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Gene: ITPR3 (inositol 1,4,5-trisphosphate receptor type 3) Homo sapiens
Symbol: ITPR3
Name: inositol 1,4,5-trisphosphate receptor type 3
Description: Exhibits inositol 1,4,5 trisphosphate binding activity and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in response to calcium ion. Localizes to the endoplasmic reticulum membrane; integral component of plasma membrane; and receptor complex. Implicated in type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ36205; inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3); inositol 1,4,5-trisphosphate receptor, type 3; insP3R3; IP3 receptor; IP3R; IP3R 3; IP3R3; type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
Mus musculus (house mouse) : Itpr3 (inositol 1,4,5-triphosphate receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Canis lupus familiaris (dog) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Sus scrofa (pig) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38633,621,322 - 33,696,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,587,951 - 33,664,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,697,139 - 33,772,329 (+)NCBINCBI36hg18NCBI36
Build 34633,697,321 - 33,772,317NCBI
Celera635,143,559 - 35,218,741 (+)NCBI
Cytogenetic Map6p21.31NCBI
HuRef633,330,927 - 33,406,007 (+)NCBIHuRef
CHM1_1633,591,516 - 33,666,641 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITPR3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733997
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.