(+)-catechin multiple interactions ISO RGD:1319403 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of FOXO3 mRNA CTD PMID:24763279 (+)-Tetrandrine multiple interactions ISO RGD:1319403 6480464 [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein more ... CTD PMID:30123091 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:1553155 6480464 epigallocatechin gallate results in decreased expression of FOXO3 protein CTD PMID:29175576 (E)-thiamethoxam increases expression ISO RGD:1553155 6480464 Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 (R)-lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein CTD PMID:22327056 (R)-lipoic acid decreases acetylation EXP 6480464 Thioctic Acid results in decreased acetylation of FOXO3 protein CTD PMID:22327056 (R)-noradrenaline multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein], SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein] CTD PMID:19168439 (R)-noradrenaline increases phosphorylation EXP 6480464 Norepinephrine results in increased phosphorylation of FOXO3 protein CTD PMID:19168439 1,2-dichloroethane decreases expression ISO RGD:1553155 6480464 ethylene dichloride results in decreased expression of FOXO3 mRNA CTD PMID:28189721 , PMID:28960355 17alpha-ethynylestradiol decreases expression ISO RGD:1553155 6480464 Ethinyl Estradiol results in decreased expression of FOXO3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1553155 6480464 Ethinyl Estradiol affects the expression of FOXO3 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1553155 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1319403 6480464 Estradiol inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:24954032 , PMID:30682495 17beta-estradiol increases expression ISO RGD:1319403 6480464 Estradiol results in increased expression of FOXO3 mRNA CTD PMID:30682495 17beta-estradiol decreases expression ISO RGD:1319403 6480464 Estradiol results in decreased expression of FOXO3 mRNA CTD PMID:19167446 17beta-estradiol decreases phosphorylation ISO RGD:1319403 6480464 Estradiol results in decreased phosphorylation of FOXO3 protein CTD PMID:24954032 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1319403 6480464 Dihydrotestosterone results in increased expression of FOXO3 mRNA CTD PMID:29581250 1H-pyrazole decreases expression ISO RGD:1553155 6480464 pyrazole results in decreased expression of FOXO3 mRNA CTD PMID:17945193 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1319403 6480464 2 more ... CTD PMID:20840854 , PMID:24954032 2,2',4,4',5,5'-hexachlorobiphenyl decreases phosphorylation ISO RGD:1319403 6480464 2 more ... CTD PMID:20840854 , PMID:24954032 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:1319403 6480464 2 more ... CTD PMID:19095052 2,3',4,4',5-Pentachlorobiphenyl multiple interactions ISO RGD:1319403 6480464 2 more ... CTD PMID:25644787 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1319403 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein] more ... CTD PMID:22266097 , PMID:24954032 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of FOXO3 mRNA CTD PMID:32109520 , PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1553155 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of FOXO3 mRNA more ... CTD PMID:17942748 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1553155 6480464 Tetrachlorodibenzodioxin results in increased expression of FOXO3 mRNA CTD PMID:18796159 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO RGD:1319403 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein CTD PMID:22266097 , PMID:24954032 2,5-hexanedione increases phosphorylation ISO RGD:1553155 6480464 2, 5-hexanedione results in increased phosphorylation of FOXO3 protein CTD PMID:33197454 2,5-hexanedione decreases expression ISO RGD:1553155 6480464 2, 5-hexanedione results in decreased expression of FOXO3 mRNA CTD PMID:33197454 2-butoxyethanol increases expression ISO RGD:1553155 6480464 n-butoxyethanol results in increased expression of FOXO3 mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:1319403 6480464 beta-methylcholine affects the expression of FOXO3 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:1319403 6480464 3 more ... CTD PMID:20840854 3,3',4,4',5-pentachlorobiphenyl decreases phosphorylation ISO RGD:1319403 6480464 3 more ... CTD PMID:20840854 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1553155 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of FOXO3 mRNA CTD PMID:26251327 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO RGD:1553155 6480464 CTNNB1 mutant form inhibits the reaction [3 more ... CTD PMID:23620592 3,5-diethoxycarbonyl-1,4-dihydrocollidine affects localization ISO RGD:1553155 6480464 3 more ... CTD PMID:23620592 3-methylcholanthrene multiple interactions EXP 6480464 [Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA CTD PMID:29094188 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1553155 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of FOXO3 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol decreases expression ISO RGD:1553155 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of FOXO3 mRNA CTD PMID:33297965 4-hydroxy-TEMPO affects phosphorylation ISO RGD:1553155 6480464 tempol affects the phosphorylation of FOXO3 protein CTD PMID:24550650 4-hydroxynon-2-enal multiple interactions ISO RGD:1553155 6480464 FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]] CTD PMID:24633890 4-nitrophenol increases expression ISO RGD:1553155 6480464 4-nitrophenol results in increased expression of FOXO3 mRNA CTD PMID:34673133 4-phenylbutyric acid multiple interactions ISO RGD:1319403 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] CTD PMID:33127495 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein] CTD PMID:34214594 5-fluorouracil affects response to substance ISO RGD:1319403 6480464 FOXO3 affects the susceptibility to Fluorouracil CTD PMID:15067352 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1553155 6480464 6-chloro-2 more ... CTD PMID:20370652 7,12-dimethyltetraphene decreases expression ISO RGD:1553155 6480464 9 more ... CTD PMID:21785161 8-Br-cAMP multiple interactions ISO RGD:1319403 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA] more ... CTD PMID:16709600 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of FOXO3 mRNA, Acrylamide results in increased expression of FOXO3 protein CTD PMID:33582169 acrylamide multiple interactions EXP 6480464 [FOXO3 mRNA co-treated with Acrylamide] results in decreased expression of CCND1 protein more ... CTD PMID:33582169 adenine multiple interactions EXP 6480464 Adenine results in increased expression of and results in increased phosphorylation of FOXO3 protein CTD PMID:35753429 aflatoxin B1 increases expression ISO RGD:1553155 6480464 Aflatoxin B1 results in increased expression of FOXO3 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:1319403 6480464 Aflatoxin B1 results in decreased methylation of FOXO3 intron CTD PMID:30157460 aldehydo-D-glucose multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:23159718 , PMID:25471227 aldehydo-D-glucose increases phosphorylation ISO RGD:1553155 6480464 Glucose results in increased phosphorylation of FOXO3 protein CTD PMID:23090186 aldehydo-D-glucose increases localization ISO RGD:1553155 6480464 Glucose results in increased localization of FOXO3 protein CTD PMID:20370652 aldehydo-D-glucose multiple interactions ISO RGD:1553155 6480464 [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose more ... CTD PMID:20370652 , PMID:23090186 all-trans-retinoic acid increases expression ISO RGD:1319403 6480464 Tretinoin results in increased expression of FOXO3 mRNA CTD PMID:23830798 alpha-naphthoflavone multiple interactions ISO RGD:1319403 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein] CTD PMID:22266097 alpha-naphthoflavone multiple interactions EXP 6480464 [Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA CTD PMID:29094188 alpha-Solamarine multiple interactions ISO RGD:1553155 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein], alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein] CTD PMID:35350913 amidotrizoic acid affects phosphorylation ISO RGD:1319403 6480464 Diatrizoate affects the phosphorylation of FOXO3 protein CTD PMID:21036957 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1319403 6480464 pyrazolanthrone inhibits the reaction [Ethanol results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:26470730 antimycin A multiple interactions ISO RGD:1553155 6480464 [FOXO1 protein co-treated with FOXO4 protein co-treated with FOXO3 protein] affects the reaction [Resveratrol inhibits the reaction [Antimycin A results in increased expression of BAX protein]] more ... CTD PMID:24040102 antimycin A decreases expression ISO RGD:1553155 6480464 Antimycin A results in decreased expression of FOXO3 protein CTD PMID:24040102 arsenic acid affects localization ISO RGD:1553155 6480464 arsenic acid affects the localization of FOXO3 protein CTD PMID:26763397 arsenite(3-) increases phosphorylation ISO RGD:1319403 6480464 arsenite results in increased phosphorylation of FOXO3 protein CTD PMID:24024143 arsenite(3-) multiple interactions ISO RGD:1319403 6480464 arsenite inhibits the reaction [G3BP1 protein binds to FOXO3 mRNA], Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein] CTD PMID:24024143 , PMID:32406909 arsenous acid affects localization ISO RGD:1319403 6480464 Arsenic Trioxide affects the localization of FOXO3 protein CTD PMID:31421153 arsenous acid increases expression ISO RGD:1319403 6480464 Arsenic Trioxide results in increased expression of FOXO3 mRNA CTD PMID:31539632 arsenous acid decreases expression ISO RGD:1319403 6480464 Arsenic Trioxide results in decreased expression of FOXO3 mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO RGD:1553155 6480464 FOXO3 protein affects the reaction [Arsenic Trioxide results in decreased expression of MKI67 protein] CTD PMID:31421153 arsenous acid multiple interactions ISO RGD:1319403 6480464 [Arsenic Trioxide co-treated with NVP-BKM120] results in increased expression of FOXO3 mRNA more ... CTD PMID:22988968 more ... arsenous acid affects response to substance ISO RGD:1553155 6480464 FOXO3 protein affects the susceptibility to Arsenic Trioxide CTD PMID:31421153 aspartame multiple interactions ISO RGD:1553155 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 astaxanthin multiple interactions ISO RGD:1553155 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 atrazine decreases expression ISO RGD:1319403 6480464 Atrazine results in decreased expression of FOXO3 mRNA CTD PMID:22378314 aucubin multiple interactions ISO RGD:1553155 6480464 aucubin inhibits the reaction [Cisplatin results in increased expression of and results in increased phosphorylation of FOXO3 protein] CTD PMID:32504734 avermectin decreases expression ISO RGD:1319403 6480464 avermectin results in decreased expression of FOXO3 protein CTD PMID:33381906 benzo[a]pyrene multiple interactions ISO RGD:1319403 6480464 2 more ... CTD PMID:20840854 , PMID:24954032 benzo[a]pyrene decreases methylation ISO RGD:1319403 6480464 Benzo(a)pyrene results in decreased methylation of FOXO3 exon CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1553155 6480464 Benzo(a)pyrene results in increased expression of FOXO3 mRNA, Benzo(a)pyrene results in increased expression of FOXO3 protein CTD PMID:19770486 more ... benzo[a]pyrene multiple interactions ISO RGD:1553155 6480464 Benzo(a)pyrene affects the reaction [AHR protein binds to FOXO3 promoter] CTD PMID:19654925 benzo[a]pyrene increases phosphorylation ISO RGD:1319403 6480464 Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein CTD PMID:20840854 , PMID:24954032 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1319403 6480464 7 more ... CTD PMID:35038060 benzo[e]pyrene increases methylation ISO RGD:1319403 6480464 benzo(e)pyrene results in increased methylation of FOXO3 intron CTD PMID:30157460 berberine multiple interactions ISO RGD:1319403 6480464 [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein, Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 bis(2-ethylhexyl) phthalate affects expression ISO RGD:1553155 6480464 Diethylhexyl Phthalate affects the expression of FOXO3 mRNA CTD PMID:31211961 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of FOXO3 mRNA CTD PMID:25181051 , PMID:34947998 bisphenol A increases expression ISO RGD:1553155 6480464 bisphenol A results in increased expression of FOXO3 mRNA CTD PMID:25594700 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of FOXO3 mRNA CTD PMID:19167457 cabazitaxel affects expression ISO RGD:1319403 6480464 cabazitaxel affects the expression of FOXO3 protein CTD PMID:32525019 cadmium atom affects response to substance ISO RGD:1553155 6480464 FOXO3 affects the susceptibility to Cadmium CTD PMID:27492225 cadmium atom increases expression ISO RGD:1553155 6480464 Cadmium results in increased expression of FOXO3 mRNA CTD PMID:27492225 cadmium atom multiple interactions ISO RGD:1553155 6480464 Cadmium results in increased expression of and results in increased phosphorylation of FOXO3 protein more ... CTD PMID:27492225 cadmium dichloride decreases activity ISO RGD:1319403 6480464 Cadmium Chloride results in decreased activity of FOXO3 protein CTD PMID:23673518 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of