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Gene: Foxo1 (forkhead box O1) Rattus norvegicus
Symbol: Foxo1
Name: forkhead box O1
Description: Exhibits DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of transcription, DNA-templated. Localizes to cytosol and nucleus. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1); PARTICIPATES IN interleukin-6 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: Fkhr; forkhead box O1A; forkhead box O1A (rhabdomyosarcoma); forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Foxo1a
Homo sapiens (human) : FOXO1 (forkhead box O1)  HGNC  Alliance
Mus musculus (house mouse) : Foxo1 (forkhead box O1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxo1 (forkhead box O1)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXO1 (forkhead box O1)
Canis lupus familiaris (dog) : FOXO1 (forkhead box O1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxo1 (forkhead box O1)
Sus scrofa (pig) : FOXO1 (forkhead box O1)
Chlorocebus sabaeus (African green monkey) : FOXO1 (forkhead box O1)
Heterocephalus glaber (naked mole-rat) : Foxo1 (forkhead box O1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02141,451,234 - 141,527,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2141,451,234 - 141,527,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02161,140,308 - 161,215,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42141,127,345 - 141,203,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12141,077,916 - 141,151,838 (+)NCBI
Celera2130,806,706 - 130,882,185 (+)NCBICelera
Cytogenetic Map2q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Foxo1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620283
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.