Gene: Runx1 (RUNX family transcription factor 1) Rattus norvegicus
Analyze
Symbol:
Runx1
Name:
RUNX family transcription factor 1
Description:
Exhibits promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including ovulation; positive regulation of progesterone secretion; and response to denervation involved in regulation of muscle adaptation. Localizes to the nucleus. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; asthma; hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human RUNX1 (RUNX family transcription factor 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; chronic myeloid leukemia pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
acute myeloid leukemia 1; Aml1; B; CBF-alpha-2; Cbfa2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-2; oncogene AML-1; PEA2-alpha; PEA2-alpha B; PEBP2-alpha; PEBP2-alpha B; polyomavirus enhancer-binding protein 2 alpha B subunit; runt related transcription factor 1; runt-related transcription factor 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
RUNX1 (RUNX family transcription factor 1) HGNC
HomoloGene, NCBI, Panther
Mus musculus (house mouse):
Runx1 (runt related transcription factor 1) HGNC
NCBI, HomoloGene, Panther
Chinchilla lanigera (long-tailed chinchilla):
Runx1 (RUNX family transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
RUNX1 (RUNX family transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
RUNX1 (RUNX family transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Runx1 (RUNX family transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
RUNX1 (RUNX family transcription factor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RUNX2 (RUNX family transcription factor 2) HGNC
OrthoDB
Homo sapiens (human):
RUNX3 (RUNX family transcription factor 3) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
RUNX1 (RUNX family transcription factor 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Runx1 (runt related transcription factor 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
runx1 (runt-related transcription factor 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
rnt-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
RunxA
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
RunxB
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER)
Drosophila melanogaster (fruit fly):
lz
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
run
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 32,765,147 - 33,003,061 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 32,769,165 - 33,003,021 (-) Ensembl Rnor_5.0 11 36,367,315 - 36,601,674 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 32,623,461 - 32,725,404 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 32,679,703 - 32,781,647 (-) NCBI Celera 11 31,494,069 - 31,582,728 (-) NCBI Celera Cytogenetic Map 11 q11 NCBI RH 3.4 Map 11 214.7 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
acute myeloid leukemia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Acute myeloid leukemia ClinVar PMID:10508512 more ... acute myeloid leukemia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Acute myeloid leukemia ClinVar PMID:10068652 more ... acute myeloid leukemia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Acute myelocytic leukemia ClinVar PMID:19357396 more ... acute myeloid leukemia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Acute myeloid leukemia ClinVar PMID:19357396 , PMID:24659740 acute myeloid leukemia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Acute myeloid leukemia ClinVar PMID:24374719 more ... Down syndrome ISO RGD:736526 8554872 ClinVar Annotator: match by term: Transient myeloproliferative disorder of Down syndrome ClinVar PMID:10068652 more ... Ependymomas ISO RGD:736526 8554872 ClinVar Annotator: match by term: Anaplastic ependymoma ClinVar PMID:23753029 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:25741868 , PMID:28492532 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10508512 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:19357396 , PMID:27112265 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:18478040 , PMID:27112265 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:30990344 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:18723428 , PMID:28492532 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:23817177 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:18723428 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:25840971 , PMID:28492532 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:12060124 , PMID:23848403 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:11830488 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10508512 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:22318203 , PMID:25840971 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10508512 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:25741868 , PMID:26175287 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10068652 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:25741868 , PMID:25840971 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:28492532 , PMID:29666006 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:20846103 , PMID:25741868 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:24764152 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:22012064 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:20955399 , PMID:28492532 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:12393679 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:25741868 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10508512 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:23753029 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:24523240 more ... Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:10508512 , PMID:25741868 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:11830488 , PMID:28492532 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by OMIM:601399 ClinVar PMID:11830488 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by OMIM:601399 ClinVar PMID:25741868 Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by OMIM:601399 ClinVar Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 8554872 ClinVar Annotator: match by term: Familial platelet disorder with associated myeloid malignancy ClinVar PMID:28492532 long QT syndrome 6 ISO RGD:736526 8554872 ClinVar Annotator: match by term: Long QT syndrome 6 ClinVar PMID:21626672 , PMID:28492532 multicentric Castleman disease ISO RGD:736526 8554872 ClinVar Annotator: match by term: TAFRO syndrome ClinVar PMID:25741868 , PMID:28492532 pancytopenia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Pancytopenia ClinVar PMID:25741868 pilocytic astrocytoma ISO RGD:736526 8554872 ClinVar Annotator: match by term: Pilocytic astrocytoma ClinVar PMID:25741868 platelet storage pool deficiency ISO RGD:736526 8554872 ClinVar Annotator: match by term: Storage pool disease of platelets ClinVar PMID:25741868 thrombocytopenia ISO RGD:736526 8554872 ClinVar Annotator: match by term: Thrombocytopenia ClinVar PMID:25741868 thyroid gland papillary carcinoma ISO RGD:736526 8554872 ClinVar Annotator: match by term: Papillary thyroid carcinoma ClinVar PMID:25741868 , PMID:28492532
Imported Annotations - CTD
acute myeloid leukemia ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18206229 more ... glioblastoma multiforme ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23582323 juvenile myelomonocytic leukemia ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26457647 myelodysplastic syndrome ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27992414 precursor B lymphoblastic lymphoma/leukemia ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15217836 , PMID:24413735 precursor lymphoblastic lymphoma/leukemia ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17255265 Prostatic Neoplasms ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17909013 rheumatoid arthritis ISO RGD:736526 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23143596 Imported Annotations - OMIM
acute myeloid leukemia ISO RGD:736526 7240710 OMIM Familial Platelet Disorder with Associated Myeloid Malignancy ISO RGD:736526 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RUNX1 mRNA] CTD PMID:31150632 (-)-cotinine affects methylation ISO RGD:736526 6480464 Cotinine affects the methylation of RUNX1 gene CTD PMID:22851337 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of RUNX1 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE decreases expression EXP 6480464 Topotecan results in decreased expression of RUNX1 mRNA CTD PMID:25729387 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression EXP 6480464 o, p'-DDT results in decreased expression of RUNX1 mRNA CTD PMID:23209616 1,1-dichloroethene increases expression ISO RGD:736527 6480464 vinylidene chloride results in increased expression of RUNX1 mRNA CTD PMID:26682919 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of RUNX1 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:736526 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of RUNX1 mRNA CTD PMID:30165855 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:736526 6480464 Dihydrotestosterone results in increased expression of RUNX1 mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736527 6480464 Tetrachlorodibenzodioxin affects the expression of RUNX1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736527 6480464 Tetrachlorodibenzodioxin results in increased expression of RUNX1 mRNA CTD PMID:19933214 , PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736526 6480464 Tetrachlorodibenzodioxin results in increased expression of RUNX1 mRNA CTD PMID:22903824 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of RUNX1 mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 5-azacytidine multiple interactions ISO RGD:736526 6480464 Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL2 promoter], Azacitidine promotes the reaction [RUNX1 protein binds to KIR2DL4 promoter] CTD PMID:18945643 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of RUNX1 mRNA CTD PMID:24780913 , PMID:25825206 aflatoxin B1 increases expression ISO RGD:736526 6480464 Aflatoxin B1 results in increased expression of RUNX1 mRNA CTD PMID:22100608 aflatoxin B1 increases methylation ISO RGD:736526 6480464 Aflatoxin B1 results in increased methylation of RUNX1 gene, Aflatoxin B1 results in increased methylation of RUNX1 intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 increases methylation ISO RGD:736526 6480464 aflatoxin B2 results in increased methylation of RUNX1 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:736526 6480464 Tretinoin results in decreased expression of RUNX1 mRNA CTD PMID:15498508 , PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of RUNX1 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:736526 6480464 Antirheumatic Agents results in decreased expression of RUNX1 mRNA CTD PMID:24449571 arsenite(3-) decreases methylation ISO RGD:736526 6480464 arsenite results in decreased methylation of RUNX1 promoter CTD PMID:23974009 asbestos affects expression ISO RGD:736526 6480464 Asbestos affects the expression of RUNX1 mRNA CTD PMID:17297452 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of RUNX1 gene CTD PMID:28931070 benzene increases expression ISO RGD:736526 6480464 Benzene results in increased expression of RUNX1 mRNA CTD PMID:19162166 benzo[a]pyrene multiple interactions ISO RGD:736527 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to RUNX1 promoter] CTD PMID:19654925 benzo[a]pyrene affects methylation ISO RGD:736526 6480464 Benzo(a)pyrene affects the methylation of RUNX1 intron CTD PMID:30157460 benzo[a]pyrene increases expression ISO RGD:736526 6480464 Benzo(a)pyrene results in increased expression of RUNX1 mRNA CTD PMID:26238291 benzo[e]pyrene increases methylation ISO RGD:736526 6480464 benzo(e)pyrene results in increased methylation of RUNX1 intron CTD PMID:30157460 beryllium sulfate multiple interactions ISO RGD:736526 6480464 beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter] CTD PMID:16314022 bifenthrin multiple interactions EXP 6480464 bifenthrin inhibits the reaction [CGA protein results in increased expression of RUNX1 mRNA] CTD PMID:21251947 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736526 6480464 Diethylhexyl Phthalate results in increased expression of RUNX1 mRNA CTD PMID:31163220 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RUNX1 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:736526 6480464 butyraldehyde results in decreased expression of RUNX1 mRNA CTD PMID:26079696 calcitriol decreases expression ISO RGD:736526 6480464 Calcitriol results in decreased expression of RUNX1 mRNA CTD PMID:16002434 calcitriol multiple interactions ISO RGD:736526 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of RUNX1 mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:736526 6480464 Calcitriol results in increased expression of RUNX1 mRNA CTD PMID:21592394 carbon nanotube increases expression ISO RGD:736527 6480464 Nanotubes, Carbon analog results in increased expression of RUNX1 mRNA, Nanotubes, Carbon results in increased expression of RUNX1 mRNA CTD PMID:25554681 chloroacetaldehyde decreases expression ISO RGD:736526 6480464 chloroacetaldehyde results in decreased expression of RUNX1 mRNA CTD PMID:25596134 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of RUNX1 mRNA CTD PMID:25596134 choline multiple interactions ISO RGD:736527 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RUNX1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RUNX1 gene CTD PMID:20938992 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of RUNX1 mRNA CTD PMID:22023808 cisplatin multiple interactions ISO RGD:736526 6480464 Cisplatin promotes the reaction [jinfukang results in decreased expression of RUNX1 mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of RUNX1 mRNA] CTD PMID:27392435 cisplatin decreases expression ISO RGD:736526 6480464 