Foxo3 (forkhead box O3) - Rat Genome Database

Name: Foxo3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Foxo3 (forkhead box O3) Rattus norvegicus

Analyze

Symbol:

Foxo3

Name:

forkhead box O3

RGD ID:

1309196

Description:

Exhibits transcription coregulator binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of programmed cell death; and response to glucocorticoid. Localizes to cytosol; mitochondrion; and nucleus. Predicted to colocalize with mitochondrial matrix. Biomarker of obesity. Orthologous to human FOXO3 (forkhead box O3); PARTICIPATES IN insulin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Fkhrl1; forkhead box O3a; forkhead box protein O3; Foxo3a; LOC294515

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FOXO3 (forkhead box O3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Foxo3 (forkhead box O3)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Foxo3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FOXO3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FOXO3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Foxo3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FOXO3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	FOXO3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Foxo3 (forkhead box O3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FOXO3B (forkhead box O3B)	HGNC	Ensembl
Alliance orthologs ³
Homo sapiens (human):	FOXO3 (forkhead box O3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Foxo3 (forkhead box O3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	foxo3b (forkhead box O3b)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	foxo3a (forkhead box O3A)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	FHL1	Alliance	DIOPT (InParanoid\|OrthoFinder)
Caenorhabditis elegans (roundworm):	daf-16	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Drosophila melanogaster (fruit fly):	foxo	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	45,669,708 - 45,764,606 (-)	NCBI
Rnor_6.0 Ensembl	20	46,428,124 - 46,519,144 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	46,428,078 - 46,519,156 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	48,111,014 - 48,206,518 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	46,171,784 - 46,262,818 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	46,194,693 - 46,284,921 (-)	NCBI
Celera	20	54,198,460 - 54,289,566 (+)	NCBI		Celera
Cytogenetic Map	20	q12-q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

Alzheimer's disease (ISO)

Carotid Artery Injuries (IEP)

choroid plexus carcinoma (ISO)

chronic obstructive pulmonary disease (ISO)

dermoid cyst of ovary (ISS)

endometrial adenocarcinoma (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Diabetes Mellitus (IEP,ISO)

Hypoxia-Ischemia, Brain (IEP)

Intimal Hyperplasia (ISO)

Left Ventricular Hypertrophy (IEP)

liver cirrhosis (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

medulloblastoma (ISO)

obesity (IEP,ISO)

prostate cancer (ISO)

rheumatoid arthritis (ISO)

Spinal Cord Injuries (IEP)

status epilepticus (ISO)

temporal lobe epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-Tetrandrine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(R)-lipoic acid (EXP)

(R)-noradrenaline (EXP)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

1H-pyrazole (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,5-hexanedione (ISO)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3,5-diethoxycarbonyl-1,4-dihydrocollidine (ISO)

3-methylcholanthrene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxynon-2-enal (ISO)

5-fluorouracil (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (ISO)

7,12-dimethyltetraphene (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-naphthoflavone (EXP,ISO)

amidotrizoic acid (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antimycin A (ISO)

arsenic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

aspartame (ISO)

astaxanthin (ISO)

atrazine (ISO)

aucubin (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

berberine (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cabazitaxel (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

casticin (ISO)

celastrol (EXP)

chlordecone (ISO)

chloroprene (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

D-glucose (EXP,ISO)

DAPT (ISO)

DDE (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dichloromethane (ISO)

diclofenac (ISO)

dieldrin (EXP)

dihydrogen (ISO)

dioxygen (EXP,ISO)

diprotium (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

eckol (ISO)

elemental selenium (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

erlotinib hydrochloride (ISO)

ethanol (ISO)

etoposide (ISO)

fenvalerate (ISO)

flutamide (EXP)

fostriecin (ISO)

fulvestrant (ISO)

furan (EXP)

gefitinib (EXP,ISO)

genistein (ISO)

glucose (EXP,ISO)

glyphosate (ISO)

hydrogen peroxide (EXP,ISO)

IC-87114 (ISO)

icariin (EXP,ISO)

isobutanol (ISO)

isoflavones (ISO)

isoprenaline (ISO)

KN-93 (ISO)

L-ascorbic acid (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

lipoic acid (EXP)

lipopolysaccharide (ISO)

luteolin (ISO)

