FOXO3 (forkhead box O3) - Rat Genome Database

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Gene: FOXO3 (forkhead box O3) Homo sapiens
Analyze
Symbol: FOXO3
Name: forkhead box O3
RGD ID: 1319403
HGNC Page HGNC
Description: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; beta-catenin binding activity; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; regulation of cellular macromolecule biosynthetic process; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within positive regulation of erythrocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in cytosol; mitochondrial outer membrane; and nucleoplasm. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Biomarker of Alzheimer's disease; endometrial adenocarcinoma; prostate cancer; rheumatoid arthritis; and temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF6q21; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3A; forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3A; FOXO3A-; MGC12739; MGC31925
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6108,559,835 - 108,684,774 (+)EnsemblGRCh38hg38GRCh38
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376108,881,028 - 109,005,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (EXP,ISO)
amidotrizoic acid  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
aspartame  (ISO)
astaxanthin  (ISO)
atrazine  (EXP)
aucubin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
C60 fullerene  (ISO)
cabazitaxel  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (EXP)
celastrol  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
D-glucose  (ISO)
DAPT  (EXP)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
dihydrogen  (EXP)
dioxygen  (EXP,ISO)
diprotium  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
eckol  (EXP)
elemental selenium  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
fostriecin  (EXP)
fulvestrant  (EXP)
furan  (ISO)
gefitinib  (EXP,ISO)
genistein  (EXP)
glucose  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (EXP,ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
isobutanol  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
KN-93  (EXP)
L-ascorbic acid  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (EXP)
metacetamol  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methoxychlor  (ISO)
methylseleninic acid  (EXP)
metoprolol  (ISO)
mifepristone  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nicotinamide  (EXP)
nitroxoline  (EXP)
okadaic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picropodophyllotoxin  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
ramipril  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
Sodium salicylate  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Tomentosin  (EXP)
trilobatin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
umbelliferone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)
zinc acetate  (EXP)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEA,ISO)
antral ovarian follicle growth  (IEA,ISO)
apoptotic process  (ISO)
brain morphogenesis  (IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to corticosterone stimulus  (IEA,ISO)
cellular response to glucose starvation  (IDA)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to oxidative stress  (ISO,ISS)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
glucose homeostasis  (ISO)
initiation of primordial ovarian follicle growth  (IEA,ISO)
mitochondrial transcription  (IMP)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell migration  (IMP)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
neuronal stem cell population maintenance  (IEA,ISO)
oocyte maturation  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of autophagy  (ISS)
positive regulation of endothelial cell apoptotic process  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IDA)
positive regulation of hydrogen peroxide-mediated programmed cell death  (IEA,ISO)
positive regulation of muscle atrophy  (ISS)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISS)
positive regulation of reactive oxygen species biosynthetic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISS)
regulation of transcription, DNA-templated  (ISO)
regulation of translation  (IDA)
response to dexamethasone  (IEA,ISO)
response to fatty acid  (ISS)
response to nutrient levels  (ISO)
response to starvation  (ISS)
response to water-immersion restraint stress  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IMP)

Cellular Component
chromatin  (ISA)
cytoplasm  (IDA)
cytosol  (IDA,ISO,TAS)
membrane  (ISO)
mitochondrial matrix  (IBA,IDA)
mitochondrial outer membrane  (IDA)
mitochondrion  (IDA,ISO)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IDA,IMP,ISO)
protein-containing complex  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Caballero-Caballero A, etal., J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.
2. Esteras N, etal., Neurobiol Aging. 2013 Apr;34(4):1090-100. doi: 10.1016/j.neurobiolaging.2012.10.014. Epub 2012 Nov 13.
3. GOA_HUMAN data from the GO Consortium
4. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
5. Imae M, etal., J Mol Endocrinol. 2003 Apr;30(2):253-62.
6. Kato M, etal., J Am Soc Nephrol. 2006 Dec;17(12):3325-35. Epub 2006 Nov 2.
7. Li DY, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):1023-7.
8. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
9. Park KW, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):742-7. Epub 2005 Jan 20.
10. Pipeline to import KEGG annotations from KEGG into RGD
11. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Relling DP, etal., J Hypertens. 2006 Mar;24(3):549-61.
