FOXO1 (forkhead box O1) - Rat Genome Database

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Gene: FOXO1 (forkhead box O1) Homo sapiens
Analyze
Symbol: FOXO1
Name: forkhead box O1
RGD ID: 737155
HGNC Page HGNC
Description: Exhibits several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hyperoxia; positive regulation of catabolic process; and regulation of apoptotic process. Localizes to cytoplasm and nucleus. Implicated in alveolar rhabdomyosarcoma. Biomarker of congestive heart failure; hepatocellular carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FKH1; FKHR; forkhead box protein O1; forkhead box protein O1A; forkhead homolog in rhabdomyosarcoma; forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1A
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: FOXO1B  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1340,469,953 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1340,555,667 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh381340,555,667 - 40,666,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371341,129,804 - 41,240,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,027,801 - 40,138,734 (-)NCBINCBI36hg18NCBI36
Build 341340,027,816 - 40,138,734NCBI
Celera1322,187,272 - 22,298,190 (-)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1321,931,318 - 22,042,054 (-)NCBIHuRef
CHM1_11341,097,585 - 41,208,493 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(S)-nicotine  (EXP)
(Z)-ligustilide  (EXP,ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
8-Br-cAMP  (EXP)
9E,11E-octadecadienoic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (ISO)
amidotrizoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
antirheumatic drug  (EXP)
arsenic acid  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
azathioprine  (EXP)
bafilomycin A1  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP)
berberine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bucladesine  (EXP)
buspirone  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP,ISO)
candesartan  (ISO)
cannabidiol  (EXP)
carbamazepine  (EXP)
carbaryl  (EXP)
carbon nanotube  (EXP,ISO)
chloroprene  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clothianidin  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cortisol  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
diclofenac  (EXP)
dicrotophos  (EXP)
dioscin  (EXP)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (EXP,ISO)
etoposide  (EXP)
formaldehyde  (EXP)
fructose  (ISO)
Geniposide  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
leflunomide  (EXP)
leptomycin B  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
medroxyprogesterone acetate  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
neomycin  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
octadecanoic acid  (ISO)
oleic acid  (ISO)
panobinostat  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perifosine  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
picloram  (ISO)
pirinixic acid  (ISO)
pomalidomide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin  (EXP)
procyanidin B2  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (EXP)
quercetin  (ISO)
raloxifene  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
spirotetramat  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sulpiride  (ISO)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (ISO)
tributylstannane  (EXP)
trichlopyr  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IMP)
autophagy  (IEA)
blood vessel development  (ISO)
cellular glucose homeostasis  (ISS)
cellular response to cold  (ISS)
cellular response to dexamethasone stimulus  (IEA,ISO)
cellular response to DNA damage stimulus  (ISS)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to hyperoxia  (IDA)
cellular response to insulin stimulus  (ISS)
cellular response to nitric oxide  (ISS)
cellular response to oxidative stress  (ISS)
cellular response to starvation  (IDA,ISS)
cytokine-mediated signaling pathway  (TAS)
enamel mineralization  (IEA,ISO)
energy homeostasis  (ISS)
fat cell differentiation  (ISS)
glucose homeostasis  (ISO)
insulin receptor signaling pathway  (IBA,ISO,ISS)
negative regulation of apoptotic process  (IDA)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISS)
negative regulation of fat cell differentiation  (ISS)
negative regulation of gene expression  (ISO)
negative regulation of stress-activated MAPK cascade  (IDA)
negative regulation of transcription, DNA-templated  (ISS)
neuronal stem cell population maintenance  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy  (IMP)
positive regulation of complement-dependent cytotoxicity  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of protein catabolic process  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
protein acetylation  (ISS)
regulation of cell population proliferation  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of type B pancreatic cell development  (TAS)
response to fatty acid  (ISS)
response to fluoride  (IEA,ISO)
response to insulin  (ISO)
temperature homeostasis  (ISS)

Cellular Component
chromatin  (ISA)
cytoplasm  (IDA,ISO)
cytosol  (ISO,ISS,TAS)
mitochondrion  (ISS)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Altomonte J, etal., J Clin Invest. 2004 Nov;114(10):1493-503.
