstm1 Neh7 Crebbp ---- Neh5 Crebbp ---- Neh4 Neh4 Neh5 Ncoa3 ---- Neh5 Ncoa3 ---- Neh4 Nfe2l2 ---- Nfe2l2 interactors Ncoa3 Chd6 Neh3 Chd6 ---- Neh3 C151 preferring 3-box BTB Neh2 mTOR signaling pathway phosphatidylinositol 3-kinase-Akt signaling pathway Cul3/Rbx1 complex Keap1 interactors Nfe2l2 interactors

Genes in Pathway:

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nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:11535066
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:11535066
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:11535066
G Chd6 chromodomain helicase DNA binding protein 6 JBrowse link 3 156,937,746 157,099,328 RGD:11535066
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:11535066
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:11535066
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:11535066
G Dpp3 dipeptidylpeptidase 3 JBrowse link 1 220,166,124 220,189,762 RGD:11535066
G Gadd45gip1 GADD45G interacting protein 1 JBrowse link 19 25,946,979 25,949,528 RGD:11535066
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:11535070
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:11535070
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:11535066
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:727319
G Maff MAF bZIP transcription factor F JBrowse link 7 120,580,743 120,592,095 RGD:11535066
G Mafg MAF bZIP transcription factor G JBrowse link 10 109,802,877 109,811,476 RGD:11535066
G Mafk MAF bZIP transcription factor K JBrowse link 12 16,923,989 16,934,706 RGD:11535066
G Ncoa3 nuclear receptor coactivator 3 JBrowse link 3 162,692,176 162,788,582 RGD:11535066
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11530066
G Palb2 partner and localizer of BRCA2 JBrowse link 1 192,064,586 192,088,547 RGD:11535066
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase JBrowse link 12 52,467,417 52,474,533 RGD:11535066
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:11535070
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:11535066
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:11535066
G Siah2 siah E3 ubiquitin protein ligase 2 JBrowse link 2 148,874,151 148,891,900 RGD:11535066
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:11535066
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:11535066

Pathway Gene Annotations

Disease Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGsk3b
acoustic neuromaCdkn1a
acute kidney failureGsk3b , Nfe2l2
Acute Lung InjuryNfe2l2
acute lymphocytic leukemiaPten
acute myeloid leukemiaCrebbp
acute myocardial infarctionGsk3b
adenocarcinomaNcoa3 , Pten
adenoid cystic carcinomaBrca1 , Crebbp , Pten
adenosine deaminase deficiencyBrca1
Alcoholic Liver DiseasesKeap1
allergic contact dermatitisNfe2l2
Alzheimer's diseaseCrebbp , Gsk3a , Gsk3b , Ikbkb , Nfe2l2
amyotrophic lateral sclerosisGsk3a , Gsk3b , Keap1 , Nfe2l2 , Sqstm1
amyotrophic lateral sclerosis type 1Crebbp
Angelman syndromeRnf4
