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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2283
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Runx1
Name: RUNX family transcription factor 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Runx1decreases expressionISORUNX1 (Homo sapiens)6480464CTDTretinoin results in decreased expression of RUNX1 mRNAPMID:15498508 PMID:23724009
Runx1increases expressionISORunx1 (Mus musculus)6480464CTDTretinoin results in increased expression of RUNX1 mRNAPMID:36189433
Runx1multiple interactionsISORunx1 (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of RUNX1 mRNA; [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of RUNX1 mRNAPMID:30951980 PMID:36189433
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