CALCIUM/CALCIUM-MEDIATED SIGNALING PATHWAY (PW:0001140)

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Description

Calcium permeates almost every aspect of cellular processes and the pathways associated with them - from proliferation to cell death, contraction and gene expression, hormone and neurotransmitter release, metabolism and synaptic plasticity. Movement of calcium ions in and outside of the cell is paramount to the maintenance of a calcium gradient four order of magnitudes between the extracellular environment and the cytoplasmic concentration of resting cells. The steep gradient allows for fast lo

Pathway Diagram:

Ariadne Genomics Inc. neurotransmitter secretion motility metabolism contraction calcium transport pathway gene expression hormone secretion Ca2+ Ca2+ stored ---> Ca2+ released Ca2+ ---> Ca2+ stored Na+ ---> Na+ in (4) Ca2+ ---> Ca2+ exchanged Na+ ---> Na+ in (3) Ca2+ ---> CA2+ pumped out Ca2+ outside ---> Ca2+ Casr calcium signaling pathway via the calcium-sensing receptor PMCAs Ca2+ ---> SKs Ca2+ released Tpcn1 ---> Ca2+ released Tpcn2 ---> Ca2+ released RYRs Ca2+ exchanged CA2+ pumped out Ca2+ stored Ca2+ ---- ITPRs IP3 ---- ITPRs Na+ Na+ in (4) cADPr cADPr ---- RYRs ITPRs NAADP ---- Tpcn1 NAADP ---- Tpcn2 Na+ in (3) Ca2+ ---- RYRs ORAIs ---- Stim2 Stim1 --+> ORAIs NCXs Ca2+ outside Ca2+ outside ---> Casr NCKXs SERCAs Ca2+ ---- Ca2+ sensors Ca2+ ---- Ca2+ buffers ORAIs ---- Stim1 Mcoln1 ---> Ca2+ released NAADP VOCs TRPs CNGs ORAIs ROCs SKs Ca2+ sensors Ca2+ buffers IP3 Mcu Stim2 Stim1 Tpcn1 Tpcn2 Mcoln1 Atp2c1 Atp2c2 Slc24a6
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Genes in Pathway:

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calcium/calcium-mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy1 adenylate cyclase 1 JBrowse link 14 87,311,970 87,429,880 RGD:6907045
G Adcy2 adenylate cyclase 2 JBrowse link 1 37,043,071 37,698,390 RGD:6907045
G Adcy3 adenylate cyclase 3 JBrowse link 6 28,570,941 28,648,848 RGD:6907045
G Adcy4 adenylate cyclase 4 JBrowse link 15 34,453,917 34,469,779 RGD:6907045
G Adcy7 adenylate cyclase 7 JBrowse link 19 19,702,307 19,762,973 RGD:6907045
G Adcy8 adenylate cyclase 8 JBrowse link 7 105,353,883 105,593,372 RGD:6907045
G Adcy9 adenylate cyclase 9 JBrowse link 10 11,392,698 11,515,406 RGD:6907045
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6907045
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:6907045
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:6907045
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:6907045
G Adra1d adrenoceptor alpha 1D JBrowse link 3 124,129,558 124,145,566 RGD:6907045
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:6907045
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6907045
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:6907045
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6907045
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:6907045
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 1 197,855,912 197,875,038 RGD:6907045
RGD:7204695
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:6907045
RGD:7204695
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:6907045
RGD:7204695
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:6907045
RGD:7204695
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 JBrowse link 4 145,704,779 145,948,997 RGD:6907045
RGD:7204695
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 JBrowse link X 157,236,400 157,312,028 RGD:6907045
RGD:7204695
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:6907045
RGD:7204695
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 JBrowse link 8 113,953,959 114,039,965 RGD:7204695
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 JBrowse link 19 52,347,480 52,404,608 RGD:7204695
G Avpr1a arginine vasopressin receptor 1A JBrowse link 7 67,341,366 67,345,290 RGD:6907045
G Avpr1b arginine vasopressin receptor 1B JBrowse link 13 48,367,307 48,378,831 RGD:6907045
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6907045
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6907045
G Bst1 bone marrow stromal cell antigen 1 JBrowse link 14 71,798,218 71,814,540 RGD:6907045
G Cabp1 calcium binding protein 1 JBrowse link 12 47,185,449 47,209,785 RGD:7204681
G Cabp2 calcium binding protein 2 JBrowse link 1 219,329,186 219,335,046 RGD:7204681
G Cabp4 calcium binding protein 4 JBrowse link 1 219,383,452 219,388,009 RGD:7204681
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
RGD:7204688
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6907045
RGD:7204688
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6907045
RGD:7204688
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6907045
RGD:7204688
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:6907045
RGD:7204688
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:6907045
RGD:7204688
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6907045
RGD:7204688
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:6907045
RGD:7204688
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:6907045
RGD:7204688
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:6907045
RGD:7204688
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:7204688
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:7204688
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:7204688
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:7204688
G Calb1 calbindin 1 JBrowse link 5 29,538,380 29,562,774 RGD:7204685
G Calb2 calbindin 2 JBrowse link 19 41,482,743 41,509,617 RGD:7204685
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:6907045
RGD:7204677
RGD:7204676
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:6907045
RGD:7204677
RGD:7204676
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:6907045
RGD:7204677
RGD:7204676
G Calml3 calmodulin-like 3 JBrowse link 17 70,070,458 70,073,697 RGD:6907045
G Calml5 calmodulin-like 5 JBrowse link 17 70,044,956 70,045,886 RGD:6907045