FOXO3 protein CTD PMID:33127495 cadmium dichloride increases expression ISO RGD:1319403 6480464 Cadmium Chloride results in increased expression of FOXO3 mRNA, Cadmium Chloride results in increased expression of FOXO3 protein CTD PMID:30682495 , PMID:33127495 cadmium dichloride decreases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in decreased susceptibility to Cadmium Chloride CTD PMID:23673518 cadmium dichloride increases phosphorylation ISO RGD:1319403 6480464 Cadmium Chloride results in increased phosphorylation of FOXO3 protein CTD PMID:23673518 cadmium dichloride multiple interactions ISO RGD:1319403 6480464 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] more ... CTD PMID:23673518 more ... caffeine increases phosphorylation ISO RGD:1319403 6480464 Caffeine results in increased phosphorylation of FOXO3 protein CTD PMID:35688186 carbamazepine affects expression ISO RGD:1319403 6480464 Carbamazepine affects the expression of FOXO3 mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:1319403 6480464 Nanotubes, Carbon results in decreased expression of FOXO3 mRNA CTD PMID:25511174 carbon nanotube decreases expression ISO RGD:1553155 6480464 Nanotubes, Carbon results in decreased expression of FOXO3 mRNA CTD PMID:25620056 carbon nanotube increases expression ISO RGD:1553155 6480464 Nanotubes more ... CTD PMID:25554681 casticin decreases expression ISO RGD:1319403 6480464 casticin results in decreased expression of FOXO3 mRNA CTD PMID:27862857 celastrol increases phosphorylation EXP 6480464 celastrol results in increased phosphorylation of FOXO3 protein CTD PMID:25903958 chlordecone increases expression ISO RGD:1553155 6480464 Chlordecone results in increased expression of FOXO3 mRNA CTD PMID:31084621 chloroprene increases expression ISO RGD:1553155 6480464 Chloroprene results in increased expression of FOXO3 mRNA CTD PMID:23125180 cisplatin multiple interactions ISO RGD:1319403 6480464 [Cisplatin co-treated with Arsenic Trioxide] results in decreased phosphorylation of FOXO3 protein more ... CTD PMID:21092744 more ... cisplatin affects localization ISO RGD:1553155 6480464 Cisplatin affects the localization of FOXO3 protein CTD PMID:33031932 cisplatin multiple interactions ISO RGD:1553155 6480464 aucubin inhibits the reaction [Cisplatin results in increased expression of and results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:32504734 , PMID:33031932 cisplatin decreases expression ISO RGD:1319403 6480464 Cisplatin results in decreased expression of FOXO3 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1553155 6480464 Cisplatin results in increased expression of FOXO3 mRNA CTD PMID:24823295 cisplatin decreases phosphorylation ISO RGD:1553155 6480464 Cisplatin results in decreased phosphorylation of FOXO3 protein CTD PMID:24823295 cisplatin multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of FOXO3 mRNA CTD PMID:33522649 cisplatin decreases phosphorylation ISO RGD:1319403 6480464 Cisplatin results in decreased phosphorylation of FOXO3 protein CTD PMID:21092744 clofibrate multiple interactions ISO RGD:1553155 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA] CTD PMID:17585979 cobalt dichloride increases expression ISO RGD:1319403 6480464 cobaltous chloride results in increased expression of FOXO3 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:1319403 6480464 [Chelating Agents binds to Copper] which results in increased expression of FOXO3 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:1319403 6480464 [Chelating Agents binds to Copper] which results in increased expression of FOXO3 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO RGD:1319403 6480464 Copper Sulfate results in increased expression of FOXO3 mRNA CTD PMID:19549813 coumarin decreases phosphorylation ISO RGD:1319403 6480464 coumarin results in decreased phosphorylation of FOXO3 protein CTD PMID:35688186 coumestrol multiple interactions ISO RGD:1319403 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FOXO3 mRNA CTD PMID:19167446 coumestrol decreases expression ISO RGD:1319403 6480464 Coumestrol results in decreased expression of FOXO3 mRNA CTD PMID:19167446 crocidolite asbestos affects expression ISO RGD:1319403 6480464 Asbestos, Crocidolite affects the expression of FOXO3 mRNA CTD PMID:17331233 crocidolite asbestos decreases expression ISO RGD:1553155 6480464 Asbestos, Crocidolite results in decreased expression of FOXO3 mRNA CTD PMID:29279043 cyclosporin A decreases expression ISO RGD:1319403 6480464 Cyclosporine results in decreased expression of FOXO3 mRNA CTD PMID:20106945 cylindrospermopsin increases expression ISO RGD:1319403 6480464 cylindrospermopsin results in increased expression of FOXO3 mRNA CTD PMID:23726867 D-glucose multiple interactions ISO RGD:1553155 6480464 [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose more ... CTD PMID:20370652 , PMID:23090186 D-glucose multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:23159718 , PMID:25471227 D-glucose increases phosphorylation ISO RGD:1553155 6480464 Glucose results in increased phosphorylation of FOXO3 protein CTD PMID:23090186 D-glucose increases localization ISO RGD:1553155 6480464 Glucose results in increased localization of FOXO3 protein CTD PMID:20370652 DAPT multiple interactions ISO RGD:1319403 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein] CTD PMID:25108166 DDE increases activity ISO RGD:1319403 6480464 Dichlorodiphenyl Dichloroethylene results in increased activity of FOXO3 protein CTD PMID:27589886 dexamethasone increases expression ISO RGD:1553155 6480464 Dexamethasone results in increased expression of FOXO3 mRNA, Dexamethasone results in increased expression of FOXO3 protein CTD PMID:22733784 , PMID:26758684 dexamethasone multiple interactions ISO RGD:1553155 6480464 Dexamethasone promotes the reaction [EP300 protein binds to FOXO3 gene], PIK3R1 mutant form inhibits the reaction [Dexamethasone results in increased expression of FOXO3 mRNA] CTD PMID:22733784 , PMID:26758684 dextran sulfate multiple interactions ISO RGD:1553155 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FOXO3 mRNA CTD PMID:29950665 diarsenic trioxide affects response to substance ISO RGD:1553155 6480464 FOXO3 protein affects the susceptibility to Arsenic Trioxide CTD PMID:31421153 diarsenic trioxide increases expression ISO RGD:1319403 6480464 Arsenic Trioxide results in increased expression of FOXO3 mRNA CTD PMID:31539632 diarsenic trioxide decreases expression ISO RGD:1319403 6480464 Arsenic Trioxide results in decreased expression of FOXO3 mRNA CTD PMID:22521957 diarsenic trioxide multiple interactions ISO RGD:1319403 6480464 [Arsenic Trioxide co-treated with