Foxo3 (forkhead box O3) - Rat Genome Database

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Gene: Foxo3 (forkhead box O3) Mus musculus
Analyze
Symbol: Foxo3
Name: forkhead box O3
RGD ID: 1553155
MGI Page MGI
Description: Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to several human genes including FOXO3 (forkhead box O3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110048B16Rik; 2010203A17Rik; C76856; FKHR; Fkhr2; FKHRL1; forkhead box O3a; forkhead box protein O3; forkhead protein FKHR2; Fox; Foxo3a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,057,841 - 42,152,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1042,057,837 - 42,152,751 (-)EnsemblGRCm39 Ensembl
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBIMGSCv36mm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(E)-thiamethoxam  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-naringenin  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP)
4-nitrophenol  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Solamarine  (EXP)
amidotrizoic acid  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (EXP)
arsenic acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspartame  (EXP)
astaxanthin  (EXP)
atrazine  (ISO)
aucubin  (EXP)
avermectin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cabazitaxel  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
casticin  (ISO)
celastrol  (ISO)
chitosan  (ISO)
chlordecone  (EXP)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
DAPT  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dichloromethane  (EXP)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dihydrogen  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
eckol  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (EXP)
flutamide  (ISO)
fostriecin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
GSK690693  (ISO)
hydrogen peroxide  (EXP,ISO)
IC-87114  (EXP)
icariin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoprenaline  (EXP)
KN-93  (ISO)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
malonaldehyde  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
medroxyprogesterone acetate  (ISO)
metacetamol  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylseleninic acid  (ISO)
metoprolol  (ISO)
mifepristone  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-phosphocreatine  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nitroxoline  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picropodophyllotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
rutin  (EXP)
salubrinal  (ISO)
Sanggenon C  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Sodium salicylate  (EXP)
streptozocin  (EXP,ISO)
tamoxifen  (EXP,ISO)
tannic acid  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thiamethoxam  (EXP)
titanium dioxide  (EXP)
Tomentosin  (ISO)
trilobatin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
tyrphostin AG 1478  (ISO)
umbelliferone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
zearalenone  (EXP)
zinc acetate  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antral ovarian follicle growth  (IMP)
apoptotic process  (IEA)
brain morphogenesis  (IGI)
canonical Wnt signaling pathway  (IGI)
cellular response to amyloid-beta  (ISO)
cellular response to corticosterone stimulus  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to oxidative stress  (IDA,IGI)
DNA damage response, signal transduction by p53 class mediator  (IDA)
extrinsic apoptotic signaling pathway in absence of ligand  (IGI)
glucose homeostasis  (IMP)
initiation of primordial ovarian follicle growth  (IMP)
mitochondrial transcription  (IMP)
negative regulation of canonical Wnt signaling pathway  (IGI)
negative regulation of cell migration  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
neuronal stem cell population maintenance  (IGI)
oocyte maturation  (IMP)
ovulation from ovarian follicle  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (IDA)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
positive regulation of miRNA transcription  (IMP)
positive regulation of muscle atrophy  (IDA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (IDA)
regulation of neural precursor cell proliferation  (IGI)
regulation of reactive oxygen species metabolic process  (IGI)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of translation  (ISO)
response to dexamethasone  (ISO)
response to fatty acid  (IDA)
response to nutrient levels  (ISO)
response to starvation  (IDA)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood vessel morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal NK cell morphology  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal oogenesis  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal polar body morphology  (IAGP)
abnormal primordial ovarian follicle morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal sleep behavior  (IEA)
abnormal superovulation  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell physiology  (IAGP)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent ovarian follicles  (IAGP)
anemia  (IAGP)
decreased apoptosis  (IAGP)
decreased bone mineral density  (IEA)
decreased circulating chloride level  (IEA)
decreased circulating insulin level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased insulin secretion  (IAGP)
decreased locomotor activity  (IEA)
decreased mature ovarian follicle number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased prepulse inhibition  (IEA)
decreased primary ovarian follicle number  (IAGP)
decreased primordial ovarian follicle number  (IAGP)
decreased startle reflex  (IEA)
decreased tumor latency  (IAGP)
dermatitis  (IAGP)
early reproductive senescence  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged ovary  (IAGP)
enlarged spleen  (IAGP)
female infertility  (IAGP)
hemolytic anemia  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased circulating estradiol level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased corpora lutea number  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hamartoma incidence  (IAGP)
increased Harderian gland tumor incidence  (IAGP)
increased heart weight  (IEA)
increased hemangioma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased hepatic hemangioma incidence  (IAGP)
increased inflammatory response  (IAGP)
increased lung adenoma incidence  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular volume  (IAGP)
increased NK cell number  (IAGP)
increased ovarian teratoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased prolactinoma incidence  (IAGP)
increased secondary ovarian follicle number  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell proliferation  (IAGP)
increased tumor incidence  (IAGP)
kidney inflammation  (IAGP)
lung inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
oocyte degeneration  (IAGP)
ovary cyst  (IAGP)
premature death  (IAGP)
prolonged QRS complex duration  (IEA)
reduced female fertility  (IAGP)
reticulocytosis  (IAGP)
salivary gland inflammation  (IAGP)
sclerocornea  (IEA)
spleen hyperplasia  (IAGP)
suppressed circulating follicle stimulating hormone level  (IAGP)
thrombocytopenia  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain. Caballero-Caballero A, etal., J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.
2. Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21. Chalhoub N, etal., Mamm Genome 2001 Dec;12(12):887-92.
3. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. Esteras N, etal., Neurobiol Aging. 2013 Apr;34(4):1090-100. doi: 10.1016/j.neurobiolaging.2012.10.014. Epub 2012 Nov 13.
4. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
5. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. Imae M, etal., J Mol Endocrinol. 2003 Apr;30(2):253-62.
6. Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. Kato M, etal., J Am Soc Nephrol. 2006 Dec;17(12):3325-35. Epub 2006 Nov 2.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
9. [Role of the FOXO3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Li DY, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):1023-7.
10. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Paik JH, etal., Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029.
15. Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27. Park KW, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):742-7. Epub 2005 Jan 20.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Relling DP, etal., J Hypertens. 2006 Mar;24(3):549-61.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
22. FoxO3a is activated and executes neuron death via Bim in response to beta-amyloid. Sanphui P and Biswas SC, Cell Death Dis. 2013 May 9;4:e625. doi: 10.1038/cddis.2013.148.
23. Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Shi C, etal., J Cell Sci. 2016 Mar 9. pii: jcs.185009.
24. FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue. Turrel-Davin F, etal., Ann Rheum Dis. 2010 Apr;69(4):755-60. doi: 10.1136/ard.2009.109991. Epub 2009 May 11.
25. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
26. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Westin SN, etal., Mol Oncol. 2015 Oct;9(8):1694-703. doi: 10.1016/j.molonc.2015.04.014. Epub 2015 May 16.
27. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
28. FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. Zhang S, etal., J Cell Biochem. 2013 Feb;114(2):354-65. doi: 10.1002/jcb.24371.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10880363   PMID:11042159   PMID:11076861   PMID:11353388   PMID:11875118   PMID:11884717   PMID:11994454   PMID:12048180   PMID:12393557   PMID:12431371  
PMID:12477932   PMID:12520002   PMID:12691919   PMID:12855809   PMID:12857750   PMID:12930811   PMID:12966085   PMID:14610273   PMID:14681479   PMID:14691534   PMID:14966295   PMID:14976264  
PMID:14978268   PMID:14980222   PMID:15069012   PMID:15084260   PMID:15109499   PMID:15308101   PMID:15322035   PMID:15326356   PMID:15383658   PMID:15569384   PMID:15618518   PMID:15746257  
PMID:15781459   PMID:15837797   PMID:15890782   PMID:15895074   PMID:16100571   PMID:16140986   PMID:16141072   PMID:16141073   PMID:16326148   PMID:16373335   PMID:16376864   PMID:16453021  
PMID:16495456   PMID:16585573   PMID:16602821   PMID:16690745   PMID:16710360   PMID:16757565   PMID:16792526   PMID:16952979   PMID:17132628   PMID:17254970   PMID:17301033   PMID:17322895  
PMID:17353275   PMID:17366632   PMID:17521387   PMID:17565040   PMID:17616716   PMID:17618288   PMID:17634411   PMID:17671650   PMID:17711846   PMID:17765928   PMID:17957242   PMID:17967808  
PMID:17974917   PMID:17975019   PMID:18005957   PMID:18022395   PMID:18037997   PMID:18045156   PMID:18054315   PMID:18054316   PMID:18158893   PMID:18218983   PMID:18230695   PMID:18239123  
PMID:18256550   PMID:18268343   PMID:18270576   PMID:18272820   PMID:18287559   PMID:18344980   PMID:18371339   PMID:18421953   PMID:18424439   PMID:18488031   PMID:18601916   PMID:18641278  
PMID:18678662   PMID:18701653   PMID:18728232   PMID:18799693   PMID:18799725   PMID:18823877   PMID:18832697   PMID:18854138   PMID:18957280   PMID:18978794   PMID:19029949   PMID:19136962  
PMID:19276113   PMID:19321440   PMID:19324885   PMID:19363483   PMID:19386638   PMID:19389373   PMID:19415678   PMID:19502585   PMID:19636295   PMID:19652361   PMID:19671690   PMID:19724863  
PMID:19730740   PMID:19747349   PMID:19786569   PMID:19800350   PMID:19837877   PMID:19842039   PMID:19850877   PMID:19896443   PMID:19896444   PMID:19917721   PMID:19920365   PMID:19933931  
PMID:19965665   PMID:20018872   PMID:20059953   PMID:20130650   PMID:20133625   PMID:20142101   PMID:20142102   PMID:20213318   PMID:20371605   PMID:20400940   PMID:20404331   PMID:20412781  
PMID:20439537   PMID:20467422   PMID:20547753   PMID:20564353   PMID:20625400   PMID:20739833   PMID:20880840   PMID:20952592   PMID:20978344   PMID:21075312   PMID:21113129   PMID:21159781  
PMID:21167754   PMID:21209944   PMID:21211055   PMID:21267068   PMID:21347845   PMID:21388966   PMID:21423206   PMID:21435455   PMID:21553025   PMID:21565617   PMID:21571225   PMID:21621563  
PMID:21628326   PMID:21653327   PMID:21690325   PMID:21730069   PMID:21865646   PMID:21873635   PMID:21884932   PMID:21893017   PMID:21965295   PMID:21978520   PMID:22025678   PMID:22094330  
PMID:22102632   PMID:22128155   PMID:22147007   PMID:22187289   PMID:22197325   PMID:22267219   PMID:22326951   PMID:22359505   PMID:22402663   PMID:22405072   PMID:22411791   PMID:22427650  
PMID:22474372   PMID:22510686   PMID:22510882   PMID:22511764   PMID:22539004   PMID:22539794   PMID:22546858   PMID:22675000   PMID:22688338   PMID:22761423   PMID:22761832   PMID:22773666  
PMID:22820375   PMID:22848740   PMID:22914323   PMID:22931788   PMID:22932683   PMID:22935140   PMID:22982991   PMID:22992773   PMID:23046823   PMID:23100026   PMID:23277488   PMID:23283301  
PMID:23315071   PMID:23322722   PMID:23349480   PMID:23382383   PMID:23389440   PMID:23420833   PMID:23444404   PMID:23461683   PMID:23471411   PMID:23568341   PMID:23603907   PMID:23620592  
PMID:23624922   PMID:23673628   PMID:23677673   PMID:23765843   PMID:23810581   PMID:23815557   PMID:23819440   PMID:23835335   PMID:23851496   PMID:23867625   PMID:23881913   PMID:23891001  
PMID:23906066   PMID:23974119   PMID:23982205   PMID:24003218   PMID:24013118   PMID:24015318   PMID:24040102   PMID:24060902   PMID:24068327   PMID:24095927   PMID:24174672   PMID:24194600  
PMID:24225087   PMID:24238962   PMID:24246780   PMID:24257750   PMID:24259566   PMID:24270422   PMID:24357321   PMID:24466179   PMID:24483844   PMID:24493802   PMID:24558442   PMID:24559722  
PMID:24570486   PMID:24580070   PMID:24586650   PMID:24749067   PMID:24781012   PMID:24856209   PMID:24859451   PMID:24871856   PMID:24952961   PMID:24966026   PMID:24971484   PMID:25010393  
PMID:25047750   PMID:25063823   PMID:25168244   PMID:25201756   PMID:25245112   PMID:25264246   PMID:25271153   PMID:25307742   PMID:25327288   PMID:25344367   PMID:25344604   PMID:25378413  
PMID:25402684   PMID:25418727   PMID:25456740   PMID:25460735   PMID:25505152   PMID:25505262   PMID:25516595   PMID:25576059   PMID:25609639   PMID:25670795   PMID:25691571   PMID:25766527  
PMID:25769609   PMID:25800339   PMID:25808402   PMID:25858807   PMID:25915474   PMID:25929834   PMID:25958091   PMID:25969990   PMID:26020233   PMID:26061565   PMID:26084022   PMID:26121028  
PMID:26173459   PMID:26209246   PMID:26232637   PMID:26287518   PMID:26302789   PMID:26327408   PMID:26343536   PMID:26410627   PMID:26452208   PMID:26470727   PMID:26470730   PMID:26507072  
PMID:26523980   PMID:26574435   PMID:26601142   PMID:26694365   PMID:26764572   PMID:26786260   PMID:26861625   PMID:26882203   PMID:26917725   PMID:26968210   PMID:27049128   PMID:27050511  
PMID:27060196   PMID:27107699   PMID:27214848   PMID:27224923   PMID:27226534   PMID:27235148   PMID:27264604   PMID:27323690   PMID:27390852   PMID:27402759   PMID:27465291   PMID:27481940  
PMID:27491024   PMID:27500836   PMID:27525440   PMID:27572106   PMID:27599659   PMID:27607577   PMID:27626380   PMID:27687729   PMID:27720640   PMID:27742544   PMID:27771355   PMID:27794418  
PMID:27856257   PMID:27956699   PMID:27994057   PMID:27998725   PMID:28011648   PMID:28077597   PMID:28170423   PMID:28213137   PMID:28229217   PMID:28250026   PMID:28286268   PMID:28300161  
PMID:28321785   PMID:28330873   PMID:28427239   PMID:28430387   PMID:28432353   PMID:28455433   PMID:28560451   PMID:28585698   PMID:28660881   PMID:28700664   PMID:28705935   PMID:28771227  
PMID:28952285   PMID:29031500   PMID:29056338   PMID:29103953   PMID:29178390   PMID:29217661   PMID:29222408   PMID:29254083   PMID:29349768   PMID:29408809   PMID:29444976   PMID:29445193  
PMID:29580989   PMID:29664021   PMID:29717119   PMID:29775231   PMID:29950509   PMID:29963746   PMID:30132880   PMID:30174230   PMID:30197237   PMID:30280799   PMID:30304480   PMID:30318050  
PMID:30323296   PMID:30459233   PMID:30500392   PMID:30511639   PMID:30523761   PMID:30718226   PMID:30765703   PMID:30860395   PMID:30912765   PMID:30964175   PMID:30973875   PMID:31147464  
PMID:31255283   PMID:31264342   PMID:31396850   PMID:31509237   PMID:31541023   PMID:31645142   PMID:31657143   PMID:31729980   PMID:31741467   PMID:31756626   PMID:31767172   PMID:31796819  
PMID:31918917   PMID:31929511   PMID:31962236   PMID:31971251   PMID:31980519   PMID:32043969   PMID:32103177   PMID:32133736   PMID:32308774   PMID:32335547   PMID:32369448   PMID:32375205  
PMID:32402289   PMID:32439763   PMID:32439985   PMID:32457280   PMID:32550900   PMID:32558394   PMID:32562311   PMID:32593214   PMID:32718291   PMID:32866521   PMID:32866886   PMID:32887751  
PMID:33110391   PMID:33147486   PMID:33215443   PMID:33293536   PMID:33351795   PMID:33505018   PMID:33510167   PMID:33577435   PMID:33634126   PMID:33649241   PMID:33727534   PMID:33812084  
PMID:33864227   PMID:33887345   PMID:33891136   PMID:33941868   PMID:33953705   PMID:33983546   PMID:33990776   PMID:34073605   PMID:34101965   PMID:34122724   PMID:34174788   PMID:34234110  
PMID:34247441   PMID:34263740   PMID:34288093   PMID:34310897   PMID:34318928   PMID:34556581   PMID:34789242   PMID:34891040   PMID:34897463   PMID:34971379   PMID:35061305   PMID:35084365  
PMID:35141958   PMID:35142084   PMID:35185597   PMID:35550124   PMID:35603175   PMID:35757763   PMID:35910798   PMID:35915222   PMID:36001955   PMID:36106640   PMID:36344492   PMID:36442857  
PMID:36451342   PMID:36500714   PMID:36601735   PMID:36843585   PMID:36864049   PMID:36977674   PMID:37027942   PMID:37197981   PMID:37298680   PMID:37400900   PMID:37494420   PMID:37499855  
PMID:37523546   PMID:37543947   PMID:37626241   PMID:37681900   PMID:37682013   PMID:37686468   PMID:37890842   PMID:38182060  


Genomics

Comparative Map Data
Foxo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,057,841 - 42,152,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1042,057,837 - 42,152,751 (-)EnsemblGRCm39 Ensembl
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBIMGSCv36mm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
FOXO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6108,559,835 - 108,684,774 (+)EnsemblGRCh38hg38GRCh38
GRCh376108,881,028 - 109,005,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36Build 36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
T2T-CHM13v2.06109,737,167 - 109,862,124 (+)NCBIT2T-CHM13v2.0
Foxo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,251,968 - 47,348,254 (-)NCBIGRCr8
mRatBN7.22045,669,708 - 45,764,606 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,672,995 - 45,764,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,391,080 - 47,482,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,041,261 - 47,132,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,737,977 - 47,829,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02046,428,078 - 46,519,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,111,014 - 48,206,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,171,784 - 46,262,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12046,194,693 - 46,284,921 (-)NCBI
Celera2054,198,460 - 54,289,566 (+)NCBICelera
Cytogenetic Map20q12-q13NCBI
Foxo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541133,655,958 - 33,770,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541133,655,958 - 33,770,829 (+)NCBIChiLan1.0ChiLan1.0
FOXO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25128,566,148 - 128,691,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16126,458,644 - 126,582,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06106,360,519 - 106,485,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16110,406,265 - 110,536,967 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,406,266 - 110,516,272 (+)Ensemblpanpan1.1panPan2
FOXO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,552,455 - 65,673,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,430,400 - 66,552,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBIUU_Cfam_GSD_1.0
Foxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,513,168 - 100,632,744 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365644,787,992 - 4,903,837 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365644,788,036 - 4,907,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,628,218 - 74,760,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,626,673 - 74,760,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,888,152 - 83,888,769 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2184,047,498 - 84,048,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FOXO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11365,175,764 - 65,303,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1365,195,376 - 65,301,725 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604037,504,633 - 37,631,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478013,622,948 - 13,740,374 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,621,733 - 13,740,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxo3
3552 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2017
Count of miRNA genes:806
Interacting mature miRNAs:1039
Transcripts:ENSMUST00000056974, ENSMUST00000105501, ENSMUST00000105502, ENSMUST00000175881, ENSMUST00000177542
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102689026446720483Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
21079434Bdym5_mbody mass QTL 5 (mouse)104054599654836096Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001376967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF114259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY965015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000056974   ⟹   ENSMUSP00000050683
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1042,061,782 - 42,152,738 (-)Ensembl
GRCm38.p6 Ensembl1042,185,786 - 42,276,742 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105501   ⟹   ENSMUSP00000101140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1042,123,427 - 42,152,751 (-)Ensembl
GRCm38.p6 Ensembl1042,247,431 - 42,276,755 (-)Ensembl
RefSeq Acc Id: ENSMUST00000105502   ⟹   ENSMUSP00000101141
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1042,057,837 - 42,152,748 (-)Ensembl
GRCm38.p6 Ensembl1042,181,841 - 42,276,752 (-)Ensembl
RefSeq Acc Id: ENSMUST00000175881   ⟹   ENSMUSP00000135380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1042,072,264 - 42,152,692 (-)Ensembl
GRCm38.p6 Ensembl1042,196,268 - 42,276,696 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177542   ⟹   ENSMUSP00000135355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1042,073,550 - 42,134,362 (-)Ensembl
GRCm38.p6 Ensembl1042,197,554 - 42,258,366 (-)Ensembl
RefSeq Acc Id: NM_001376967   ⟹   NP_001363896
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391042,057,841 - 42,152,691 (-)NCBI
GRCm381042,181,845 - 42,276,695 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019740   ⟹   NP_062714
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391042,057,841 - 42,152,691 (-)NCBI
GRCm381042,181,845 - 42,276,695 (-)NCBI
MGSCv371041,905,592 - 41,996,548 (-)RGD
Celera1043,062,294 - 43,153,032 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062714   ⟸   NM_019740
- UniProtKB: D3Z6Y6 (UniProtKB/Swiss-Prot),   Q05CZ4 (UniProtKB/Swiss-Prot),   Q9WVH4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001363896   ⟸   NM_001376967
- UniProtKB: Q9WVH4 (UniProtKB/Swiss-Prot),   D3Z6Y6 (UniProtKB/Swiss-Prot),   Q05CZ4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000101140   ⟸   ENSMUST00000105501
RefSeq Acc Id: ENSMUSP00000101141   ⟸   ENSMUST00000105502
RefSeq Acc Id: ENSMUSP00000135355   ⟸   ENSMUST00000177542
RefSeq Acc Id: ENSMUSP00000050683   ⟸   ENSMUST00000056974
RefSeq Acc Id: ENSMUSP00000135380   ⟸   ENSMUST00000175881
Protein Domains
Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVH4-F1-model_v2 AlphaFold Q9WVH4 1-672 view protein structure

Promoters
RGD ID:6818919
Promoter ID:MM_KWN:4009
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:UC007EYK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361041,901,726 - 41,905,222 (-)MPROMDB
RGD ID:6819317
Promoter ID:MM_KWN:4010
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:UC007EYO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361041,994,641 - 41,995,667 (-)MPROMDB
RGD ID:6819320
Promoter ID:MM_KWN:4011
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000105501,   ENSMUST00000105502,   NM_019740,   UC007EYN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361041,996,391 - 41,997,427 (-)MPROMDB
RGD ID:8671886
Promoter ID:EPDNEW_M13974
Type:single initiation site
Name:Foxo3_2
Description:Mus musculus forkhead box O3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13975  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381042,275,636 - 42,275,696EPDNEW
RGD ID:8671888
Promoter ID:EPDNEW_M13975
Type:initiation region
Name:Foxo3_1
Description:Mus musculus forkhead box O3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13974  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381042,276,695 - 42,276,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890081 AgrOrtholog
Ensembl Genes ENSMUSG00000048756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000056974 ENTREZGENE
  ENSMUST00000056974.4 UniProtKB/Swiss-Prot
  ENSMUST00000105501.2 UniProtKB/TrEMBL
  ENSMUST00000105502 ENTREZGENE
  ENSMUST00000105502.8 UniProtKB/Swiss-Prot
  ENSMUST00000175881.8 UniProtKB/Swiss-Prot
  ENSMUST00000177542.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1690 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX-bd UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56484 UniProtKB/Swiss-Prot
MGD MGI:1890081 ENTREZGENE
NCBI Gene 56484 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN O UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN O3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX_bdg UniProtKB/Swiss-Prot
PhenoGen Foxo3 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z6Y6 ENTREZGENE
  FOXO3_MOUSE UniProtKB/Swiss-Prot
  H3BKE2_MOUSE UniProtKB/TrEMBL
  H9KUZ0_MOUSE UniProtKB/TrEMBL
  Q05CZ4 ENTREZGENE
  Q3TX10_MOUSE UniProtKB/TrEMBL
  Q9WVH4 ENTREZGENE
UniProt Secondary D3Z6Y6 UniProtKB/Swiss-Prot
  Q05CZ4 UniProtKB/Swiss-Prot