Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) - Rat Genome Database

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Gene: Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) Rattus norvegicus
Symbol: Itpr3
Name: inositol 1,4,5-trisphosphate receptor, type 3
RGD ID: 2934
Description: Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including apical plasma membrane; brush border; and nuclear outer membrane. Is active in endoplasmic reticulum membrane and presynapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol 1, 4, 5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; IP3R 3; IP3R-3; IP3R3; IP3R3X; type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2205,136,968 - 5,202,339 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,862,755 - 5,927,561 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,224,499 - 5,289,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,702,534 - 5,768,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
Adenophostin A  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium oxalate  (EXP)
calcium(0)  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-aspartic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
galactose  (EXP)
genistein  (EXP)
glyoxylic acid  (EXP)
glyphosate  (ISO)
halothane  (ISO)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
melatonin  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. Blondel O, etal., J Biol Chem 1993 May 25;268(15):11356-63.
2. Protein kinase C decreases the apparent affinity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells. Caron AZ, etal., Cell Calcium. 2007 Sep;42(3):323-31. Epub 2007 Feb 23.
3. Protein kinase A increases the binding affinity and the Ca2+ release activity of the inositol 1,4,5-trisphosphate receptor type 3 in RINm5F cells. Chaloux B, etal., Biol Cell. 2007 Jul;99(7):379-88.
4. Translational mobility of the type 3 inositol 1,4,5-trisphosphate receptor Ca2+ release channel in endoplasmic reticulum membrane. Ferreri-Jacobia M, etal., J Biol Chem. 2005 Feb 4;280(5):3824-31. Epub 2004 Nov 10.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hirata K, etal., Hepatology 2002 Aug;36(2):284-96.
8. Proteasomal activation mediates down-regulation of inositol 1,4,5-trisphosphate receptor and calcium mobilization in rat pancreatic islets. Lee B, etal., Endocrinology 2001 May;142(5):1744-51.
9. Characterization of inositol 1,4,5-trisphosphate receptor isoform mRNA expression and regulation in rat pancreatic islets, RINm5F cells and betaHC9 cells. Lee B, etal., J Mol Endocrinol 1998 Aug;21(1):31-9.
10. Single-channel properties in endoplasmic reticulum membrane of recombinant type 3 inositol trisphosphate receptor. Mak DO, etal., J Gen Physiol. 2000 Mar;115(3):241-56.
11. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. Maranto AR J Biol Chem. 1994 Jan 14;269(2):1222-30.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle. Murthy KS and Zhou H, Am J Physiol Gastrointest Liver Physiol 2003 Feb;284(2):G221-30.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor. Nerou EP, etal., Biochem J 2001 Apr 1;355(Pt 1):59-69.
16. Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Nicolay NH, etal., J Neurosci Res. 2007 Jul;85(9):2026-36.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptor. Pantazaka E and Taylor CW, J Biol Chem. 2011 Jul 1;286(26):23378-87. doi: 10.1074/jbc.M111.236372. Epub 2011 May 5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Characterization of ryanodine receptors in rat colonic epithelium. Prinz G and Diener M, Acta Physiol (Oxf). 2008 Jun;193(2):151-62. doi: 10.1111/j.1748-1716.2007.01802.x. Epub 2007 Nov 15.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
25. The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. Schulman JJ, etal., J Biol Chem. 2013 Aug 30;288(35):25340-9. doi: 10.1074/jbc.M113.496570. Epub 2013 Jul 24.
26. Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain. Sharp AH, etal., J Comp Neurol. 1999 Apr 5;406(2):207-20.
27. Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B. Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Signaling proteins in the axoglial apparatus of sciatic nerve nodes of Ranvier. Toews JC, etal., Glia. 2007 Jan 15;55(2):202-13.
30. Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. Tovey SC, etal., J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26.
31. Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Tu H, etal., Biophys J. 2005 Feb;88(2):1046-55. Epub 2004 Nov 8.
32. Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Vanderheyden V, etal., Biochim Biophys Acta. 2009 Jun;1793(6):959-70. doi: 10.1016/j.bbamcr.2008.12.003. Epub 2008 Dec 16.
33. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
34. An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes. Vazquez G, etal., EMBO J 2002 Sep 2;21(17):4531-8.
35. Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells. Vermassen E, etal., J Cell Sci. 2003 Apr 1;116(Pt 7):1269-77.
36. Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells. Zanner R, etal., Am J Physiol Cell Physiol 2002 Feb;282(2):C374-82.
Additional References at PubMed
PMID:9139693   PMID:10191279   PMID:10828023   PMID:11149946   PMID:11285228   PMID:11875073   PMID:11939501   PMID:12088506   PMID:14681927   PMID:14983008   PMID:14983009   PMID:15175012  
PMID:15184066   PMID:15890645   PMID:16014380   PMID:16107208   PMID:16122796   PMID:16840702   PMID:17257671   PMID:17327232   PMID:17636122   PMID:17916355   PMID:17925404   PMID:18417102  
PMID:18434513   PMID:18535093   PMID:19052258   PMID:19217932   PMID:19348050   PMID:19429061   PMID:19946888   PMID:20463231   PMID:20643058   PMID:20813840   PMID:21030605   PMID:21062895  
PMID:21071436   PMID:21302308   PMID:21700703   PMID:22878752   PMID:23137780   PMID:23382219   PMID:24469450   PMID:25242084   PMID:25482245   PMID:29476059  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2205,136,968 - 5,202,339 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,862,755 - 5,927,561 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,224,499 - 5,289,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,702,534 - 5,768,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38633,621,322 - 33,696,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,620,365 - 33,696,574 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,589,099 - 33,664,339 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,697,139 - 33,772,329 (+)NCBINCBI36Build 36hg18NCBI36
Build 34633,697,321 - 33,772,317NCBI
Celera635,143,559 - 35,218,741 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,330,927 - 33,406,007 (+)NCBIHuRef
CHM1_1633,591,516 - 33,666,641 (+)NCBICHM1_1
T2T-CHM13v2.0633,442,464 - 33,517,747 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391727,275,976 - 27,341,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,276,278 - 27,341,197 (+)EnsemblGRCm39 Ensembl
GRCm381727,057,002 - 27,122,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,057,304 - 27,122,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,194,249 - 27,259,168 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,785,125 - 26,849,812 (+)NCBIMGSCv36mm8
Celera1727,593,736 - 27,658,505 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.68NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554372,055,805 - 2,106,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,055,782 - 2,106,709 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1643,967,322 - 44,042,624 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,194,531 - 33,269,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,303,454 - 34,378,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,303,454 - 34,378,215 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1122,970,613 - 3,050,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,805,187 - 3,048,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,997,254 - 3,066,455 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,313,122 - 3,382,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,313,138 - 3,381,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,980,128 - 3,049,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,061,183 - 3,130,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,159,323 - 3,228,541 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494638,641,843 - 38,705,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,254,932 - 25,318,491 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,254,937 - 25,318,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl729,835,922 - 29,901,309 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,835,922 - 29,901,305 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,443,858 - 34,509,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11738,381,862 - 38,456,505 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,381,743 - 38,456,499 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,459,448 - 33,535,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475423,229,281 - 23,281,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,228,690 - 23,281,552 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Itpr3
831 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:59
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,202,073 - 5,202,262 (+)MAPPERmRatBN7.2
Rnor_6.0205,711,437 - 5,711,625NCBIRnor6.0
Rnor_5.0207,775,092 - 7,775,280UniSTSRnor5.0
RGSC_v3.4205,357,237 - 5,357,425UniSTSRGSC3.4
Celera206,781,510 - 6,781,698UniSTS
RH 3.4 Map2056.24UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,201,999 - 5,202,211 (+)MAPPERmRatBN7.2
Rnor_6.0205,711,363 - 5,711,574NCBIRnor6.0
Rnor_5.0207,775,018 - 7,775,229UniSTSRnor5.0
RGSC_v3.4205,357,163 - 5,357,374UniSTSRGSC3.4
Celera206,781,436 - 6,781,647UniSTS
RH 3.4 Map2056.24UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,201,193 - 5,201,672 (+)MAPPERmRatBN7.2
Rnor_6.0205,710,557 - 5,711,035NCBIRnor6.0
Rnor_5.0207,774,212 - 7,774,690UniSTSRnor5.0
RGSC_v3.4205,356,357 - 5,356,835UniSTSRGSC3.4
Celera206,780,630 - 6,781,108UniSTS
Cytogenetic Map20p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 1 7 24 30 5
Low 43 47 32 12 32 8 11 74 11 11 6 8
Below cutoff 9 9 9


RefSeq Acc Id: ENSRNOT00000090925   ⟹   ENSRNOP00000075066
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)Ensembl
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)Ensembl
RefSeq Acc Id: NM_013138   ⟹   NP_037270
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2205,136,968 - 5,202,339 (+)NCBI
Rnor_6.0205,646,097 - 5,711,702 (+)NCBI
Rnor_5.0207,711,508 - 7,775,357 (+)NCBI
RGSC_v3.4205,292,430 - 5,357,502 (+)RGD
Celera206,717,488 - 6,781,775 (+)RGD
Protein Sequences
Protein RefSeqs NP_037270 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41446 (Get FASTA)   NCBI Sequence Viewer  
  ACT21452 (Get FASTA)   NCBI Sequence Viewer  
  EDL96876 (Get FASTA)   NCBI Sequence Viewer  
  EDL96877 (Get FASTA)   NCBI Sequence Viewer  
  EDL96878 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075066
GenBank Protein Q63269 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037270   ⟸   NM_013138
- UniProtKB: Q63269 (UniProtKB/Swiss-Prot),   C7E1V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075066   ⟸   ENSRNOT00000090925
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63269-F1-model_v2 AlphaFold Q63269 1-2670 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2934 AgrOrtholog
BioCyc Gene G2FUF-4496 BioCyc
Ensembl Genes ENSRNOG00000052795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090925 ENTREZGENE
  ENSRNOT00000090925.3 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25679 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itpr3 PhenoGen
PROSITE MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052795 RatGTEx
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218650
UniProt A0A0G2K9N6_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpr3  inositol 1,4,5-trisphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itpr3  inositol 1, 4, 5-triphosphate receptor 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 729040
gene_function ligand activated calcium ion selective channel 68695
gene_function ligand activated calcium ion selective channel 69501
gene_physical_interaction binds inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate 729040
gene_process responsible for initiating and propagating cytosolic Ca++ signals evoked by receptors linked to IP3 formation 68695