GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Foxo3 | increases phosphorylation | EXP | | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of FOXO3 protein | PMID:28983604 | Foxo3 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Oxygen] affects the localization of and results in decreased phosphorylation of FOXO3 protein; sanggenone C inhibits the reaction [Oxygen deficiency results in increased phosphorylation of FOXO3 protein] | PMID:21159781 PMID:28983604 | Foxo3 | increases expression | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of FOXO3 mRNA | PMID:22629407 | Foxo3 | multiple interactions | ISO | FOXO3 (Homo sapiens) | 6480464 | CTD | [Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein; icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]; Niacinamide promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]; resveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein]; SIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein] | PMID:25472572 | Foxo3 | multiple interactions | ISO | Foxo3 (Mus musculus) | 6480464 | CTD | Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of FOXO3 mRNA] | PMID:22629407 | | ||||||||||||||||||||||
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