GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Foxo3 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of FOXO3 mRNA; Doxorubicin results in decreased expression of FOXO3 protein | PMID:34358621 PMID:35987278 | Foxo3 | decreases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in decreased phosphorylation of FOXO3 protein | PMID:23639627 | Foxo3 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein]; Phosphocreatine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein]; Tannic Acid inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 mRNA] | PMID:34358621 PMID:35987278 | Foxo3 | decreases expression | ISO | FOXO3 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of FOXO3 mRNA | PMID:29803840 | Foxo3 | decreases phosphorylation | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased phosphorylation of FOXO3 protein | PMID:36572231 | Foxo3 | increases expression | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of FOXO3 mRNA | PMID:25896364 PMID:28329872 | Foxo3 | increases phosphorylation | ISO | FOXO3 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of FOXO3 protein | PMID:17935137 PMID:25856345 | Foxo3 | increases response to substance | ISO | FOXO3 (Homo sapiens) | 6480464 | CTD | FOXO3 protein results in increased susceptibility to Doxorubicin | PMID:19211844 | Foxo3 | multiple interactions | ISO | FOXO3 (Homo sapiens) | 6480464 | CTD | [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Doxorubicin; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Doxorubicin]; wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein] | PMID:17935137 PMID:19211844 | Foxo3 | multiple interactions | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Gallic Acid inhibits the reaction [Doxorubicin results in decreased phosphorylation of FOXO3 protein] | PMID:36572231 | | ||||||||||||||||||||||
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