13. RGD automated import pipeline for gene-chemical interactions
14. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
15. Sanphui P and Biswas SC, Cell Death Dis. 2013 May 9;4:e625. doi: 10.1038/cddis.2013.148.
16. Turrel-Davin F, etal., Ann Rheum Dis. 2010 Apr;69(4):755-60. doi: 10.1136/ard.2009.109991. Epub 2009 May 11.
17. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
18. Westin SN, etal., Mol Oncol. 2015 Oct;9(8):1694-703. doi: 10.1016/j.molonc.2015.04.014. Epub 2015 May 16.
19. Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
20. Zhang S, etal., J Cell Biochem. 2013 Feb;114(2):354-65. doi: 10.1002/jcb.24371.
Additional References at PubMed
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PMID:22107151   PMID:22128155   PMID:22139133   PMID:22159921   PMID:22209974   PMID:22223847   PMID:22310285   PMID:22349704   PMID:22394200   PMID:22411791   PMID:22430142   PMID:22435562  
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PMID:26972000   PMID:26993517   PMID:27058291   PMID:27058618   PMID:27071935   PMID:27091996   PMID:27113546   PMID:27125259   PMID:27127880   PMID:27167185   PMID:27173435   PMID:27214848  
PMID:27237816   PMID:27283899   PMID:27284014   PMID:27390852   PMID:27411103   PMID:27448972   PMID:27452907   PMID:27458157   PMID:27470586   PMID:27481940   PMID:27522666   PMID:27524627  
PMID:27529982   PMID:27532863   PMID:27621247   PMID:27633065   PMID:27669435   PMID:27685445   PMID:27694344   PMID:27698266   PMID:27699813   PMID:27743201   PMID:27769056   PMID:27777301  
PMID:27793938   PMID:27825133   PMID:27840901   PMID:27841661   PMID:27881235   PMID:27886165   PMID:27890702   PMID:27893718   PMID:27936162   PMID:27936216   PMID:28006785   PMID:28036259  
PMID:28046000   PMID:28055019   PMID:28065597   PMID:28099944   PMID:28122308   PMID:28137654   PMID:28139510   PMID:28250026   PMID:28260024   PMID:28295288   PMID:28358423   PMID:28398822  
PMID:28424160   PMID:28430387   PMID:28436938   PMID:28466777   PMID:28473536   PMID:28507102   PMID:28514442   PMID:28526626   PMID:28554751   PMID:28611215   PMID:28621049   PMID:28661534  
PMID:28688900   PMID:28699185   PMID:28718761   PMID:28722347   PMID:28733463   PMID:28765909   PMID:28802579   PMID:28869600   PMID:28889023   PMID:28905195   PMID:28952285   PMID:28977569  
PMID:28989024   PMID:29049183   PMID:29072689   PMID:29080747   PMID:29099866   PMID:29136142   PMID:29141605   PMID:29143599   PMID:29147649   PMID:29180117   PMID:29220389   PMID:29234056  
PMID:29257235   PMID:29258239   PMID:29301589   PMID:29301793   PMID:29326312   PMID:29339071   PMID:29361949   PMID:29365018   PMID:29411515   PMID:29421536   PMID:29433738   PMID:29439954  
PMID:29445193   PMID:29498217   PMID:29500870   PMID:29507755   PMID:29509190   PMID:29518547   PMID:29533771   PMID:29551204   PMID:29565456   PMID:29588373   PMID:29602130   PMID:29620202  
PMID:29676828   PMID:29688278   PMID:29695725   PMID:29716743   PMID:29733381   PMID:29792850   PMID:29859273   PMID:29925039   PMID:29963746   PMID:29967111   PMID:30045773   PMID:30066886  
PMID:30091834   PMID:30118760   PMID:30119891   PMID:30138933   PMID:30185800   PMID:30307642   PMID:30483771   PMID:30513302   PMID:30514328   PMID:30518851   PMID:30539857   PMID:30542728  
PMID:30623608   PMID:30661960   PMID:30691517   PMID:30718226   PMID:30816512   PMID:30833270   PMID:30853185   PMID:30873749   PMID:30980364   PMID:30980385   PMID:31004738   PMID:31009445  
PMID:31013711   PMID:31022422   PMID:31087222   PMID:31149050   PMID:31190335   PMID:31212215   PMID:31240850   PMID:31241240   PMID:31296961   PMID:31309340   PMID:31312024   PMID:31431660  
PMID:31477637   PMID:31488102   PMID:31504797   PMID:31533653   PMID:31537383   PMID:31541023   PMID:31546924   PMID:31560953   PMID:31567281   PMID:31598681   PMID:31637660   PMID:31672029  
PMID:31680314   PMID:31691337   PMID:31695022   PMID:31712122   PMID:31727006   PMID:31771044   PMID:31801949   PMID:31811910   PMID:31856089   PMID:31856677   PMID:31861249   PMID:31903146  
PMID:31922245   PMID:31957819   PMID:31980519   PMID:32004564   PMID:32016978   PMID:32020223   PMID:32035615   PMID:32054096   PMID:32124950   PMID:32142859   PMID:32217071   PMID:32234881  