Animal Mammary NeoplasmsBrca1 , Cdkn1a
Arsenic PoisoningCdkn1a
asthmaNfe2l2 , Pten
atrial fibrillationCdkn1a
atrial heart septal defectCrebbp
attention deficit hyperactivity disorderCrebbp
autism spectrum disorderPten
autistic disorderCrebbp , Pten
autosomal dominant polycystic kidney diseaseCdkn1a
autosomal dominant pseudohypoaldosteronism type 1Cul3
autosomal recessive limb-girdle muscular dystrophy type 2ABrca1
Bannayan-Riley-Ruvalcaba syndromePten
Barrett's esophagusCdkn1a
basal cell carcinomaPalb2
biliary atresiaPten
bipolar disorderGsk3a , Gsk3b
bladder urothelial carcinomaCrebbp , Pten
Bone NeoplasmsNcoa3
Bowen's DiseaseCdkn1a
brain diseasePten
Brain InjuriesCdkn1a , Gsk3b , Nfe2l2
Brain NeoplasmsPten
breast cancerBrca1 , Ikbkb , Ncoa3 , Palb2 , Pten
Breast Cancer, FamilialBrca1 , Palb2
breast carcinomaBrca1 , Ncoa3 , Palb2
breast ductal carcinomaBrca1
Breast NeoplasmsBrca1 , Cdkn1a , Ncoa3 , Palb2 , Pten
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca1
carcinomaBrca1 , Cdkn1a , Pten
CardiomegalyGsk3b , Pten
cataractNfe2l2 , Pten
Cell Transformation, NeoplasticBrca1 , Gsk3b , Pten
central nervous system diseaseCrebbp
cerebral cavernous malformationPten
Cerebral HemorrhageSqstm1
cervical cancerBrca1
cervix uteri carcinoma in situBrca1 , Cdkn1a , Pten
Chemical and Drug Induced Liver InjuryKeap1 , Nfe2l2
cholesteatoma of middle earCdkn1a
Choroidal NeovascularizationIkbkb
Chromosome BreakageBrca1 , Nfe2l2
chronic kidney diseaseNfe2l2
chronic obstructive pulmonary diseaseNfe2l2
Chronic Tubulointerstitial NephropathyNfe2l2
cognitive disorderGsk3b
colon cancerBrca1 , Gsk3b , Ikbkb , Pten
Colonic NeoplasmsCdkn1a , Gsk3b
colorectal adenocarcinomaGsk3b
colorectal cancerNfe2l2
Colorectal NeoplasmsCrebbp , Pten
Congenital CholesteatomaCdkn1a
congenital myasthenic syndromeBrca1
congenital myasthenic syndrome 10Brca1
congestive heart failureGsk3b , Nfe2l2
Cowden syndromePten
Cowden-Like SyndromePten
Craniofacial AbnormalitiesPten
degenerative disc diseaseGsk3b
developmental coordination disorderPten
Developmental DisabilitiesCrebbp , Pten
diabetes mellitusPten
Diabetes Mellitus, Experimental Cdkn1a , Gsk3a , Ikbkb , Nfe2l2
Diabetic CardiomyopathiesNfe2l2
diabetic encephalopathyGsk3b
Diabetic NephropathiesCdkn1a , Gsk3b , Keap1 , Nfe2l2 , Pten
diabetic retinopathyKeap1 , Nfe2l2
dilated cardiomyopathyGsk3a
disease of cellular proliferationBrca1 , Pten
Disease ProgressionKeap1 , Pten
Drug-Induced DyskinesiaGsk3b
Drug-Related Side Effects and Adverse ReactionsNfe2l2
ductal carcinoma in situCdkn1a
end stage renal failureKeap1
endometrial cancerPten
endometrial carcinomaGsk3b , Pten
endometrial hyperplasiaPten
Endometrial NeoplasmsCdkn1a , Gsk3b , Nfe2l2 , Pten
Endometrioid CarcinomasPten
Esophageal NeoplasmsCdkn1a
Experimental ArthritisGsk3b , Ikbkb
Experimental Autoimmune EncephalomyelitisNfe2l2
Experimental ColitisNfe2l2
Experimental Liver CirrhosisCdkn1a , Nfe2l2
Experimental Liver NeoplasmsCdkn1a
Experimental MelanomaIkbkb