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:7204686
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6907045
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6907045
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:6907045
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6907045
G Camk4 calcium/calmodulin-dependent protein kinase IV JBrowse link 18 25,746,878 25,975,962 RGD:6907045
G Casq1 calsequestrin 1 JBrowse link 13 90,592,676 90,602,365 RGD:7204686
G Casq2 calsequestrin 2 JBrowse link 2 204,512,361 204,568,643 RGD:7204686
G Cckar cholecystokinin A receptor JBrowse link 14 59,610,939 59,619,786 RGD:6907045
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:6907045
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:6907045
G Chp1 calcineurin-like EF-hand protein 1 JBrowse link 3 111,354,506 111,389,998 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 1 192,169,634 192,173,228 RGD:6907045
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6907045
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:6907045
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:6907045
G Chrm5 cholinergic receptor, muscarinic 5 JBrowse link 3 103,966,451 104,018,815 RGD:6907045
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6907045
G Cnga1 cyclic nucleotide gated channel alpha 1 JBrowse link 14 38,155,771 38,171,107 RGD:7204690
G Cnga2 cyclic nucleotide gated channel alpha 2 JBrowse link 16 69,878,513 69,899,075 RGD:7204690
G Cnga3 cyclic nucleotide gated channel alpha 3 JBrowse link 9 43,807,412 43,858,225 RGD:7204690
G Cnga4 cyclic nucleotide gated channel alpha 4 JBrowse link 1 170,238,959 170,246,858 RGD:7204690
G Cngb1 cyclic nucleotide gated channel beta 1 JBrowse link 19 10,142,440 10,206,618 RGD:7204690
G Cngb3 cyclic nucleotide gated channel beta 3 JBrowse link 5 33,097,353 33,507,467 RGD:7204690
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6907045
G Cysltr2 cysteinyl leukotriene receptor 2 JBrowse link 15 54,903,290 54,941,742 RGD:6907045
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:6907045
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:6907045
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:6907045
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:6907045
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:6907045
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:6907045
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:6907045
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:6907045
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:6907045
G Gnal G protein subunit alpha L JBrowse link 18 62,805,406 62,946,133 RGD:6907045
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6907045
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:6907045
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6907045
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6907045
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C JBrowse link 10 103,798,290 103,816,923 RGD:6907045
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D JBrowse link 1 101,819,068 101,859,146 RGD:6907045
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:6907045
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:6907045
G Grpr gastrin releasing peptide receptor JBrowse link X 32,746,259 32,786,266 RGD:6907045
G Guca1a guanylate cyclase activator 1A JBrowse link 9 15,609,804 15,620,030 RGD:7204681
G Guca1b guanylate cyclase activator 1B JBrowse link 9 15,621,083 15,629,017 RGD:7204681
G Guca2b guanylate cyclase activator 2B JBrowse link 5 138,695,591 138,697,641 RGD:7204681
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6907045
G Hrh2 histamine receptor H 2 JBrowse link 17 10,912,959 10,931,389 RGD:6907045
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6907045
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:6907045
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:6907045
G Htr4 5-hydroxytryptamine receptor 4 JBrowse link 18 57,637,013 57,820,317 RGD:6907045
G Htr5a 5-hydroxytryptamine receptor 5A JBrowse link 4 199,916 209,599 RGD:6907045
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B JBrowse link 13 37,479,758 37,492,680 RGD:6907045
G Htr6 5-hydroxytryptamine receptor 6 JBrowse link 5 157,501,202 157,518,870 RGD:6907045
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:6907045
G Itpka inositol-trisphosphate 3-kinase A JBrowse link 3 111,545,007 111,553,605 RGD:6907045
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:6907045
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6907045
RGD:7204693
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6907045
RGD:7204693
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 JBrowse link 20 5,645,894 5,711,702 RGD:6907045
RGD:7204693
G Kcnip1 potassium voltage-gated channel interacting protein 1 JBrowse link 10 18,558,128 18,942,677 RGD:7204681
G Kcnip2 potassium voltage-gated channel interacting protein 2 JBrowse link 1 265,549,610 265,573,393 RGD:7204681
G Kcnip3 potassium voltage-gated channel interacting protein 3 JBrowse link 3 120,023,062 120,087,650 RGD:7204681
G Kcnip4 potassium voltage-gated channel interacting protein 4 JBrowse link 14 65,549,362 66,749,181 RGD:7204681
G Kcnn1 potassium calcium-activated channel subfamily N member 1 JBrowse link 16 20,325,270 20,349,163 RGD:7204683
G Kcnn2 potassium calcium-activated channel subfamily N member 2 JBrowse link 18 39,331,894 39,479,574 RGD:7204683
G Kcnn3 potassium calcium-activated channel subfamily N member 3 JBrowse link 2 188,837,280 188,991,794 RGD:7204683
G Kcnn4 potassium calcium-activated channel subfamily N member 4 JBrowse link 1 81,227,855 81,245,986 RGD:7204683
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:6907045
G Ltb4r2 leukotriene B4 receptor 2 JBrowse link 15 34,446,478 34,448,220 RGD:6907045
G Mcoln1 mucolipin 1 JBrowse link 12 2,054,629 2,068,682 RGD:7204689
G Mcu mitochondrial calcium uniporter JBrowse link 20 29,037,452 29,199,224 RGD:7204696