PMID:32323858   PMID:32332845   PMID:32368828   PMID:32373957   PMID:32398139   PMID:32424736   PMID:32427691   PMID:32445925   PMID:32495863   PMID:32572890   PMID:32614786   PMID:32615282  
PMID:32694731   PMID:32705235   PMID:32712101   PMID:32786113   PMID:32840296   PMID:32851102   PMID:32869942   PMID:32920731   PMID:32986769   PMID:33112260   PMID:33180382   PMID:33260156  
PMID:33298101   PMID:33317466   PMID:33412391   PMID:33507936   PMID:33953705   PMID:33976188   PMID:34073605  


Genomics

Comparative Map Data
FOXO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6108,559,835 - 108,684,774 (+)EnsemblGRCh38hg38GRCh38
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376108,881,028 - 109,005,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
Foxo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,057,841 - 42,152,691 (-)NCBIGRCm39mm39
GRCm39 Ensembl1042,057,837 - 42,152,751 (-)Ensembl
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBImm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
Foxo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22045,669,708 - 45,764,606 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02046,428,078 - 46,519,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02048,111,014 - 48,206,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,171,784 - 46,262,818 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12046,194,693 - 46,284,921 (-)NCBI
Celera2054,198,460 - 54,289,566 (+)NCBICelera
Cytogenetic Map20q12-q13NCBI
Foxo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541133,655,958 - 33,770,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541133,655,958 - 33,770,829 (+)NCBIChiLan1.0ChiLan1.0
FOXO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16110,406,265 - 110,536,967 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,406,266 - 110,516,272 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06106,360,519 - 106,485,676 (+)NCBIMhudiblu_PPA_v0panPan3
FOXO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,552,455 - 65,673,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBI
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBI
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBI
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBI
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBI
Foxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,513,168 - 100,632,744 (+)NCBI
SpeTri2.0NW_0049365644,788,036 - 4,907,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,628,217 - 74,760,328 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,626,673 - 74,760,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,888,152 - 83,888,769 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2184,047,498 - 84,048,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FOXO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11365,175,764 - 65,303,107 (-)NCBI
ChlSab1.1 Ensembl1365,195,376 - 65,301,725 (-)Ensembl
Vero_WHO_p1.0NW_02366604037,504,633 - 37,631,342 (-)NCBI
Foxo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478013,621,733 - 13,740,399 (-)NCBI

Position Markers
D6S2431  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,908,036 - 108,908,228UniSTSGRCh37
Build 366109,014,729 - 109,014,921RGDNCBI36
Celera6109,654,172 - 109,654,364RGD
Cytogenetic Map6q21UniSTS
HuRef6106,475,243 - 106,475,426UniSTS
Marshfield Genetic Map6118.08UniSTS
deCODE Assembly Map6112.98UniSTS
SGC33792  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,989,397 - 108,989,522UniSTSGRCh37
Build 366109,096,090 - 109,096,215RGDNCBI36
Celera6109,735,531 - 109,735,656RGD
Cytogenetic Map6q21UniSTS
HuRef6106,556,589 - 106,556,714UniSTS
GeneMap99-GB4 RH Map6459.92UniSTS
Whitehead-RH Map6682.2UniSTS
NCBI RH Map61406.9UniSTS
RH69580  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,001,748 - 109,001,932UniSTSGRCh37
Build 366109,108,441 - 109,108,625RGDNCBI36
Celera6109,747,890 - 109,748,074RGD
Cytogenetic Map6q21UniSTS
HuRef6106,568,948 - 106,569,132UniSTS
RH75343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,005,771 - 109,005,959UniSTSGRCh37
GRCh371718,569,248 - 18,569,435UniSTSGRCh37
