Foxo3 (forkhead box O3) - Rat Genome Database

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Gene: Foxo3 (forkhead box O3) Rattus norvegicus
Analyze
Symbol: Foxo3
Name: forkhead box O3
RGD ID: 1309196
Description: Enables transcription coregulator binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of programmed cell death; and response to glucocorticoid. Located in cytoplasm and nucleus. Biomarker of obesity. Orthologous to human FOXO3 (forkhead box O3); PARTICIPATES IN insulin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fkhrl1; forkhead box O3a; forkhead box protein O3; Foxo3a; LOC294515
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,251,968 - 47,348,254 (-)NCBIGRCr8
mRatBN7.22045,669,708 - 45,764,606 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,672,995 - 45,764,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,391,080 - 47,482,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,041,261 - 47,132,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,737,977 - 47,829,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02046,428,078 - 46,519,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,111,014 - 48,206,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,171,784 - 46,262,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12046,194,693 - 46,284,921 (-)NCBI
Celera2054,198,460 - 54,289,566 (+)NCBICelera
Cytogenetic Map20q12-q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
adenine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-Solamarine  (ISO)
amidotrizoic acid  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
aucubin  (ISO)
avermectin  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cabazitaxel  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
celastrol  (EXP)
chitosan  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
DAPT  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
dihydrogen  (ISO)
dioxygen  (EXP,ISO)
diprotium  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
eckol  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (ISO)
flutamide  (EXP)
fostriecin  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
gefitinib  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
GSK690693  (ISO)
hydrogen peroxide  (EXP,ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
indole-3-methanol  (ISO)
Inotodiol  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
KN-93  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (EXP,ISO)
linagliptin  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
medroxyprogesterone acetate  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-phosphocreatine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nicotinamide  (ISO)
nitroxoline  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picropodophyllotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ramipril  (EXP)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
rutin  (ISO)
salubrinal  (ISO)
Sanggenon C  (EXP)
sapanisertib  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP,ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
streptozocin  (EXP,ISO)
tamoxifen  (ISO)
tannic acid  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thiamethoxam  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
trilobatin  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
Ulipristal  (EXP)
umbelliferone  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antral ovarian follicle growth  (IEA,ISO)
brain morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to corticosterone stimulus  (IEP)
cellular response to glucose starvation  (IEA,ISO)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to oxidative stress  (IEA,ISO)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
initiation of primordial ovarian follicle growth  (IEA,ISO)
mitochondrial transcription  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of neuron differentiation  (IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neuronal stem cell population maintenance  (IEA,ISO)
oocyte maturation  (IEA,ISO)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of autophagy  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of hydrogen peroxide-mediated programmed cell death  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of muscle atrophy  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
regulation of translation  (IEA,ISO)
response to dexamethasone  (IEP)
response to fatty acid  (IEA,ISO)
response to nutrient levels  (IEP)
response to starvation  (IEA,ISO)
response to water-immersion restraint stress  (IEP)
response to xenobiotic stimulus  (IEP)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IEA,ISO)
membrane  (IEA,ISO)
mitochondrial matrix  (IBA,IEA,ISO)
mitochondrial outer membrane  (IEA,ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)
RNA polymerase II transcription repressor complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain. Caballero-Caballero A, etal., J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.
2. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Chamberlain W, etal., Biochem Cell Biol. 2012 Apr;90(2):200-8. doi: 10.1139/o11-082. Epub 2012 Jan 31.
3. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. Esteras N, etal., Neurobiol Aging. 2013 Apr;34(4):1090-100. doi: 10.1016/j.neurobiolaging.2012.10.014. Epub 2012 Nov 13.
4. Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells. Fujino K, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:148-53. doi: 10.1016/j.neulet.2013.10.050. Epub 2013 Oct 29.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
8. Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway in the duodenal mucosa of rats subjected to water immersion and restraint stress. Huang P, etal., Genet Mol Res. 2012 Sep 19;11(4):4775-88. doi: 10.4238/2012.September.19.2.
9. Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. Imae M, etal., J Mol Endocrinol. 2003 Apr;30(2):253-62.
10. Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. Kato M, etal., J Am Soc Nephrol. 2006 Dec;17(12):3325-35. Epub 2006 Nov 2.
11. SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. Kumarswamy R, etal., Eur Heart J. 2012 May;33(9):1067-75. doi: 10.1093/eurheartj/ehs043. Epub 2012 Feb 23.