G Mlnr motilin receptor JBrowse link 19 55,176,617 55,183,562 RGD:6907045
G Mylk myosin light chain kinase JBrowse link 11 69,013,060 69,260,039 RGD:6907045
G Mylk2 myosin light chain kinase 2 JBrowse link 3 148,386,185 148,397,851 RGD:6907045
G Mylk3 myosin light chain kinase 3 JBrowse link 19 27,388,163 27,442,451 RGD:6907045
G Ncs1 neuronal calcium sensor 1 JBrowse link 3 10,556,250 10,602,672 RGD:7204681
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6907045
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6907045
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6907045
G Ntsr1 neurotensin receptor 1 JBrowse link 3 175,982,313 176,046,345 RGD:6907045
G Ocm2 oncomodulin 2 JBrowse link 12 12,611,121 12,634,472 RGD:7204685
G Orai1 ORAI calcium release-activated calcium modulator 1 JBrowse link 12 38,981,903 38,995,570 RGD:7204692
G Orai2 ORAI calcium release-activated calcium modulator 2 JBrowse link 12 23,544,483 23,564,602 RGD:7204692
G Orai3 ORAI calcium release-activated calcium modulator 3 JBrowse link 1 199,217,504 199,222,363 RGD:7204692
G Oxtr oxytocin receptor JBrowse link 4 144,399,326 144,417,598 RGD:6907045
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:6907045
G P2rx2 purinergic receptor P2X 2 JBrowse link 12 52,397,666 52,401,005 RGD:6907045
G P2rx3 purinergic receptor P2X 3 JBrowse link 3 72,403,992 72,447,801 RGD:6907045
G P2rx4 purinergic receptor P2X 4 JBrowse link 12 39,308,022 39,325,673 RGD:6907045
G P2rx5 purinergic receptor P2X 5 JBrowse link 10 59,725,438 59,737,126 RGD:6907045
G P2rx6 purinergic receptor P2X 6 JBrowse link 11 87,434,929 87,445,221 RGD:6907045
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:6907045
G Pde1a phosphodiesterase 1A JBrowse link 3 66,803,247 67,263,658 RGD:6907045
G Pde1b phosphodiesterase 1B JBrowse link 7 145,117,951 145,147,711 RGD:6907045
G Pde1c phosphodiesterase 1C JBrowse link 4 86,359,762 86,925,044 RGD:6907045
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:6907045
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:6907045
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:6907045
G Phka2 phosphorylase kinase regulatory subunit alpha 2 JBrowse link X 35,970,650 36,926,616 RGD:6907045
G Phkb phosphorylase kinase regulatory subunit beta JBrowse link 19 22,031,684 22,281,788 RGD:6907045
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 JBrowse link 12 30,450,431 30,464,314 RGD:6907045
G Phkg2 phosphorylase kinase catalytic subunit gamma 2 JBrowse link 1 199,019,298 199,032,053 RGD:6907045
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6907045
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6907045
G Plcd1 phospholipase C, delta 1 JBrowse link 8 127,753,514 127,782,070 RGD:6907045
G Plcd3 phospholipase C, delta 3 JBrowse link 10 91,164,778 91,186,067 RGD:6907045
G Plcd4 phospholipase C, delta 4 JBrowse link 9 81,816,395 81,844,364 RGD:6907045
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:6907045
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:6907045
G Plcz1 phospholipase C, zeta 1 JBrowse link 4 174,125,072 174,181,524 RGD:6907045
G Pln phospholamban JBrowse link 20 34,633,157 34,642,904 RGD:6907045
G Ppid peptidylprolyl isomerase D JBrowse link 2 178,354,830 178,366,843 RGD:6907045
G Ppidl1 peptidylprolyl isomerase D-like 1 JBrowse link 9 121,456,762 121,458,035 RGD:6907045
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:6907045
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:6907045
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:6907045
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptafr platelet-activating factor receptor JBrowse link 5 150,746,284 150,775,675 RGD:6907045
G Ptger1 prostaglandin E receptor 1 JBrowse link 19 24,799,422 24,803,373 RGD:6907045
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:6907045
G Ptgfr prostaglandin F receptor JBrowse link 2 257,005,813 257,039,036 RGD:6907045
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:6907045
G Pvalb parvalbumin JBrowse link 7 119,428,657 119,443,674 RGD:7204685
G Rcvrn recoverin JBrowse link 10 54,246,250 54,253,996 RGD:7204681
G RGD1564956 similar to calcium binding protein P22 JBrowse link 5 70,747,534 70,749,967 RGD:6907045
G RGD1565588 similar to calcium binding protein P22 JBrowse link 4 6,477,461 6,479,158 RGD:6907045
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:7204694
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:6907045
RGD:7204694
G Ryr3 ryanodine receptor 3 JBrowse link 3 104,117,307 104,665,151 RGD:6907045
RGD:7204694
G S100a1 S100 calcium binding protein A1 JBrowse link 2 189,900,505 189,905,348 RGD:1579960
RGD:7204682
G S100a4 S100 calcium-binding protein A4 JBrowse link 2 189,997,278 189,999,587 RGD:7204682
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:7204682
G S100g S100 calcium binding protein G JBrowse link X 33,442,820 33,445,714 RGD:7204685
G Slc24a1 solute carrier family 24 member 1 JBrowse link 8 70,409,683 70,438,352 RGD:7204698
G Slc24a2 solute carrier family 24 member 2 JBrowse link 5 105,336,287 105,579,959 RGD:7204698
G Slc24a3 solute carrier family 24 member 3 JBrowse link 3 139,333,942 139,835,728 RGD:7204698
G Slc24a4 solute carrier family 24 member 4 JBrowse link 6 126,015,799 126,158,727 RGD:7204698
G Slc25a31 solute carrier family 25 member 31 JBrowse link 2 127,538,323 127,554,276 RGD:6907045
G Slc25a4 solute carrier family 25 member 4 JBrowse link 16 49,266,903 49,270,698 RGD:6907045
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6907045
G Slc25a6 solute carrier family 25 member 6 JBrowse link 18 70,959,872 70,961,040 RGD:6907045
G Slc8a1 solute carrier family 8 member A1 JBrowse link 6 4,244,076 4,564,262 RGD:6907045
RGD:7204698
G Slc8a2 solute carrier family 8 member A2 JBrowse link 1 78,029,555 78,054,042 RGD:6907045
RGD:7204698
G Slc8a3 solute carrier family 8 member A3 JBrowse link 6 104,889,500 105,099,408 RGD:6907045
RGD:7204698