Build 366109,112,464 - 109,112,652RGDNCBI36
Celera6109,751,705 - 109,751,893RGD
Cytogenetic Map6q21UniSTS
Cytogenetic Map17p11.2UniSTS
HuRef6106,572,973 - 106,573,161UniSTS
RH78823  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,004,511 - 109,004,634UniSTSGRCh37
GRCh371718,570,576 - 18,570,699UniSTSGRCh37
Build 366109,111,204 - 109,111,327RGDNCBI36
Celera6109,750,443 - 109,750,567RGD
Cytogenetic Map6q21UniSTS
Cytogenetic Map17p11.2UniSTS
HuRef6106,571,712 - 106,571,835UniSTS
RH79704  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376109,001,671 - 109,001,921UniSTSGRCh37
Build 366109,108,364 - 109,108,614RGDNCBI36
Celera6109,747,813 - 109,748,063RGD
Cytogenetic Map6q21UniSTS
HuRef6106,568,871 - 106,569,121UniSTS
GeneMap99-GB4 RH Map6457.14UniSTS
RH67795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,570,649 - 18,570,776UniSTSGRCh37
GRCh376109,004,434 - 109,004,561UniSTSGRCh37
Build 366109,111,127 - 109,111,254RGDNCBI36
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map6q21UniSTS
HuRef6106,571,635 - 106,571,762UniSTS
D17S1454E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,985,384 - 108,985,578UniSTSGRCh37
GRCh371718,574,697 - 18,574,891UniSTSGRCh37
Build 366109,092,077 - 109,092,271RGDNCBI36
Celera6109,731,517 - 109,731,711RGD
Cytogenetic Map6q21UniSTS
Cytogenetic Map17p11.2UniSTS
HuRef6106,552,575 - 106,552,769UniSTS
FOXO3A_4088  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,573,112 - 18,573,873UniSTSGRCh37
GRCh376109,001,339 - 109,002,105UniSTSGRCh37
Build 366109,108,032 - 109,108,798RGDNCBI36
Celera6109,747,481 - 109,748,247RGD
HuRef6106,568,539 - 106,569,306UniSTS
A008N03  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,989,301 - 108,989,525UniSTSGRCh37
Build 366109,095,994 - 109,096,218RGDNCBI36
Celera6109,735,435 - 109,735,659RGD
Cytogenetic Map6q21UniSTS
HuRef6106,556,493 - 106,556,717UniSTS
GeneMap99-GB4 RH Map6466.71UniSTS
NCBI RH Map61401.1UniSTS
RH65484  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,573,746 - 18,573,923UniSTSGRCh37
GRCh376109,001,289 - 109,001,466UniSTSGRCh37
Build 366109,107,982 - 109,108,159RGDNCBI36
Celera6109,747,431 - 109,747,608RGD
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map6q21UniSTS
HuRef6106,568,489 - 106,568,666UniSTS
GeneMap99-GB4 RH Map6460.02UniSTS
SHGC-36190  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,912,958 - 108,913,086UniSTSGRCh37
Build 366109,019,651 - 109,019,779RGDNCBI36
Celera6109,659,094 - 109,659,222RGD
Cytogenetic Map6q21UniSTS
HuRef6106,480,155 - 106,480,283UniSTS
GeneMap99-G3 RH Map64046.0UniSTS
MARC_14315-14316:1007670343:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371718,574,768 - 18,575,255UniSTSGRCh37
GRCh376108,985,021 - 108,985,507UniSTSGRCh37
Build 366109,091,714 - 109,092,200RGDNCBI36
Celera6109,731,154 - 109,731,640RGD
HuRef6106,552,212 - 106,552,698UniSTS
D11S2560  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p12.1-p11.2UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map8q21.13UniSTS
Cytogenetic Map18p11.22UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map8p22-p21UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map12p13.33UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map3p21.2UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map6q27UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map2q12.1UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map8q11.21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map12q23-q24.1UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map12p13.2UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q26.2-q27UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic MapXp11.2UniSTS
Cytogenetic Map20q11.2UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map18p11.32UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map14q31.1UniSTS
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map8q24.21UniSTS