Cisplatin results in decreased expression of RUNX1 mRNA CTD PMID:25596134 , PMID:27594783 clodronic acid increases expression ISO RGD:736526 6480464 Clodronic Acid results in increased expression of RUNX1 mRNA CTD PMID:25596134 cobalt atom multiple interactions ISO RGD:736526 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA CTD PMID:20105288 cobalt dichloride increases expression ISO RGD:736526 6480464 cobaltous chloride results in increased expression of RUNX1 mRNA CTD PMID:20105288 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of RUNX1 mRNA CTD PMID:24386269 cobalt(2+) multiple interactions ISO RGD:736526 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA CTD PMID:20105288 cocaine affects expression EXP 6480464 Cocaine affects the expression of RUNX1 mRNA CTD PMID:20187946 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon] CTD PMID:22684629 Colforsin dapropate hydrochloride affects splicing EXP 6480464 Colforsin affects the splicing of RUNX1 exon CTD PMID:22684629 copper(II) sulfate increases expression ISO RGD:736526 6480464 Copper Sulfate results in increased expression of RUNX1 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:736527 6480464 Asbestos, Crocidolite results in increased expression of RUNX1 mRNA CTD PMID:23917077 crocidolite asbestos affects expression ISO RGD:736526 6480464 Asbestos, Crocidolite affects the expression of RUNX1 mRNA CTD PMID:17331233 , PMID:25757056 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of RUNX1 mRNA CTD PMID:25596134 DDE increases activity ISO RGD:736526 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of RUNX1 protein CTD PMID:27589886 dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of RUNX1 mRNA] CTD PMID:21149847 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of RUNX1 mRNA CTD PMID:21266533 dicrotophos increases expression ISO RGD:736526 6480464 dicrotophos results in increased expression of RUNX1 mRNA CTD PMID:28302478 diethylstilbestrol decreases expression ISO RGD:736527 6480464 Diethylstilbestrol results in decreased expression of RUNX1 mRNA CTD PMID:15171707 dioxygen increases expression ISO RGD:736526 6480464 Oxygen deficiency results in increased expression of RUNX1 mRNA CTD PMID:25596134 doxorubicin increases response to substance ISO RGD:736526 6480464 RUNX1 gene mutant form results in increased susceptibility to Doxorubicin CTD PMID:15217836 doxorubicin decreases expression ISO RGD:736526 6480464 Doxorubicin results in decreased expression of RUNX1 mRNA CTD PMID:29803840 doxorubicin increases expression ISO RGD:736526 6480464 Doxorubicin results in increased expression of RUNX1 mRNA CTD PMID:30031762 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of RUNX1 mRNA CTD PMID:29391264 etoposide increases response to substance ISO RGD:736526 6480464 RUNX1 gene mutant form results in increased susceptibility to Etoposide CTD PMID:15217836 etoposide increases mutagenesis ISO RGD:736526 6480464 Etoposide results in increased mutagenesis of RUNX1 gene CTD PMID:28624474 folic acid multiple interactions ISO RGD:736527 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RUNX1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RUNX1 gene CTD PMID:20938992 hydroxyurea increases expression ISO RGD:736526 6480464 Hydroxyurea results in increased expression of RUNX1 protein mutant form CTD PMID:16532439 indometacin increases expression ISO RGD:736526 6480464 Indomethacin results in increased expression of RUNX1 mRNA CTD PMID:24737281 irinotecan decreases expression ISO RGD:736526 6480464 Irinotecan metabolite results in decreased expression of RUNX1 mRNA, Irinotecan results in decreased expression of RUNX1 mRNA CTD PMID:15956246 L-methionine multiple interactions ISO RGD:736527 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RUNX1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RUNX1 gene CTD PMID:20938992 lead diacetate increases expression ISO RGD:736527 6480464 lead acetate results in increased expression of RUNX1 mRNA CTD PMID:20542052 , PMID:21829687 lead nitrate multiple interactions ISO RGD:736527 6480464 lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA], lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA] CTD PMID:11891201 leflunomide increases expression ISO RGD:736526 6480464 leflunomide results in increased expression of RUNX1 mRNA CTD PMID:28988120 malathion increases expression ISO RGD:736526 6480464 Malathion results in increased expression of RUNX1 mRNA mutant form CTD PMID:28624474 medroxyprogesterone acetate increases expression ISO RGD:736526 6480464 Medroxyprogesterone Acetate results in increased expression of RUNX1 mRNA CTD PMID:18497975 metformin increases