RGD Reference Report - Smad transcription factors. - Rat Genome Database

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Smad transcription factors.

Authors: Massagué, Joan  Seoane, Joan  Wotton, David 
Citation: Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
RGD ID: 2302137
Pubmed: PMID:16322555   (View Abstract at PubMed)
DOI: DOI:10.1101/gad.1350705   (Journal Full-text)

Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of regulatory devices exerts control over each step of the Smad pathway. This knowledge is enabling work on more complex questions about the organization, integration, and modulation of Smad-dependent transcriptional programs. We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups. Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior.



RGD Manual Annotations

1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ATF3Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Atf3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOATF3 (Homo sapiens) RGD 
Atf3Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOATF3 (Homo sapiens) RGD 
CREBBPHumantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
CrebbpRattransforming growth factor-beta Smad dependent signaling pathway   ISOCREBBP (Homo sapiens) RGD 
CrebbpMousetransforming growth factor-beta Smad dependent signaling pathway   ISOCREBBP (Homo sapiens) RGD 
FOXH1Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
FOXO1Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
FOXO3Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
FOXO4Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Foxh1Rattransforming growth factor-beta Smad dependent signaling pathway   ISOFOXH1 (Homo sapiens) RGD 
Foxh1Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOFOXH1 (Homo sapiens) RGD 
Foxo1Rattransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO1 (Homo sapiens) RGD 
Foxo1Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO1 (Homo sapiens) RGD 
Foxo3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO3 (Homo sapiens) RGD 
Foxo3Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO3 (Homo sapiens) RGD 
Foxo4Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO4 (Homo sapiens) RGD 
Foxo4Rattransforming growth factor-beta Smad dependent signaling pathway   ISOFOXO4 (Homo sapiens) RGD 
RUNX1Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
RUNX2Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
1 to 20 of 27 rows

Genes (Rattus norvegicus)
Atf3  (activating transcription factor 3) Crebbp  (CREB binding protein) Foxh1  (forkhead box H1)
Foxo1  (forkhead box O1) Foxo3  (forkhead box O3) Foxo4  (forkhead box O4)
Runx1  (RUNX family transcription factor 1) Runx2  (RUNX family transcription factor 2) Runx3  (RUNX family transcription factor 3)

Genes (Mus musculus)
Atf3  (activating transcription factor 3) Crebbp  (CREB binding protein) Foxh1  (forkhead box H1)
Foxo1  (forkhead box O1) Foxo3  (forkhead box O3) Foxo4  (forkhead box O4)
Runx1  (runt related transcription factor 1) Runx2  (runt related transcription factor 2) Runx3  (runt related transcription factor 3)

Genes (Homo sapiens)
ATF3  (activating transcription factor 3) CREBBP  (CREB binding protein) FOXH1  (forkhead box H1)
FOXO1  (forkhead box O1) FOXO3  (forkhead box O3) FOXO4  (forkhead box O4)
RUNX1  (RUNX family transcription factor 1) RUNX2  (RUNX family transcription factor 2) RUNX3  (RUNX family transcription factor 3)