12. [Role of the FOXO3a transcription factor in neuronal apoptosis in neonatal rats with hypoxic-ischemic brain damage]. Li DY, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2013 Nov;15(11):1023-7.
13. Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. Li YN, etal., Oxid Med Cell Longev. 2014;2014:320513. doi: 10.1155/2014/320513. Epub 2014 Jan 22.
14. FOXO3a is involved in the apoptosis of naked oocytes and oocytes of primordial follicles from neonatal rat ovaries. Liu H, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):722-7. doi: 10.1016/j.bbrc.2009.02.138. Epub 2009 Mar 1.
15. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
16. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. McClung JM, etal., J Physiol. 2007 Nov 15;585(Pt 1):203-15. Epub 2007 Oct 4.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Paik JH, etal., Cell. 2007 Jan 26;128(2):309-23. doi: 10.1016/j.cell.2006.12.029.
19. Activated forkhead transcription factor inhibits neointimal hyperplasia after angioplasty through induction of p27. Park KW, etal., Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):742-7. Epub 2005 Jan 20.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. Relling DP, etal., J Hypertens. 2006 Mar;24(3):549-61.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
25. FoxO3a is activated and executes neuron death via Bim in response to beta-amyloid. Sanphui P and Biswas SC, Cell Death Dis. 2013 May 9;4:e625. doi: 10.1038/cddis.2013.148.
26. Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models. Shi C, etal., J Cell Sci. 2016 Mar 9. pii: jcs.185009.
27. FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue. Turrel-Davin F, etal., Ann Rheum Dis. 2010 Apr;69(4):755-60. doi: 10.1136/ard.2009.109991. Epub 2009 May 11.
28. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
29. FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells. Wang H, etal., Mol Neurobiol. 2013 Feb;47(1):24-36. doi: 10.1007/s12035-012-8357-7. Epub 2012 Oct 21.
30. The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells. Wang H, etal., Psychopharmacology (Berl). 2013 Jul;228(1):129-41. doi: 10.1007/s00213-013-3017-9. Epub 2013 Mar 15.
31. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Westin SN, etal., Mol Oncol. 2015 Oct;9(8):1694-703. doi: 10.1016/j.molonc.2015.04.014. Epub 2015 May 16.
32. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
33. FOXO3a/p27kip1 expression and essential role after acute spinal cord injury in adult rat. Zhang S, etal., J Cell Biochem. 2013 Feb;114(2):354-65. doi: 10.1002/jcb.24371.
34. FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. Zhang S, etal., PLoS One. 2013 Nov 20;8(11):e80342. doi: 10.1371/journal.pone.0080342. eCollection 2013.
Additional References at PubMed
PMID:10102273   PMID:10995739   PMID:11353388   PMID:11875118   PMID:11964479   PMID:12027802   PMID:12048180   PMID:12130673   PMID:12431371   PMID:12855809   PMID:12857750   PMID:12930811  
PMID:12969136   PMID:14565960   PMID:14734530   PMID:14966295   PMID:14978268   PMID:15084260   PMID:15322035   PMID:15383658   PMID:15604409   PMID:15781459   PMID:15905404   PMID:16455781  
PMID:16751106   PMID:16952979   PMID:17079231   PMID:17158337   PMID:17482685   PMID:17521387   PMID:17894357   PMID:18054315   PMID:18054316   PMID:18202312   PMID:18287535   PMID:18458087  
PMID:18465250   PMID:18593906   PMID:18615585   PMID:18644837   PMID:18703049   PMID:18772130   PMID:18787191   PMID:18802749   PMID:18845647   PMID:18959820   PMID:19168439   PMID:19188590  
PMID:19623194   PMID:19696026   PMID:19864323   PMID:19896444   PMID:19933931   PMID:19959771   PMID:20105289   PMID:20211690   PMID:20371612   PMID:20371624   PMID:20404335   PMID:20492357  
PMID:20651833   PMID:20850791   PMID:21162126   PMID:21259047   PMID:21329882   PMID:21443457   PMID:21549807   PMID:21562855   PMID:21887848   PMID:21909393   PMID:22702057   PMID:22761832  
PMID:23151077   PMID:23152492   PMID:23239110   PMID:23283301   PMID:23292098   PMID:23382383   PMID:23640897   PMID:23948278   PMID:24257750   PMID:24260294   PMID:24289330   PMID:24441545  
PMID:24483844   PMID:24567336   PMID:24871856   PMID:24967006   PMID:25057926   PMID:25327288   PMID:25341033   PMID:25402826   PMID:25415049   PMID:25655933   PMID:26086369   PMID:26342801  
PMID:26494002   PMID:26523980   PMID:26546832   PMID:26786260   PMID:27076782   PMID:27129298   PMID:27521792   PMID:27547294   PMID:27686254   PMID:27694219   PMID:27919684   PMID:28006785  
PMID:28078537   PMID:28246104   PMID:28499802   PMID:29030976   PMID:29272015   PMID:29380557   PMID:29445193   PMID:29664021   PMID:30259391   PMID:30323296   PMID:30402830   PMID:30407372  
PMID:30945300   PMID:31543343   PMID:31927057   PMID:32141452   PMID:32169420   PMID:32398139   PMID:32558131   PMID:33061795   PMID:33127810   PMID:33215443   PMID:33463060   PMID:33777313  
PMID:33879840   PMID:34708398   PMID:34998813   PMID:35036441   PMID:35997271   PMID:36156740   PMID:36894806   PMID:36922709   PMID:37018819   PMID:37267686   PMID:37534549   PMID:37585996  


Genomics

Comparative Map Data
Foxo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82047,251,968 - 47,348,254 (-)NCBIGRCr8
mRatBN7.22045,669,708 - 45,764,606 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2045,672,995 - 45,764,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2047,391,080 - 47,482,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02047,041,261 - 47,132,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02047,737,977 - 47,829,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02046,428,078 - 46,519,156 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02048,111,014 - 48,206,518 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,171,784 - 46,262,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12046,194,693 - 46,284,921 (-)NCBI
Celera2054,198,460 - 54,289,566 (+)NCBICelera
Cytogenetic Map20q12-q13NCBI
FOXO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386108,559,825 - 108,684,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6108,559,835 - 108,684,774 (+)EnsemblGRCh38hg38GRCh38
GRCh376108,881,028 - 109,005,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,987,719 - 109,112,664 (+)NCBINCBI36Build 36hg18NCBI36
Build 346108,987,718 - 109,108,647NCBI
Celera6109,627,171 - 109,751,905 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6106,448,666 - 106,573,173 (+)NCBIHuRef
CHM1_16109,143,966 - 109,268,930 (+)NCBICHM1_1
T2T-CHM13v2.06109,737,167 - 109,862,124 (+)NCBIT2T-CHM13v2.0
Foxo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,057,841 - 42,152,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1042,057,837 - 42,152,751 (-)EnsemblGRCm39 Ensembl
GRCm381042,181,845 - 42,276,695 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,181,841 - 42,276,755 (-)EnsemblGRCm38mm10GRCm38
MGSCv371041,905,592 - 41,996,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361041,874,201 - 41,965,157 (-)NCBIMGSCv36mm8
Celera1043,062,294 - 43,153,032 (-)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1022.79NCBI
Foxo3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541133,655,958 - 33,770,829 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541133,655,958 - 33,770,829 (+)NCBIChiLan1.0ChiLan1.0
FOXO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25128,566,148 - 128,691,309 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16126,458,644 - 126,582,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06106,360,519 - 106,485,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16110,406,265 - 110,536,967 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6110,406,266 - 110,516,272 (+)Ensemblpanpan1.1panPan2
FOXO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11265,552,455 - 65,673,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1265,552,310 - 65,670,198 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1265,368,393 - 65,489,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01266,431,072 - 66,552,185 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1266,430,400 - 66,552,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11265,781,942 - 65,903,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01265,630,050 - 65,751,117 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01265,902,223 - 66,023,273 (+)NCBIUU_Cfam_GSD_1.0
Foxo3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946100,513,168 - 100,632,744 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365644,787,992 - 4,903,837 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365644,788,036 - 4,907,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,628,218 - 74,760,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,626,673 - 74,760,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,888,152 - 83,888,769 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2184,047,498 - 84,048,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p13NCBI
FOXO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11365,175,764 - 65,303,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1365,195,376 - 65,301,725 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604037,504,633 - 37,631,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxo3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478013,622,948 - 13,740,374 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,621,733 - 13,740,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxo3
543 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:61
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000000327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat

Markers in Region
BE109870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,740,009 - 45,740,159 (-)MAPPERmRatBN7.2
Rnor_6.02046,452,517 - 46,452,666NCBIRnor6.0
Rnor_5.02048,136,600 - 48,136,749UniSTSRnor5.0
RGSC_v3.42046,237,990 - 46,238,139UniSTSRGSC3.4
Celera2054,222,999 - 54,223,148UniSTS
RH 3.4 Map20487.83UniSTS
Cytogenetic Map20q13UniSTS
BF390390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,673,383 - 45,673,541 (-)MAPPERmRatBN7.2
Rnor_6.02046,519,233 - 46,519,390NCBIRnor6.0
Rnor_5.02048,202,685 - 48,202,842UniSTSRnor5.0
RGSC_v3.42046,171,550 - 46,171,707UniSTSRGSC3.4
Celera2054,289,643 - 54,289,800UniSTS
RH 3.4 Map20487.13UniSTS
Cytogenetic Map20q13UniSTS
Foxo3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22045,686,222 - 45,686,740 (-)MAPPERmRatBN7.2
Rnor_6.02046,506,041 - 46,506,558NCBIRnor6.0
Rnor_5.02048,189,548 - 48,190,065UniSTSRnor5.0
RGSC_v3.42046,184,402 - 46,184,919UniSTSRGSC3.4
Celera2054,276,425 - 54,276,942UniSTS
Cytogenetic Map20q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000000327   ⟹   ENSRNOP00000000327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2045,672,995 - 45,764,561 (-)Ensembl
Rnor_6.0 Ensembl2046,428,124 - 46,519,144 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076818   ⟹   ENSRNOP00000068195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2046,429,222 - 46,505,895 (+)Ensembl
RefSeq Acc Id: NM_001106395   ⟹   NP_001099865
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,255,878 - 47,346,845 (-)NCBI
mRatBN7.22045,673,618 - 45,764,606 (-)NCBI
Rnor_6.02046,428,078 - 46,519,156 (+)NCBI
Rnor_5.02048,111,014 - 48,206,518 (+)NCBI
RGSC_v3.42046,171,784 - 46,262,818 (-)RGD
Celera2054,198,460 - 54,289,566 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098617   ⟹   XP_038954545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82047,251,968 - 47,348,254 (-)NCBI
mRatBN7.22045,669,708 - 45,764,531 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099865 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99711 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000327
  ENSRNOP00000000327.3
RefSeq Acc Id: NP_001099865   ⟸   NM_001106395
- UniProtKB: D3ZBQ1 (UniProtKB/TrEMBL),   A6K6Z2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000327   ⟸   ENSRNOT00000000327
Ensembl Acc Id: ENSRNOP00000068195   ⟸   ENSRNOT00000076818
RefSeq Acc Id: XP_038954545   ⟸   XM_039098617
- Peptide Label: isoform X1
- UniProtKB: D3ZBQ1 (UniProtKB/TrEMBL),   A6K6Z2 (UniProtKB/TrEMBL)
Protein Domains
Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBQ1-F1-model_v2 AlphaFold D3ZBQ1 1-672 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701665
Promoter ID:EPDNEW_R12189
Type:initiation region
Name:Foxo3_1
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12190  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02046,428,125 - 46,428,185EPDNEW
RGD ID:13701669
Promoter ID:EPDNEW_R12190
Type:single initiation site
Name:Foxo3_2
Description:forkhead box O3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12189  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02046,429,184 - 46,429,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309196 AgrOrtholog
BioCyc Gene G2FUF-3361 BioCyc
Ensembl Genes ENSRNOG00000000299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000327 ENTREZGENE
  ENSRNOT00000000327.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.250.1690 UniProtKB/TrEMBL
InterPro FOXO-TAD UniProtKB/TrEMBL
  FOXO_KIX-bd UniProtKB/TrEMBL
  TF_fork_head UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:294515 UniProtKB/TrEMBL
NCBI Gene 294515 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN O UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN O3-RELATED UniProtKB/TrEMBL
Pfam Fork_head UniProtKB/TrEMBL
  FOXO-TAD UniProtKB/TrEMBL
  FOXO_KIX_bdg UniProtKB/TrEMBL
PhenoGen Foxo3 PhenoGen
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000299 RatGTEx
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A6K6Z2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-04 Foxo3  forkhead box O3  Foxo3a  forkhead box O3a   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Foxo3a  forkhead box O3a   Foxo3a_predicted  forkhead box O3a (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Foxo3a_predicted  forkhead box O3a (predicted)  Foxo3_predicted  forkhead box O3 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Foxo3_predicted  forkhead box O3 (predicted)      Symbol and Name status set to approved 70820 APPROVED