Cytogenetic Map12q22-q23.1UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map7p14-p13UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map6q22-q23UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map6p24UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map9q31.1UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map3q25.31UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map14q32.32UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map6q14.1UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map5q11UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR96hsa-miR-96-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21203424
MIR96hsa-miR-96-5pOncomiRDBexternal_infoNANA23262295
MIR96hsa-miR-96-5pOncomiRDBexternal_infoNANA21203424
MIR222hsa-miR-222-3pOncomiRDBexternal_infoNANA20388878
MIR23Ahsa-miR-23a-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22084234
MIR23Ahsa-miR-23a-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22095742
MIR221hsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//ChIP//Luciferase reporter assay//Western Functional MTI20388878
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA20388878
MIR222hsa-miR-222-3pMirtarbaseexternal_infoqRT-PCR//ChIP//Luciferase reporter assay//Western Functional MTI20388878
MIR155hsa-miR-155-5pOncomiRDBexternal_infoNANA20371610
MIR155hsa-miR-155-3pMirecordsexternal_info{unchanged}NA20371610
MIR155hsa-miR-155-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20371610
MIR155hsa-miR-155-5pMirtarbaseexternal_infoFlow//Immunoblot//Immunofluorescence//ImmunohistocFunctional MTI21304824
MIR155hsa-miR-155-5pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)19650740
MIR182hsa-miR-182-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19188590
MIR182hsa-miR-182-5pOncomiRDBexternal_infoNANA23262295
MIR182hsa-miR-182-5pOncomiRDBexternal_infoNANA19188590

Predicted Target Of
Summary Value
Count of predictions:4084
Count of miRNA genes:1006
Interacting mature miRNAs:1210
Transcripts:ENST00000343882, ENST00000406360, ENST00000540898
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2381 2326 1203 379 1254 221 4321 1867 2637 318 1419 1587 171 1203 2765 3
Low 54 661 520 244 661 244 34 329 1079 100 38 25 4 1 1 23 1 1
Below cutoff 2 4 3 36 1 18 1 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005266867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005266868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF032886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI554317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA389775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD101760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK390614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000343882   ⟹   ENSP00000339527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,559,835 - 108,684,774 (+)Ensembl
RefSeq Acc Id: ENST00000406360   ⟹   ENSP00000385824
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,560,917 - 108,684,774 (+)Ensembl
RefSeq Acc Id: ENST00000540898   ⟹   ENSP00000446316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6108,656,346 - 108,680,751 (+)Ensembl
RefSeq Acc Id: NM_001455   ⟹   NP_001446
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,560,917 - 108,684,774 (+)NCBI
GRCh376108,881,026 - 109,005,972 (+)NCBI
Build 366108,988,762 - 109,112,664 (+)NCBI Archive
HuRef6106,448,666 - 106,573,173 (+)ENTREZGENE
CHM1_16109,145,009 - 109,268,930 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201559   ⟹   NP_963853
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,559,825 - 108,684,774 (+)NCBI
GRCh376108,881,026 - 109,005,972 (+)NCBI
Build 366108,987,719 - 109,112,664 (+)NCBI Archive
HuRef6106,448,666 - 106,573,173 (+)ENTREZGENE
CHM1_16109,143,966 - 109,268,930 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005266867   ⟹   XP_005266924
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,561,762 - 108,684,769 (+)NCBI
GRCh376108,881,026 - 109,005,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005266868   ⟹   XP_005266925
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,656,330 - 108,684,769 (+)NCBI
GRCh376108,881,026 - 109,005,972 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535626   ⟹   XP_011533928
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,561,904 - 108,684,769 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535628   ⟹   XP_011533930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,585,153 - 108,684,769 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011535629   ⟹   XP_011533931
