Foxo1 (forkhead box O1) - Rat Genome Database

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Gene: Foxo1 (forkhead box O1) Rattus norvegicus
Symbol: Foxo1
Name: forkhead box O1
RGD ID: 620283
Description: Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of DNA-templated transcription. Located in cytosol and nucleus. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1); PARTICIPATES IN interleukin-6 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Previously known as: Fkhr; forkhead box O1A; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Foxo1a
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22136,312,168 - 136,390,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,888,018 - 142,963,653 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02141,000,299 - 141,075,747 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02135,636,484 - 135,712,091 (+)NCBIRnor_WKY
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(R)-adrenaline  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (ISO)
9E,11E-octadecadienoic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-phellandrene  (ISO)
AM-251  (ISO)
amidotrizoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
fluvastatin  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
Geniposide  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
herbicide  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroxyurea  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
neomycin  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perifosine  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picloram  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pomalidomide  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin  (ISO)
procyanidin B2  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
spirotetramat  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sulpiride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tributylstannane  (ISO)
trichlopyr  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO,ISS)
autophagy  (IEA)
blood vessel development  (ISO)
canonical Wnt signaling pathway  (ISO)
cell differentiation  (IEA)
cellular response to dexamethasone stimulus  (IEP)
cellular response to DNA damage stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (IEP)
cellular response to hyperoxia  (ISO,ISS)
cellular response to insulin stimulus  (ISO,ISS)
cellular response to nitric oxide  (ISO,ISS)
cellular response to oxidative stress  (ISO,ISS)
cellular response to starvation  (ISO,ISS)
DNA-templated transcription elongation  (ISO)
enamel mineralization  (IEP)
glucose homeostasis  (ISO)
insulin receptor signaling pathway  (IBA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (IMP)
negative regulation of fat cell differentiation  (ISO,ISS)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion  (ISO,ISS)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
neuronal stem cell population maintenance  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of autophagy  (ISO,ISS)
positive regulation of complement-dependent cytotoxicity  (ISO)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of gluconeogenesis  (ISO,ISS)
positive regulation of protein catabolic process  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
response to fatty acid  (ISO,ISS)
response to fluoride  (IEP)
response to insulin  (IEP)

Cellular Component
cytoplasm  (IDA,ISO,ISS)
cytosol  (IDA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA,ISO)


References - curated
# Reference Title Reference Citation
1. Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. Altomonte J, etal., J Clin Invest. 2004 Nov;114(10):1493-503.
2. Excessive fluoride reduces Foxo1 expression in dental epithelial cells of the rat incisor. Gao J, etal., Eur J Oral Sci. 2014 Oct;122(5):317-23. doi: 10.1111/eos.12148. Epub 2014 Sep 3.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Transcriptional genomics associates FOX transcription factors with human heart failure. Hannenhalli S, etal., Circulation. 2006 Sep 19;114(12):1269-76. Epub 2006 Sep 4.
6. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
7. Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway. Huang Y, etal., J Cell Physiol. 2018 Oct;233(10):6693-6704. doi: 10.1002/jcp.26469. Epub 2018 Apr 25.
8. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. Huang ZP, etal., J Clin Invest. 2015 Nov 2;125(11):4122-34. doi: 10.1172/JCI82423. Epub 2015 Oct 5.
9. NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in hepatocellular carcinoma and thereby suppresses tumor proliferation and invasion. Jiang J, etal., J Biol Chem. 2017 Nov 24;292(47):19146-19159. doi: 10.1074/jbc.M117.793760. Epub 2017 Sep 27.
10. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Kloting N, etal., Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):146-54.
11. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
12. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. McClung JM, etal., J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Nagashima T, etal., Mol Pharmacol. 2010 Nov;78(5):961-70. doi: 10.1124/mol.110.065714. Epub 2010 Aug 24.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Paik JH, etal., Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. The vertebrae of prematurely aging mice as a skeletal model of involutional osteoporosis. Portal-Nunez S, etal., Histol Histopathol. 2013 Nov;28(11):1473-81. Epub 2013 May 15.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. Ropelle ER, etal., J Physiol. 2009 May 1;587(Pt 9):2069-76. doi: 10.1113/jphysiol.2008.164202. Epub 2009 Mar 9.
26. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
27. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. Schmoll D, etal., J Biol Chem 2000 Nov 17;275(46):36324-33.
28. Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein. Wu K, etal., Endocrinology. 2010 Aug;151(8):3566-76. doi: 10.1210/en.2010-0204. Epub 2010 May 25.
29. Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. Xie X, etal., J Diabetes Res. 2018 Aug 16;2018:6254340. doi: 10.1155/2018/6254340. eCollection 2018.
30. The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. Yan L, etal., Biochem J. 2012 Jun 1;444(2):239-47. doi: 10.1042/BJ20111606.
31. Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. Zhang X, etal., Endocrinology. 2009 Sep;150(9):4065-73. doi: 10.1210/en.2009-0343. Epub 2009 May 14.
Additional References at PubMed
PMID:7862145   PMID:10871843   PMID:11237865   PMID:11311120   PMID:11353388   PMID:11875118   PMID:12228231   PMID:12488434   PMID:12724332   PMID:12783775   PMID:12857750   PMID:12891709  
PMID:12969136   PMID:14500580   PMID:14565960   PMID:14978268   PMID:15057822   PMID:15184386   PMID:15256269   PMID:15905404   PMID:16027169   PMID:16455781   PMID:16604086   PMID:16670091  
PMID:16952979   PMID:17090532   PMID:17107961   PMID:17317782   PMID:17482685   PMID:17550780   PMID:17681146   PMID:17950246   PMID:17972158   PMID:17986386   PMID:18162514   PMID:18202312  
PMID:18293098   PMID:18304430   PMID:18356527   PMID:18388859   PMID:18420577   PMID:18497885   PMID:18555008   PMID:18680538   PMID:18765640   PMID:18815134   PMID:18972406   PMID:19037106  
PMID:19168598   PMID:19221179   PMID:19332486   PMID:19483080   PMID:19690465   PMID:19696026   PMID:19696738   PMID:19837876   PMID:19850732   PMID:19896444   PMID:19959771   PMID:20033367  
PMID:20079455   PMID:20081110   PMID:20543840   PMID:20973227   PMID:21097394   PMID:21149440   PMID:21196578   PMID:21281824   PMID:21317886   PMID:21332026   PMID:21385937   PMID:21545834  
PMID:21549807   PMID:21817126   PMID:21972093   PMID:21991327   PMID:22012952   PMID:22086006   PMID:22209681   PMID:22511764   PMID:22733486   PMID:22940604   PMID:23002242   PMID:23152492  
PMID:23247844   PMID:23500899   PMID:23555761   PMID:23788637   PMID:23803610   PMID:23906066   PMID:24212932   PMID:24280217   PMID:24440707   PMID:24807827   PMID:24967006   PMID:25062567  
PMID:25147338   PMID:25288788   PMID:25344740   PMID:25399953   PMID:25796372   PMID:26029993   PMID:26123583   PMID:26342801   PMID:26361145   PMID:26518453   PMID:26727601   PMID:26935354  
PMID:26944797   PMID:26962001   PMID:27288017   PMID:27328024   PMID:27542118   PMID:27547294   PMID:27577745   PMID:27663689   PMID:27979659   PMID:28118532   PMID:28283331   PMID:28536427  
PMID:28738025   PMID:28790135   PMID:29446047   PMID:30217602   PMID:30345866   PMID:30360646   PMID:30376839   PMID:30411113   PMID:30551436   PMID:30629029   PMID:30654931   PMID:31223614  
PMID:31582213   PMID:31871187   PMID:31889343   PMID:32450616   PMID:32620714   PMID:32654176   PMID:32845875   PMID:32868747   PMID:33049085   PMID:33108705   PMID:33296068   PMID:33349993  
PMID:33355375   PMID:33722671   PMID:33840298   PMID:33875617   PMID:33955666   PMID:34194603   PMID:34661985   PMID:34673854   PMID:34761005   PMID:34845564   PMID:34871948   PMID:34943780  
PMID:35198097   PMID:35688305   PMID:35947892  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22136,312,168 - 136,390,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,888,018 - 142,963,653 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02141,000,299 - 141,075,747 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02135,636,484 - 135,712,091 (+)NCBIRnor_WKY
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBICelera
Cytogenetic Map2q26NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381340,555,667 - 40,666,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1340,555,667 - 40,666,641 (-)EnsemblGRCh38hg38GRCh38
GRCh371341,129,804 - 41,240,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361340,027,801 - 40,138,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 341340,027,816 - 40,138,734NCBI
Celera1322,187,272 - 22,298,190 (-)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1321,931,318 - 22,042,054 (-)NCBIHuRef
CHM1_11341,097,585 - 41,208,493 (-)NCBICHM1_1
T2T-CHM13v2.01339,774,673 - 39,885,620 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39352,175,758 - 52,257,530 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl352,175,757 - 52,260,642 (+)EnsemblGRCm39 Ensembl
GRCm38352,268,337 - 52,350,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl352,268,336 - 52,353,221 (+)EnsemblGRCm38mm10GRCm38
MGSCv37352,072,259 - 52,154,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36352,356,303 - 52,437,467 (+)NCBIMGSCv36mm8
Celera352,001,471 - 52,082,927 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map323.19NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554315,797,359 - 5,890,758 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11340,351,680 - 40,462,439 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01321,763,729 - 21,874,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.125603,433 - 706,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl25603,543 - 702,825 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25700,411 - 804,085 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025700,621 - 804,447 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25700,891 - 800,342 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.125603,299 - 707,347 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025596,320 - 700,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025663,424 - 767,068 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945161,725,964 - 161,815,163 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365655,210,014 - 5,302,436 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365655,210,014 - 5,299,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1115,317,124 - 15,410,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,317,222 - 15,410,059 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21115,548,296 - 15,550,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1318,916,849 - 19,027,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl318,920,651 - 19,027,707 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605725,219,605 - 25,330,187 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247481,413,983 - 1,529,992 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247481,413,754 - 1,529,646 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Foxo1
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:111
Interacting mature miRNAs:120
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2127447387143657569Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22136,315,443 - 136,315,658 (+)MAPPERmRatBN7.2
Rnor_6.02141,454,510 - 141,454,724NCBIRnor6.0
Rnor_5.02161,143,584 - 161,143,798UniSTSRnor5.0
RGSC_v3.42141,130,621 - 141,130,835UniSTSRGSC3.4
Celera2130,809,982 - 130,810,196UniSTS
RH 3.4 Map2850.8UniSTS
Cytogenetic Map2q26UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 21 26 14 15 14 26 34 31 11
Low 22 31 27 4 27 8 11 48 1 10 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018244   ⟹   ENSRNOP00000018244
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2136,312,168 - 136,387,790 (+)Ensembl
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)Ensembl
RefSeq Acc Id: NM_001191846   ⟹   NP_001178775
Rat AssemblyChrPosition (strand)Source
mRatBN7.22136,312,168 - 136,387,790 (+)NCBI
Rnor_6.02141,451,234 - 141,527,016 (+)NCBI
Rnor_5.02161,140,308 - 161,215,605 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBI
RefSeq Acc Id: XM_039103268   ⟹   XP_038959196
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22136,348,113 - 136,390,603 (+)NCBI
RefSeq Acc Id: XM_039103269   ⟹   XP_038959197
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22136,312,897 - 136,390,603 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178775 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG09779 (Get FASTA)   NCBI Sequence Viewer  
  EDM14970 (Get FASTA)   NCBI Sequence Viewer  
  G3V7R4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178775   ⟸   NM_001191846
- UniProtKB: G3V7R4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018244   ⟸   ENSRNOT00000018244
RefSeq Acc Id: XP_038959197   ⟸   XM_039103269
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959196   ⟸   XM_039103268
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7R4-F1-model_v2 AlphaFold G3V7R4 1-649 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620283 AgrOrtholog
BioCyc Gene G2FUF-53120 BioCyc
Ensembl Genes ENSRNOG00000013397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018244 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018244 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX-bd UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:84482 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
  FOXO-TAD UniProtKB/Swiss-Prot
  FOXO_KIX_bdg UniProtKB/Swiss-Prot
PhenoGen Foxo1 PhenoGen
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Foxo1  forkhead box O1  Foxo1a  forkhead box O1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Foxo1a  forkhead box O1A    forkhead box O1A (rhabdomyosarcoma)  Name updated 1299863 APPROVED
2002-08-07 Foxo1a  forkhead box O1A (rhabdomyosarcoma)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process induces the glucose-6-phosphatase promoter activity via interaction with an insulin response unit (IRU) 632718