G Slc8b1 solute carrier family 8 member B1 JBrowse link 12 41,566,980 41,590,294 RGD:7204696
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:6907045
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:6907045
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:7204692
G Stim2 stromal interaction molecule 2 JBrowse link 14 59,198,180 59,323,947 RGD:7204692
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:7204679
RGD:2311146
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:7204679
RGD:2311148
G Syt9 synaptotagmin 9 JBrowse link 1 171,592,703 171,769,780 RGD:2311148
RGD:2311146
G Tacr1 tachykinin receptor 1 JBrowse link 4 113,247,236 113,416,139 RGD:6907045
G Tacr2 tachykinin receptor 2 JBrowse link 20 31,892,515 31,905,153 RGD:6907045
G Tacr3 tachykinin receptor 3 JBrowse link 2 240,021,152 240,118,971 RGD:6907045
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:6907045
G Tnnc1 troponin C1, slow skeletal and cardiac type JBrowse link 16 7,292,207 7,295,238 RGD:6907045
RGD:7204682
G Tnnc2 troponin C2, fast skeletal type JBrowse link 3 161,243,607 161,246,335 RGD:6907045
RGD:7204682
G Tpcn1 two pore segment channel 1 JBrowse link 12 41,507,784 41,566,847 RGD:7204697
G Tpcn2 two pore segment channel 2 JBrowse link 1 218,419,182 218,448,902 RGD:7204697
G Trhr thyrotropin releasing hormone receptor JBrowse link 7 83,113,641 83,153,520 RGD:6907045
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 JBrowse link 8 103,503,982 103,554,905 RGD:6907045
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 JBrowse link 4 70,947,615 70,974,004 RGD:7204689
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 JBrowse link 4 70,918,631 70,934,291 RGD:7204689
G Vdac1 voltage-dependent anion channel 1 JBrowse link 10 37,724,915 37,752,827 RGD:6907045
G Vdac2 voltage-dependent anion channel 2 JBrowse link 15 2,634,622 2,648,548 RGD:6907045
G Vdac3 voltage-dependent anion channel 3 JBrowse link 16 74,292,466 74,308,910 RGD:6907045
calcineurin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:1579951
G Nfatc3 nuclear factor of activated T-cells 3 JBrowse link 19 38,039,542 38,114,003 RGD:1579951
G Nfatc4 nuclear factor of activated T-cells 4 JBrowse link 15 34,493,163 34,502,238 RGD:1579951
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:1579951
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:1579951
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link 15 51,896,427 51,968,075 RGD:1579951
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha JBrowse link 14 100,311,224 100,360,879 RGD:1579951
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta JBrowse link 5 64,945,583 64,946,578 RGD:1579951
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:1581652
calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207060
RGD:7207059
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207060
RGD:7207059
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:7207059
RGD:7207227
RGD:7207060
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7207227
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207060
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:7207060
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:7207060
G Rgs12 regulator of G-protein signaling 12 JBrowse link 14 80,975,239 81,069,519 RGD:7207227
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:7207227
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:7207227
G Rgs5 regulator of G-protein signaling 5 JBrowse link 13 87,966,820 88,002,831 RGD:7207228
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:7207227
calcium/calmodulin dependent kinase 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:7240708
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:7240708
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:7240704
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:7240705
RGD:7240708
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:7240705
RGD:7240708
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:7240705
RGD:7240708
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:7240704
RGD:7240705
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:7240704
RGD:7240705
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:7240705
RGD:7240708
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:7240705
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 JBrowse link 5 156,876,706 156,878,486 RGD:7240706
RGD:7240707
G Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 JBrowse link 11 83,975,430 83,976,557 RGD:7240706
RGD:7240707
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:7240705
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:7240704
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:7240705
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:7240705
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:7240704
RGD:7240705
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:7241019
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:7241019
G Lrrc7 leucine rich repeat containing 7 JBrowse link 2 264,910,594 265,300,860 RGD:7240705
G Pln phospholamban JBrowse link 20 34,633,157 34,642,904 RGD:7240708
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E JBrowse link 10 74,548,270 74,679,858 RGD:7241020
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:7241020
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:7241020
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:7241020
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:7240708
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:7240708
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:7240705
calcium/calmodulin dependent kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:1581866

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassSmall conductance calcium activated potasssium channels (SKs)
Functional ClassCa2+ sensorsclasses of Ca2+ sensors
Functional ClassCa2+ bufferscytosolic and organellar Ca2+ buffers

