Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) - Rat Genome Database
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Gene: Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) Rattus norvegicus
Analyze
Symbol: Itpr3
Name: inositol 1,4,5-trisphosphate receptor, type 3
RGD ID: 2934
Description: Exhibits several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Localizes to several cellular components, including brush border; neuronal cell body; and nuclear outer membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; Adenophostin A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inositol 1, 4, 5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; IP3R 3; IP3R-3; IP3R3; IP3R3X; type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
Orthologs:
Homo sapiens (human) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)  HGNC  Alliance
Mus musculus (house mouse) : Itpr3 (inositol 1,4,5-triphosphate receptor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Canis lupus familiaris (dog) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Sus scrofa (pig) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Chlorocebus sabaeus (African green monkey) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Heterocephalus glaber (naked mole-rat) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
Adenophostin A  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (EXP)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
monosodium L-glutamate  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Blondel O, etal., J Biol Chem 1993 May 25;268(15):11356-63.
2. Caron AZ, etal., Cell Calcium. 2007 Sep;42(3):323-31. Epub 2007 Feb 23.
3. Chaloux B, etal., Biol Cell. 2007 Jul;99(7):379-88.
4. Ferreri-Jacobia M, etal., J Biol Chem. 2005 Feb 4;280(5):3824-31. Epub 2004 Nov 10.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hirata K, etal., Hepatology 2002 Aug;36(2):284-96.
8. Lee B, etal., Endocrinology 2001 May;142(5):1744-51.
9. Lee B, etal., J Mol Endocrinol 1998 Aug;21(1):31-9.
10. Mak DO, etal., J Gen Physiol. 2000 Mar;115(3):241-56.
11. Maranto AR J Biol Chem. 1994 Jan 14;269(2):1222-30.
12. MGD data from the GO Consortium
13. Murthy KS and Zhou H, Am J Physiol Gastrointest Liver Physiol 2003 Feb;284(2):G221-30.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Nerou EP, etal., Biochem J 2001 Apr 1;355(Pt 1):59-69.
16. Nicolay NH, etal., J Neurosci Res. 2007 Jul;85(9):2026-36.
17. OMIM Disease Annotation Pipeline
18. Pantazaka E and Taylor CW, J Biol Chem. 2011 Jul 1;286(26):23378-87. doi: 10.1074/jbc.M111.236372. Epub 2011 May 5.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. RGD automated data pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
24. Schulman JJ, etal., J Biol Chem. 2013 Aug 30;288(35):25340-9. doi: 10.1074/jbc.M113.496570. Epub 2013 Jul 24.
25. Sharp AH, etal., J Comp Neurol. 1999 Apr 5;406(2):207-20.
26. Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
27. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Toews JC, etal., Glia. 2007 Jan 15;55(2):202-13.
29. Tovey SC, etal., J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26.
30. Tu H, etal., Biophys J. 2005 Feb;88(2):1046-55. Epub 2004 Nov 8.
31. Vanderheyden V, etal., Biochim Biophys Acta. 2009 Jun;1793(6):959-70. doi: 10.1016/j.bbamcr.2008.12.003. Epub 2008 Dec 16.
32. Vazquez G, etal., EMBO J 2002 Sep 2;21(17):4531-8.
33. Vermassen E, etal., J Cell Sci. 2003 Apr 1;116(Pt 7):1269-77.
34. Zanner R, etal., Am J Physiol Cell Physiol 2002 Feb;282(2):C374-82.
Additional References at PubMed
PMID:9139693   PMID:10191279   PMID:10828023   PMID:11149946   PMID:11285228   PMID:11875073   PMID:11939501   PMID:12088506   PMID:14681927   PMID:14983008   PMID:14983009   PMID:15175012  
PMID:15184066   PMID:15890645   PMID:16014380   PMID:16107208   PMID:16122796   PMID:16840702   PMID:17257671   PMID:17327232   PMID:17636122   PMID:17916355   PMID:17925404   PMID:18417102  
PMID:18434513   PMID:18535093   PMID:19052258   PMID:19217932   PMID:19348050   PMID:19429061   PMID:19946888   PMID:20463231   PMID:20643058   PMID:20813840   PMID:21030605   PMID:21062895  
PMID:21071436   PMID:21302308   PMID:21700703   PMID:22878752   PMID:23137780   PMID:23382219   PMID:24469450   PMID:25242084   PMID:25482245   PMID:29476059  


Genomics

Comparative Map Data
Itpr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
ITPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl633,620,365 - 33,696,574 (+)EnsemblGRCh38hg38GRCh38
GRCh38633,621,322 - 33,696,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,587,951 - 33,664,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,697,139 - 33,772,329 (+)NCBINCBI36hg18NCBI36
Build 34633,697,321 - 33,772,317NCBI
Celera635,143,559 - 35,218,741 (+)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,330,927 - 33,406,007 (+)NCBIHuRef
CHM1_1633,591,516 - 33,666,641 (+)NCBICHM1_1
Itpr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,275,976 - 27,341,197 (+)NCBI
GRCm381727,057,002 - 27,122,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,057,304 - 27,122,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,194,249 - 27,259,168 (+)NCBIGRCm37mm9NCBIm37
MGSCv361726,785,125 - 26,849,812 (+)NCBImm8
Celera1727,593,736 - 27,658,505 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.68NCBI
Itpr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,055,805 - 2,106,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,055,782 - 2,106,709 (+)NCBIChiLan1.0ChiLan1.0
ITPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1634,303,454 - 34,378,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,303,454 - 34,378,215 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0633,194,531 - 33,269,788 (+)NCBIMhudiblu_PPA_v0panPan3
ITPR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl122,805,187 - 3,048,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1122,970,613 - 3,050,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Itpr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647625,254,937 - 25,318,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,835,898 - 29,902,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,835,922 - 29,901,305 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,443,858 - 34,509,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1738,381,743 - 38,456,499 (-)Ensembl
ChlSab1.11738,381,862 - 38,456,505 (-)NCBI
Itpr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475423,228,690 - 23,281,552 (-)NCBI

Position Markers
RH129560  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0205,711,437 - 5,711,625NCBIRnor6.0
Rnor_5.0207,775,092 - 7,775,280UniSTSRnor5.0
RGSC_v3.4205,357,237 - 5,357,425UniSTSRGSC3.4
Celera206,781,510 - 6,781,698UniSTS
Cytogenetic Map20p12UniSTS
RH 3.4 Map2056.24UniSTS
RH129567  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0205,711,363 - 5,711,574NCBIRnor6.0
Rnor_5.0207,775,018 - 7,775,229UniSTSRnor5.0
RGSC_v3.4205,357,163 - 5,357,374UniSTSRGSC3.4
Celera206,781,436 - 6,781,647UniSTS
Cytogenetic Map20p12UniSTS
RH 3.4 Map2056.24UniSTS
PMC275467P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0205,710,557 - 5,711,035NCBIRnor6.0
Rnor_5.0207,774,212 - 7,774,690UniSTSRnor5.0
RGSC_v3.4205,356,357 - 5,356,835UniSTSRGSC3.4
Celera206,780,630 - 6,781,108UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2020187706567419Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2040391135875448Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2048554689899946Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)20485546810800530Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000011516
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 7 24 30 5
Low 43 47 32 12 32 8 11 74 11 11 6 8
Below cutoff 9 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01099683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01099694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ233031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000090925   ⟹   ENSRNOP00000075066
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)Ensembl
RefSeq Acc Id: NM_013138   ⟹   NP_037270
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,646,097 - 5,711,702 (+)NCBI
Rnor_5.0207,711,508 - 7,775,357 (+)NCBI
RGSC_v3.4205,292,430 - 5,357,502 (+)RGD
Celera206,717,488 - 6,781,775 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772710   ⟹   XP_008770932
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,645,894 - 5,711,702 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037270   ⟸   NM_013138
- UniProtKB: Q63269 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008770932   ⟸   XM_008772710
- Peptide Label: isoform X1
- UniProtKB: C7E1V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075066   ⟸   ENSRNOT00000090925
Protein Domains
MIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2934 AgrOrtholog
Ensembl Genes ENSRNOG00000052795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075066 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090925 ENTREZGENE, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25679 UniProtKB/Swiss-Prot
NCBI Gene 25679 ENTREZGENE
PANTHER PTHR45816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itpr3 PhenoGen
PRINTS INSP3RECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218650
UniGene Rn.11242 ENTREZGENE
UniProt C7E1V1 ENTREZGENE, UniProtKB/TrEMBL
  ITPR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpr3  inositol 1,4,5-trisphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itpr3  inositol 1, 4, 5-triphosphate receptor 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 729040
gene_function ligand activated calcium ion selective channel 68695
gene_function ligand activated calcium ion selective channel 69501
gene_physical_interaction binds inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate 729040
gene_process responsible for initiating and propagating cytosolic Ca++ signals evoked by receptors linked to IP3 formation 68695