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,656,208 - 108,684,769 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017010585   ⟹   XP_016866074
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,567,990 - 108,684,769 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017010586   ⟹   XP_016866075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,567,990 - 108,684,769 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_963853   ⟸   NM_201559
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001446   ⟸   NM_001455
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005266924   ⟸   XM_005266867
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005266925   ⟸   XM_005266868
- Peptide Label: isoform X3
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533928   ⟸   XM_011535626
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011533930   ⟸   XM_011535628
- Peptide Label: isoform X3
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533931   ⟸   XM_011535629
- Peptide Label: isoform X3
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866074   ⟸   XM_017010585
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016866075   ⟸   XM_017010586
- Peptide Label: isoform X3
- UniProtKB: O43524 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000385824   ⟸   ENST00000406360
RefSeq Acc Id: ENSP00000339527   ⟸   ENST00000343882
RefSeq Acc Id: ENSP00000446316   ⟸   ENST00000540898

Promoters
RGD ID:7208839
Promoter ID:EPDNEW_H10165
Type:initiation region
Name:FOXO3_1
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10166  EPDNEW_H10167  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,559,825 - 108,559,885EPDNEW
RGD ID:7208841
Promoter ID:EPDNEW_H10166
Type:initiation region
Name:FOXO3_2
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10165  EPDNEW_H10167  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,560,960 - 108,561,020EPDNEW
RGD ID:7208843
Promoter ID:EPDNEW_H10167
Type:initiation region
Name:FOXO3_3
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10165  EPDNEW_H10166  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386108,656,325 - 108,656,385EPDNEW
RGD ID:6804247
Promoter ID:HG_KWN:54571
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000041722,   UC003PSN.2
Position:
Human AssemblyChrPosition (strand)Source
Build 366108,987,361 - 108,987,861 (+)MPROMDB
RGD ID:6804243
Promoter ID:HG_KWN:54572
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001455
Position:
Human AssemblyChrPosition (strand)Source
Build 366108,988,181 - 108,988,681 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 copy number loss See cases [RCV000134806] Chr6:102356502..111049879 [GRCh38]
Chr6:102804377..111371082 [GRCh37]
Chr6:102911070..111477775 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1 copy number loss See cases [RCV000138006] Chr6:107370141..115827482 [GRCh38]
Chr6:107691345..116148646 [GRCh37]
Chr6:107798038..116255339 [NCBI36]
Chr6:6q21-22.1
pathogenic
GRCh38/hg38 6q21(chr6:108531375-108589781)x1 copy number loss See cases [RCV000139850] Chr6:108531375..108589781 [GRCh38]
Chr6:108852578..108910984 [GRCh37]
Chr6:108959271..109017677 [NCBI36]
Chr6:6q21
uncertain significance
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1
pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1 copy number loss See cases [RCV000139465] Chr6:96609994..122161548 [GRCh38]
Chr6:97057870..122482694 [GRCh37]
Chr6:97164591..122524393 [NCBI36]
Chr6:6q16.1-22.31
pathogenic
GRCh38/hg38 6q21(chr6:107445281-110547907)x1 copy number loss See cases [RCV000141382] Chr6:107445281..110547907 [GRCh38]
Chr6:107766485..110869110 [GRCh37]
Chr6:107873178..110975803 [NCBI36]
Chr6:6q21
pathogenic
GRCh38/hg38 6q21-22.31(chr6:106503719-125781219)x1 copy number loss See cases [RCV000141587] Chr6:106503719..125781219 [GRCh38]
Chr6:106951594..126102365 [GRCh37]
Chr6:107058287..126144058 [NCBI36]
Chr6:6q21-22.31
pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1 copy number loss See cases [RCV000142287] Chr6:103279465..113934239 [GRCh38]
Chr6:103727340..114255403 [GRCh37]
Chr6:103834033..114362096 [NCBI36]
Chr6:6q16.3-21
pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1 copy number loss See cases [RCV000143227] Chr6:100054889..120488154 [GRCh38]
Chr6:100502765..120809300 [GRCh37]
Chr6:100609486..120850999 [NCBI36]
Chr6:6q16.3-22.31
pathogenic
NM_001455.4(FOXO3):c.583A>T (p.Lys195Ter) single nucleotide variant Choroid plexus carcinoma [RCV000505594] Chr6:108561791 [GRCh38]
Chr6:108882994 [GRCh37]
Chr6:6q21
other
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1 copy number loss See cases [RCV000510703] Chr6:97384446..110247755 [GRCh37]
Chr6:6q16.1-21
pathogenic
NM_001455.4(FOXO3):c.699G>A (p.Trp233Ter) single nucleotide variant Medulloblastoma [RCV000505635] Chr6:108663532 [GRCh38]
Chr6:108984735 [GRCh37]
Chr6:6q21
other
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 copy number loss See cases [RCV000512470] Chr6:94202605..109878834 [GRCh37]
Chr6:6q16.1-21
pathogenic
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1
pathogenic
GRCh37/hg19 6q21(chr6:108325097-108908760)x1 copy number loss not provided [RCV000682706] Chr6:108325097..108908760 [GRCh37]
Chr6:6q21
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q21(chr6:108879008-108881206)x1 copy number loss not provided [RCV000745970] Chr6:108879008..108881206 [GRCh37]
Chr6:6q21
benign
GRCh37/hg19 6q21(chr6:108879008-108883086)x1 copy number loss not provided [RCV000745971] Chr6:108879008..108883086 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.419C>T (p.Ala140Val) single nucleotide variant not provided [RCV000950149] Chr6:108561627 [GRCh38]
Chr6:108882830 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.747G>A (p.Arg249=) single nucleotide variant not provided [RCV000948740] Chr6:108663580 [GRCh38]
Chr6:108984783 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.504C>T (p.Arg168=) single nucleotide variant not provided [RCV000892183] Chr6:108561712 [GRCh38]
Chr6:108882915 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.1021G>A (p.Ala341Thr) single nucleotide variant not provided [RCV000963034] Chr6:108663854 [GRCh38]
Chr6:108985057 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.1494C>T (p.Thr498=) single nucleotide variant not provided [RCV000892867] Chr6:108664327 [GRCh38]
Chr6:108985530 [GRCh37]
Chr6:6q21
likely benign
NM_001455.4(FOXO3):c.1185G>A (p.Thr395=) single nucleotide variant not provided [RCV000892218] Chr6:108664018 [GRCh38]
Chr6:108985221 [GRCh37]
Chr6:6q21
benign
NM_001455.4(FOXO3):c.432C>T (p.Ser144=) single nucleotide variant not provided [RCV000910763] Chr6:108561640 [GRCh38]
Chr6:108882843 [GRCh37]
Chr6:6q21
likely benign
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3 copy number gain Microcephaly [RCV001251053] Chr6:101296547..117004249 [GRCh37]
Chr6:6q16.3-22.1
pathogenic
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1 copy number loss Deletion 6q16 q21 [RCV001263224] Chr6:98949950..114533905 [GRCh37]
Chr6:6q16.1-21
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3821 AgrOrtholog
COSMIC FOXO3 COSMIC
Ensembl Genes ENSG00000118689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000339527 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385824 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446316 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000343882 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000406360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000540898 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000118689 GTEx
HGNC ID HGNC:3821 ENTREZGENE
Human Proteome Map FOXO3 Human Proteome Map
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX-bd UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2309 UniProtKB/Swiss-Prot
NCBI Gene 2309 ENTREZGENE
OMIM 602681 OMIM
Pfam Forkhead UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX_bdg UniProtKB/Swiss-Prot
PharmGKB PA28239 PharmGKB
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXO3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B4DVZ6 UniProtKB/Swiss-Prot
  E1P5E6 UniProtKB/Swiss-Prot
  O15171 UniProtKB/Swiss-Prot
  Q5T2I7 UniProtKB/Swiss-Prot
  Q9BZ04 UniProtKB/Swiss-Prot