LY294002 (EXP,ISO)

malonaldehyde (ISO)

manganese atom (EXP)

manganese(0) (EXP)

medroxyprogesterone acetate (ISO)

metacetamol (ISO)

metformin (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

methylseleninic acid (ISO)

metoprolol (EXP)

mifepristone (ISO)

monocrotaline (EXP)

monosodium L-glutamate (ISO)

motexafin gadolinium (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-acetyl-L-cysteine (EXP,ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nefazodone (ISO)

nickel dichloride (EXP,ISO)

nicotinamide (ISO)

nitroxoline (ISO)

okadaic acid (ISO)

paracetamol (ISO)

paraquat (ISO)

PD 0325901 (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

phenformin (EXP)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

picropodophyllotoxin (ISO)

pirinixic acid (ISO)

platycodin D (ISO)

propiconazole (ISO)

quercetin (ISO)

ramipril (EXP)

resveratrol (EXP,ISO)

SB 203580 (EXP,ISO)

SB 431542 (EXP,ISO)

selenium atom (ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (EXP,ISO)

sirolimus (ISO)

sodium arsenite (ISO)

Sodium salicylate (ISO)

streptozocin (EXP,ISO)

tamoxifen (ISO)

testosterone (EXP,ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

Tomentosin (ISO)

trilobatin (EXP)

triphenyl phosphate (EXP)

Triptolide (ISO)

triptonide (ISO)

tris(2-chloroethyl) phosphate (ISO)

troglitazone (ISO)

tyrphostin AG 1478 (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

wortmannin (ISO)

zearalenone (ISO)

zinc acetate (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (IDA)

antral ovarian follicle growth (ISO)

apoptotic process (IEP)

brain morphogenesis (ISO)

cellular response to amyloid-beta (IEP)

cellular response to corticosterone stimulus (IEP)

cellular response to glucose starvation (ISO)

cellular response to glucose stimulus (IEP)

cellular response to hypoxia (IEP)

cellular response to nerve growth factor stimulus (IEP)

cellular response to oxidative stress (ISO)

DNA damage response, signal transduction by p53 class mediator (ISO)

extrinsic apoptotic signaling pathway in absence of ligand (ISO)

glucose homeostasis (ISO)

initiation of primordial ovarian follicle growth (ISO)

mitochondrial transcription (ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

negative regulation of cell migration (ISO)

negative regulation of neuron differentiation (IMP)

negative regulation of transcription by RNA polymerase II (ISO)

neuronal stem cell population maintenance (ISO)

oocyte maturation (ISO)

ovulation from ovarian follicle (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of autophagy (ISO)

positive regulation of endothelial cell apoptotic process (IMP)

positive regulation of erythrocyte differentiation (ISO)

positive regulation of hydrogen peroxide-mediated programmed cell death (IMP)

positive regulation of muscle atrophy (ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of pri-miRNA transcription by RNA polymerase II (ISO)

positive regulation of reactive oxygen species biosynthetic process (IMP)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription, DNA-templated (ISO)

regulation of neural precursor cell proliferation (ISO)

regulation of reactive oxygen species metabolic process (ISO)

regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of transcription, DNA-templated (ISO)

regulation of translation (ISO)

response to dexamethasone (IEP)

response to drug (IEP)

response to fatty acid (ISO)

response to nutrient levels (IEP)

response to starvation (ISO)

response to water-immersion restraint stress (IEP)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

cytoplasm (IDA,ISO)

cytosol (IDA,ISO)

membrane (ISO)

mitochondrial matrix (IBA,ISO)

mitochondrial outer membrane (ISO)

mitochondrion (IDA,ISO)

nucleoplasm (ISO,TAS)

nucleus (IBA,IDA,ISO)

protein-containing complex (ISO)

Molecular Function

beta-catenin binding (ISO)

chromatin DNA binding (ISO)

DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

mitochondrial transcription factor activity (ISO)

protein binding (ISO)

protein kinase binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

transcription coregulator binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

endometrial cancer pathway (IEA)

insulin signaling pathway (ISO)

neurotrophic factor signaling pathway (IEA)

non-small cell lung carcinoma pathway (IEA)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

