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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxo3
Name: forkhead box O3
Acc ID: CHEBI:65819
Term: eckol
Definition: A phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity.
Chemical ID: MESH:C060311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxo3increases phosphorylationISOFOXO3 (Homo sapiens)6480464CTDeckol results in increased phosphorylation of FOXO3 proteinPMID:24700636
Foxo3multiple interactionsISOFOXO3 (Homo sapiens)6480464CTDFOXO3 mutant form inhibits the reaction [eckol results in increased expression of SOD2 protein]PMID:24700636
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