Sik1 (salt-inducible kinase 1) - Rat Genome Database

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Gene: Sik1 (salt-inducible kinase 1) Rattus norvegicus
Analyze
Symbol: Sik1
Name: salt-inducible kinase 1
RGD ID: 69407
Description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of sodium ion transport. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protein kinase KID2; salt-inducible protein kinase; salt-inducible protein kinase 1; serine/threonine-protein kinase SIK1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK; Sik; SIK-1; SNF1-like kinase; Snf1lk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2209,949,407 - 9,959,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,947,396 - 9,958,991 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,650,232 - 10,659,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,011,124 - 10,020,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,478,619 - 10,488,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,670,747 - 10,680,279 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,668,411 - 10,680,283 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,845,508 - 12,855,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,282,203 - 10,291,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,280,420 - 10,292,014 (-)NCBI
Celera2011,458,458 - 11,467,962 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,6-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
astemizole  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (EXP)
chromium atom  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP,ISO)
fenoterol  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP,ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
mabuterol  (ISO)
melphalan  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of the nuclear localization domain of salt-inducible kinase. Katoh Y, etal., Endocr Res 2002 Nov;28(4):315-8.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Sjostrom M, etal., Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16922-7. Epub 2007 Oct 15.
6. Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal. Wang Z, etal., FEBS Lett 1999 Jun 18;453(1-2):135-9.
Additional References at PubMed
PMID:12200423   PMID:12624099   PMID:14976552   PMID:15134808   PMID:15177563   PMID:15511237   PMID:16148943   PMID:16306228   PMID:16817901   PMID:17468767   PMID:18348280   PMID:19103603  
PMID:19244231   PMID:19470703   PMID:19622832   PMID:19657284   PMID:20140255   PMID:21549091   PMID:21954104   PMID:22109884   PMID:23349925   PMID:23993098   PMID:25384047   PMID:25918234  
PMID:26210066   PMID:26567857   PMID:31233505   PMID:32106109  