extrahepatic cholestasisKeap1 , Nfe2l2
facioscapulohumeral muscular dystrophyCdkn1a
familial meningiomaPten
Familial Paget's Disease of BoneSqstm1
Fanconi anemiaBrca1 , Palb2
Fanconi anemia complementation group ABrca1
Fanconi anemia complementation group NPalb2
fatty liver diseaseKeap1 , Nfe2l2 , Pten
fetal alcohol spectrum disorderPten
Fetal Growth RetardationNfe2l2
Fetal MacrosomiaPten
follicular lymphomaCrebbp
follicular thyroid carcinomaPten
Fuchs' endothelial dystrophyCdkn1a
gallbladder cancerKeap1
Gallbladder NeoplasmsKeap1
gastric adenocarcinomaCrebbp , Pten
Gastrointestinal DiseasesKeap1 , Nfe2l2
Gastrointestinal NeoplasmsPten
genetic diseaseCrebbp , Cul3 , Pten
glaucomaCrebbp , Sqstm1
glioblastoma multiformeCrebbp , Pten
growth hormone secreting pituitary adenomaCdkn1a
head and neck squamous cell carcinomaCrebbp , Nfe2l2 , Pten
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedCdkn1a
heart diseaseGsk3b
Hepatic InsufficiencyKeap1 , Nfe2l2
Hepatitis B, ChronicKeap1
hepatocellular adenomaPten
hepatocellular carcinomaCdkn1a , Crebbp , Nfe2l2 , Pten
HepatomegalyKeap1 , Nfe2l2 , Pten
hereditary breast ovarian cancer syndromeBrca1 , Palb2
Hereditary Neoplastic SyndromesBrca1 , Palb2 , Pten , Skp1
Hirschsprung Disease 1Crebbp
human immunodeficiency virus infectious diseaseCdkn1a
Huntington's diseaseCrebbp , Nfe2l2
HyperplasiaBrca1 , Cdkn1a , Ikbkb , Nfe2l2
hypertensionBrca1 , Gsk3b , Ikbkb , Nfe2l2 , Pten , Sqstm1
HypertrophyCdkn1a , Pten
idiopathic interstitial pneumoniaKeap1
Immunodeficiency 15BIkbkb
in situ carcinomaPten
inflammatory bowel diseaseIkbkb
Insulin ResistanceIkbkb , Pten
intellectual disabilityPten
Intestinal NeoplasmsCdkn1a , Gsk3b
intestinal pseudo-obstructionPten
intrahepatic cholestasisMafg
invasive ductal carcinomaBrca1 , Palb2
inverted papillomaCdkn1a
juvenile polyposis syndromePten
juvenile rheumatoid arthritisMaff
Keratoconus 1Skp1
keratosisKeap1 , Nfe2l2
kidney diseaseCdkn1a , Nfe2l2
Kidney Reperfusion InjuryIkbkb
Language Development DisordersPten
laryngeal squamous cell carcinomaCdkn1a
Left Ventricular HypertrophyGsk3a , Pten
lens diseaseSiah2
LEOPARD syndromePten
leukemiaNcoa3 , Pten
Lip NeoplasmsCdkn1a
lipoid nephrosisCdkn1a
liver benign neoplasmCdkn1a , Nfe2l2
liver cancerCrebbp
liver cirrhosisNfe2l2
Liver Reperfusion InjuryGsk3b , Nfe2l2
localized sclerodermaCdkn1a
long QT syndromePten
lung adenocarcinomaNfe2l2
lung diseaseNfe2l2
Lung NeoplasmsCdkn1a , Pten
lung small cell carcinomaCrebbp , Pten
lung squamous cell carcinomaCrebbp , Nfe2l2 , Pten
Lymphatic MetastasisCdkn1a , Pten
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessivePten
macular degenerationCdkn1a , Nfe2l2 , Sqstm1
malignant gliomaCdkn1a , Pten
malignant mesotheliomaCdkn1a
Mammary Neoplasms, ExperimentalBrca1 , Gsk3b , Nfe2l2 , Pten
mantle cell lymphomaGsk3b
maxillary sinus squamous cell carcinomaCdkn1a
megakaryocytic leukemiaPten
melanomaCdkn1a , Crebbp , Cul3 , Palb2 , Pten
Menke-Hennekam Syndrome 1Crebbp
mental depressionGsk3a , Gsk3b