expression EXP 6480464 Metformin results in increased expression of RUNX1 mRNA CTD PMID:25596134 methapyrilene increases methylation ISO RGD:736526 6480464 Methapyrilene results in increased methylation of RUNX1 intron CTD PMID:30157460 ochratoxin A decreases expression ISO RGD:736526 6480464 ochratoxin A results in decreased expression of RUNX1 mRNA CTD PMID:30763683 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of RUNX1 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:736527 6480464 Acetaminophen affects the expression of RUNX1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:736526 6480464 Acetaminophen results in increased expression of RUNX1 mRNA CTD PMID:29067470 permethrin increases mutagenesis ISO RGD:736526 6480464 Permethrin results in increased mutagenesis of RUNX1 gene CTD PMID:28624474 permethrin increases expression ISO RGD:736526 6480464 Permethrin results in increased expression of RUNX1 mRNA mutant form CTD PMID:28624474 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA] CTD PMID:23223575 serpentine asbestos decreases expression ISO RGD:736526 6480464 Asbestos, Serpentine results in decreased expression of RUNX1 mRNA CTD PMID:21148743 serpentine asbestos increases expression ISO RGD:736527 6480464 Asbestos, Serpentine results in increased expression of RUNX1 mRNA CTD PMID:23917077 silicon dioxide increases expression ISO RGD:736526 6480464 Silicon Dioxide analog results in increased expression of RUNX1 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:736527 6480464 Silicon Dioxide results in increased expression of RUNX1 mRNA CTD PMID:19073995 silver atom increases expression ISO RGD:736526 6480464 Silver results in increased expression of RUNX1 mRNA CTD PMID:26014281 silver(0) increases expression ISO RGD:736526 6480464 Silver results in increased expression of RUNX1 mRNA CTD PMID:26014281 silver(1+) increases expression ISO RGD:736526 6480464 Silver results in increased expression of RUNX1 mRNA CTD PMID:26014281 sodium arsenate increases expression ISO RGD:736527 6480464 sodium arsenate results in increased expression of RUNX1 mRNA CTD PMID:21795629 sodium arsenite affects methylation ISO RGD:736526 6480464 sodium arsenite affects the methylation of RUNX1 gene CTD PMID:28589171 Soman increases expression EXP 6480464 Soman results in increased expression of RUNX1 mRNA CTD PMID:19281266 tamibarotene affects expression ISO RGD:736526 6480464 tamibarotene affects the expression of RUNX1 mRNA CTD PMID:15498508 tamoxifen increases expression ISO RGD:736527 6480464 Tamoxifen results in increased expression of RUNX1 mRNA CTD PMID:25123088 tamoxifen increases expression ISO RGD:736526 6480464 Tamoxifen results in increased expression of RUNX1 mRNA CTD PMID:15590111 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of RUNX1 mRNA CTD PMID:21515302 testosterone multiple interactions ISO RGD:736526 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of RUNX1 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:736526 6480464 Testosterone results in increased expression of RUNX1 mRNA CTD PMID:21592394 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RUNX1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of RUNX1 mRNA CTD PMID:31150632 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of RUNX1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of RUNX1 mRNA CTD PMID:25729387 trichloroethene decreases expression ISO RGD:736527 6480464 Trichloroethylene results in decreased expression of RUNX1 mRNA CTD PMID:22407948 troglitazone increases expression ISO RGD:736526 6480464 troglitazone results in increased expression of RUNX1 mRNA CTD PMID:19140230 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of RUNX1 mRNA CTD PMID:21515302 tungsten decreases expression ISO RGD:736527 6480464 Tungsten results in decreased expression of RUNX1 mRNA CTD PMID:30912803 Tungsten carbide multiple interactions ISO RGD:736526 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of RUNX1 mRNA CTD PMID:20105288 tungsten(4+) decreases expression ISO RGD:736527 6480464 Tungsten results in decreased expression of RUNX1 mRNA CTD PMID:30912803 undecane increases expression EXP 6480464 undecane results in increased expression of RUNX1 protein CTD PMID:17337753 urethane increases expression ISO RGD:736526 6480464 Urethane results in increased expression of RUNX1 mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:736526 6480464 Valproic Acid results in decreased methylation of RUNX1 gene CTD PMID:29154799 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of RUNX1 mRNA CTD PMID:19015723 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of RUNX1 mRNA CTD PMID:23034163 warfarin increases expression EXP 6480464 Warfarin results in increased expression of RUNX1 mRNA CTD PMID:23223575 warfarin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Warfarin results in increased expression of RUNX1 mRNA] CTD PMID:23223575
