Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) - Rat Genome Database

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Gene: Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3) Rattus norvegicus
Analyze
Symbol: Itpr3
Name: inositol 1,4,5-trisphosphate receptor, type 3
RGD ID: 2934
Description: Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including brush border; neuronal cell body; and nuclear outer membrane. Is active in presynapse. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol 1, 4, 5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; IP3R 3; IP3R-3; IP3R3; IP3R3X; type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2205,136,968 - 5,202,339 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)Ensembl
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
Adenophostin A  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-aspartic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
galactose  (EXP)
genistein  (EXP)
glyphosate  (ISO)
halothane  (ISO)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
melatonin  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Blondel O, etal., J Biol Chem 1993 May 25;268(15):11356-63.
2. Caron AZ, etal., Cell Calcium. 2007 Sep;42(3):323-31. Epub 2007 Feb 23.
3. Chaloux B, etal., Biol Cell. 2007 Jul;99(7):379-88.
4. Ferreri-Jacobia M, etal., J Biol Chem. 2005 Feb 4;280(5):3824-31. Epub 2004 Nov 10.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hirata K, etal., Hepatology 2002 Aug;36(2):284-96.
8. Lee B, etal., Endocrinology 2001 May;142(5):1744-51.
9. Lee B, etal., J Mol Endocrinol 1998 Aug;21(1):31-9.
10. Mak DO, etal., J Gen Physiol. 2000 Mar;115(3):241-56.
11. Maranto AR J Biol Chem. 1994 Jan 14;269(2):1222-30.
12. MGD data from the GO Consortium
13. Murthy KS and Zhou H, Am J Physiol Gastrointest Liver Physiol 2003 Feb;284(2):G221-30.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Nerou EP, etal., Biochem J 2001 Apr 1;355(Pt 1):59-69.
16. Nicolay NH, etal., J Neurosci Res. 2007 Jul;85(9):2026-36.
17. OMIM Disease Annotation Pipeline
18. Pantazaka E and Taylor CW, J Biol Chem. 2011 Jul 1;286(26):23378-87. doi: 10.1074/jbc.M111.236372. Epub 2011 May 5.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. RGD automated data pipeline
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
24. Schulman JJ, etal., J Biol Chem. 2013 Aug 30;288(35):25340-9. doi: 10.1074/jbc.M113.496570. Epub 2013 Jul 24.
25. Sharp AH, etal., J Comp Neurol. 1999 Apr 5;406(2):207-20.
26. Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
27. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Toews JC, etal., Glia. 2007 Jan 15;55(2):202-13.
29. Tovey SC, etal., J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26.
30. Tu H, etal., Biophys J. 2005 Feb;88(2):1046-55. Epub 2004 Nov 8.
31. Vanderheyden V, etal., Biochim Biophys Acta. 2009 Jun;1793(6):959-70. doi: 10.1016/j.bbamcr.2008.12.003. Epub 2008 Dec 16.
32. Vazquez G, etal., EMBO J 2002 Sep 2;21(17):4531-8.
33. Vermassen E, etal., J Cell Sci. 2003 Apr 1;116(Pt 7):1269-77.
34. Zanner R, etal., Am J Physiol Cell Physiol 2002 Feb;282(2):C374-82.
Additional References at PubMed
PMID:9139693   PMID:10191279   PMID:10828023   PMID:11149946   PMID:11285228   PMID:11875073   PMID:11939501   PMID:12088506   PMID:14681927   PMID:14983008   PMID:14983009   PMID:15175012  
PMID:15184066   PMID:15890645   PMID:16014380   PMID:16107208   PMID:16122796   PMID:16840702   PMID:17257671   PMID:17327232   PMID:17636122   PMID:17916355   PMID:17925404   PMID:18417102  
PMID:18434513   PMID:18535093   PMID:19052258   PMID:19217932   PMID:19348050   PMID:19429061   PMID:19946888   PMID:20463231   PMID:20643058   PMID:20813840   PMID:21030605   PMID:21062895  
PMID:21071436   PMID:21302308   PMID:21700703   PMID:22878752   PMID:23137780   PMID:23382219   PMID:24469450   PMID:25242084   PMID:25482245   PMID:29476059  


Genomics

Comparative Map Data
Itpr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2205,136,968 - 5,202,339 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)Ensembl
Rnor_6.0205,645,894 - 5,711,702 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,711,508 - 7,775,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,292,430 - 5,357,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1205,292,656 - 5,357,727 (+)NCBI
Celera206,717,488 - 6,781,775 (+)NCBICelera
Cytogenetic Map20p12NCBI
ITPR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,621,322 - 33,696,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl633,620,365 - 33,696,574 (+)EnsemblGRCh38hg38GRCh38
GRCh37633,589,099 - 33,664,339 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,697,139 - 33,772,329 (+)NCBINCBI36hg18NCBI36
Build 34633,697,321 - 33,772,317NCBI
Celera635,143,559 - 35,218,741 (+)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,330,927 - 33,406,007 (+)NCBIHuRef
CHM1_1633,591,516 - 33,666,641 (+)NCBICHM1_1
T2T-CHM13v2.0633,442,507 - 33,517,747 (+)NCBI
Itpr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,275,976 - 27,341,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl1727,276,278 - 27,341,197 (+)Ensembl
GRCm381727,057,002 - 27,122,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,057,304 - 27,122,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,194,249 - 27,259,168 (+)NCBIGRCm37mm9NCBIm37
MGSCv361726,785,125 - 26,849,812 (+)NCBImm8
Celera1727,593,736 - 27,658,505 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.68NCBI
Itpr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,055,805 - 2,106,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,055,782 - 2,106,709 (+)NCBIChiLan1.0ChiLan1.0
ITPR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1634,303,454 - 34,378,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,303,454 - 34,378,215 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0633,194,531 - 33,269,788 (+)NCBIMhudiblu_PPA_v0panPan3
ITPR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,970,613 - 3,050,254 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,805,187 - 3,048,938 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,997,254 - 3,066,455 (+)NCBI
ROS_Cfam_1.0123,313,122 - 3,382,514 (+)NCBI
ROS_Cfam_1.0 Ensembl123,313,138 - 3,381,269 (+)Ensembl
UMICH_Zoey_3.1122,980,128 - 3,049,212 (+)NCBI
UNSW_CanFamBas_1.0123,061,183 - 3,130,533 (+)NCBI
UU_Cfam_GSD_1.0123,159,323 - 3,228,541 (+)NCBI
Itpr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,641,843 - 38,705,335 (+)NCBI
SpeTri2.0NW_00493647625,254,937 - 25,318,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,835,898 - 29,902,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,835,922 - 29,901,305 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,443,858 - 34,509,094 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,381,862 - 38,456,505 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,381,743 - 38,456,499 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604433,459,448 - 33,535,324 (+)NCBIVero_WHO_p1.0
Itpr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,229,281 - 23,281,621 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475423,228,690 - 23,281,552 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH129560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,202,073 - 5,202,262 (+)MAPPERmRatBN7.2
Rnor_6.0205,711,437 - 5,711,625NCBIRnor6.0
Rnor_5.0207,775,092 - 7,775,280UniSTSRnor5.0
RGSC_v3.4205,357,237 - 5,357,425UniSTSRGSC3.4
Celera206,781,510 - 6,781,698UniSTS
RH 3.4 Map2056.24UniSTS
Cytogenetic Map20p12UniSTS
RH129567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,201,999 - 5,202,211 (+)MAPPERmRatBN7.2
Rnor_6.0205,711,363 - 5,711,574NCBIRnor6.0
Rnor_5.0207,775,018 - 7,775,229UniSTSRnor5.0
RGSC_v3.4205,357,163 - 5,357,374UniSTSRGSC3.4
Celera206,781,436 - 6,781,647UniSTS
RH 3.4 Map2056.24UniSTS
Cytogenetic Map20p12UniSTS
PMC275467P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,201,193 - 5,201,672 (+)MAPPERmRatBN7.2
Rnor_6.0205,710,557 - 5,711,035NCBIRnor6.0
Rnor_5.0207,774,212 - 7,774,690UniSTSRnor5.0
RGSC_v3.4205,356,357 - 5,356,835UniSTSRGSC3.4
Celera206,780,630 - 6,781,108UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:56
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000011516
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 7 24 30 5
Low 43 47 32 12 32 8 11 74 11 11 6 8
Below cutoff 9 9 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090925   ⟹   ENSRNOP00000075066
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,136,441 - 5,202,337 (+)Ensembl
Rnor_6.0 Ensembl205,646,097 - 5,711,702 (+)Ensembl
RefSeq Acc Id: NM_013138   ⟹   NP_037270
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2205,136,968 - 5,202,339 (+)NCBI
Rnor_6.0205,646,097 - 5,711,702 (+)NCBI
Rnor_5.0207,711,508 - 7,775,357 (+)NCBI
RGSC_v3.4205,292,430 - 5,357,502 (+)RGD
Celera206,717,488 - 6,781,775 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037270   ⟸   NM_013138
- Sequence:
RefSeq Acc Id: ENSRNOP00000075066   ⟸   ENSRNOT00000090925
Protein Domains
MIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63269-F1-model_v2 AlphaFold Q63269 1-2670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2934 AgrOrtholog
BioCyc Gene G2FUF-4496 BioCyc
Ensembl Genes ENSRNOG00000052795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075066 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090925 ENTREZGENE, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25679 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25679 ENTREZGENE
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itpr3 PhenoGen
PRINTS INSP3RECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218650
UniProt C7E1V1_RAT UniProtKB/TrEMBL
  ITPR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpr3  inositol 1,4,5-trisphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Itpr3  inositol 1,4,5-triphosphate receptor, type 3  Itpr3  inositol 1,4,5-triphosphate receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itpr3  inositol 1, 4, 5-triphosphate receptor 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 729040
gene_function ligand activated calcium ion selective channel 68695
gene_function ligand activated calcium ion selective channel 69501
gene_physical_interaction binds inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate 729040
gene_process responsible for initiating and propagating cytosolic Ca++ signals evoked by receptors linked to IP3 formation 68695