Micronuclei, Chromosome-DefectiveNfe2l2
middle cerebral artery infarctionGsk3b , Ikbkb , Nfe2l2
mouth diseaseBrca1
Mouth NeoplasmsPten
Multiple AbnormalitiesCrebbp , Gsk3b , Pten
Multiple Hamartoma SyndromePten
Muscle SpasticityCrebbp
muscular atrophyGsk3b , Ikbkb
muscular dystrophyPten
Muscular Dystrophy-Dystroglycanopathy (congenital with brain and eye anomalies), Type A, 11Brca1
myelodysplastic syndromeCrebbp
myocardial infarctionGsk3b , Nfe2l2
Myocardial Reperfusion InjuryGsk3b , Nfe2l2 , Pten
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessPten
Neoplasm MetastasisCdkn1a , Pten
nephronophthisis-like nephropathy 1Rbx1
Nerve Sheath NeoplasmsPten
Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy, Childhood-OnsetSqstm1
Neurodevelopmental DisordersCul3 , Pten
neuronal ceroid lipofuscinosis 6Gsk3b
non-small cell lung carcinomaKeap1 , Ncoa3 , Nfe2l2 , Pten
Nonaka MyopathySqstm1
nonalcoholic fatty liver diseaseNfe2l2
obesityIkbkb , Ncoa3
ocular hypertensionCdkn1a
Oral Lichen PlanusCdkn1a
oral mucosa leukoplakiaCdkn1a
oral squamous cell carcinomaCdkn1a
ovarian cancerBrca1 , Palb2
Ovarian NeoplasmsBrca1 , Cdkn1a , Gsk3b , Palb2 , Pten
ovary serous adenocarcinomaBrca1
Paget's disease of boneSqstm1
pancreatic cancerBrca1 , Palb2 , Pten
pancreatic carcinomaBrca1 , Cdkn1a
pancreatic ductal adenocarcinomaIkbkb
pancreatic ductal carcinomaCdkn1a , Nfe2l2
pancreatic endocrine carcinomaPalb2
Pancreatic Intraepithelial NeoplasiaIkbkb
Pancreatitis, Experimental, Acute Cdkn1a
papillary renal cell carcinomaNfe2l2 , Pten
Parkinson's diseaseGsk3b
Parkinsonian DisordersGsk3a
peripheral nervous system neoplasmPten
persistent fetal circulation syndromePten
Phyllodes TumorCdkn1a
Pituitary NeoplasmsCdkn1a
Porokeratosis 2, Palmar, Plantar, and Disseminated TypeBrca1
portal hypertensionPten
pre-malignant neoplasmCdkn1a
precursor lymphoblastic lymphoma/leukemiaCrebbp
Premature AgingBrca1 , Cdkn1a , Nfe2l2
premature ovarian failureNfe2l2
primary biliary cirrhosisCdkn1a , Keap1 , Nfe2l2
primary open angle glaucomaCdkn1a
prostate adenocarcinomaIkbkb , Pten
prostate cancerBrca1 , Cdkn1a , Ikbkb , Ncoa3 , Pten
Prostate Cancer, SomaticPten
prostate carcinoma in situPten
prostatic hypertrophyPten
Prostatic NeoplasmsBrca1 , Cdkn1a , Chd6 , Crebbp , Cul3 , Gsk3b , Keap1 , Ncoa3 , Nfe2l2 , Palb2 , Pten
Proteus syndromePten
Pseudohypoaldosteronism, Type IIECul3
psoriasisCdkn1a , Ikbkb
PTEN hamartoma tumor syndromePten
pulmonary emphysemaKeap1 , Nfe2l2
pulmonary fibrosisNfe2l2
pulmonary hypertensionCdkn1a
punctate palmoplantar keratoderma type IIBrca1
renal carcinomaPten
renal cell carcinomaKeap1 , Nfe2l2 , Pten
renal hypertensionCdkn1a
Reperfusion InjuryCdkn1a , Keap1 , Pten
retinitis pigmentosaPten
Rubinstein-Taybi syndromeCrebbp
Salivary Gland NeoplasmsCdkn1a
schizophreniaGsk3a , Gsk3b
sciatic neuropathyGsk3b
sebaceous gland neoplasmCdkn1a
SepsisCdkn1a , Gsk3b , Keap1
serous cystadenocarcinomaCdkn1a
Sezary's diseaseCrebbp , Pten
skin diseasePten
skin melanomaPten
Skin NeoplasmsCdkn1a , Nfe2l2
spina bifidaCrebbp
Spinal Cord InjuriesNfe2l2
split hand-foot malformationBtrc
sporadic breast cancerPten
squamous cell carcinomaCdkn1a , Crebbp , Ncoa3 , Nfe2l2
status epilepticusGsk3b
Stevens-Johnson syndromeCul1 , Rbx1
stomach carcinomaCdkn1a
stomach diseasePten
Stomach NeoplasmsCdkn1a
Subarachnoid HemorrhageGsk3b , Nfe2l2
substance-related disorderGsk3b , Pten
systemic lupus erythematosusCdkn1a
T-Cell LymphomaCdkn1a
Testicular NeoplasmsRnf4
Thumb DeformityCrebbp
Thyroid NeoplasmsCdkn1a , Pten
Tongue NeoplasmsCdkn1a
tongue squamous cell carcinomaCdkn1a
toxic encephalopathyNfe2l2
transient cerebral ischemiaIkbkb , Keap1 , Pten
transitional cell carcinomaCdkn1a , Chd6 , Crebbp , Nfe2l2 , Pten
Transplant RejectionIkbkb
Triple Negative Breast NeoplasmsPalb2
Tumor Predisposition SyndromeBrca1 , Palb2 , Pten
type 2 diabetes mellitusGadd45gip1 , Gsk3b , Ikbkb , Nfe2l2
ulcerative colitisCdkn1a
ureteral obstructionKeap1
urinary bladder cancerBrca1 , Cdkn1a , Chd6 , Crebbp , Pten
uterine carcinosarcomaPten
Uterine Cervical NeoplasmsCdkn1a , Crebbp , Nfe2l2 , Pten
Uterine NeoplasmsNfe2l2 , Pten
VACTERL/VATER Association with HydrocephalusPten
vascular dementiaGsk3b
Vascular System InjuriesNfe2l2
visual epilepsyNfe2l2 , Pten
Pathway Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayIkbkb
adenosine signaling pathwayIkbkb
aldosterone signaling pathwayCrebbp
altered phosphatidylinositol 3-kinase signaling pathwayPten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPten
Alzheimer's disease pathwayGsk3b
androgen signaling pathwayCrebbp , Ncoa3
apoptotic cell death pathwayIkbkb
ataxia telangiectasia-mutated (ATM) signaling pathwayBrca1 , Rnf4
B cell receptor signaling pathwayGsk3b , Ikbkb
basal cell carcinoma pathwayGsk3b
Bone morphogenetic proteins signaling pathwayGsk3b
cell cycle pathway, mitoticCdkn1a , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
ceramide signaling pathwayIkbkb
Chagas disease pathwayIkbkb
chemokine mediated signaling pathwayGsk3a , Gsk3b , Ikbkb
chronic myeloid leukemia pathwayCdkn1a , Ikbkb
colorectal cancer pathwayGsk3b
cortisol signaling pathwayCrebbp , Ncoa3
endometrial cancer pathwayGsk3b , Pten
Endoplasmic Reticulum-associated degradation pathwayCul1 , Nfe2l2 , Rbx1 , Skp1
epidermal growth factor/neuregulin signaling pathwayCdkn1a , Gsk3b
estrogen signaling pathwayCrebbp , Ncoa3 , Siah2
FasL mediated signaling pathwayIkbkb
forkhead class A signaling pathwayBrca1 , Crebbp , Ncoa3
G1/S transition pathwayCdkn1a
glioma pathwayCdkn1a , Pten
glycogen biosynthetic pathwayGsk3a , Gsk3b
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb
Hedgehog signaling pathwayBtrc , Crebbp , Gsk3b
hepatitis C pathwayCdkn1a , Gsk3b , Ikbkb
histone modification pathwayCrebbp
homologous recombination pathway of double-strand break repairBrca1
Huntington's disease pathwayCrebbp
hypoxia inducible factor pathwayCrebbp , Rbx1
influenza A pathwayCrebbp , Gsk3b , Ikbkb
inositol phosphate metabolic pathwayPten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayGsk3b
insulin signaling pathwayGsk3b , Ikbkb
interleukin-1 signaling pathwayIkbkb , Sqstm1
Jak-Stat signaling pathwayCrebbp
long term depressionGsk3b
long term potentiationCrebbp
measles pathwayGsk3b
melanoma pathwayCdkn1a , Pten
mitochondrial autophagy pathwayPgam5 , Sqstm1
mitogen activated protein kinase signaling pathwayIkbkb
mTOR signaling pathwayIkbkb
neddylation pathwayCul1 , Cul3 , Rbx1
neurotrophic factor signaling pathwayGsk3b , Ikbkb
NOD-like receptor signaling pathwayIkbkb
non-small cell lung carcinoma pathwayPten
Notch signaling pathwayCdkn1a , Crebbp , Cul1 , Skp1
nuclear factor kappa B signaling pathwayBtrc , Cul1 , Ikbkb , Rbx1 , Skp1
nuclear factor, erythroid 2 like 2 signaling pathwayBrca1 , Btrc , Cdkn1a , Chd6 , Crebbp , Cul1 , Cul3 , Dpp3 , Gadd45gip1 , Gsk3a , Gsk3b , Ikbkb , Keap1 , Maff , Mafg , Mafk , Ncoa3 , Nfe2l2 , Palb2 , Pgam5 , Pten , Rbx1 , Rnf4 , Siah2 , Skp1 , Sqstm1
nucleotide excision repair pathwayRbx1
p53 signaling pathwayBrca1 , Cdkn1a , Crebbp , Gsk3b , Pten
pancreatic cancer pathwayIkbkb , Pten
phosphatidylinositol 3-kinase class I signaling pathwayPten
phosphatidylinositol 3-kinase signaling pathwayPten
phosphatidylinositol 3-kinase-Akt signaling pathwayCdkn1a , Gsk3a , Gsk3b , Pten
phosphoinositide metabolic pathwayPten
platelet-derived growth factor signaling pathwayPten
prostate cancer pathwayCdkn1a , Crebbp , Gsk3b , Ikbkb , Pten
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul1 , Cul3 , Rbx1
Reelin signaling pathwayGsk3b
renal cell carcinoma pathwayCrebbp , Rbx1
retinoic acid signaling pathwayNcoa3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayIkbkb
RNA polymerase I transcription pathwayCrebbp
small cell lung carcinoma pathwayIkbkb , Pten
T cell receptor signaling pathwayGsk3b , Ikbkb
tamoxifen pharmacodynamics pathwayNcoa3
Toll-like receptor signaling pathwayIkbkb
toxoplasmosis pathwayIkbkb
Trail mediated signaling pathwayIkbkb
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Cul1 , Rbx1 , Skp1
tuberculosis pathwayCrebbp
tumor necrosis factor mediated signaling pathwayIkbkb , Sqstm1
type 2 diabetes mellitus pathwayIkbkb
type II interferon signaling pathwayCrebbp
ubiquitin/proteasome degradation pathwayBrca1 , Btrc , Cul1 , Cul3 , Keap1 , Rbx1 , Skp1
urinary bladder cancer pathwayCdkn1a
vinblastine pharmacodynamics pathwayCdkn1a
vincristine pharmacodynamics pathwayCdkn1a
vindesine pharmacodynamics pathwayCdkn1a
vinorelbine pharmacodynamics pathwayCdkn1a
Wnt signaling pathwayBtrc , Crebbp , Cul1 , Gsk3b , Rbx1 , Skp1
Wnt signaling, canonical pathwayBtrc , Crebbp , Cul3 , Gsk3a , Gsk3b
Phenotype Annotations Associated with Genes in the nuclear factor, erythroid 2 like 2 signaling pathway

References Associated with the nuclear factor, erythroid 2 like 2 signaling pathway:

Ontology Path Diagram:

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