Biological Process behavioral response to pain ISO RGD:736527 1624291 (MGI:MGI:3619829, PMID:16446141) RGD MGI:MGI:3619829 , PMID:16446141 cellular response to transforming growth factor beta stimulus ISO RGD:736527 1624291 (MGI:MGI:5532214, PMID:23861879) RGD MGI:MGI:5532214 , PMID:23861879 central nervous system development ISO RGD:736527 1624291 MGI:MGI:3043614 (MGI:MGI:3759935 , PMID:16174759) RGD MGI:MGI:3759935 , PMID:16174759 chondrocyte differentiation IBA MGI:MGI:102672 , PANTHER:PTN000942785 13792537 PMID:21873635 GO_Central definitive hemopoiesis ISO RGD:736527 1624291 MGI:MGI:1857580 (MGI:MGI:1335631 , PMID:10207104) RGD MGI:MGI:1335631 , PMID:10207104 embryonic hemopoiesis ISO RGD:736527 1624291 MGI:MGI:3043614 (MGI:MGI:3759935 , PMID:16174759) RGD MGI:MGI:3759935 , PMID:16174759 hair follicle morphogenesis ISO RGD:736527 1624291 MGI:MGI:3043614 (MGI:MGI:3692798 , PMID:17011173) RGD MGI:MGI:3692798 , PMID:17011173 hemopoiesis ISO RGD:736526 1624291 (PMID:21873977) RGD PMID:21873977 hemopoiesis IBA PANTHER:PTN000237028 more ... 13792537 PMID:21873635 GO_Central hemopoiesis IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 in utero embryonic development ISO RGD:736527 1624291 MGI:MGI:3043614 (MGI:MGI:3759935 , PMID:16174759) RGD MGI:MGI:3759935 , PMID:16174759 liver development ISO RGD:736527 1624291 MGI:MGI:3043614 (MGI:MGI:3759935 , PMID:16174759) RGD MGI:MGI:3759935 , PMID:16174759 myeloid cell differentiation ISO RGD:736526 1624291 (PMID:11742995) RGD PMID:11742995 myeloid progenitor cell differentiation ISO RGD:736527 1624291 (MGI:MGI:3838687, PMID:19182774) RGD MGI:MGI:3838687 , PMID:19182774 negative regulation of CD4-positive, alpha-beta T cell differentiation ISS UniProtKB:Q03347 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of CD4-positive, alpha-beta T cell differentiation ISO RGD:736527 1624291 (MGI:MGI:3772948, PMID:18258917) RGD MGI:MGI:3772948 , PMID:18258917 negative regulation of cell population proliferation ISO RGD:736527 1624291 (MGI:MGI:5575695, PMID:24582971) RGD MGI:MGI:5575695 , PMID:24582971 negative regulation of granulocyte differentiation ISO RGD:736526 1624291 (PMID:9199349) RGD PMID:9199349 negative regulation of transcription by RNA polymerase II ISS UniProtKB:Q03347 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription by RNA polymerase II ISO RGD:736527 1624291 (MGI:MGI:3772948, PMID:18258917) RGD MGI:MGI:3772948 , PMID:18258917 negative regulation of transcription, DNA-templated ISO RGD:736527 1624291 (MGI:MGI:3710039, PMID:17377532) RGD MGI:MGI:3710039 , PMID:17377532 neuron development ISO RGD:736527 1624291 (MGI:MGI:3619829, PMID:16446141) RGD MGI:MGI:3619829 , PMID:16446141 neuron differentiation ISO RGD:736527 1624291 MGI:MGI:2668479 (MGI:MGI:3047175 , PMID:15240886) RGD MGI:MGI:3047175 , PMID:15240886 neuron differentiation IBA MGI:MGI:99852 , PANTHER:PTN000237028 13792537 PMID:21873635 GO_Central neuron fate commitment ISO RGD:736527 1624291 (MGI:MGI:5641108, PMID:25834056) RGD MGI:MGI:5641108 , PMID:25834056 ovulation IEP 9831388 RGD positive regulation of angiogenesis ISO RGD:736527 1624291 (MGI:MGI:1860995, PMID:10943840) RGD MGI:MGI:1860995 , PMID:10943840 positive regulation of angiogenesis ISS UniProtKB:Q03347 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of CD8-positive, alpha-beta T cell differentiation ISS UniProtKB:Q03347 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of CD8-positive, alpha-beta T cell differentiation ISO RGD:736527 1624291 (MGI:MGI:3772948, PMID:18258917) RGD MGI:MGI:3772948 , PMID:18258917 positive regulation of cell maturation ISO RGD:736527 1624291 (MGI:MGI:5575695, PMID:24582971) RGD MGI:MGI:5575695 , PMID:24582971 positive regulation of granulocyte differentiation ISO RGD:736526 1624291 (PMID:9199349) RGD PMID:9199349 positive regulation of granulocyte differentiation ISS UniProtKB:Q01196 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of granulocyte differentiation IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of interferon-gamma production ISO RGD:736527 1624291 (MGI:MGI:3710039, PMID:17377532) RGD MGI:MGI:3710039 , PMID:17377532 positive regulation of interleukin-2 production ISO RGD:736526 1624291 (PMID:17377532) RGD PMID:17377532 positive regulation of interleukin-2 production ISO RGD:736527 1624291 (MGI:MGI:3710039, PMID:17377532) RGD MGI:MGI:3710039 , PMID:17377532 positive regulation of interleukin-2 production IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of progesterone secretion IMP 6482842 RGD positive regulation of transcription by RNA polymerase II ISO RGD:736527 1624291 (MGI:MGI:3831587, PMID:19090621) RGD MGI:MGI:3831587 , PMID:19090621 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:736526 1624291 (PMID:10207087), (PMID:14970218), (PMID:20972335), (PMID:21873977), (PMID:9199349) RGD PMID:10207087 more ... positive regulation of transcription, DNA-templated IMP 11251715 RGD positive regulation of transcription, DNA-templated ISS UniProtKB:Q03347 1600115 GO_REF:0000024 UniProt GO_REF:0000024 positive regulation of transcription, DNA-templated ISO RGD:736527 1624291 (MGI:MGI:4868293, PMID:21151104) RGD MGI:MGI:4868293 , PMID:21151104 positive regulation of transcription, DNA-templated ISO RGD:736526 1624291 (PMID:10207087), (PMID:11742995), (PMID:14970218), (PMID:9199349) RGD PMID:10207087 more ... regulation of hair follicle cell proliferation ISO RGD:736527 1624291 MGI:MGI:3711451 (MGI:MGI:4949803 , PMID:21464233) RGD MGI:MGI:4949803 , PMID:21464233 regulation of signal transduction ISO RGD:736527 1624291 MGI:MGI:3711451 (MGI:MGI:4949803 , PMID:21464233) RGD MGI:MGI:4949803 , PMID:21464233 regulation of T cell anergy ISO RGD:736527 1624291 (MGI:MGI:3710039, PMID:17377532) RGD MGI:MGI:3710039 , PMID:17377532 regulation of transcription, DNA-templated ISO RGD:736527 1624291 (MGI:MGI:2673083, PMID:12807883) RGD MGI:MGI:2673083 , PMID:12807883 response to denervation involved in regulation of muscle adaptation IEP 634721 RGD response to retinoic acid ISO RGD:736527 1624291 (MGI:MGI:3799604, PMID:18439490) RGD MGI:MGI:3799604 , PMID:18439490 skeletal system development ISO RGD:736527 1624291 MGI:MGI:2668479 (MGI:MGI:3528197 , PMID:15389629) RGD MGI:MGI:3528197 , PMID:15389629 Cellular Component basement membrane ISO RGD:736527 1624291 (MGI:MGI:3692798, PMID:17011173) RGD MGI:MGI:3692798 , PMID:17011173 core-binding factor complex TAS 13524617 PMID:18258917 UniProt cytosol IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular membrane-bounded organelle ISO RGD:736526 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:736526 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 634721 RGD nucleus IBA MGI:MGI:102672 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:736526 1624291 (PMID:7862156) RGD PMID:7862156 nucleus ISO RGD:736527 1624291 (MGI:MGI:3710039 more ... RGD MGI:MGI:3710039 more ... Molecular Function ATP binding IEA InterPro:IPR000040 1600115 GO_REF:0000002 InterPro GO_REF:0000002 calcium ion binding ISO RGD:736526 1624291 (PMID:12217689) RGD PMID:12217689 DNA binding ISO RGD:736526 1624291 (PMID:12217689), (PMID:8413232), (PMID:9199349) RGD PMID:12217689 more ... DNA binding ISO RGD:736527 1624291 (MGI:MGI:2673083 more ... RGD MGI:MGI:2673083 more ... DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:736526 1624291 (PMID:9199349) RGD PMID:9199349 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:736527 1624291 (MGI:MGI:2673083, PMID:12807883) RGD MGI:MGI:2673083 , PMID:12807883 DNA-binding transcription factor activity ISO RGD:736526 1624291 (PMID:14970218), (PMID:9199349) RGD PMID:14970218 , PMID:9199349 DNA-binding transcription factor activity, RNA polymerase II-specific IBA MGI:MGI:102672 , PANTHER:PTN000237028 13792537 PMID:21873635 GO_Central promoter-specific chromatin binding IDA 11251715 RGD protein binding ISO RGD:736526 1624291 UniProtKB:P16371 more ... RGD PMID:10207087 more ... protein binding ISO RGD:736527 1624291 UniProtKB:P27577 more ... RGD MGI:MGI:3690807 more ... protein heterodimerization activity ISO RGD:736526 1624291 (PMID:8413232) RGD PMID:8413232 protein homodimerization activity ISO RGD:736526 1624291 (PMID:10856244) RGD PMID:10856244 repressing transcription factor binding ISO RGD:736527 1624291 UniProtKB:P77782 (MGI:MGI:2655026 , PMID:12551949) RGD MGI:MGI:2655026 , PMID:12551949 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:Q01196 , ensembl:ENSP000003003051600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:736527 1624291 (MGI:MGI:3710039, PMID:17377532) RGD MGI:MGI:3710039 , PMID:17377532 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:736526 1624291 (PMID:17377532) RGD PMID:17377532 RNA polymerase II regulatory region sequence-specific DNA binding ISO RGD:736526 1624291 (PMID:9199349) RGD PMID:9199349 sequence-specific double-stranded DNA binding IDA 11251715 RGD transcription factor binding ISO RGD:736526 1624291 (PMID:9199349) RGD PMID:9199349 transcription regulatory region DNA binding ISO RGD:736526 1624291 (PMID:21873977) RGD PMID:21873977
Gene-Chemical Interaction Annotations