2. GOA_HUMAN data from the GO Consortium
3. Hannenhalli S, etal., Circulation. 2006 Sep 19;114(12):1269-76. Epub 2006 Sep 4.
4. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
5. Jiang J, etal., J Biol Chem. 2017 Nov 24;292(47):19146-19159. doi: 10.1074/jbc.M117.793760. Epub 2017 Sep 27.
6. Kloting N, etal., Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):146-54.
7. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
8. Nagashima T, etal., Mol Pharmacol. 2010 Nov;78(5):961-70. doi: 10.1124/mol.110.065714. Epub 2010 Aug 24.
9. Online Mendelian Inheritance in Man, OMIM (TM).
10. Pipeline to import KEGG annotations from KEGG into RGD
11. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Portal-Nunez S, etal., Histol Histopathol. 2013 Nov;28(11):1473-81. Epub 2013 May 15.
13. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. RGD automated import pipeline for gene-chemical interactions
15. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
16. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
17. Xie X, etal., J Diabetes Res. 2018 Aug 16;2018:6254340. doi: 10.1155/2018/6254340. eCollection 2018.
18. Yan L, etal., Biochem J. 2012 Jun 1;444(2):239-47. doi: 10.1042/BJ20111606.
Additional References at PubMed
PMID:7630639   PMID:7862145   PMID:8275086   PMID:8634710   PMID:8790412   PMID:9479491   PMID:10358014   PMID:10358075   PMID:10783894   PMID:10871843   PMID:10973497   PMID:11030146  
PMID:11237865   PMID:11311120   PMID:11353774   PMID:11435445   PMID:11672436   PMID:11735247   PMID:11893744   PMID:11896584   PMID:11980723   PMID:12039929   PMID:12150827   PMID:12163409  
PMID:12228231   PMID:12242297   PMID:12477932   PMID:12482965   PMID:12493691   PMID:12519792   PMID:12560069   PMID:12606503   PMID:12921955   PMID:12960271   PMID:12966085   PMID:14664696  
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PMID:19549905   PMID:19563779   PMID:19574223   PMID:19584310   PMID:19633686   PMID:19675556   PMID:19686743   PMID:19696738   PMID:19727442   PMID:19740748   PMID:19757185   PMID:19772960  
PMID:19787258   PMID:19793722   PMID:19887561   PMID:19893043   PMID:19948975   PMID:19953635   PMID:19956688   PMID:20018872   PMID:20033803   PMID:20061393   PMID:20095040   PMID:20125105  
PMID:20151947   PMID:20351326   PMID:20353756   PMID:20357092   PMID:20406953   PMID:20412774   PMID:20485516   PMID:20543840   PMID:20682687   PMID:20719862   PMID:20819778   PMID:20868688  
PMID:20874444   PMID:20884733   PMID:20933505   PMID:21069157   PMID:21075101   PMID:21116854   PMID:21177767   PMID:21177856   PMID:21179458   PMID:21185807   PMID:21238503   PMID:21298325  
PMID:21320536   PMID:21321994   PMID:21373837   PMID:21388494   PMID:21396404   PMID:21423212   PMID:21440011   PMID:21440577   PMID:21442235   PMID:21505104   PMID:21510935   PMID:21539865  
PMID:21541992   PMID:21613825   PMID:21655267   PMID:21666686   PMID:21670150   PMID:21696576   PMID:21697492   PMID:21708191   PMID:21747041   PMID:21775495   PMID:21804543   PMID:21873635  
PMID:21993163   PMID:22013015   PMID:22072736   PMID:22089931   PMID:22159921   PMID:22180177   PMID:22197543   PMID:22213032   PMID:22266855   PMID:22315317   PMID:22343918   PMID:22374423  
PMID:22389493   PMID:22400069   PMID:22411791   PMID:22454413   PMID:22489460   PMID:22510882   PMID:22515357   PMID:22538365   PMID:22552808   PMID:22569260   PMID:22622204   PMID:22653055  
