Iddm37 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm37 (Insulin dependent diabetes mellitus QTL 37) Rattus norvegicus

Symbol: Iddm37
Name: Insulin dependent diabetes mellitus QTL 37
RGD ID: 2305926
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: plasma glucose level   (CMO:0000042)    
LOD Score: 6.0
P Value: Not Available
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8201,533,083 - 46,533,083RGD_MAPPER_PIPELINE
mRatBN7.2201,527,842 - 46,527,842RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0202,018,654 - 47,018,654RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0204,059,279 - 49,059,279RGDRnor5.0
RGSC_v3.4201,616,332 - 46,616,332RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: LEW.1WR1/WorBrm WF.ART2/Wor 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Ubd is a candidate Gene for Iddm37


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37Rattype 1 diabetes mellitus  IAGP 2313174 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37Ratinsulitis  IDA 2313174 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37Ratplasma glucose level  IDA 2313174 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37RatKilham rat virus  IDA 2313174 RGD 
Iddm37Ratpoly I:C  IDA 2313174 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37Ratblood glucose test strip read by electrochemical glucometer  IDA 2313174 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37RatLEW.1WR1/WorBrm  IEA 2313174 RGD 
Iddm37RatWF.ART2/Wor  IEA 2313174 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm37Ratblood glucose amount  IDA 2313174 RGD 


#
Reference Title
Reference Citation
1. VIRUS-INDUCED AUTOIMMUNE DIABETES IN THE LEW.1WR1 RAT REQUIRES Iddm14 AND A GENETIC LOCUS PROXIMAL TO THE MAJOR HISTOCOMPATIBILITY COMPLEX. Blankenhorn EP, etal., Diabetes. 2009 Aug 31.
2. QTL registered by Dr. Blankenhorn Personal communication between Dr. Elizabeth P. Blankenhorn and the RGD curators.

Related QTL Description Reference
Iddm14 interacts with RGD:2313174



1 to 20 of 1051 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1302981Zfp57zinc finger protein 572015213231534884Rat
1595816RT1-M5RT1 class Ib, locus M52015464961548948Rat
1562593RT1-M4RT1 class Ib, locus M42015520721555823Rat
1597084Rps15-ps1ribosomal protein S15, pseudogene 12015645011564989Rat
1598232RT1-M6-1RT1 class I, locus M6, gene 12015662201569151Rat
1564067Znrd1as1ZNRD1 antisense RNA 12015681051595084Rat
1595815RT1-M6-2RT1 class I, locus M6, gene 22015832671587099Rat
1303114Polr1hRNA polymerase I subunit H2015949361598854Rat
1303163Ppp1r11protein phosphatase 1, regulatory (inhibitor) subunit 112016013501604857Rat
628854Rnf39ring finger protein 392016047941610283Rat
7513962LOC102554813uncharacterized LOC1025548132016156941622041Rat
1308607Trim31tripartite motif-containing 312016531651666494Rat
1359645Trim40tripartite motif-containing 402016761141685906Rat
1597065Ppp1cb-ps1protein phosphatase 1, catalytic subunit, beta isoform, pseudogene 12016776631678586Rat
1597066Rpl39-ps1ribosomal protein 39 pseudogene 12016880771688661Rat
1597067Pbp-psPbp pseudogene2016889191689377Rat
1359438Trim10tripartite motif-containing 102016895541698948Rat
6496746Trim15tripartite motif containing 152017009051710249Rat
1597068Trim15-ps1tripartite motif-containing 15, pseudogene 12017014311704183Rat
1359126Trim26tripartite motif-containing 262017082971731176Rat

1 to 20 of 1051 rows
1 to 20 of 1100 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10654D20Wox72692090086529008921Ratregion
11106D20Arb6309203706125337061562Ratregion
11206D20Arb21642026463952646556Ratregion
11206D20Arb21642026664952666654Ratregion
11207D20Wox52592026588952659158Ratregion
11208D20Mgh32462034177563417890Ratregion
11208D20Mgh32462035168013516931Ratregion
11209D20Wox42412034177613417890Ratregion
11209D20Wox42412035168063516931Ratregion
34260D20Mgh51062090397199039825Ratregion
34280D20Mgh41102066915966691706Ratregion
34349D20Mgh61342015826631582799Ratregion
34749D20UW11422036216493621791Ratregion
34749D20UW11422036216493621791Ratregion
11428D20Wox31152036216563621771Ratregion
11428D20Wox31152036216563621771Ratregion
33563D20Mit5247201748945817489705Ratregion
35993D20Rat11127203723675537236906Ratregion
35993D20Rat11127203773437637734527Ratregion
36382D20Mgh7146201078849410788640Ratregion
1 to 20 of 1100 rows

Flank 1: (D20Rat47)
Rat AssemblyChrPosition (strand)Source
GRCr8201,533,083 - 1,533,200 (+)Marker Load Pipeline
mRatBN7.2201,527,842 - 1,527,959 (+)MAPPER
Rnor_6.0202,018,654 - 2,018,770NCBI
Rnor_5.0204,059,279 - 4,059,395UniSTS
RGSC_v3.4201,616,332 - 1,616,449RGD
RGSC_v3.4201,616,333 - 1,616,449UniSTS
RGSC_v3.1201,616,333 - 1,616,449RGD
Celera202,236,388 - 2,236,504UniSTS
RH 3.4 Map2015.8UniSTS
RH 3.4 Map2015.8RGD
RH 2.0 Map200.0RGD
SHRSP x BN Map200.0RGD
Cytogenetic Map20p12UniSTS


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat

1 to 10 of 46 rows


Note Type Note Reference
qtl_general measurement method: diabetes was induced by KRV; animals screened 3 times a week for glycosuria (diagnosed on the basis of plasma glucose concentrations >250 mg/dL); pancreata was taken out and fixed in 10% formalin and scored for insulitis 2313174
qtl_general inducing agent: Kilham rat virus; poly I:C was injected to 20-25 days old rats on -3, -2 and -1 days and then with KRV(107 plague forming units) on day 0 2313174
qtl_general number of animals used: 182 (LEW.1WR1/WorBrm x WF.ART2/Wor)F2 rats 2313174