References - curated


1.	Caballero-Caballero A, etal., J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.
2.	Chamberlain W, etal., Biochem Cell Biol. 2012 Apr;90(2):200-8. doi: 10.1139/o11-082. Epub 2012 Jan 31.
3.	Esteras N, etal., Neurobiol Aging. 2013 Apr;34(4):1090-100. doi: 10.1016/j.neurobiolaging.2012.10.014. Epub 2012 Nov 13.
4.	Fujino K, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:148-53. doi: 10.1016/j.neulet.2013.10.050. Epub 2013 Oct 29.
5.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	GOA data from the GO Consortium
7.	Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
8.	Huang P, etal., Genet Mol Res. 2012 Sep 19;11(4):4775-88. doi: 10.4238/2012.September.19.2.
9.	Imae M, etal., J Mol Endocrinol. 2003 Apr;30(2):253-62.
10.	Kato M, etal., J Am Soc Nephrol. 2006 Dec;17(12):3325-35. Epub 2006 Nov 2.
11.	Kumarswamy R, etal., Eur Heart J. 2012 May;33(9):1067-75. doi: 10.1093/eurheartj/ehs043. Epub 2012 Feb 23.
12.	Li DY, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):1023-7.
13.	Li YN, etal., Oxid Med Cell Longev. 2014;2014:320513. doi: 10.1155/2014/320513. Epub 2014 Jan 22.
14.	Liu H, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):722-7. doi: 10.1016/j.bbrc.2009.02.138. Epub 2009 Mar 1.
15.	Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
16.	McClung JM, etal., J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.
17.	MGD data from the GO Consortium
18.	Park KW, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):742-7. Epub 2005 Jan 20.
19.	Pipeline to import KEGG annotations from KEGG into RGD
20.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21.	Relling DP, etal., J Hypertens. 2006 Mar;24(3):549-61.
22.	RGD automated import pipeline for gene-chemical interactions
23.	Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
24.	Sanphui P and Biswas SC, Cell Death Dis. 2013 May 9;4:e625. doi: 10.1038/cddis.2013.148.
25.	Turrel-Davin F, etal., Ann Rheum Dis. 2010 Apr;69(4):755-60. doi: 10.1136/ard.2009.109991. Epub 2009 May 11.
26.	Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
27.	Wang H, etal., Mol Neurobiol. 2013 Feb;47(1):24-36. doi: 10.1007/s12035-012-8357-7. Epub 2012 Oct 21.
28.	Wang H, etal., Psychopharmacology (Berl). 2013 Jul;228(1):129-41. doi: 10.1007/s00213-013-3017-9. Epub 2013 Mar 15.
29.	Westin SN, etal., Mol Oncol. 2015 Oct;9(8):1694-703. doi: 10.1016/j.molonc.2015.04.014. Epub 2015 May 16.
30.	Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
31.	Zhang S, etal., J Cell Biochem. 2013 Feb;114(2):354-65. doi: 10.1002/jcb.24371.
32.	Zhang S, etal., PLoS One. 2013 Nov 20;8(11):e80342. doi: 10.1371/journal.pone.0080342. eCollection 2013.

Additional References at PubMed

PMID:10102273	PMID:10995739	PMID:11353388	PMID:11875118	PMID:11964479	PMID:12027802	PMID:12048180	PMID:12130673	PMID:12431371	PMID:12855809	PMID:12857750	PMID:12930811
PMID:12969136	PMID:14565960	PMID:14734530	PMID:14966295	PMID:14978268	PMID:15084260	PMID:15322035	PMID:15383658	PMID:15604409	PMID:15781459	PMID:15905404	PMID:16455781
PMID:16751106	PMID:16952979	PMID:17079231	PMID:17158337	PMID:17482685	PMID:17521387	PMID:17894357	PMID:18054315	PMID:18054316	PMID:18202312	PMID:18287535	PMID:18458087
PMID:18465250	PMID:18593906	PMID:18615585	PMID:18644837	PMID:18703049	PMID:18772130	PMID:18787191	PMID:18802749	PMID:18845647	PMID:18959820	PMID:19168439	PMID:19188590
PMID:19623194	PMID:19696026	PMID:19864323	PMID:19896444	PMID:19933931	PMID:19959771	PMID:20105289	PMID:20211690	PMID:20371612	PMID:20371624	PMID:20404335	PMID:20492357
PMID:20651833	PMID:20850791	PMID:21162126	PMID:21259047	PMID:21329882	PMID:21443457	PMID:21549807	PMID:21562855	PMID:21887848	PMID:21909393	PMID:22702057	PMID:22761832
PMID:23151077	PMID:23152492	PMID:23239110	PMID:23283301	PMID:23292098	PMID:23382383	PMID:23640897	PMID:23948278	PMID:24257750	PMID:24260294	PMID:24289330	PMID:24441545
PMID:24483844	PMID:24567336	PMID:24871856	PMID:24967006	PMID:25057926	PMID:25327288	PMID:25341033	PMID:25402826	PMID:25415049	PMID:25655933	PMID:26086369	PMID:26342801
PMID:26494002	PMID:26523980	PMID:26546832	PMID:26786260	PMID:27076782	PMID:27129298	PMID:27521792	PMID:27547294	PMID:27686254	PMID:27694219	PMID:27919684	PMID:28006785
PMID:28078537	PMID:28246104	PMID:28499802	PMID:29030976	PMID:29272015	PMID:29380557	PMID:29445193	PMID:29664021	PMID:29761857	PMID:30259391	PMID:30323296	PMID:30402830
PMID:30407372	PMID:30945300	PMID:31543343	PMID:31927057	PMID:32141452	PMID:32169420