Genomics

Comparative Map Data
Sik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2209,949,407 - 9,959,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,947,396 - 9,958,991 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,650,232 - 10,659,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,011,124 - 10,020,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,478,619 - 10,488,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,670,747 - 10,680,279 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,668,411 - 10,680,283 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,845,508 - 12,855,040 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,282,203 - 10,291,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,280,420 - 10,292,014 (-)NCBI
Celera2011,458,458 - 11,467,962 (-)NCBICelera
Cytogenetic Map20p12NCBI
SIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,414,483 - 43,427,131 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,414,483 - 43,427,131 (-)EnsemblGRCh38hg38GRCh38
GRCh372144,834,363 - 44,847,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,658,823 - 43,671,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 342143,658,826 - 43,671,436NCBI
Celera2129,940,650 - 29,953,256 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,202,979 - 30,223,345 (-)NCBIHuRef
CHM1_12144,394,974 - 44,407,557 (-)NCBICHM1_1
T2T-CHM13v2.02141,769,738 - 41,782,385 (-)NCBIT2T-CHM13v2.0
Sik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,063,222 - 32,074,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,063,224 - 32,074,778 (-)EnsemblGRCm39 Ensembl
GRCm381731,844,248 - 31,855,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,844,250 - 31,855,804 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,981,195 - 31,992,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,572,967 - 31,584,494 (-)NCBIMGSCv36mm8
Celera1732,760,486 - 32,771,258 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.25NCBI
Sik1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540738,739,062 - 38,749,758 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540738,739,062 - 38,749,293 (+)NCBIChiLan1.0ChiLan1.0
SIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12134,278,914 - 34,290,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02129,675,040 - 29,689,408 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12142,975,914 - 42,987,948 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2142,975,920 - 42,987,948 (-)Ensemblpanpan1.1panPan2
SIK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13137,455,130 - 37,466,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3136,610,274 - 36,622,021 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,998,123 - 37,010,456 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,998,129 - 37,008,807 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,867,482 - 36,879,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,852,129 - 36,863,810 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,344,622 - 37,356,464 (-)NCBIUU_Cfam_GSD_1.0
Sik1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,683,495 - 36,693,046 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500774,092 - 784,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500774,749 - 784,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,454,718 - 206,465,807 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,454,695 - 206,465,802 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,759,862 - 216,764,885 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103219558
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,204,386 - 87,217,044 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,204,357 - 87,216,180 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605415,257,361 - 15,270,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sik1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474527,528,929 - 27,539,552 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474527,529,037 - 27,539,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sik1
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:27
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000001579
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
RH134693  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,947,586 - 9,947,792 (+)MAPPERmRatBN7.2
Rnor_6.02010,668,929 - 10,669,134NCBIRnor6.0
Rnor_5.02012,843,690 - 12,843,895UniSTSRnor5.0
RGSC_v3.42010,280,385 - 10,280,590UniSTSRGSC3.4
Celera2011,456,771 - 11,456,976UniSTS
RH 3.4 Map20137.1UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 24 23 11 19 11 45 27 33 11
Low 2 19 34 30 30 8 11 29 8 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001579   ⟹   ENSRNOP00000001579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,947,396 - 9,958,991 (-)Ensembl
Rnor_6.0 Ensembl2010,668,411 - 10,680,283 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103104   ⟹   ENSRNOP00000092362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,947,396 - 9,958,991 (-)Ensembl
RefSeq Acc Id: NM_021693   ⟹   NP_067725
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2209,949,407 - 9,958,939 (-)NCBI
Rnor_6.02010,670,747 - 10,680,279 (-)NCBI
Rnor_5.02012,845,508 - 12,855,040 (-)NCBI
RGSC_v3.42010,282,203 - 10,291,735 (-)RGD
Celera2011,458,458 - 11,467,962 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099047   ⟹   XP_038954975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2209,949,415 - 9,959,036 (-)NCBI
RefSeq Acc Id: XM_039099048   ⟹   XP_038954976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2209,949,415 - 9,959,036 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067725   ⟸   NM_021693
- UniProtKB: Q9R081 (UniProtKB/Swiss-Prot),   Q9R1U5 (UniProtKB/Swiss-Prot),   A6JK13 (UniProtKB/TrEMBL),   A0A8I6AVK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001579   ⟸   ENSRNOT00000001579
RefSeq Acc Id: XP_038954976   ⟸   XM_039099048
- Peptide Label: isoform X1
- UniProtKB: Q9R1U5 (UniProtKB/Swiss-Prot),   Q9R081 (UniProtKB/Swiss-Prot),   A6JK13 (UniProtKB/TrEMBL),   A0A8I6AVK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954975   ⟸   XM_039099047
- Peptide Label: isoform X1
- UniProtKB: Q9R1U5 (UniProtKB/Swiss-Prot),   Q9R081 (UniProtKB/Swiss-Prot),   A6JK13 (UniProtKB/TrEMBL),   A0A8I6AVK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092362   ⟸   ENSRNOT00000103104
Protein Domains
Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1U5-F1-model_v2 AlphaFold Q9R1U5 1-776 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701481
Promoter ID:EPDNEW_R12004
Type:initiation region
Name:Sik1_1
Description:salt-inducible kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,680,348 - 10,680,408EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69407 AgrOrtholog
BioCyc Gene G2FUF-4301 BioCyc
Ensembl Genes ENSRNOG00000001189 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001579 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103104.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_SIK1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59329 UniProtKB/Swiss-Prot
NCBI Gene 59329 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sik1 PhenoGen
PIRSF Ser/Thr_PK_SNF1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001189 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AVK6 ENTREZGENE, UniProtKB/TrEMBL
  A6JK13 ENTREZGENE, UniProtKB/TrEMBL
  Q9R081 ENTREZGENE
  Q9R1U5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9R081 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Sik1  salt-inducible kinase 1  Snf1lk  SNF1-like kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Snf1lk  SNF1-like kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference