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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo3
Name: forkhead box O3
Acc ID: CHEBI:29073
Term: L-ascorbic acid
Definition: The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.
Chemical ID: MESH:D001205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo3affects localizationISOFOXO3 (Homo sapiens)6480464CTDAscorbic Acid affects the localization of FOXO3 proteinPMID:32913121
Foxo3increases expressionISOFOXO3 (Homo sapiens)6480464CTDAscorbic Acid results in increased expression of FOXO3 mRNAPMID:32913121
Foxo3increases expressionISOFoxo3 (Mus musculus)6480464CTDAscorbic Acid results in increased expression of FOXO3 mRNAPMID:32913121
Foxo3multiple interactionsISOFOXO3 (Homo sapiens)6480464CTDAscorbic Acid results in increased expression of and results in decreased phosphorylation of FOXO3 protein; FOXO3 protein affects the reaction [Ascorbic Acid results in decreased expression of PCSK9 protein]; FOXO3 protein affects the reaction [Ascorbic Acid results in increased expression of LDLR protein]PMID:32913121
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