Genomics

Comparative Map Data

Foxo3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	45,669,708 - 45,764,606 (-)	NCBI
Rnor_6.0 Ensembl	20	46,428,124 - 46,519,144 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	46,428,078 - 46,519,156 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	48,111,014 - 48,206,518 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	46,171,784 - 46,262,818 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	46,194,693 - 46,284,921 (-)	NCBI
Celera	20	54,198,460 - 54,289,566 (+)	NCBI		Celera
Cytogenetic Map	20	q12-q13	NCBI

FOXO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	108,559,835 - 108,684,774 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	108,559,825 - 108,684,774 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	108,881,028 - 109,005,977 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	108,987,719 - 109,112,664 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	108,987,718 - 109,108,647	NCBI
Celera	6	109,627,171 - 109,751,905 (+)	NCBI
Cytogenetic Map	6	q21	NCBI
HuRef	6	106,448,666 - 106,573,173 (+)	NCBI		HuRef
CHM1_1	6	109,143,966 - 109,268,930 (+)	NCBI		CHM1_1

Foxo3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	42,057,841 - 42,152,691 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	42,057,837 - 42,152,751 (-)	Ensembl
GRCm38	10	42,181,845 - 42,276,695 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	42,181,841 - 42,276,755 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	41,905,592 - 41,996,548 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	41,874,201 - 41,965,157 (-)	NCBI			mm8
Celera	10	43,062,294 - 43,153,032 (-)	NCBI		Celera
Cytogenetic Map	10	B2	NCBI
cM Map	10	22.79	NCBI

Foxo3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	33,655,958 - 33,770,829 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	33,655,958 - 33,770,829 (+)	NCBI	ChiLan1.0	ChiLan1.0

FOXO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	110,406,265 - 110,536,967 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	110,406,266 - 110,516,272 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	106,360,519 - 106,485,676 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

FOXO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	65,552,455 - 65,673,467 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	65,552,310 - 65,670,198 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	65,368,393 - 65,489,406 (+)	NCBI
ROS_Cfam_1.0	12	66,431,072 - 66,552,185 (+)	NCBI
UMICH_Zoey_3.1	12	65,781,942 - 65,903,154 (+)	NCBI
UNSW_CanFamBas_1.0	12	65,630,050 - 65,751,117 (+)	NCBI
UU_Cfam_GSD_1.0	12	65,902,223 - 66,023,273 (+)	NCBI

Foxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	100,513,168 - 100,632,744 (+)	NCBI
SpeTri2.0	NW_004936564	4,788,036 - 4,907,600 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FOXO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	74,628,217 - 74,760,328 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	74,626,673 - 74,760,323 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	83,888,152 - 83,888,769 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	1	84,047,498 - 84,048,900 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	1	p13	NCBI

FOXO3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	65,175,764 - 65,303,107 (-)	NCBI
ChlSab1.1 Ensembl	13	65,195,376 - 65,301,725 (-)	Ensembl

Foxo3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624780	13,621,733 - 13,740,399 (-)	NCBI

Position Markers

BE109870

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	45,740,009 - 45,740,159 (-)	MAPPER
Rnor_6.0	20	46,452,517 - 46,452,666	NCBI	Rnor6.0
Rnor_5.0	20	48,136,600 - 48,136,749	UniSTS	Rnor5.0
RGSC_v3.4	20	46,237,990 - 46,238,139	UniSTS	RGSC3.4
Celera	20	54,222,999 - 54,223,148	UniSTS
RH 3.4 Map	20	487.83	UniSTS
Cytogenetic Map	20	q13	UniSTS

BF390390

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	45,673,383 - 45,673,541 (-)	MAPPER
Rnor_6.0	20	46,519,233 - 46,519,390	NCBI	Rnor6.0
Rnor_5.0	20	48,202,685 - 48,202,842	UniSTS	Rnor5.0
RGSC_v3.4	20	46,171,550 - 46,171,707	UniSTS	RGSC3.4
Celera	20	54,289,643 - 54,289,800	UniSTS
RH 3.4 Map	20	487.13	UniSTS
Cytogenetic Map	20	q13	UniSTS

Foxo3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	45,686,222 - 45,686,740 (-)	MAPPER
Rnor_6.0	20	46,506,041 - 46,506,558	NCBI	Rnor6.0
Rnor_5.0	20	48,189,548 - 48,190,065	UniSTS	Rnor5.0
RGSC_v3.4	20	46,184,402 - 46,184,919	UniSTS	RGSC3.4
Celera	20	54,276,425 - 54,276,942	UniSTS
Cytogenetic Map	20	q13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	2018654	47018654	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	2999707	47999707	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	4108956	49108956	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	13834309	56205956	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	13834309	56205956	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17827096	56205956	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	18872150	49108956	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20858470	56205956	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26608843	56205956	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26608843	56205956	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26608843	56205956	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26712323	56205956	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	30913481	56205956	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	61
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000000327
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	36	21	19	21	1	1	56	34	34	11	1
Low	1	17	21	20		20	7	10	18	1	7		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000327 ⟹ ENSRNOP00000000327

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	46,428,124 - 46,519,144 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076818 ⟹ ENSRNOP00000068195

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	46,429,222 - 46,505,895 (+)	Ensembl

RefSeq Acc Id:

NM_001106395 ⟹ NP_001099865

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	45,673,618 - 45,764,606 (-)	NCBI
Rnor_6.0	20	46,428,078 - 46,519,156 (+)	NCBI
Rnor_5.0	20	48,111,014 - 48,206,518 (+)	NCBI
RGSC_v3.4	20	46,171,784 - 46,262,818 (-)	RGD
Celera	20	54,198,460 - 54,289,566 (+)	RGD

Sequence:

show sequence

GCTCCCTGCGAGTGTCTATAACTTTGTGCTGCTGCCGCGGCCGCCCTGCTCGTGGAAGGGAGGA
GGAGGAATGTGGAAGGCGGCGGCGCAGCACAGGCTGACAGGCGGTTCCTCCGGCGGGCTGCGGC
GGCGGCCCGAGCGTCCCCTCGTCGCGGTGCCCTGGGCTCGCGCGGAATCGTACGCCCTCCCGCC
TCGTCCCTGAAGGGAAGGAGCCGAGGTAGCTGGAGCTCGAGCCTTCGCGGCGCCCTGTCCCTCC
CCCGCCGCACCCAGCCTGGGCGCGAGAGGAGAGAGCAAGAGCCCAAGCCGCGGGCGGCGGGCAG
GCAGCGAAGATGGCAGAGGCACCAGCCTCCCCGGTCCCGCTCTCTCCGCTCGAAGTGGAGCTGG
ACCCAGAGTTCGAGCCACAGAGTCGGCCACGCTCCTGTACGTGGCCCCTGCAGAGGCCGGAGCT
GCAGGCGAGCCCGGCCAAGCCCTCGGGGGAGACGGCGGCAGACTCCATGATCCCCGAGGAGGAC
GACGATGAAGACGACGAGGACAGCGGCGGCCGAGGCAGCTCGGCCATGGTGATCGGTGGCGGCG
TGAGCAGTGCGCTGGGCTCCGGGCTGCTCCTCGAAGATTCGGCCAGGCTGCTGTCTCCCGGAGG
GCAGGACCTCGGGACGGGGCCAGCGTCCTCCGCAGGCGCGCTGAGTGGGGGCACGCAGACGCAG
CTGCAGCCTCAGCAGCCACTGCCACCGCCGCAGCCGGGGGCGGCTGGGGGCTCTGGGCAACCGA
GGAAATGCTCCTCGCGGCGGAATGCCTGGGGGAACCTGTCCTACGCTGACCTGATCACCCGCGC
CATCGAGAGCTCCCCGGACAAACGGCTCACTTTGTCCCAGATCTACGAGTGGATGGTGCGCTGT
GTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCGGGCTGGAAGAACTCCATCCGCC
ACAACCTGTCACTGCACAGCCGTTTCATGCGGGTTCAGAACGAAGGGACTGGCAAGAGCTCTTG
GTGGATCATCAACCCCGATGGGGGAAAGAGTGGGAAGGCTCCCCGGCGGCGGGCCGTCTCCATG
GACAACAGCAACAAGTACACCAAGAGCCGAGGCCGGGCAGCCAAGAAGAAGGCGGCCCTGCAGG
CTGCCCCAGAGTCGGCAGACGACAGCCCTTCCCAACTCTCCAAGTGGCCGGGCAGCCCCACATC
CCGCAGCAGCGACGAGCTGGACGCCTGGACCGACTTCCGCTCGCGCACCAATTCCAACGCCAGC
ACCGTGAGCGGCCGCCTGTCACCCATCTTGGCGAGCACGGAGCTGGATGACGTCCAGGACGATG
ACGGGCCCCTCTCCCCCATGCTCTACAGCAGCTCTGCCAGCCTGTCGCCTTCCGTAAGCAAGCC
GTGTACCGTGGAGCTGCCGCGGCTGACTGACATGGCGGGCACCATGAATCTGAACGATGGGCTG
GCCGAGAACCTCATGGATGACCTGCTAGATAACATCGCGCTCCCGCCCTCCCAGGCGTCGCCTC
CTGGCGGGCTTATGCAGCGGAGCTCCAGCTTCCCGTACACCGCCAAGAGCTCCGGCCTGGGCTC
CCCAACCAGCTCCTTTAACAGTACCGTGTTCGGACCTGCGTCACTCAACTCCCTGCGCCAGTCG
CCCATGCAGACCATCCAGGAGAACAGACCAGCCACCTTTTCTTCCGTGTCGCACTACGGCAACC
AGACACTCCAAGACCTGCTCACTTCGGACTCGCTCAGCCACAGCGATGTCATGATGACCCAGTC
AGACCCCTTGATGTCTCAGGCTAGCACCGCTGTGTCCGCCCAGAACGCCCGCCGGAACGTGATG
CTTCGCAACGACCCAATGATGTCCTTTGCCGCCCAGCCTACCCAGGGGAGTTTGGTCAATCAGA
ACTTGCTCCACCACCAGCACCAAACCCAGGGCGCTCTTGGTGGCAGCCGTGCCTTGTCAAATTC
TGTCAGCAACATGGGCTTGAGTGACTCCAGCAGCCTCGGCTCAGCCAAACACCAGCAGCAGTCT
CCCGTCAGCCAGTCTATGCAAACCCTCTCGGACTCTCTCTCAGGCTCCTCACTGTATTCAGCCA
GTGCAAACCTTCCCGTCATGGGTCACGACAAGTTCCCCAGTGACTTGGACCTGGACATGTTCAA
TGGGAGCTTGGAGTGTGACATGGAGTCCATCATCCGTAGCGAACTCATGGATGCCGATGGGTTG
GATTTTAACTTTGACTCCCTCATCTCCACACAGAACGTTGTTGGTTTGAACGTGGGGAACTTCA
CTGGTGCTAAGCAGGCCTCATCTCAAAGCTGGGTGCCAGGCTGAAGGATCACTGAGGAAAGGGG
AAATGGGCAAAGCAGACCCTCAAACTGACCGAAGACCTACAGAGAAAAAAACCCTTTGCCAAAT
CTGCTCTCAGCCAGTGGACAGTGAACCCCGTTTACAGCTTGACACCTTTGTGACTCCCACGCCA
TCTTCCTAACCCAGCAGAGACTGTTAGCAGCCCTGGCCCTGGGTGAAGCCCTTTCCCGTGGAGC
AGAACTCTATAACGTATGCAAATCTAACTCATCTGCAAGTGACCTGCCATCGTGGACAGCACCC
ATCAGCATCCCTACTCCAGAGCACACCGGGAGCCCCGGCTGCGGCGATTCCGTACTGTTTCAGG
ATCGTGATGGTTTAGGGGATATTTTAAGTGTCATTTTGTGTTTGTTTCCTTTGACCCTCTTGAG
TTTTTTTACACACAGTAACCTGCAGTATTTTTCTGTTGAAAACGTTGACTGTCCTTTCCCTAGC
ACACTTAAAAAGCAGAAGGAAGGTGTTGTGTCAGTTCCCAGTCTGAGCTTTTGAGCCTGTGGAA
CTCCG

hide sequence

RefSeq Acc Id:

XM_039098617 ⟹ XP_038954545

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	45,669,708 - 45,764,531 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099865	(Get FASTA)	NCBI Sequence Viewer
	XP_038954545	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99711	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099865 ⟸ NM_001106395

- UniProtKB:

D3ZBQ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEDDDE
DDEDSGGRGSSAMVIGGGVSSALGSGLLLEDSARLLSPGGQDLGTGPASSAGALSGGTQTQLQP
QQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPY
FKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGGKSGKAPRRRAVSMDNS
NKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVS
GRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKPCTVELPRLTDMAGTMNLNDGLAEN
LMDDLLDNIALPPSQASPPGGLMQRSSSFPYTAKSSGLGSPTSSFNSTVFGPASLNSLRQSPMQ
TIQENRPATFSSVSHYGNQTLQDLLTSDSLSHSDVMMTQSDPLMSQASTAVSAQNARRNVMLRN
DPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPVS
QSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFN
FDSLISTQNVVGLNVGNFTGAKQASSQSWVPG

hide sequence

RefSeq Acc Id:

ENSRNOP00000000327 ⟸ ENSRNOT00000000327

RefSeq Acc Id:

ENSRNOP00000068195 ⟸ ENSRNOT00000076818

RefSeq Acc Id:	XP_038954545 ⟸ XM_039098617
- Peptide Label:	isoform X1

Protein Domains

Fork-head

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701665

Promoter ID:

EPDNEW_R12189

Type:

initiation region

Name:

Foxo3_1

Description:

forkhead box O3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R12190

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	46,428,125 - 46,428,185	EPDNEW

RGD ID:

13701669

Promoter ID:

EPDNEW_R12190

Type:

single initiation site

Name:

Foxo3_2

Description:

forkhead box O3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R12189

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	46,429,184 - 46,429,244	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	48113986	48113987	T	G	snv	SR/JrHsd (MCW)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	46429946	46429947	T	G	snv	SR/JrHsd (MCW)
20	46505861	46505862	G	C	snv	MR/N (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309196	AgrOrtholog
Ensembl Genes	ENSRNOG00000000299	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000327	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000068195	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000327	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000076818	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	FOXO-TAD	UniProtKB/TrEMBL
	FOXO_KIX-bd	UniProtKB/TrEMBL
	TF_fork_head	UniProtKB/TrEMBL
	TF_fork_head_CS_2	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:294515	UniProtKB/TrEMBL
NCBI Gene	294515	ENTREZGENE
Pfam	Fork_head	UniProtKB/TrEMBL
	FOXO-TAD	UniProtKB/TrEMBL
	FOXO_KIX_bdg	UniProtKB/TrEMBL
PhenoGen	Foxo3	PhenoGen
PRINTS	FORKHEAD	UniProtKB/TrEMBL
PROSITE	FORK_HEAD_2	UniProtKB/TrEMBL
	FORK_HEAD_3	UniProtKB/TrEMBL
SMART	SM00339	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A096MJN1_RAT	UniProtKB/TrEMBL
	D3ZBQ1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-11-04	Foxo3	forkhead box O3	Foxo3a	forkhead box O3a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Foxo3a	forkhead box O3a	Foxo3a_predicted	forkhead box O3a (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Foxo3a_predicted	forkhead box O3a (predicted)	Foxo3_predicted	forkhead box O3 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-12	Foxo3_predicted	forkhead box O3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)