Runx1 (RUNX family transcription factor 1) - Rat Genome Database

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Gene: Runx1 (RUNX family transcription factor 1) Rattus norvegicus
Symbol: Runx1
Name: RUNX family transcription factor 1
RGD ID: 2283
Description: Enables promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of progesterone secretion; positive regulation of transcription by RNA polymerase II; and response to denervation involved in regulation of muscle adaptation. Part of chromatin. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; chronic myeloid leukemia pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acute myeloid leukemia 1; Aml1; B; CBF-alpha-2; Cbfa2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-2; oncogene AML-1; PEA2-alpha; PEA2-alpha B; PEBP2-alpha; PEBP2-alpha B; polyomavirus enhancer-binding protein 2 alpha B subunit; runt related transcription factor 1; runt-related transcription factor 1
RGD Orthologs
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21131,839,880 - 32,074,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,843,764 - 32,074,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,538,494 - 40,630,001 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01133,209,969 - 33,301,480 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,368,563 - 32,460,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,765,147 - 33,003,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,769,165 - 33,003,021 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,367,315 - 36,601,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,623,461 - 32,725,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,679,703 - 32,781,647 (-)NCBI
Celera1131,494,069 - 31,582,728 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute megakaryocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
anaplastic ependymoma  (ISO)
asthma  (ISO)
atypical chronic myeloid leukemia  (ISO)
autoimmune disease  (ISO)
autosomal dominant intellectual developmental disorder 7  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
blood platelet disease  (ISO)
Bone Fractures  (IEP)
cardiomyopathy  (ISO)
colon signet ring adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
endometrial cancer  (ISO)
endometriosis  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Leukemia  (ISO)
Experimental Mammary Neoplasms  (IEP)
Familial Platelet Disorder with Associated Myeloid Malignancy  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade ependymoma  (ISO)
Intestinal Neoplasms  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
long QT syndrome 6  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoid leukemia  (ISO)
middle cerebral artery infarction  (IAGP)
multicentric Castleman disease  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
pancytopenia  (ISO)
Parkinson's disease 20  (ISO)
platelet storage pool deficiency  (ISO)
Prostatic Neoplasms  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (ISO)
Spina Bifida Cystica  (IDA)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Therapy-related Acute Myeloid Leukemia  (ISO)
thrombocytopenia  (ISO)
transient myeloproliferative syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyltryptophan  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beryllium sulfate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
choline  (ISO)
cidofovir anhydrous  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
etoposide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP,ISO)
quercetin  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to pain  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
central nervous system development  (ISO)
chondrocyte differentiation  (IBA,IEA)
definitive hemopoiesis  (ISO)
embryonic hemopoiesis  (ISO)
hair follicle morphogenesis  (ISO)
hemopoiesis  (IBA,IEA,ISO)
in utero embryonic development  (ISO)
liver development  (ISO)
myeloid cell differentiation  (ISO)
myeloid leukocyte differentiation  (IEA,ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of CD4-positive, alpha-beta T cell differentiation  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of granulocyte differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
neuron development  (ISO)
neuron differentiation  (IBA,IEA,ISO)
neuron fate commitment  (ISO)
ossification  (IBA,IEA)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of CD8-positive, alpha-beta T cell differentiation  (ISO,ISS)
positive regulation of cell maturation  (ISO)
positive regulation of developmental process  (IEA)
positive regulation of DNA-templated transcription  (IMP,ISO,ISS)
positive regulation of granulocyte differentiation  (IEA,ISO,ISS)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of progesterone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
positive regulation of type II interferon production  (ISO)
regulation of cell differentiation  (IBA,IEA)
regulation of DNA-templated transcription  (ISO)
regulation of hair follicle cell proliferation  (ISO)
regulation of signal transduction  (ISO)
regulation of T cell anergy  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to denervation involved in regulation of muscle adaptation  (IEP)
response to retinoic acid  (ISO)
skeletal system development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes. Agca C, etal., Mol Reprod Dev. 2013 Feb;80(2):102-17. doi: 10.1002/mrd.22141.
2. Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2. Bertrand-Philippe M, etal., J Biol Chem 2004 Jun 4;279(23):24530-9. Epub 2004 Mar 29.
3. Transcriptomics of post-stroke angiogenesis in the aged brain. Buga AM, etal., Front Aging Neurosci. 2014 Mar 18;6:44. doi: 10.3389/fnagi.2014.00044. eCollection 2014.
4. RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome. Chen CY, etal., Br J Haematol. 2007 Nov;139(3):405-14.
5. Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia. Cho EK, etal., Korean J Intern Med. 2003 Mar;18(1):13-20.
6. AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma. Choi SJ, etal., Blood. 2003 May 15;101(10):3778-83. Epub 2003 Jan 30.
7. Epigenetic dysregulation of key developmental genes in radiation-induced rat mammary carcinomas. Daino K, etal., Int J Cancer. 2018 Jul 15;143(2):343-354. doi: 10.1002/ijc.31309. Epub 2018 Feb 23.
8. Different gene expression profiles in metastasizing midgut carcinoid tumors. Edfeldt K, etal., Endocr Relat Cancer. 2011 Jul 11;18(4):479-89. doi: 10.1530/ERC-10-0256. Print 2011 Aug.
9. Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract. Fijneman RJ, etal., Cancer Sci. 2012 Mar;103(3):593-9. doi: 10.1111/j.1349-7006.2011.02189.x. Epub 2012 Jan 19.
10. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Ford AM, etal., Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4584-8.
11. NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia. Gattenlohner S, etal., Am J Pathol 2003 Sep;163(3):1081-90.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model. Gonzalez de Aguilar JL, etal., Physiol Genomics. 2008 Jan 17;32(2):207-18. Epub 2007 Nov 13.
15. Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia. Grossmann V, etal., Haematologica. 2011 Dec;96(12):1874-7. doi: 10.3324/haematol.2011.043919. Epub 2011 Aug 9.
16. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Growney JD, etal., Blood. 2005 Jul 15;106(2):494-504. Epub 2005 Mar 22.
17. RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking. Haley KJ, etal., Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L693-701. Epub 2011 Jul 29.
18. The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer. Ishikawa R, etal., Jpn J Clin Oncol. 2016 Feb;46(2):185-9. doi: 10.1093/jjco/hyv187. Epub 2015 Dec 18.
19. Luteinizing hormone-induced RUNX1 regulates the expression of genes in granulosa cells of rat periovulatory follicles. Jo M and Curry TE Jr, Mol Endocrinol. 2006 Sep;20(9):2156-72. Epub 2006 May 4.
20. Allelic based gene-gene interactions in rheumatoid arthritis. Jung J, etal., BMC Proc. 2009 Dec 15;3 Suppl 7:S76.
21. Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. Kara M, etal., Gene. 2015 Aug 1;567(1):81-6. doi: 10.1016/j.gene.2015.04.065. Epub 2015 Apr 27.
22. No influence of SLC22A4 C6607T and RUNX1 G24658C genotypic variants on the circulating carnitine ester profile in patients with rheumatoid arthritis. Komlosi K, etal., Clin Exp Rheumatol. 2008 Jan-Feb;26(1):61-6.
23. Gene expression profiling of the rat endometriosis model. Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
24. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Kundu M, etal., Blood. 2005 Nov 15;106(10):3621-4. Epub 2005 Jul 28.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. LncRNA RUNX1-IT1 is Downregulated in Endometrial Cancer and Binds to miR-21 Precursor to Suppress Its Maturation. Liang M, etal., Cancer Manag Res. 2020 Dec 30;12:13451-13459. doi: 10.2147/CMAR.S272165. eCollection 2020.
27. Down-regulation of lncRNA-NEF indicates poor prognosis in intrahepatic cholangiocarcinoma. Liang Z, etal., Biosci Rep. 2019 May 21;39(5). pii: BSR20181573. doi: 10.1042/BSR20181573. Print 2019 May 31.
28. Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells. Liu J, etal., Endocrinology. 2009 Jul;150(7):3291-300. doi: 10.1210/en.2008-1527. Epub 2009 Apr 2.
29. Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta. Ma W, etal., Birth Defects Res A Clin Mol Teratol. 2015 Sep;103(9):772-9. doi: 10.1002/bdra.23401. Epub 2015 Jul 14.
30. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Down-regulation of RUNX1, RUNX3 and CBFbeta in hepatocellular carcinomas in an early stage of hepatocarcinogenesis. Miyagawa K, etal., Anticancer Res. 2006 Sep-Oct;26(5B):3633-43.
33. Molecular Characterization of Colorectal Signet-Ring Cell Carcinoma Using Whole-Exome and RNA Sequencing. Nam JY, etal., Transl Oncol. 2018 Aug;11(4):836-844. doi: 10.1016/j.tranon.2018.04.007. Epub 2018 May 7.
34. An Association and Meta-Analysis of Esophageal Squamous Cell Carcinoma Risk Associated with PLCE1 rs2274223, C20orf54 rs13042395 and RUNX1 rs2014300 Polymorphisms. Nariman-Saleh-Fam Z, etal., Pathol Oncol Res. 2020 Apr;26(2):681-692. doi: 10.1007/s12253-019-00579-3. Epub 2019 Jan 21.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population. Orozco G, etal., J Rheumatol. 2006 Jul;33(7):1235-9.
38. Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome. Patel A, etal., Neurosci Lett. 2011 Jan 7;487(2):144-8. Epub 2010 Oct 12.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2 alpha B gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21. Preudhomme C, etal., Blood. 2000 Oct 15;96(8):2862-9.
41. Loss of RUNX1 is associated with aggressive lung adenocarcinomas. Ramsey J, etal., J Cell Physiol. 2018 Apr;233(4):3487-3497. doi: 10.1002/jcp.26201. Epub 2017 Nov 1.
42. Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases. Reichard KK, etal., Mod Pathol. 2011 Dec;24(12):1606-11. doi: 10.1038/modpathol.2011.118. Epub 2011 Aug 5.
43. GOA pipeline RGD automated data pipeline
44. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Comprehensive gene review and curation RGD comprehensive gene curation
47. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
48. CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy. Roulston D, etal., Blood. 1998 Oct 15;92(8):2879-85.
49. Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Sakakura C, etal., Int J Cancer. 2005 Jan 10;113(2):221-8. doi: 10.1002/ijc.20551.
50. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Setoguchi R, etal., Science. 2008 Feb 8;319(5864):822-5. doi: 10.1126/science.1151844.
51. Sox9 expression during fracture repair. Shintaku Y, etal., Cells Tissues Organs. 2011;194(1):38-48. doi: 10.1159/000322557. Epub 2011 Jan 22.
52. Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies. Takata Y, etal., J Hum Genet. 2008;53(2):163-73. Epub 2007 Dec 18.
53. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Tang JL, etal., Blood. 2009 Dec 17;114(26):5352-61. doi: 10.1182/blood-2009-05-223784. Epub 2009 Oct 6.
54. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
55. Runx1 and C/EBPbeta transcription factors directly up-regulate P2X3 gene transcription. Ugarte GD, etal., J Cell Physiol. 2012 Apr;227(4):1645-52. doi: 10.1002/jcp.22882.
56. Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury. Wang T, etal., PLoS One. 2011;6(12):e28908. Epub 2011 Dec 21.
57. Runx1 Deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells. Wong WF, etal., J Immunol. 2012 May 2.
58. Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Wotton S, etal., Cancer Res. 2002 Dec 15;62(24):7181-5.
59. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Yanagida M, etal., Oncogene. 2005 Jun 30;24(28):4477-85.
60. Overexpression or knock-down of runt-related transcription factor 1 affects BCR-ABL-induced proliferation and migration in vitro and leukemogenesis in vivo in mice. Yang LJ, etal., Chin Med J (Engl). 2009 Feb 5;122(3):331-7.
61. AML1 is expressed in skeletal muscle and is regulated by innervation. Zhu X, etal., Mol Cell Biol 1994 Dec;14(12):8051-7.
Additional References at PubMed
PMID:7774816   PMID:7862156   PMID:8413232   PMID:9199349   PMID:10207087   PMID:10207104   PMID:10856244   PMID:10943840   PMID:11742995   PMID:12217689   PMID:12551949   PMID:12807883  
PMID:14970218   PMID:15240886   PMID:15389629   PMID:16174759   PMID:16446141   PMID:17011173   PMID:17377532   PMID:18439490   PMID:19090621   PMID:19182774   PMID:20972335   PMID:21151104  
PMID:21464233   PMID:21873977   PMID:22082260   PMID:23018770   PMID:23861879   PMID:24582971   PMID:25834056   PMID:33410373   PMID:33785732   PMID:37201407   PMID:37936072   PMID:38040660  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21131,839,880 - 32,074,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,843,764 - 32,074,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,538,494 - 40,630,001 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01133,209,969 - 33,301,480 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,368,563 - 32,460,190 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,765,147 - 33,003,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,769,165 - 33,003,021 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,367,315 - 36,601,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,623,461 - 32,725,404 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,679,703 - 32,781,647 (-)NCBI
Celera1131,494,069 - 31,582,728 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382134,787,801 - 35,049,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,787,801 - 36,004,667 (-)EnsemblGRCh38hg38GRCh38
GRCh372136,160,098 - 36,421,599 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map21q22.12NCBI
HuRef2121,639,088 - 21,900,490 (-)NCBIHuRef
CHM1_12135,722,384 - 35,983,819 (-)NCBICHM1_1
T2T-CHM13v2.02133,170,406 - 33,432,142 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391692,398,354 - 92,622,962 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,398,354 - 92,623,037 (-)EnsemblGRCm39 Ensembl
GRCm381692,601,466 - 92,826,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,601,466 - 92,826,149 (-)EnsemblGRCm38mm10GRCm38
MGSCv371692,601,711 - 92,826,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,492,963 - 92,586,187 (-)NCBIMGSCv36mm8
Celera1693,683,427 - 93,779,296 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.7NCBI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13130,170,859 - 30,420,344 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3130,170,605 - 30,420,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3129,270,454 - 29,519,721 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,472,070 - 29,721,306 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3129,472,109 - 29,721,439 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13129,337,954 - 29,586,748 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03129,353,308 - 29,602,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,843,623 - 30,092,833 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13198,371,837 - 198,638,189 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,371,835 - 198,635,648 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213208,205,560 - 208,304,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Variants in Runx1
1510 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:30
Interacting mature miRNAs:37
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,843,898 - 31,844,078 (+)MAPPERmRatBN7.2
Rnor_6.01132,769,170 - 32,769,349NCBIRnor6.0
Rnor_5.01136,371,338 - 36,371,517UniSTSRnor5.0
RGSC_v3.41132,623,466 - 32,623,645UniSTSRGSC3.4
Celera1131,494,204 - 31,494,383UniSTS
Cytogenetic Map11q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,843,894 - 31,844,083 (+)MAPPERmRatBN7.2
Rnor_6.01132,769,166 - 32,769,354NCBIRnor6.0
Rnor_5.01136,371,334 - 36,371,522UniSTSRnor5.0
RGSC_v3.41132,623,462 - 32,623,650UniSTSRGSC3.4
Celera1131,494,200 - 31,494,388UniSTS
RH 3.4 Map11214.7UniSTS
Cytogenetic Map11q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,935,941 - 31,936,039 (+)MAPPERmRatBN7.2
Rnor_6.01132,859,334 - 32,859,431NCBIRnor6.0
Rnor_5.01136,461,473 - 36,461,570UniSTSRnor5.0
RGSC_v3.41132,725,914 - 32,726,011UniSTSRGSC3.4
Celera1131,583,238 - 31,583,335UniSTS
Cytogenetic Map11q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,899,854 - 31,900,033 (+)MAPPERmRatBN7.2
Rnor_6.01132,823,272 - 32,823,450NCBIRnor6.0
Rnor_5.01136,425,577 - 36,425,755UniSTSRnor5.0
RGSC_v3.41132,688,701 - 32,688,879UniSTSRGSC3.4
Celera1131,547,295 - 31,547,473UniSTS
RH 3.4 Map11205.5UniSTS
Cytogenetic Map11q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 14 5 6
Low 3 31 37 29 5 29 8 11 39 35 27 5 8
Below cutoff 12 12 12 12 35 9


RefSeq Acc Id: ENSRNOT00000002313   ⟹   ENSRNOP00000002313
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,843,764 - 31,935,431 (-)Ensembl
Rnor_6.0 Ensembl1132,769,165 - 32,858,830 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084134   ⟹   ENSRNOP00000070750
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,843,764 - 32,074,542 (-)Ensembl
Rnor_6.0 Ensembl1132,769,219 - 33,003,021 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096598   ⟹   ENSRNOP00000080156
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,843,764 - 31,935,431 (-)Ensembl
RefSeq Acc Id: NM_017325   ⟹   NP_059021
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,843,764 - 31,935,431 (-)NCBI
Rnor_6.01132,769,035 - 32,858,825 (-)NCBI
Rnor_5.01136,367,315 - 36,601,674 (-)NCBI
RGSC_v3.41132,623,461 - 32,725,404 (-)RGD
Celera1131,494,069 - 31,582,728 (-)NCBI
RefSeq Acc Id: XM_008768598   ⟹   XP_008766820
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,839,880 - 32,074,427 (-)NCBI
Rnor_6.01132,765,147 - 33,003,061 (-)NCBI
RefSeq Acc Id: XM_008768599   ⟹   XP_008766821
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,839,880 - 32,074,427 (-)NCBI
Rnor_6.01132,765,147 - 33,003,061 (-)NCBI
RefSeq Acc Id: XM_017598053   ⟹   XP_017453542
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,839,880 - 32,074,427 (-)NCBI
Rnor_6.01132,765,147 - 33,003,061 (-)NCBI
RefSeq Acc Id: XM_039088599   ⟹   XP_038944527
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,839,880 - 32,074,360 (-)NCBI
RefSeq Acc Id: NP_059021   ⟸   NM_017325
- UniProtKB: Q63046 (UniProtKB/Swiss-Prot),   A6JLK8 (UniProtKB/TrEMBL),   A6JLK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766821   ⟸   XM_008768599
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008766820   ⟸   XM_008768598
- Peptide Label: isoform X2
- UniProtKB: A6JLK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453542   ⟸   XM_017598053
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYQ4 (UniProtKB/TrEMBL),   A6JLK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002313   ⟸   ENSRNOT00000002313
RefSeq Acc Id: ENSRNOP00000070750   ⟸   ENSRNOT00000084134
RefSeq Acc Id: XP_038944527   ⟸   XM_039088599
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYQ4 (UniProtKB/TrEMBL),   A6JLK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080156   ⟸   ENSRNOT00000096598
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63046-F1-model_v2 AlphaFold Q63046 1-450 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698070
Promoter ID:EPDNEW_R8594
Type:single initiation site
Description:runt-related transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R8595  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01132,858,782 - 32,858,842EPDNEW
RGD ID:13698075
Promoter ID:EPDNEW_R8595
Type:multiple initiation site
Description:runt-related transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R8594  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01133,003,012 - 33,003,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2283 AgrOrtholog
BioCyc Gene G2FUF-21830 BioCyc
Ensembl Genes ENSRNOG00000001704 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002313 ENTREZGENE
  ENSRNOT00000002313.5 UniProtKB/Swiss-Prot
  ENSRNOT00000084134.2 UniProtKB/TrEMBL
  ENSRNOT00000096598.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AML1_Runt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Runt_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Runx_central_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RunxI_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Runt-rel_RUNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50662 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Runt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RunxI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Runx1 PhenoGen
PIRSF TF_Runt-rel_RUNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001704 RatGTEx
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220056
  Q63046 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Runx1  RUNX family transcription factor 1  Runx1  runt-related transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-17 Runx1  runt-related transcription factor 1  Runx1  runt related transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-06-26 Cbfa2  Core-binding factor, runt domain, alpha subunit 2 (acute myeloid leukemia 1 oncogene)      Symbol and Name withdrawn 67952 WITHDRAWN
2001-06-26 Runx1  Runt related transcription factor 1      Symbol and Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is responsible for a form of acute myeloid leukemia 634721
gene_function human homolog is a DNA binding protein 634721
gene_process involved in skeletal muscle gene regulation 634721