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Gene: RUNX1 (RUNX family transcription factor 1) Homo sapiens
Symbol: RUNX1
Name: RUNX family transcription factor 1
RGD ID: 30309966
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; calcium ion binding activity; and protein dimerization activity. Involved in myeloid cell differentiation; positive regulation of gene expression; and regulation of granulocyte differentiation. Localizes to nucleoplasm. Implicated in acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute myeloid leukemia 1 protein; AML1; AML1-EVI-1; AML1-EVI-1 fusion protein; AMLCR1; CBF2alpha; CBFA2; core-binding factor, runt domain, alpha subunit 2; EVI-1; mutant RUNX1; oncogene AML-1; PEA2-alpha B; PEBP2-alpha B; PEBP2aB; PEBP2alpha; polyomavirus enhancer-binding protein 2 alpha B subunit; runt related transcription factor 1; runt-related transcription factor 1; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2134,787,801 - 36,004,667 (-)EnsemblGRCh38hg38GRCh38
GRCh382134,787,801 - 35,049,334 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372136,160,098 - 36,421,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map21q22.12NCBI
HuRef2121,639,088 - 21,900,490 (-)NCBIHuRef
CHM1_12135,722,384 - 35,983,819 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - uncurated


Comparative Map Data



Nucleotide Sequences
Protein Sequences
Clinical Variants