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Gene: ATF3 (activating transcription factor 3) Homo sapiens
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Symbol: ATF3
Name: activating transcription factor 3
Description: Exhibits DNA-binding transcription factor activity; RNA polymerase II regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of TRAIL-activated apoptotic signaling pathway; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Localizes to the CHOP-ATF3 complex; nucleolus; and nucleoplasm. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3; FLJ41705
Orthologs:
Mus musculus (house mouse) : Atf3 (activating transcription factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atf3 (activating transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf3 (activating transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF3 (activating transcription factor 3)
Canis lupus familiaris (dog) : ATF3 (activating transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf3 (activating transcription factor 3)
Sus scrofa (pig) : ATF3 (activating transcription factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,565,334 - 212,620,777 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,738,676 - 212,794,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,805,320 - 210,860,740 (+)NCBINCBI36hg18NCBI36
Build 341209,170,507 - 209,182,494NCBI
Celera1185,964,759 - 186,020,178 (+)NCBI
Cytogenetic Map1q32.3NCBI
HuRef1183,415,472 - 183,470,943 (+)NCBIHuRef
CHM1_11214,011,558 - 214,066,986 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ATF3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735760
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.