NVP-BKM120] results in increased expression of FOXO3 mRNA more ... CTD PMID:22988968 more ... diarsenic trioxide affects localization ISO RGD:1319403 6480464 Arsenic Trioxide affects the localization of FOXO3 protein CTD PMID:31421153 diarsenic trioxide multiple interactions ISO RGD:1553155 6480464 FOXO3 protein affects the reaction [Arsenic Trioxide results in decreased expression of MKI67 protein] CTD PMID:31421153 diazinon increases methylation ISO RGD:1319403 6480464 Diazinon results in increased methylation of FOXO3 gene CTD PMID:22964155 dichloromethane increases expression ISO RGD:1553155 6480464 Methylene Chloride results in increased expression of FOXO3 mRNA CTD PMID:28392392 diclofenac affects expression ISO RGD:1319403 6480464 Diclofenac affects the expression of FOXO3 mRNA CTD PMID:24752500 diclofenac decreases expression ISO RGD:1553155 6480464 Diclofenac results in decreased expression of FOXO3 mRNA CTD PMID:26934552 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of FOXO3 mRNA CTD PMID:22546817 diethyl maleate increases expression ISO RGD:1319403 6480464 diethyl maleate results in increased expression of FOXO3 mRNA CTD PMID:33545341 dihydrogen increases expression ISO RGD:1319403 6480464 Hydrogen results in increased expression of FOXO3 protein CTD PMID:26271894 dihydrogen multiple interactions ISO RGD:1319403 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]], Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein] CTD PMID:26271894 dioxygen increases expression ISO RGD:1553155 6480464 Oxygen deficiency results in increased expression of FOXO3 mRNA CTD PMID:22629407 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Oxygen] affects the localization of and results in decreased phosphorylation of FOXO3 protein CTD PMID:21159781 dioxygen multiple interactions ISO RGD:1319403 6480464 [Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein more ... CTD PMID:25472572 dioxygen multiple interactions ISO RGD:1553155 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of FOXO3 mRNA] CTD PMID:22629407 diprotium increases expression ISO RGD:1319403 6480464 Hydrogen results in increased expression of FOXO3 protein CTD PMID:26271894 diprotium multiple interactions ISO RGD:1319403 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]], Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein] CTD PMID:26271894 dorsomorphin multiple interactions ISO RGD:1319403 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]] CTD PMID:26271894 dorsomorphin multiple interactions ISO RGD:1553155 6480464 dorsomorphin inhibits the reaction [Cadmium results in increased phosphorylation of FOXO3 protein] CTD PMID:27492225 doxorubicin multiple interactions ISO RGD:1319403 6480464 [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Doxorubicin more ... CTD PMID:17935137 , PMID:19211844 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of FOXO3 protein CTD PMID:34358621 doxorubicin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein], Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein] CTD PMID:34358621 doxorubicin decreases expression ISO RGD:1319403 6480464 Doxorubicin results in decreased expression of FOXO3 mRNA CTD PMID:29803840 doxorubicin increases expression ISO RGD:1553155 6480464 Doxorubicin results in increased expression of FOXO3 mRNA CTD PMID:25896364 , PMID:28329872 doxorubicin increases phosphorylation ISO RGD:1319403 6480464 Doxorubicin results in increased phosphorylation of FOXO3 protein CTD PMID:17935137 , PMID:25856345 doxorubicin decreases phosphorylation EXP 6480464 Doxorubicin results in decreased phosphorylation of FOXO3 protein CTD PMID:23639627 doxorubicin increases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in increased susceptibility to Doxorubicin CTD PMID:19211844 eckol multiple interactions ISO RGD:1319403 6480464 FOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein] CTD PMID:24700636 eckol increases phosphorylation ISO RGD:1319403 6480464 eckol results in increased phosphorylation of FOXO3 protein CTD PMID:24700636 elemental selenium multiple interactions ISO RGD:1319403 6480464 Selenium results in decreased phosphorylation of and results in increased activity of FOXO3 protein CTD PMID:17339365 Enterolactone multiple interactions ISO RGD:1319403 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FOXO3 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:1319403 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FOXO3 protein CTD PMID:23301498 epoxiconazole decreases expression ISO RGD:1553155 6480464 epoxiconazole results in decreased expression of FOXO3 mRNA CTD PMID:35436446 erlotinib hydrochloride decreases phosphorylation ISO RGD:1319403 6480464 Erlotinib Hydrochloride results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 ethanol increases expression ISO RGD:1553155 6480464 Ethanol results in increased expression of FOXO3 mRNA CTD PMID:25460735 , PMID:30319688 ethanol multiple interactions ISO RGD:1319403 6480464 [Ethanol co-treated with FOXO3 protein] results in increased expression of BCL2L11 mRNA more ... CTD PMID:24582693 , PMID:26470730 ethanol affects localization ISO RGD:1553155 6480464 Ethanol affects the localization of FOXO3 protein CTD PMID:24095927 ethanol increases phosphorylation ISO RGD:1319403 6480464 Ethanol results in increased phosphorylation of FOXO3 protein CTD PMID:26470730 ethanol multiple interactions ISO RGD:1553155 6480464 Ethanol affects the expression of and affects the splicing of FOXO3 mRNA more ... CTD PMID:24095927 more ... etoposide increases phosphorylation ISO RGD:1319403 6480464 Etoposide results in increased phosphorylation of FOXO3 protein CTD PMID:17935137 etoposide increases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in increased susceptibility to Etoposide CTD PMID:19211844 etoposide multiple interactions ISO RGD:1319403 6480464 [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide more ... CTD PMID:17935137 , PMID:19211844 fenvalerate affects methylation ISO RGD:1553155 6480464 fenvalerate affects the methylation of FOXO3 gene CTD PMID:23548413 flutamide multiple interactions EXP 6480464 Flutamide results in increased phosphorylation of and results in decreased activity of FOXO3 protein CTD PMID:20850791 fostriecin multiple interactions ISO RGD:1319403 6480464 fostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of FOXO3 protein]] CTD PMID:24954032 fulvestrant multiple interactions ISO RGD:1319403 6480464 Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of FOXO3 mRNA] CTD PMID:30682495 furan increases expression EXP 6480464 furan results in increased expression of FOXO3 mRNA CTD PMID:26194646 gefitinib increases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in increased susceptibility to gefitinib CTD PMID:18089711 gefitinib increases expression EXP 6480464 Gefitinib results in increased expression of FOXO3 mRNA more ... CTD PMID:32370496 gefitinib multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of FOXO3 mRNA] CTD PMID:32370496 gefitinib multiple interactions ISO RGD:1319403 6480464 gefitinib results in decreased phosphorylation of and affects the localization of FOXO3 protein CTD PMID:18089711 genistein multiple interactions ISO RGD:1319403 6480464 FOXO3 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein more ... CTD PMID:28688900 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of FOXO3 mRNA CTD PMID:33387578 glucose multiple interactions ISO RGD:1553155 6480464 [[Resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose more ... CTD PMID:20370652 , PMID:23090186 glucose increases phosphorylation ISO RGD:1553155 6480464 Glucose results in increased phosphorylation of FOXO3 protein CTD PMID:23090186 glucose multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:23159718 , PMID:25471227 glucose increases localization ISO RGD:1553155 6480464 Glucose results in increased localization of FOXO3 protein CTD PMID:20370652 glyphosate increases expression ISO RGD:1319403 6480464 glyphosate results in increased expression of FOXO3 mRNA CTD PMID:31295307 GSK690693 decreases phosphorylation ISO RGD:1319403 6480464 GSK690693 results in decreased phosphorylation of FOXO3 protein CTD PMID:35259468 hydrogen peroxide multiple interactions ISO RGD:1553155 6480464 [Hydrogen Peroxide co-treated with N-(oxo-5 more ... CTD PMID:20883752 , PMID:31494107 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of FOXO3 protein CTD PMID:30104959 hydrogen peroxide affects localization EXP 6480464 Hydrogen Peroxide affects the localization of FOXO3 protein CTD PMID:21159781 hydrogen peroxide increases phosphorylation EXP 6480464 Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein CTD PMID:19168439 , PMID:23159718 hydrogen peroxide multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein] more ... CTD PMID:19168439 , PMID:30104959 hydrogen peroxide multiple interactions ISO RGD:1319403 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA] more ... CTD PMID:16709600 more ... hydrogen peroxide increases expression ISO RGD:1319403 6480464 Hydrogen Peroxide results in increased expression of FOXO3 mRNA, Hydrogen Peroxide results in increased expression of FOXO3 protein CTD PMID:16709600 , PMID:25108166 hydrogen peroxide increases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in increased susceptibility to Hydrogen Peroxide CTD PMID:16709600 hydrogen peroxide increases phosphorylation ISO RGD:1553155 6480464 Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein CTD PMID:20883752 IC-87114 multiple interactions ISO RGD:1553155 6480464 IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein] CTD PMID:16179367 IC-87114 decreases phosphorylation ISO RGD:1553155 6480464 IC 87114 results in decreased phosphorylation of FOXO3 protein CTD PMID:16179367 icariin affects localization EXP 6480464 icariin affects the localization of FOXO3 protein CTD PMID:25472572 icariin multiple interactions ISO RGD:1319403 6480464 icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein], Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]] CTD PMID:25472572 isobutanol multiple interactions ISO RGD:1319403 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of FOXO3 mRNA CTD PMID:29432896 isoflavones increases expression ISO RGD:1319403 6480464 Isoflavones results in increased expression of FOXO3 mRNA, Isoflavones results in increased expression of FOXO3 protein CTD PMID:17374662 isoprenaline increases expression ISO RGD:1553155 6480464 Isoproterenol results in increased expression of FOXO3 mRNA CTD PMID:20003209 KN-93 multiple interactions ISO RGD:1319403 6480464 KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein], KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 L-ascorbic acid affects localization ISO RGD:1319403 6480464 Ascorbic Acid affects the localization of FOXO3 protein CTD PMID:32913121 L-ascorbic acid increases expression ISO RGD:1553155 6480464 Ascorbic Acid results in increased expression of FOXO3 mRNA CTD PMID:32913121 L-ascorbic acid multiple interactions ISO RGD:1319403 6480464 Ascorbic Acid results in increased expression of and results in decreased phosphorylation of FOXO3 protein more ... CTD PMID:32913121 L-ascorbic acid increases expression ISO RGD:1319403 6480464 Ascorbic Acid results in increased expression of FOXO3 mRNA CTD PMID:32913121 lead(0) affects expression ISO RGD:1319403 6480464 Lead affects the expression of FOXO3 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1319403 6480464 Lead affects the expression of FOXO3 mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:1319403 6480464 leflunomide results in increased expression of FOXO3 mRNA CTD PMID:28988120 lipoic acid multiple interactions EXP 6480464 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein CTD PMID:22327056 lipoic acid decreases acetylation EXP 6480464 Thioctic Acid results in decreased acetylation of FOXO3 protein CTD PMID:22327056 lipopolysaccharide increases phosphorylation ISO RGD:1553155 6480464 Lipopolysaccharides results in increased phosphorylation of FOXO3 protein CTD PMID:19293636 lipopolysaccharide multiple interactions ISO RGD:1553155 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein], resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein] CTD PMID:19293636 luteolin multiple interactions ISO RGD:1319403 6480464 Luteolin results in increased expression of and results in increased phosphorylation of FOXO3 protein more ... CTD PMID:32268164 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:19168439 more ... LY294002 increases expression EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of FOXO3 mRNA CTD PMID:32370496 LY294002 decreases phosphorylation ISO RGD:1319403 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 LY294002 multiple interactions ISO RGD:1319403 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of FOXO3 protein more ... CTD PMID:19211844 , PMID:25644787 LY294002 decreases phosphorylation ISO RGD:1553155 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein CTD PMID:16179367 LY294002 multiple interactions ISO RGD:1553155 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:16179367 more ... malonaldehyde multiple interactions ISO RGD:1553155 6480464 FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde]] CTD PMID:24633890 manganese atom multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:24787138 manganese atom affects localization EXP 6480464 Manganese affects the localization of FOXO3 protein CTD PMID:24787138 manganese(0) affects localization EXP 6480464 Manganese affects the localization of FOXO3 protein CTD PMID:24787138 manganese(0) multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:24787138 medroxyprogesterone acetate multiple interactions ISO RGD:1319403 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 mRNA] more ... CTD PMID:16709600 metacetamol decreases expression ISO RGD:1553155 6480464 3-hydroxyacetanilide results in decreased expression of FOXO3 mRNA CTD PMID:18544908 metformin decreases expression EXP 6480464 Metformin results in decreased expression of FOXO3 mRNA CTD PMID:31324951 methamphetamine decreases phosphorylation EXP 6480464 Methamphetamine results in decreased phosphorylation of FOXO3 protein CTD PMID:34214594 methamphetamine multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Methamphetamine results in decreased phosphorylation of FOXO3 protein] more ... CTD PMID:34214594 methamphetamine affects localization EXP 6480464 Methamphetamine affects the localization of FOXO3 protein CTD PMID:34214594 methapyrilene increases methylation ISO RGD:1319403 6480464 Methapyrilene results in increased methylation of FOXO3 intron CTD PMID:30157460 methoxychlor decreases expression EXP 6480464 Methoxychlor results in decreased expression of FOXO3 mRNA CTD PMID:23303685 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of FOXO3 gene CTD PMID:23303685 methylseleninic acid multiple interactions ISO RGD:1319403 6480464 methylselenic acid results in decreased phosphorylation of and results in increased activity of FOXO3 protein CTD PMID:17339365 metoprolol decreases expression EXP 6480464 Metoprolol results in decreased expression of FOXO3 protein CTD PMID:18703049 mifepristone multiple interactions ISO RGD:1319403 6480464 Mifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein] CTD PMID:22266097 monocrotaline decreases phosphorylation EXP 6480464 Monocrotaline results in decreased phosphorylation of FOXO3 protein CTD PMID:18801959 monosodium L-glutamate multiple interactions ISO RGD:1553155 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 motexafin gadolinium increases expression ISO RGD:1319403 6480464 motexafin gadolinium results in increased expression of FOXO3 mRNA CTD PMID:16357179 motexafin gadolinium multiple interactions ISO RGD:1319403 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA CTD PMID:16357179 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine decreases expression ISO RGD:1319403 6480464 N more ... CTD PMID:12756304 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein] more ... CTD PMID:23159718 more ... N-acetyl-L-cysteine multiple interactions ISO RGD:1319403 6480464 Acetylcysteine inhibits the reaction [tomentosin results in increased expression of FOXO3 protein] CTD PMID:30917517 N-acetyl-L-cysteine multiple interactions ISO RGD:1553155 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein], Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein] CTD PMID:20883752 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1319403 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in increased expression of FOXO3 protein] CTD PMID:31421153 N-phosphocreatine multiple interactions EXP 6480464 Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein] CTD PMID:34358621 nefazodone increases expression ISO RGD:1319403 6480464 nefazodone results in increased expression of FOXO3 mRNA CTD PMID:27288927 nickel dichloride increases expression ISO RGD:1319403 6480464 nickel chloride results in increased expression of FOXO3 mRNA CTD PMID:17312168 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of FOXO3 mRNA CTD PMID:22546817 nicotinamide multiple interactions ISO RGD:1319403 6480464 [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein more ... CTD PMID:23022493 more ... nitroxoline multiple interactions ISO RGD:1319403 6480464 nitroxoline inhibits the reaction [Hydrogen Peroxide results in decreased expression of and affects the localization of FOXO3 protein], nitroxoline results in decreased expression of and affects the localization of FOXO3 protein CTD PMID:31638783 okadaic acid multiple interactions ISO RGD:1319403 6480464 Okadaic Acid inhibits the reaction [2 more ... CTD PMID:24954032 oleanolic acid affects localization ISO RGD:1319403 6480464 Oleanolic Acid affects the localization of FOXO3 protein CTD PMID:35690101 oleanolic acid multiple interactions ISO RGD:1319403 6480464 Oleanolic Acid results in increased expression of and results in increased phosphorylation of FOXO3 protein CTD PMID:35690101 ozone multiple interactions ISO RGD:1553155 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of FOXO3 mRNA CTD PMID:34911549 paracetamol multiple interactions ISO RGD:1553155 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXO3 mRNA] CTD PMID:17585979 paracetamol increases expression ISO RGD:1319403 6480464 Acetaminophen results in increased expression of FOXO3 mRNA CTD PMID:21420995 , PMID:26690555 paracetamol affects expression ISO RGD:1553155 6480464 Acetaminophen affects the expression of FOXO3 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1553155 6480464 Acetaminophen results in increased expression of FOXO3 mRNA CTD PMID:18544908 paraquat multiple interactions ISO RGD:1553155 6480464 FOXO3 mutant form inhibits the reaction [Paraquat results in increased expression of BCL2L11 mRNA] CTD PMID:23620592 paraquat affects expression ISO RGD:1553155 6480464 Paraquat affects the expression of FOXO3 mRNA CTD PMID:29287252 paraquat increases response to substance ISO RGD:1553155 6480464 FOXO3 protein results in increased susceptibility to Paraquat CTD PMID:23620592 PD 0325901 increases expression ISO RGD:1319403 6480464 mirdametinib results in increased expression of FOXO3 protein CTD PMID:32268164 PD 0325901 multiple interactions ISO RGD:1319403 6480464 mirdametinib inhibits the reaction [Luteolin results in increased phosphorylation of FOXO3 protein], mirdametinib promotes the reaction [Luteolin results in increased expression of FOXO3 protein] CTD PMID:32268164 perfluorononanoic acid decreases expression ISO RGD:1319403 6480464 perfluoro-n-nonanoic acid results in decreased expression of FOXO3 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid increases activity ISO RGD:1319403 6480464 perfluorooctane sulfonic acid results in increased activity of FOXO3 protein CTD PMID:27589886 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 FOXO3 protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of BCL2L11 protein], perfluorooctane sulfonic acid results in increased expression of and affects the localization of FOXO3 protein CTD PMID:31588057 phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of FOXO3 mRNA CTD PMID:31324951 phenobarbital affects expression ISO RGD:1553155 6480464 Phenobarbital affects the expression of FOXO3 mRNA CTD PMID:23091169 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1319403 6480464 FOXO3 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2] CTD PMID:21705328 phorbol 13-acetate 12-myristate increases activity ISO RGD:1319403 6480464 Tetradecanoylphorbol Acetate results in increased activity of FOXO3 protein CTD PMID:21705328 phorbol 13-acetate 12-myristate decreases phosphorylation ISO RGD:1319403 6480464 Tetradecanoylphorbol Acetate results in decreased phosphorylation of FOXO3 protein CTD PMID:21705328 picropodophyllotoxin multiple interactions ISO RGD:1319403 6480464 [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein], [picropodophyllin results in decreased activity of IGF1R protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 pirinixic acid decreases expression ISO RGD:1553155 6480464 pirinixic acid results in decreased expression of FOXO3 mRNA CTD PMID:18445702 platycodin D increases expression ISO RGD:1319403 6480464 platycodin D results in increased expression of FOXO3 protein CTD PMID:25431082 platycodin D multiple interactions ISO RGD:1319403 6480464 MDM2 protein inhibits the reaction [platycodin D results in increased expression of FOXO3 protein] CTD PMID:25431082 platycodin D decreases expression ISO RGD:1319403 6480464 platycodin D results in decreased expression of FOXO3 protein modified form CTD PMID:25431082 propiconazole decreases expression ISO RGD:1553155 6480464 propiconazole results in decreased expression of FOXO3 mRNA CTD PMID:21278054 quercetin decreases phosphorylation ISO RGD:1319403 6480464 Quercetin results in decreased phosphorylation of FOXO3 protein CTD PMID:23099361 quercetin multiple interactions ISO RGD:1319403 6480464 Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein] CTD PMID:25108166 ramipril multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein CTD PMID:31062909 remdesivir increases expression ISO RGD:1319403 6480464 remdesivir results in increased expression of FOXO3 protein CTD PMID:35417658 resveratrol decreases response to substance ISO RGD:1319403 6480464 FOXO3 protein results in decreased susceptibility to resveratrol CTD PMID:20012470 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of FOXO3 protein CTD PMID:18077353 , PMID:24040416 resveratrol increases activity ISO RGD:1319403 6480464 resveratrol results in increased activity of FOXO3 protein CTD PMID:21209944 more ... resveratrol decreases phosphorylation ISO RGD:1319403 6480464 resveratrol results in decreased phosphorylation of FOXO3 protein CTD PMID:18222423 more ... resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of FOXO3 protein CTD PMID:23792339 resveratrol affects localization ISO RGD:1319403 6480464 resveratrol affects the localization of FOXO3 protein CTD PMID:23022493 , PMID:23975182 resveratrol increases expression ISO RGD:1553155 6480464 resveratrol results in increased expression of FOXO3 mRNA CTD PMID:22610192 , PMID:23975182 resveratrol increases expression ISO RGD:1319403 6480464 resveratrol results in increased expression of FOXO3 mRNA, resveratrol results in increased expression of FOXO3 protein CTD PMID:23022493 more ... resveratrol multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]] more ... CTD PMID:23792339 more ... resveratrol decreases phosphorylation ISO RGD:1553155 6480464 resveratrol results in decreased phosphorylation of FOXO3 protein CTD PMID:21980390 , PMID:23090186 resveratrol multiple interactions ISO RGD:1553155 6480464 6-chloro-2 more ... CTD PMID:19293636 more ... resveratrol multiple interactions ISO RGD:1319403 6480464 [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of FOXO3 protein more ... CTD PMID:17513867 more ... rutin multiple interactions ISO RGD:1553155 6480464 Rutin inhibits the reaction [Cisplatin affects the localization of FOXO3 protein] CTD PMID:33031932 salubrinal multiple interactions ISO RGD:1319403 6480464 salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of FOXO3 protein] CTD PMID:33127495 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] CTD PMID:24787138 SB 203580 multiple interactions ISO RGD:1319403 6480464 SB 203580 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein], SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 SB 431542 multiple interactions ISO RGD:1553155 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein] CTD PMID:23159718 SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein] CTD PMID:23159718 selenium atom multiple interactions ISO RGD:1319403 6480464 Selenium results in decreased phosphorylation of and results in increased activity of FOXO3 protein CTD PMID:17339365 sevoflurane decreases phosphorylation ISO RGD:1553155 6480464 Sevoflurane results in decreased phosphorylation of FOXO3 protein CTD PMID:35350913 sevoflurane multiple interactions ISO RGD:1553155 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein] more ... CTD PMID:35350913 silver atom increases expression ISO RGD:1319403 6480464 Silver results in increased expression of FOXO3 mRNA CTD PMID:26014281 silver(0) increases expression ISO RGD:1319403 6480464 Silver results in increased expression of FOXO3 mRNA CTD PMID:26014281 simvastatin multiple interactions ISO RGD:1553155 6480464 Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein], IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein] CTD PMID:20883752 , PMID:27734117 simvastatin affects localization ISO RGD:1553155 6480464 Simvastatin affects the localization of FOXO3 protein CTD PMID:27734117 simvastatin decreases phosphorylation EXP 6480464 Simvastatin results in decreased phosphorylation of FOXO3 protein CTD PMID:19001041 simvastatin decreases expression EXP 6480464 Simvastatin results in decreased expression of FOXO3 protein CTD PMID:19001041 simvastatin increases phosphorylation ISO RGD:1553155 6480464 Simvastatin results in increased phosphorylation of FOXO3 protein CTD PMID:20883752 sirolimus multiple interactions ISO RGD:1319403 6480464 [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein more ... CTD PMID:21092744 sirolimus increases phosphorylation ISO RGD:1319403 6480464 [Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein CTD PMID:21092744 sodium arsenite multiple interactions ISO RGD:1553155 6480464 SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]] more ... CTD PMID:25979314 sodium arsenite multiple interactions ISO RGD:1319403 6480464 [sodium arsenite co-treated with tetrandrine] affects the expression of and affects the phosphorylation of FOXO3 protein, [sodium arsenite co-treated with tetrandrine] results in increased expression of FOXO3 protein CTD PMID:30123091 sodium arsenite affects expression ISO RGD:1319403 6480464 sodium arsenite affects the expression of FOXO3 protein CTD PMID:30123091 sodium arsenite increases expression ISO RGD:1553155 6480464 sodium arsenite results in increased expression of FOXO3 mRNA, sodium arsenite results in increased expression of FOXO3 protein CTD PMID:19822182 , PMID:23143138 sodium arsenite increases acetylation ISO RGD:1553155 6480464 sodium arsenite results in increased acetylation of FOXO3 protein CTD PMID:25979314 sodium arsenite decreases expression ISO RGD:1319403 6480464 sodium arsenite results in decreased expression of FOXO3 protein modified form CTD PMID:23219847 sodium fluoride multiple interactions ISO RGD:1553155 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in increased acetylation of FOXO3 protein CTD PMID:34780879 sodium fluoride multiple interactions ISO RGD:1319403 6480464 [Sodium Fluoride results in increased abundance of Fluorides] which results in increased acetylation of FOXO3 protein, SIRT3 protein inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased acetylation of FOXO3 protein] CTD PMID:34780879 Sodium salicylate decreases phosphorylation ISO RGD:1553155 6480464 Sodium Salicylate results in decreased phosphorylation of FOXO3 protein CTD PMID:21303813 Sodium salicylate increases expression ISO RGD:1553155 6480464 Sodium Salicylate results in increased expression of FOXO3 protein CTD PMID:21303813 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of FOXO3 protein CTD PMID:18703049 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein more ... CTD PMID:23792339 , PMID:31062909 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of FOXO3 protein, Streptozocin results in increased expression of FOXO3 protein modified form CTD PMID:17082237 , PMID:23792339 streptozocin increases expression ISO RGD:1553155 6480464 Streptozocin results in increased expression of FOXO3 protein modified form CTD PMID:17082237 tamoxifen affects expression ISO RGD:1553155 6480464 Tamoxifen affects the expression of FOXO3 mRNA CTD PMID:17555576 testosterone decreases phosphorylation ISO RGD:1553155 6480464 Testosterone results in decreased phosphorylation of FOXO3 protein CTD PMID:20403060 testosterone multiple interactions EXP 6480464 Testosterone deficiency results in increased phosphorylation of and results in decreased activity of FOXO3 protein more ... CTD PMID:19926828 , PMID:20850791 testosterone multiple interactions ISO RGD:1553155 6480464 Testosterone results in increased activity of and results in increased localization of FOXO3 protein CTD PMID:20032061 tetrachloromethane affects expression ISO RGD:1553155 6480464 Carbon Tetrachloride affects the expression of FOXO3 mRNA CTD PMID:31919559 thiamethoxam increases expression ISO RGD:1553155 6480464 Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 titanium dioxide increases expression ISO RGD:1553155 6480464 titanium dioxide results in increased expression of FOXO3 mRNA CTD PMID:29128614 , PMID:29264374 titanium dioxide multiple interactions ISO RGD:1553155 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FOXO3 mRNA CTD PMID:29950665 Tomentosin multiple interactions ISO RGD:1319403 6480464 Acetylcysteine inhibits the reaction [tomentosin results in increased expression of FOXO3 protein], FOXO3 protein affects the reaction [tomentosin results in increased expression of CDKN1B protein] CTD PMID:30917517 Tomentosin increases expression ISO RGD:1319403 6480464 tomentosin results in increased expression of FOXO3 protein CTD PMID:30917517 trilobatin multiple interactions EXP 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein] CTD PMID:30104959 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of FOXO3 mRNA CTD PMID:30589522 Triptolide decreases phosphorylation ISO RGD:1553155 6480464 triptolide results in decreased phosphorylation of FOXO3 protein CTD PMID:32061799 triptonide increases expression ISO RGD:1553155 6480464 triptonide results in increased expression of FOXO3 mRNA CTD PMID:33045310 tris(2-chloroethyl) phosphate decreases expression ISO RGD:1319403 6480464 tris(chloroethyl)phosphate results in decreased expression of FOXO3 protein CTD PMID:30090360 troglitazone decreases expression ISO RGD:1553155 6480464 troglitazone results in decreased expression of FOXO3 mRNA CTD PMID:28973697 tyrphostin AG 1478 multiple interactions ISO RGD:1319403 6480464 [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 umbelliferone multiple interactions EXP 6480464 7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA] CTD PMID:33522649 urethane increases expression ISO RGD:1319403 6480464 Urethane results in increased expression of FOXO3 mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:1319403 6480464 Valproic Acid results in decreased expression of FOXO3 mRNA CTD PMID:19101580 , PMID:28001369 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of FOXO3 mRNA CTD PMID:29427782 valproic acid increases methylation ISO RGD:1319403 6480464 Valproic Acid results in increased methylation of FOXO3 gene CTD PMID:28853863 more ... valproic acid affects expression ISO RGD:1553155 6480464 Valproic Acid affects the expression of FOXO3 mRNA CTD PMID:17963808 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of FOXO3 mRNA CTD PMID:23034163 , PMID:23869203 wortmannin multiple interactions ISO RGD:1319403 6480464 Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein] more ... CTD PMID:17935137 more ... wortmannin decreases phosphorylation ISO RGD:1319403 6480464 wortmannin results in decreased phosphorylation of FOXO3 protein CTD PMID:25856345 xanthohumol multiple interactions ISO RGD:1319403 6480464 FOXO3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein], FOXO3 protein affects the reaction [xanthohumol results in increased expression of BBC3 protein] CTD PMID:35259468 xanthohumol decreases phosphorylation ISO RGD:1319403 6480464 xanthohumol results in decreased phosphorylation of FOXO3 protein CTD PMID:35259468 zearalenone decreases expression ISO RGD:1553155 6480464 Zearalenone results in decreased expression of FOXO3 mRNA CTD PMID:30717214 zinc acetate multiple interactions ISO RGD:1319403 6480464 [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA CTD PMID:16357179 zinc acetate increases expression ISO RGD:1319403 6480464 Zinc Acetate results in increased expression of FOXO3 mRNA CTD PMID:16357179 zinc sulfate increases expression ISO RGD:1319403 6480464 Zinc Sulfate results in increased expression of FOXO3 mRNA CTD PMID:12756304
