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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo3
Name: forkhead box O3
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo3increases expressionEXP 6480464CTDAcrylamide results in increased expression of FOXO3 mRNA; Acrylamide results in increased expression of FOXO3 proteinPMID:33582169
Foxo3multiple interactionsEXP 6480464CTD[FOXO3 mRNA co-treated with Acrylamide] results in decreased expression of CCND1 protein; [FOXO3 mRNA co-treated with Acrylamide] results in increased expression of CDKN1A protein; [MIR193B mRNA co-treated with Acrylamide] results in decreased expression of FOXO3 protein; FOXO3 protein promotes the reaction [Acrylamide results in decreased expression of CCND1 mRNA]; FOXO3 protein promotes the reaction [Acrylamide results in increased expression of CDKN1A mRNA]; MIR193B mRNA inhibits the reaction [Acrylamide results in increased expression of FOXO3 mRNA]PMID:33582169
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