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the calcium/calcium-mediated signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyChrm2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyChrm1 , Chrm3 , Chrm5 , Gna11 , Gna14 , Gnaq
acetylcholine signaling pathway via nicotinic acetylcholine receptorChrna7
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3
adenosine signaling pathwayAdcy2 , Adora2a , Adora2b , Gnas , Prkacb
ADP-ribosylation pathway, cyclic ribosylationBst1 , Cd38
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAdrb1 , Adrb2 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
aldosterone signaling pathwayPrkca , Prkcb , Prkcg
alfentanil pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
altered epidermal growth factor/neuregulin signaling pathwayEgfr , Erbb2
altered visual phototransduction pathwayCnga1 , Cngb1 , Guca1b
Alzheimer disease pathwayAtp2a1 , Atp2a2 , Atp2a3 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Chp1 , Chp2 , Gnaq , Grin1 , Grin2a , Grin2c , Grin2d , Itpr1 , Itpr2 , Itpr3 , Nos1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588 , Ryr3
amiodarone pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
amlodipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
amyotrophic lateral sclerosis disease pathwayChp1 , Chp2 , Grin1 , Grin2a , Grin2c , Grin2d , Nos1 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588
angiotensin II signaling pathwayAgtr1a , Agtr1b
angiotensin II signaling pathway via AT1 receptorAgtr1a , Agtr1b , Gna11 , Gnaq
angiotensin II signaling pathway via AT2 receptorErbb3
angiotensin III signaling pathwayAgtr1a , Agtr1b
angiotensin III signaling pathway via AT1 receptorAgtr1a , Agtr1b
antigen processing and presentation pathwayCalr
apoptotic cell death pathwayChp1 , Chp2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkx , RGD1564956 , RGD1565588
arginine and proline metabolic pathwayNos1 , Nos2 , Nos3
arginine:glycine amidinotransferase deficiency pathwayNos1
arrhythmogenic right ventricular cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
atenolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
B cell receptor signaling pathwayChp1 , Chp2 , Plcg2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkcb , RGD1564956 , RGD1565588
benazepril pharmacodynamics pathwayAgtr1a
betaxolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
bile acid transport pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Gnas , Kcnn2 , Prkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
bladder cancer pathwayEgfr , Erbb2
bupivacaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
bupranolol drug pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
bupranolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
buprenorphine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
calcineurin signaling pathwayPpp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2
calcium transport pathwayAtp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Itpr1 , Itpr2 , Itpr3 , Mcoln1 , Mcu , Orai1 , Orai2 , Orai3 , Ryr1 , Ryr2 , Ryr3 , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Stim1 , Stim2 , Tpcn1 , Tpcn2 , Trpv5 , Trpv6
calcium/calcium-mediated signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Adora2a , Adora2b , Adra1a , Adra1b , Adra1d , Adrb1 , Adrb2 , Adrb3 , Agtr1a , Agtr1b , Atp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Avpr1a , Avpr1b , Bdkrb1 , Bdkrb2 , Bst1 , Cabp1 , Cabp2 , Cabp4 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Calb1 , Calb2 , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Calr , Camk2a , Camk2b , Camk2d , Camk2g , Camk4 , Casq1 , Casq2 , Cckar , Cckbr , Cd38 , Chp1 , Chp2 , Chrm1 , Chrm2 , Chrm3 , Chrm5 , Chrna7 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Cysltr1 , Cysltr2 , Drd1 , Drd5 , Ednra , Ednrb , Egfr , Erbb2 , Erbb3 , Erbb4 , F2r , Gna11 , Gna14 , Gna15 , Gnal , Gnaq , Gnas , Grin1 , Grin2a , Grin2c , Grin2d , Grm1 , Grm5 , Grpr , Guca1a , Guca1b , Guca2b , Hrh1 , Hrh2 , Htr2a , Htr2b , Htr2c , Htr4 , Htr5a , Htr5b , Htr6 , Htr7 , Itpka , Itpkb , Itpr1 , Itpr2 , Itpr3 , Kcnip1 , Kcnip2 , Kcnip3 , Kcnip4 , Kcnn1 , Kcnn2 , Kcnn3 , Kcnn4 , Lhcgr , Ltb4r2 , Mcoln1 , Mcu , Mlnr , Mylk , Mylk2 , Mylk3 , Ncs1 , Nos1 , Nos2 , Nos3 , Ntsr1 , Ocm2 , Orai1 , Orai2 , Orai3 , Oxtr , P2rx1 , P2rx2 , P2rx3 , P2rx4 , P2rx5 , P2rx6 , P2rx7 , Pde1a , Pde1b , Pde1c , Pdgfra , Pdgfrb , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Plcd1 , Plcd3 , Plcd4 , Plce1 , Plcg1 , Plcg2 , Plcz1 , Pln , Ppid , Ppidl1 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Ptafr , Ptger1 , Ptger3 , Ptgfr , Ptk2b , Pvalb , Rcvrn , RGD1564956 , RGD1565588 , Ryr1 , Ryr2 , Ryr3 , S100a1 , S100a4 , S100b , S100g , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Sphk1 , Sphk2 , Stim1 , Stim2 , Syt1 , Syt7 , Syt9 , Tacr1 , Tacr2 , Tacr3 , Tbxa2r , Tnnc1 , Tnnc2 , Tpcn1 , Tpcn2 , Trhr , Trpc1 , Trpv5 , Trpv6 , Vdac1 , Vdac2 , Vdac3
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c , Cacnb2 , Calm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g , Grin1 , Grin2a , Pln , Ryr2
calcium/calmodulin dependent kinase signaling pathwayEdnrb
candesartan pharmacodynamics pathwayAgtr1a
captopril pharmacodynamics pathwayAgtr1a
carvedilol pharmacodynamics pathwayAdra1a , Adrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
ceramide signaling pathwayEgfr , Erbb2 , Sphk2
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkaca , Prkacb , Prkcb , Prkx , Ptk2b
chloroprocaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
cilazapril pharmacodynamics pathwayAgtr1a
cimetidine pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
cimetidine pharmacokinetics pathwayHrh2
citalopram pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
coagulation cascade pathwayBdkrb1 , Bdkrb2 , F2r
cocaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
codeine and morphine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
complement system pathwayBdkrb1 , Bdkrb2 , F2r
corticotropin-releasing hormone signaling pathwayGnas
cytokine mediated signaling pathwayEgfr , Pdgfra , Pdgfrb
desipramine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
dilated cardiomyopathy pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Adrb1 , Atp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Gnas , Pln , Prkaca , Prkacb , Prkx , Ryr2 , Slc8a1 , Tnnc1
diltiazem pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
diphenoxylate pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
disopyramide pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
dobutamine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
dopamine signaling pathwayDrd1 , Drd5 , Ppp3ca , Ppp3cb , Ppp3cc , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsAdcy2 , Drd1 , Drd5 , Gnal , Gnas , Prkacb
doxorubicin pharmacokinetics pathwayNos3
E-cadherin signaling pathwayEgfr , Plcg1
eicosanoid signaling pathwayEgfr , Gna11 , Gna14 , Gna15 , Gnaq , Nos3 , Plcb2 , Prkaca , Prkca , Prkcg , Tbxa2r
electron transport chain pathwaySlc25a4
enalapril pharmacodynamics pathwayAgtr1a
endocytosis pathwayAdrb1 , Adrb2 , Adrb3 , Egfr , Erbb3 , Erbb4 , F2r , Pdgfra
endometrial cancer pathwayEgfr , Erbb2
Endoplasmic Reticulum-associated degradation pathwayCalr
endothelin signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Cysltr1 , Cysltr2 , Ednra , Ednrb , Gna11 , Gna14 , Gna15 , Gnal , Gnaq , Nos2 , Plcb1 , Plcb2 , Plcb3 , Prkca , Prkcg , Ptk2b
Entamoeba histolyca infection pathwayAdcy1 , Gna11 , Gna14 , Gna15 , Gnal , Gnaq , Gnas , Nos2 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
ephrin - ephrin receptor bidirectional signaling axisPlcg1
epidermal growth factor/neuregulin signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Egfr , Erbb2 , Erbb3 , Erbb4 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
epinephrine signaling pathway via adrenergic receptor betaAdrb1 , Adrb2 , Gnas
eprosartan pharmacodynamics pathwayAgtr1a
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayPlcg1 , Plcg2
escitalopram pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
esmolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
esomeprazole pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
estrogen signaling pathwayPpid
ethylmorphine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
excitatory synaptic transmission pathwayGrin1 , Grin2a
Fabry disease pathwaySphk2
famotidine pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
Fc epsilon receptor mediated signaling pathwayPlcg1 , Plcg2 , Prkca , Prkcg
Fc gamma receptor mediated signaling pathwayPlcg1 , Plcg2 , Prkca , Prkcb , Prkcg , Sphk1 , Sphk2
felodipine pharmacokinetics pathwayCacna1c , Cacnb1
fentanyl pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
fibroblast growth factor signaling pathwayCamk2a , Plcg1 , Ptk2b
flecainde pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
fluoxetine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
follicle-stimulating hormone signaling pathwayAdcy2 , Gnas , Prkacb
forasartsn pharmacodynamics pathwayAgtr1a
fosinopril pharmacodynamics pathwayAgtr1a
fosphenytoin pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
G protein mediated signaling pathwayF2r , Plcd1
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAdrb2 , Bdkrb1 , Bdkrb2 , Chrm2 , Oxtr
G protein mediated signaling pathway via Galphaq familyAdra1a , Adra1b , Adra1d , Agtr1a , Agtr1b , Avpr1a , Avpr1b , Bdkrb1 , Bdkrb2 , Chrm1 , Chrm3 , Chrm5 , Drd1 , Drd5 , Gna11 , Gna14 , Gna15 , Gnaq , Oxtr , Plcb1 , Plcb2 , Plcb3 , Plcb4
G protein mediated signaling pathway via Galphas familyAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Adrb1 , Adrb2 , Adrb3 , Avpr1b , Drd1 , Drd5 , Gnal , Gnas , Lhcgr
Gaucher disease pathwaySphk2
gefitinib pharmacodynamics pathwayEgfr
gliclazide pharmacodynamics pathwayCacna1a , Cacnb1
glioma pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Camk2a , Camk2b , Camk2d , Camk2g , Egfr , Pdgfra , Pdgfrb , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
globoid cell leukodystrophy disease pathwaySphk2
glucagon signaling pathwayGnas
glutamate signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Cacna1a , Cacna1c , Cacna1d , Chp1 , Chp2 , Gnaq , Gnas , Grin1 , Grin2a , Grin2c , Grin2d , Grm1 , Grm5 , Itpr1 , Itpr2 , Itpr3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , RGD1564956 , RGD1565588 , Trpc1
glyburide pharmacodynamics pathwayCacna1a , Cacnb1
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2
gonadotropin-releasing hormone signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Camk2a , Camk2b , Camk2d , Camk2g , Egfr , Gna11 , Gnaq , Gnas , Itpr1 , Itpr2 , Itpr3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkaca , Prkacb , Prkca , Prkcb , Prkx , Ptk2b
granulocyte-macrophage colony-stimulating factor signaling pathwayPrkaca , Prkacb
guanidinoacetate methyltransferase deficiency pathwayNos1
gyrate atrophy pathwayNos1
Hedgehog signaling pathwayPrkaca , Prkacb , Prkx
hepatitis C virus infection pathwayEgfr
heroin pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
histamine signaling pathway, immunologicalAdcy2 , Gnas , Hrh2 , Prkacb
Huntington disease pathwayGnaq , Grin1 , Grm1 , Grm5 , Itpr1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppid , Ppidl1 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Vdac1 , Vdac2 , Vdac3
hydrocodone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
hydromorphone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
hyperornithinemia-hyperammonemia-homocitrullinemia syndrome pathwayNos1
hyperprolinemia disease pathwayNos1
hyperprolinemia type II disease pathwayNos1
hypertrophic cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1 , Tnnc1
hypoxia inducible factor pathwayAdora2a , Nos2
ibutilide pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
imipramine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
inflammatory response pathwayEdnra , Ednrb