PMID:22675169   PMID:22761423   PMID:22761592   PMID:22821817   PMID:22865884   PMID:22931788   PMID:22992773   PMID:23002242   PMID:23025577   PMID:23029264   PMID:23035900   PMID:23041154  
PMID:23059127   PMID:23077062   PMID:23105097   PMID:23142810   PMID:23160481   PMID:23255113   PMID:23263330   PMID:23277279   PMID:23291589   PMID:23381604   PMID:23389878   PMID:23401241  
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PMID:24741631   PMID:24746199   PMID:24762137   PMID:24839223   PMID:24886245   PMID:24895270   PMID:24916379   PMID:24956219   PMID:24977668   PMID:24979718   PMID:24983498   PMID:25009184  
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PMID:25364236   PMID:25398439   PMID:25414190   PMID:25416447   PMID:25420919   PMID:25472505   PMID:25483711   PMID:25566967   PMID:25584414   PMID:25609649   PMID:25623117   PMID:25625287  
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PMID:27534652   PMID:27559048   PMID:27566573   PMID:27577745   PMID:27588498   PMID:27616439   PMID:27626385   PMID:27634871   PMID:27688110   PMID:27707884   PMID:27746366   PMID:27751825  
PMID:27769097   PMID:27835585   PMID:27878235   PMID:27890702   PMID:27903254   PMID:27924058   PMID:27936162   PMID:27974199   PMID:28049237   PMID:28087474   PMID:28096479   PMID:28099936  
PMID:28135285   PMID:28138962   PMID:28160461   PMID:28182362   PMID:28189723   PMID:28205554   PMID:28223045   PMID:28223425   PMID:28225038   PMID:28249601   PMID:28279977   PMID:28283331  
PMID:28339037   PMID:28343375   PMID:28349071   PMID:28400278   PMID:28430387   PMID:28446439   PMID:28460412   PMID:28485164   PMID:28514442   PMID:28539329   PMID:28559138   PMID:28615069  
PMID:28621049   PMID:28641336   PMID:28655758   PMID:28666797   PMID:28681509   PMID:28685544   PMID:28710059   PMID:28711779   PMID:28719355   PMID:28733463   PMID:28733598   PMID:28738025  
PMID:28774833   PMID:28790135   PMID:28791406   PMID:28802579   PMID:28821161   PMID:28837808   PMID:28860538   PMID:28965871   PMID:28970066   PMID:28973411   PMID:28994342   PMID:29138552  
PMID:29146205   PMID:29157981   PMID:29238041   PMID:29249185   PMID:29269047   PMID:29323718   PMID:29328406   PMID:29331376   PMID:29334763   PMID:29338713   PMID:29355652   PMID:29367756  
PMID:29395067   PMID:29409027   PMID:29448096   PMID:29466794   PMID:29496617   PMID:29507755   PMID:29512721   PMID:29569762   PMID:29574902   PMID:29590615   PMID:29622548   PMID:29724916  
PMID:29727907   PMID:29739037   PMID:29749437   PMID:29762826   PMID:29797665   PMID:29867121   PMID:29901128   PMID:29928873   PMID:29940761   PMID:29963746   PMID:29966750   PMID:30001537  
PMID:30002415   PMID:30016365   PMID:30021884   PMID:30024610   PMID:30078216   PMID:30088951   PMID:30138596   PMID:30142277   PMID:30144329   PMID:30190424   PMID:30206735   PMID:30216501  
PMID:30227407   PMID:30262997   PMID:30272296   PMID:30333121   PMID:30423812   PMID:30452456   PMID:30463848   PMID:30478420   PMID:30535125   PMID:30535458   PMID:30556236   PMID:30614794  
PMID:30629029   PMID:30664534   PMID:30689742   PMID:30690883   PMID:30728292   PMID:30731134   PMID:30783090   PMID:30790508   PMID:30799084   PMID:30825235   PMID:30841958   PMID:30873749  
PMID:30878647   PMID:30944148   PMID:30964354   PMID:30967498   PMID:31027497   PMID:31030593   PMID:31063815   PMID:31095939   PMID:31098771   PMID:31243340   PMID:31261027   PMID:31300419  
PMID:31301310   PMID:31302815   PMID:31308176   PMID:31322188   PMID:31367853   PMID:31368152   PMID:31389596   PMID:31400752   PMID:31416776   PMID:31425691   PMID:31442424   PMID:31492105  
PMID:31526292   PMID:31547433   PMID:31554600   PMID:31578374   PMID:31601652   PMID:31629675   PMID:31695788   PMID:31696486   PMID:31712122   PMID:31714185   PMID:31754475   PMID:31765819  
PMID:31819175   PMID:31823759   PMID:31836325   PMID:31844113   PMID:31888661   PMID:31894487   PMID:31900915   PMID:31936903   PMID:31980519   PMID:32016462   PMID:32057517   PMID:32075913  
PMID:32094299   PMID:32178422   PMID:32187044   PMID:32224523   PMID:32279994   PMID:32281255   PMID:32332845   PMID:32359391   PMID:32364530   PMID:32373978   PMID:32375544   PMID:32522566  
PMID:32541947   PMID:32590022   PMID:32868076   PMID:32879318   PMID:32964916   PMID:32986769   PMID:33356954  


Genomics

Comparative Map Data
FOXO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1340,469,953 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1340,555,667 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh381340,555,667 - 40,666,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371341,129,804 - 41,240,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,027,801 - 40,138,734 (-)NCBINCBI36hg18NCBI36
Build 341340,027,816 - 40,138,734NCBI
Celera1322,187,272 - 22,298,190 (-)NCBI
Cytogenetic Map13q14.11NCBI
HuRef1321,931,318 - 22,042,054 (-)NCBIHuRef
CHM1_11341,097,585 - 41,208,493 (-)NCBICHM1_1
Foxo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39352,175,758 - 52,257,530 (+)NCBIGRCm39mm39
GRCm39 Ensembl352,175,757 - 52,260,642 (+)Ensembl
GRCm38352,268,337 - 52,350,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl352,268,336 - 52,353,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv37352,072,259 - 52,154,031 (+)NCBIGRCm37mm9NCBIm37
MGSCv36352,356,303 - 52,437,467 (+)NCBImm8
Celera352,001,471 - 52,082,927 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map323.19NCBI
Foxo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22136,312,168 - 136,390,603 (+)NCBI
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBICelera
Cytogenetic Map2q26NCBI
Foxo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554315,797,359 - 5,890,758 (+)NCBIChiLan1.0ChiLan1.0
FOXO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11340,351,680 - 40,462,439 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01321,763,729 - 21,874,279 (-)NCBIMhudiblu_PPA_v0panPan3
FOXO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125603,433 - 706,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl25603,543 - 702,825 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25700,411 - 804,085 (+)NCBI
ROS_Cfam_1.025700,621 - 804,447 (+)NCBI
UMICH_Zoey_3.125603,299 - 707,347 (+)NCBI
UNSW_CanFamBas_1.025596,320 - 700,167 (+)NCBI
UU_Cfam_GSD_1.025663,424 - 767,068 (+)NCBI
Foxo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,725,964 - 161,815,163 (+)NCBI
SpeTri2.0NW_0049365655,210,014 - 5,299,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,317,124 - 15,410,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,317,222 - 15,410,059 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21115,548,296 - 15,550,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXO1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1318,916,849 - 19,027,776 (-)NCBI
ChlSab1.1 Ensembl318,920,651 - 19,027,707 (-)Ensembl
Foxo1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247481,413,754 - 1,529,646 (-)NCBI

Position Markers
D13S1162  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,132,680 - 41,133,009UniSTSGRCh37
Build 361340,030,680 - 40,031,009RGDNCBI36
Celera1322,190,151 - 22,190,480RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,934,197 - 21,934,526UniSTS
TNG Radiation Hybrid Map1311445.0UniSTS
Stanford-G3 RH Map13930.0UniSTS
GeneMap99-GB4 RH Map13128.59UniSTS
Whitehead-RH Map13125.1UniSTS
NCBI RH Map13341.3UniSTS
GeneMap99-G3 RH Map13926.0UniSTS
RH93960  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,130,002 - 41,130,151UniSTSGRCh37
Build 361340,028,002 - 40,028,151RGDNCBI36
Celera1322,187,473 - 22,187,622RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,931,519 - 21,931,668UniSTS
GeneMap99-GB4 RH Map13128.59UniSTS
SHGC-82099  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,162,513 - 41,162,839UniSTSGRCh37
Build 361340,060,513 - 40,060,839RGDNCBI36
Celera1322,219,970 - 22,220,296RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,964,012 - 21,964,338UniSTS
TNG Radiation Hybrid Map1311462.0UniSTS
RH119158  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,172,243 - 41,172,513UniSTSGRCh37
Build 361340,070,243 - 40,070,513RGDNCBI36
Celera1322,229,700 - 22,229,970RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,973,743 - 21,974,013UniSTS
TNG Radiation Hybrid Map1311466.0UniSTS
D13S1051  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,215,242 - 41,215,437UniSTSGRCh37
Build 361340,113,242 - 40,113,437RGDNCBI36
Celera1322,272,699 - 22,272,894RGD
Cytogenetic Map13q14.1UniSTS
HuRef1322,016,729 - 22,016,924UniSTS
G64954  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,172,013 - 41,172,311UniSTSGRCh37
Build 361340,070,013 - 40,070,311RGDNCBI36
Celera1322,229,470 - 22,229,768RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,973,513 - 21,973,811UniSTS
TNG Radiation Hybrid Map1311466.0UniSTS
SHGC-153775  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,188,328 - 41,188,665UniSTSGRCh37
Build 361340,086,328 - 40,086,665RGDNCBI36
Celera1322,245,785 - 22,246,122RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,989,828 - 21,990,165UniSTS
TNG Radiation Hybrid Map429516.0UniSTS
PMC25098P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,134,001 - 41,134,417UniSTSGRCh37
Build 361340,032,001 - 40,032,417RGDNCBI36
Celera1322,191,472 - 22,191,888RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,935,518 - 21,935,934UniSTS
FOXO1A_111  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,129,701 - 41,130,617UniSTSGRCh37
Build 361340,027,701 - 40,028,617RGDNCBI36
Celera1322,187,172 - 22,188,088RGD
HuRef1321,931,218 - 21,932,134UniSTS
RH47740  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,170,186 - 41,170,309UniSTSGRCh37
Build 361340,068,186 - 40,068,309RGDNCBI36
Celera1322,227,643 - 22,227,766RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,971,686 - 21,971,809UniSTS
GeneMap99-GB4 RH Map13128.59UniSTS
NCBI RH Map13335.5UniSTS
D13S1447  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,191,063 - 41,191,164UniSTSGRCh37
Build 361340,089,063 - 40,089,164RGDNCBI36
Celera1322,248,520 - 22,248,621RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,992,551 - 21,992,652UniSTS
GeneMap99-GB4 RH Map13131.28UniSTS
Whitehead-RH Map13126.8UniSTS
Whitehead-YAC Contig Map13 UniSTS
SHGC-63663  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,224,731 - 41,224,827UniSTSGRCh37
Build 361340,122,731 - 40,122,827RGDNCBI36
Celera1322,282,188 - 22,282,284RGD
Cytogenetic Map13q14.1UniSTS
HuRef1322,026,218 - 22,026,314UniSTS
TNG Radiation Hybrid Map1311486.0UniSTS
RH78770  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371341,133,131 - 41,133,297UniSTSGRCh37
Build 361340,031,131 - 40,031,297RGDNCBI36
Celera1322,190,602 - 22,190,768RGD
Cytogenetic Map13q14.1UniSTS
HuRef1321,934,648 - 21,934,814UniSTS
GeneMap99-GB4 RH Map13128.59UniSTS
NCBI RH Map13335.5UniSTS
RH74854  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13q14.1UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR183hsa-miR-183-5pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
MIR183hsa-miR-183-5pMirecordsexternal_infoNANA20028871
MIR186hsa-miR-186-5pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
MIR96hsa-miR-96-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19574223
MIR96hsa-miR-96-5pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
MIR96hsa-miR-96-5pOncomiRDBexternal_infoNANA19574223
MIR96hsa-miR-96-3pMirecordsexternal_infoNANA20028871
MIR186hsa-miR-186-5pMirecordsexternal_infoNANA20028871
MIR27Ahsa-miR-27a-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19574223
MIR27Ahsa-miR-27a-3pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
MIR27Ahsa-miR-27a-3pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI22213032
MIR370hsa-miR-370-3pOncomiRDBexternal_infoNANA23029264
MIR135Bhsa-miR-135b-5pOncomiRDBexternal_infoNANA22042699
MIR27Ahsa-miR-27a-3pMirecordsexternal_infoNANA20028871
MIR27Ahsa-miR-27a-3pOncomiRDBexternal_infoNANA19574223
MIR223hsa-miR-223-3pMirtarbaseexternal_infoFlow//Immunocytochemistry//Luciferase reporter assFunctional MTI22569260
MIR223hsa-miR-223-3pOncomiRDBexternal_infoNANA22569260
MIR153-2hsa-miR-153Mirecordsexternal_infoNANA20028871
MIR182hsa-miR-182-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19574223
MIR182hsa-miR-182-5pOncomiRDBexternal_infoNANA19574223

Predicted Target Of
Summary Value
Count of predictions:1194
Count of miRNA genes:723
Interacting mature miRNAs:808
Transcripts:ENST00000379561, ENST00000473775
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2043 1720 1285 339 1152 214 4191 1642 1297 229 1305 1433 134 1 1203 2674 3 2
Low 392 1268 440 284 787 250 165 553 2431 187 155 175 39 1 114 3
Below cutoff 3 3 1 1 11 1 1 2 6 2 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000379561   ⟹   ENSP00000368880
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1340,555,667 - 40,666,641 (-)Ensembl
RefSeq Acc Id: ENST00000473775
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1340,560,759 - 40,562,764 (-)Ensembl
RefSeq Acc Id: ENST00000655267
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1340,560,759 - 40,665,915 (-)Ensembl
RefSeq Acc Id: ENST00000660760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1340,560,767 - 40,665,877 (-)Ensembl
RefSeq Acc Id: NM_002015   ⟹   NP_002006
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381340,555,667 - 40,666,641 (-)NCBI
GRCh371341,129,801 - 41,240,734 (-)ENTREZGENE
Build 361340,027,801 - 40,138,734 (-)NCBI Archive
HuRef1321,931,318 - 22,042,054 (-)ENTREZGENE
CHM1_11341,097,585 - 41,208,493 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535008   ⟹   XP_011533310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381340,555,680 - 40,615,317 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535010   ⟹   XP_011533312
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381340,555,680 - 40,566,368 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002006   ⟸   NM_002015
- UniProtKB: Q12778 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533310   ⟸   XM_011535008
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011533312   ⟸   XM_011535010
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000368880   ⟸   ENST00000379561

Promoters
RGD ID:6790881
Promoter ID:HG_KWN:17637
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   Lymphoblastoid
Transcripts:OTTHUMT00000044635
Position:
Human AssemblyChrPosition (strand)Source
Build 361340,034,631 - 40,035,262 (-)MPROMDB
RGD ID:6790882
Promoter ID:HG_KWN:17638
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:UC010ACC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361340,083,196 - 40,083,696 (-)MPROMDB
RGD ID:6790879
Promoter ID:HG_KWN:17640
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002015
Position:
Human AssemblyChrPosition (strand)Source
Build 361340,137,731 - 40,139,607 (-)MPROMDB
RGD ID:7226265
Promoter ID:EPDNEW_H18878
Type:initiation region
Name:FOXO1_1
Description:forkhead box O1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18879  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381340,666,588 - 40,666,648EPDNEW
RGD ID:7226269
Promoter ID:EPDNEW_H18879
Type:initiation region
Name:FOXO1_2
Description:forkhead box O1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18878  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381340,667,050 - 40,667,110EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002015.3(FOXO1):c.631-25862T>C single nucleotide variant Lung cancer [RCV000097906] Chr13:40586722 [GRCh38]
Chr13:41160859 [GRCh37]
Chr13:13q14.11
uncertain significance
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000050293] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q12.3-21.33(chr13:30697728-69471973)x1 copy number loss See cases [RCV000051373] Chr13:30697728..69471973 [GRCh38]
Chr13:31271865..70046105 [GRCh37]
Chr13:30169865..68944106 [NCBI36]
Chr13:13q12.3-21.33
pathogenic
GRCh38/hg38 13q13.3-14.11(chr13:35232476-41375955)x1 copy number loss See cases [RCV000051375] Chr13:35232476..41375955 [GRCh38]
Chr13:35806613..41950091 [GRCh37]
Chr13:34704613..40848091 [NCBI36]
Chr13:13q13.3-14.11
pathogenic
GRCh38/hg38 13q13.3-14.2(chr13:38558617-47502862)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051377]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051377]|See cases [RCV000051377] Chr13:38558617..47502862 [GRCh38]
Chr13:39132754..48076997 [GRCh37]
Chr13:38030754..46974998 [NCBI36]
Chr13:13q13.3-14.2
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-31.1(chr13:30318913-83610426)x3 copy number gain See cases [RCV000053737] Chr13:30318913..83610426 [GRCh38]
Chr13:30893050..84184561 [GRCh37]
Chr13:29791050..83082562 [NCBI36]
Chr13:13q12.3-31.1
pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34
pathogenic
GRCh38/hg38 13q13.3-21.31(chr13:36777318-62955876)x1 copy number loss See cases [RCV000133696] Chr13:36777318..62955876 [GRCh38]
Chr13:37351455..63530009 [GRCh37]
Chr13:36249455..62428010 [NCBI36]
Chr13:13q13.3-21.31
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.3-21.32(chr13:31553608-65470367)x3 copy number gain See cases [RCV000135808] Chr13:31553608..65470367 [GRCh38]
Chr13:32127745..66044499 [GRCh37]
Chr13:31025745..64942500 [NCBI36]
Chr13:13q12.3-21.32
pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-14.11(chr13:19671934-40914767)x3 copy number gain See cases [RCV000137892] Chr13:19671934..40914767 [GRCh38]
Chr13:20246074..41488903 [GRCh37]
Chr13:19144074..40386903 [NCBI36]
Chr13:13q12.11-14.11
pathogenic
GRCh38/hg38 13q12.3-14.2(chr13:31018160-48491204)x1 copy number loss See cases [RCV000138723] Chr13:31018160..48491204 [GRCh38]
Chr13:31592297..49065340 [GRCh37]
Chr13:30490297..47963341 [NCBI36]
Chr13:13q12.3-14.2
pathogenic
GRCh38/hg38 13q13.1-31.1(chr13:32531486-86757044)x3 copy number gain See cases [RCV000138339] Chr13:32531486..86757044 [GRCh38]
Chr13:33105623..87409299 [GRCh37]
Chr13:32003623..86207300 [NCBI36]
Chr13:13q13.1-31.1
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q13.3-21.32(chr13:37864226-67963788)x1 copy number loss See cases [RCV000140744] Chr13:37864226..67963788 [GRCh38]
Chr13:38438363..68537920 [GRCh37]
Chr13:37336363..67435921 [NCBI36]
Chr13:13q13.3-21.32
pathogenic
GRCh38/hg38 13q13.3-14.3(chr13:38514177-51425214)x1 copy number loss See cases [RCV000140788] Chr13:38514177..51425214 [GRCh38]
Chr13:39088314..51999350 [GRCh37]
Chr13:37986314..50897351 [NCBI36]
Chr13:13q13.3-14.3
pathogenic
GRCh38/hg38 13q14.11(chr13:39860568-43580405)x3 copy number gain See cases [RCV000142892] Chr13:39860568..43580405 [GRCh38]
Chr13:40434705..44154541 [GRCh37]
Chr13:39332705..43052541 [NCBI36]
Chr13:13q14.11
uncertain significance
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000148244] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q14.11(chr13:40791939-41173483)x3 copy number gain See cases [RCV000447578] Chr13:40791939..41173483 [GRCh37]
Chr13:13q14.11
likely benign
GRCh37/hg19 13q13.1-21.31(chr13:32946120-62698217)x1 copy number loss See cases [RCV000446067] Chr13:32946120..62698217 [GRCh37]
Chr13:13q13.1-21.31
pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q14.11(chr13:41202702-41506651)x4 copy number gain not provided [RCV000683513] Chr13:41202702..41506651 [GRCh37]
Chr13:13q14.11
uncertain significance
GRCh37/hg19 13q11-22.1(chr13:19436286-74045459)x3 copy number gain not provided [RCV000683572] Chr13:19436286..74045459 [GRCh37]
Chr13:13q11-22.1
pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34
pathogenic
NM_002015.4(FOXO1):c.921T>C (p.Phe307=) single nucleotide variant not provided [RCV000880297] Chr13:40560570 [GRCh38]
Chr13:41134707 [GRCh37]
Chr13:13q14.11
benign
NM_002015.4(FOXO1):c.999C>T (p.Thr333=) single nucleotide variant not provided [RCV000974359] Chr13:40560492 [GRCh38]
Chr13:41134629 [GRCh37]
Chr13:13q14.11
benign
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
NM_002015.4(FOXO1):c.1506G>A (p.Ser502=) single nucleotide variant not provided [RCV000968857] Chr13:40559985 [GRCh38]
Chr13:41134122 [GRCh37]
Chr13:13q14.11
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3819 AgrOrtholog
COSMIC FOXO1 COSMIC
Ensembl Genes ENSG00000150907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000368880 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000379561 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000150907 GTEx
HGNC ID HGNC:3819 ENTREZGENE
Human Proteome Map FOXO1 Human Proteome Map
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX-bd UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2308 UniProtKB/Swiss-Prot
NCBI Gene 2308 ENTREZGENE
OMIM 136533 OMIM
  268220 OMIM
Pfam Forkhead UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX_bdg UniProtKB/Swiss-Prot
PharmGKB FOXO1A RGD, PharmGKB
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXO1_HUMAN UniProtKB/Swiss-Prot
  L8E9Y8_HUMAN UniProtKB/TrEMBL
  Q12778 ENTREZGENE
UniProt Secondary O43523 UniProtKB/Swiss-Prot
  Q5VYC7 UniProtKB/Swiss-Prot
  Q6NSK6 UniProtKB/Swiss-Prot