influenza A virus infection pathwayPrkca , Prkcb , Vdac1
inositol metabolic pathwayItpka , Plcd3
inositol phosphate metabolic pathwayItpka , Itpkb , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Plcd1 , Plcd3 , Plcd4 , Plce1 , Plcg1 , Plcg2 , Plcz1
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCalm1 , Calm2 , Calm3
insulin secretion pathwayCacna1a , Cacna1c , Cacna1d , Syt7 , Syt9
insulin signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx
interleukin-12 signaling pathwayNos2 , Ppp3ca , Ppp3cb , Ppp3r1 , Sphk2
interleukin-2 signaling pathwayPrkcb , Ptk2b
interleukin-23 signaling pathwayNos2
interleukin-3 signaling pathwayPrkaca , Prkacb
irbesartan pharmacodynamics pathwayAgtr1a
isoprenaline pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
isradipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
Jak-Stat signaling pathwayPtk2b
kallikrein-kinin cascade pathwayBdkrb1 , Bdkrb2
kinin signaling pathwayBdkrb1 , Bdkrb2
lansoprazole pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
Leishmania infection pathwayNos2 , Prkcb
levacetylmethadol pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
levobunolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
levobupivacaine phgarmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
levorphanol pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
lidocaine pharmacodynamics pathwayAdra1a , Adrb1 , Agtr1a , Atp2a2 , Cacna1a , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Drd1 , Grin1 , Grin2a , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
lisinopril pharmacodynamics pathwayAgtr1a
long term depressionCacna1a , Drd1 , Drd5 , Gna11 , Gnaq , Gnas , Grin2a , Grm1 , Grm5 , Itpr1 , Itpr2 , Itpr3 , Nos1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
long term potentiationAdcy1 , Adcy8 , Cacna1c , Calm1 , Calm2 , Calm3 , Calml3 , Calml5 , Camk2a , Camk2b , Camk2d , Camk2g , Camk4 , Chp1 , Chp2 , Drd1 , Drd5 , Gnaq , Grin1 , Grin2a , Grin2c , Grin2d , Grm1 , Grm5 , Itpr1 , Itpr2 , Itpr3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , RGD1564956 , RGD1565588
losartan pharmacodynamics pathwayAgtr1a
luteinizing hormone signaling pathwayAdcy2 , Gnas , Lhcgr , Prkacb
measles infection pathwayTacr1
melanocortin system pathwayAdcy2 , Gnas , Prkacb
melanoma pathwayEgfr , Pdgfra , Pdgfrb
mepivacaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
metachromatic leukodystrophy disease pathwaySphk2
methadone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
methadone pharmacokinetics pathwayGrin1 , Grin2a
metoprolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
mexiletine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
mitogen activated protein kinase signaling pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Chp1 , Chp2 , Egfr , Erbb2 , Pdgfra , Pdgfrb , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , RGD1564956 , RGD1565588
moexipril pharmacodynamics pathwayAgtr1a
monoterpenoid biosynthetic pathwayBst1 , Cd38
mTOR signaling pathwayPrkca
Mycobacterium tuberculosis infection pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Camk2a , Camk2b , Camk2d , Camk2g , Chp1 , Chp2 , Nos2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588 , Sphk1 , Sphk2
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Camk2g , Plcg1
nadolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
nalbuphine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
naloxone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
naltrexone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
nebivolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
neurotrophic factor signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Camk2a , Camk2b , Camk2d , Camk2g , Camk4 , Plcg1 , Plcg2
niacin metabolic pathwayBst1 , Cd38
nicotine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
nifedipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
nimodipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
nisoldipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
nitrendipine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
nizatidine pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
non-small cell lung cancer pathwayEgfr , Erbb2 , Plcg1 , Plcg2 , Prkca , Prkcb , Prkcg
nuclear factor kappa B signaling pathwayPrkca
olmesartan pharmacodynamics pathwayAgtr1a
omeprazole pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxybuprocaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
oxycodone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
oxymorphone pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
oxytocin signaling pathwayGna11 , Gnaq , Oxtr
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b
pancreatic cancer pathwayEgfr , Erbb2
panitumumab pharmacodynamics pathwayEgfr
pantoprazole pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
Parkinson disease pathwayNos1 , Ppid , Ppidl1 , Slc25a31 , Slc25a4 , Slc25a5 , Slc25a6 , Vdac1 , Vdac2 , Vdac3
penbutolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
pentazocine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
peptide and protein hormone signaling pathwayLhcgr
perindopril pharmacodynamics pathwayAgtr1a
phagocytosis pathwayCalr , Nos1
phenytoin pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
phosphatidylinositol 3-kinase class I signaling pathwayPlcg1 , Plcg2
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Itpka , Itpkb , Itpr1 , Itpr2 , Itpr3 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Plcd1 , Plcd3 , Plcd4 , Plce1 , Plcg1 , Plcg2 , Plcz1 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayPrkaca
phosphoinositide metabolic pathwayEgfr , Erbb2 , Plcb1
pindolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
pirenzepine pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
platelet-derived growth factor signaling pathwayPdgfra , Pdgfrb , Plcg1 , Prkca , Sphk1
potassium channel inhibitors pharmacodynamics pathwayCacna1a , Cacnb1
prilocaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
prion diseases pathwayPrkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
procaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
prolidase deficiency pathwayNos1
propranolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
prostaglandin D2 signaling pathwayAdcy2 , Gnas , Prkacb
prostaglandin I2 signaling pathwayAdcy2 , Gnas , Mylk , Prkacb
prostate cancer pathwayEgfr , Erbb2 , Pdgfra , Pdgfrb
protease mediated signaling via protease-activated receptor 1F2r
protein kinase A (PKA) signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Pde1a , Pde1b , Pde1c , Prkaca , Prkacb
protein kinase C (PKC) signaling pathwayPlcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
purine metabolic pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Pde1a , Pde1b , Pde1c
quinapril pharmacodynamics pathwayAgtr1a
quinidine pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
rabeprazole pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
ramipril pharmacodynamics pathwayAgtr1a
ranitidine pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayGrin2a
remifentanil pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
renin-angiotensin cascade pathwayAgtr1a , Agtr1b
retinitis pigmentosa pathwayCnga1 , Cngb1 , Guca1b
Rho/Rac/Cdc42 mediated signaling pathwayAdrb1 , Ednra , Ptk2b
ribosome biogenesis pathwayPrkcb
ropivacaine pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
roxatidine acetate pharmacodynamics pathwayCckbr , Chrm3 , Hrh2
scatter factor/hepatocyte growth factor signaling pathwayPlcg1
schizophrenia pathwayKcnn3 , Ppp3cc
serotonin signaling pathway via receptors engaging G alphas protein familyAdcy2 , Gnas , Htr4 , Htr6 , Htr7 , Prkacb
small cell lung cancer pathwayNos2
sotalol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
sphingolipid metabolic pathwaySphk1 , Sphk2
sphingosine 1-phosphate signaling pathwayGna11 , Gna14 , Gna15 , Gnaq , Pdgfrb , Plcb2 , Plcg1 , Sphk1 , Sphk2
spirapril pharmacodynamics pathwayAgtr1a
Staphylococcus aureus infection pathwayPtafr
syndecan signaling pathwayEgfr , Prkaca , Prkca
systemic lupus erythematosus pathwayGrin2a
T cell receptor signaling pathwayChp1 , Chp2 , Plcg1 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , RGD1564956 , RGD1565588
telmisartan pharmacodynamics pathwayAgtr1a
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayPtk2b
timolol pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
Toxoplasma gondii infection pathwayNos2
tramadol pharmacodynamics pathwayAdra1a , Cacna1a , Cacnb1 , Drd1 , Grin1 , Grin2a , Kcnip2
trandolapril pharmacodynamics pathwayAgtr1a
transforming growth factor-beta Smad dependent signaling pathwayCamk2a
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma brucei infection pathwayGnaq , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Prkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayAdcy1 , Bdkrb2 , Calr , Gna11 , Gna14 , Gna15 , Gnal , Gnaq , Gnas , Nos2 , Plcb1 , Plcb2 , Plcb3 , Plcb4
type 2 diabetes mellitus pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
type II interferon signaling pathwayCalm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
valsartan pharmacodynamics pathwayAgtr1a
vascular endothelial growth factor signaling pathwayCalm1 , Calm2 , Calm3 , Chp1 , Chp2 , Nos3 , Plcg1 , Plcg2 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkca , Prkcb , Prkcg , Ptk2b , RGD1564956 , RGD1565588 , Sphk1 , Sphk2
vasopressin signaling pathwayAvpr1a , Avpr1b , Gna11 , Gnaq , Gnas
vasopressin signaling pathway via receptor type 1Avpr1a , Avpr1b , Gna11 , Gnaq
vasopressin signaling pathway via receptor type 2Adcy2 , Adcy3 , Adcy9 , Gnas , Prkaca , Prkacb , Prkx
verapamil pharmacodynamics pathwayAdrb1 , Agtr1a , Atp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Calm1 , Chrm2 , Itpr1 , Kcnip2 , Mylk , Plcb1 , Pln , Prkaca , Ryr2 , Slc8a1 , Tnnc1 , Tnnc2
visual phototransduction pathwayCalm1 , Calm2 , Calm3 , Calml3 , Calml5 , Cnga1 , Cnga3 , Cngb1 , Cngb3 , Guca1a , Guca1b , Rcvrn , Slc24a1 , Slc24a2
Wnt signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Chp1 , Chp2 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , RGD1564956 , RGD1565588
Wnt signaling, non-canonical pathwayCamk2a
Phenotype Annotations Associated with Genes in the calcium/calcium-mediated signaling pathway
Phenotype TermsGene Symbols
abnormal apoptosisCalr
abnormal axon morphologyCacna1b
abnormal body temperature homeostasisCckar
abnormal coat/hair pigmentationEdnrb
abnormal depression-related behaviorPlcb1
abnormal enteric ganglia morphologyEdnrb
abnormal estrous cycleEgfr
abnormal fear/anxiety-related behaviorCckbr
abnormal gaitCacna1a
abnormal muscle developmentCacna1s
abnormal nociception after inflammationF2r
abnormal object recognition memoryDrd1
abnormal olfactionAdcy3
abnormal passive avoidance behaviorDrd1
abnormal sleep patternDrd1
abnormal spleen B cell follicle morphologyEdnrb
abnormal spleen developmentEdnrb
abnormal taste sensitivityCckar
acute pancreas inflammationEdnra
aganglionic megacolonEdnrb
cardiac hypertrophyAgtr1b , Ppp3ca , Ppp3cb
congestive heart failureAdrb2
decreased neuron apoptosisEdnrb
decreased spleen red pulp amountEdnrb
decreased susceptibility to induced joint inflammationBdkrb1
decreased thymus weightEdnrb
demyelinationCacna1b
glomerulosclerosisEdnra
heart left ventricle hypertrophyEdnra , Egfr
hyperactivityDrd1
hypopigmentationEdnrb
impaired wound healingBdkrb1
increased body temperatureEdnrb
increased cell proliferationEdnrb
increased grooming behaviorDrd1
increased metastatic potentialErbb2
increased susceptibility to ischemic brain injuryGrin2a
increased systemic arterial blood pressureEdnrb
increased systemic arterial systolic blood pressureAtp2a3 , Ednra
kidney cystsEdnra , Ednrb
polyphagiaCckar
reduced female fertilityAdcy3
renal fibrosisEgfr
renal interstitial fibrosisEdnra , Ednrb
small spleenEdnrb

References Associated with the calcium/calcium-mediated signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: