CALCIUM/CALCIUM-MEDIATED SIGNALING PATHWAY (PW:0001140)
Description
Calcium permeates almost every aspect of cellular processes and the pathways associated with them - from proliferation to cell death, contraction and gene expression, hormone and neurotransmitter release, metabolism and synaptic plasticity. Movement of calcium ions in and outside of the cell is paramount to the maintenance of a calcium gradient four order of magnitudes between the extracellular environment and the cytoplasmic concentration of resting cells. The steep gradient allows for fast local increases in cytoplasmic concentration that underlie the broad range of cellular functions mediated by calcium signaling. Ca2+ entry into the cell or release into the cytoplasm, its extrusion or uptake, are broadly described in the calcium transport interactive pathway diagram -
click here to access it directly ,
(or on the diagram to get to its ontology report). The molecules/classes involved in the many aspects of Ca2+ transport are integral components of the 'calcium signaling kit' and thus present in the current diagram. The synopsis describes the sensors and buffers, the receptor and channels that respond to/are activated by Ca2+; these molecules/classes are highlighted in the diagram.
Ca2+, mostly a second messenger, interacts with a broad range of calcium binding, calcium-sensing molecules. Binding of Ca2+ triggers conformational changes that allow the sensors to interact with and modulate the activity of their target effectors.
By far the most prominent calcium sensor is calmodulin (CaM) - a small and ubiquitous molecule conserved throughout evolution that regulates the activity of a large array of targets employing several interaction modes. CaM has a dumbbell-like structure whose lobes house two EF-hand motifs , Ca2+ binding sites with distinct affinities and kinetics for the metal ion. In addition, its interaction mode with targets can modulate the apparent affinity for calcium. Notable CaM targets include calmodulin kinases and calcineurin. Calcineurin is a serine-threonine phosphatase whose Ca2+/CaM dependent signaling activity results in activation of transcription factors and changes in gene expression important for immune and neuronal functions. CaM regulates voltage operated channels (VOCs): the Ca2+ dependent negative feedback of L-type Cacna1c (Cav1.2) is accomplished via CaM; the P/Q type Cacna1a (Cav2.1) on the other hand exhibits Ca2+CaM dependent facilitation and inactivation. In both cases the CaM lobes play distinct roles. CaM in its apo- (Ca2+ free) form acts as a partial agonist of ryanodine receptors (RYRs), whereas the Ca2+ bound sensor acts as an inhibitor. CaM is also a constitutive component of several protein complexes, including the Ca2+ activated K+ channels, discussed further in this synopsis.
Other sensors include synaptotagmins, the neuronal calcium sensor proteins (NCS), troponin C, and members of the CaBP and S100 families of EF-hand containing proteins, only present in vertebrates. Synaptotagmins of which Syt1 is the best studied member, are transmembrane proteins that employ a C2 Ca2+ binding domain; metal coordination is provided by both the protein and membrane lipids. The two C2 domains of Syt1 bind three and two Ca2+ ions, respectively. Syt1 appears to be involved in synaptic vesicle exocytosis and is localized in presynaptic terminals. Proposed Ca2+ sensors, important for the secretion of insulin-containing granules in the pancreatic beta cells are Syt7 and 9. Of note is the fact that several steps underlie vesicular exocytosis; synaptotagmins are believed to be involved in the Ca2+ dependent interaction with the SNARE complex, the main engine of membrane fusion. However, both synaptotagmins and the SNARE complex, along with other proteins probably function in other exocytic steps, such as docking and/or priming.
The NCS family comprises 14 members with four EF-hands motifs, of which some may not be functional. Members, such as guanylate cyclases and recoverin, are only found in the retina. Other members include the widely expressed and better studied Ncs1, the less well characterized visin-like proteins (VSNLs: hippocalcin, neurocalcin delta, and Vilip 1-3) and the four K+ channel- interacting proteins (KChIPs). KChIPs associate with transient voltage-gated potassium channels and stimulate their traffic to the plasma membrane and depending on member identity may carry out other functions as well.
There are two troponin C genes, skeletal and cardiac, each comprising four EF-hands. Troponin, which is composed of three gene products - troponin C, I and T, exerts a major role in the regulation of excitation-contraction coupling. Troponin, in association with tropomyosin, confers the Ca2+ sensitivity of actomyosin underlying the role Ca2+ play in the regulation of muscle contraction.
Of the CaBP family, Cabp1 and 4 are the better studied system and appear to be involved in the regulation of Ca2+ channels. Long and short splice variants of CaBP1 and 2 lead to subtle differences in their localization; functional information is available for the long CaBP1 isoform. Two additional proteins known as calneuron 1 and 2 might represent a subclass of CaBP.
The S100 family - a relatively new comer to the sensor list whose members exhibit a canonical EF-hand and a 'pseudo EF-hand' unique to this family which in some cases, has lost the ability to bind Ca2+. Some family members are only present in human while others appear to be common to both human and rodents with S100a1 present in heart and S100b in the brain. Other S100 proteins can be found in the heart but in lower amounts; for instance S100A4 with which S100A1 can form a heterodimer and S100A1 also heterodimerizes with S100B. Some S100 proteins also bind zinc and copper; depending on the identity of the protein, Zn2+ may either increase or decrease the affinity for Ca2+ binding.
Potassium and chloride channels are calcium sensitive/calcium activated channels. Ca2+ entry via various channels or released from intracellular stores, activates the small conductance K+ channels (SK, Kcnn1-3). SKs don't directly bind Ca2+; when Ca2+ binds CaM, constitutively associated with the intracellular CaM binding domain , highly conserved across the family, the resulting conformational changes lead to opening of the channel's gate. Casein kinase acts on closed channels to decrease Ca2+ sensitivity while protein phosphatase 2A acts on opened ones to increase sensitivity, via phosphorylation and dephosphorylation of SK-associated CaM. The two enzymes are constitutively bound to Sk2 and 3 (Kcnn2 and 3). Models predict multiple contacts on the intracellular termini of the pore-forming subunits for the kinase; one domain C-terminal positioned with respect to the CaM binding site for the phosphatase. The channels are expressed throughout the nervous system and play important roles in synaptic plasticity, learning and memory. Much less is known about calcium activated chloride channels. Despite name/nomenclature, CLCA is an unlikely Ca2+ activated chloride channel (family members related to the bovine protein first purified, have been cloned). A protein known as TMEM16A (known as ANO1) may be the bona fide Ca2+ activated Cl- channel; more work needs to be done to unveil the function and mechanism of TMEM16A and whether the other TMEM16 family members share them (not shown).
In what may be the only instance of a first messenger role, Ca2+ binds to and activates the calcium sensing receptor (Casr), a G protein coupled receptor that triggers several intracellular cascades in a cell-specific manner. The pathway plays a prominent role in calcium homeostasis by regulating the expression and secretion of parathyroid hormone (Pth) and renal calcium reabsorption.
Another class of Ca2+ binding proteins is represented by buffers whose role is to chelate and therefore regulate the concentration of available metal ion. Unlike sensors, buffers do not undergo conformational changes; however, some might and as such could potentially also act as sensors. Cytosolic buffers are represented by parvalbumin alpha and beta (the function of beta/oncomodulin is not well known), calbindin - with the 28K Calb1 and the 9K S100g proteins, and calretinin; all members of the EF-hand family. The organellar ER buffer is calreticulin which also acts as a molecular chaperone together with calnexin and disulfide isomerase Pdia3, known as ERp57. In the SR, calsequestrins provide the buffering function with Casq1 in skeletal and Casq2 in cardiac muscle, respectively.
The regulated availability of the free metal ion and the interaction with its many sensors, the movement of Ca2+ in and out of cell and organelles, the calcium-mediated signaling and calcium transport pathways are inextricably connected. Together, they are components of the 'calcium signaling kit' and together, they orchestrate the homeostasis of what is probably the most versatile element in the kingdoms of life. To see the ontology report for annotations, Gviewer and download, click here . [Click to see associated KEGG map map04020 ]...(less)
Pathway Diagram:
Genes in Pathway:
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Adcy1
adenylate cyclase 1
IEA
KEGG
rno:04020
NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
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Adcy2
adenylate cyclase 2
IEA
KEGG
rno:04020
NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236
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Adcy3
adenylate cyclase 3
IEA
KEGG
rno:04020
NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
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Adcy4
adenylate cyclase 4
IEA
KEGG
rno:04020
NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
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Adcy7
adenylate cyclase 7
IEA
KEGG
rno:04020
NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
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Adcy8
adenylate cyclase 8
IEA
KEGG
rno:04020
NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
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Adcy9
adenylate cyclase 9
IEA
KEGG
rno:04020
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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Adora2a
adenosine A2a receptor
IEA
KEGG
rno:04020
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Adora2b
adenosine A2B receptor
IEA
KEGG
rno:04020
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Adra1a
adrenoceptor alpha 1A
IEA
KEGG
rno:04020
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra1b
adrenoceptor alpha 1B
IEA
KEGG
rno:04020
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Adra1d
adrenoceptor alpha 1D
IEA
KEGG
rno:04020
NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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Adrb1
adrenoceptor beta 1
IEA
KEGG
rno:04020
NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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Adrb2
adrenoceptor beta 2
IEA
KEGG
rno:04020
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Adrb3
adrenoceptor beta 3
IEA
KEGG
rno:04020
NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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Agtr1a
angiotensin II receptor, type 1a
IEA
KEGG
rno:04020
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr1b
angiotensin II receptor, type 1b
IEA
KEGG
rno:04020
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
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Atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp2b1
ATPase plasma membrane Ca2+ transporting 1
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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Atp2b2
ATPase plasma membrane Ca2+ transporting 2
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
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Atp2b3
ATPase plasma membrane Ca2+ transporting 3
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775
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Atp2b4
ATPase plasma membrane Ca2+ transporting 4
IEA ISO
KEGG RGD
PMID:19789383
rno:04020, RGD:7204695
NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
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Atp2c1
ATPase secretory pathway Ca2+ transporting 1
ISO
RGD
PMID:19789383
RGD:7204695
NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006
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Atp2c2
ATPase secretory pathway Ca2+ transporting 2
ISO
RGD
PMID:19789383
RGD:7204695
NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368
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Avpr1a
arginine vasopressin receptor 1A
IEA
KEGG
rno:04020
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Avpr1b
arginine vasopressin receptor 1B
IEA
KEGG
rno:04020
NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792
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Bdkrb1
bradykinin receptor B1
IEA
KEGG
rno:04020
NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
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Bdkrb2
bradykinin receptor B2
IEA
KEGG
rno:04020
NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
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Bst1
bone marrow stromal cell antigen 1
IEA
KEGG
rno:04020
NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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Cabp1
calcium binding protein 1
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927
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Cabp2
calcium binding protein 2
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 1:201,374,649...201,380,469
Ensembl chr 1:201,375,276...201,380,469
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Cabp4
calcium binding protein 4
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 1:201,428,671...201,442,950
Ensembl chr 1:201,428,672...201,433,172
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Cacna1b
calcium voltage-gated channel subunit alpha1 B
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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Cacna1e
calcium voltage-gated channel subunit alpha1 E
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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Cacna1f
calcium voltage-gated channel subunit alpha1 F
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413
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Cacna1g
calcium voltage-gated channel subunit alpha1 G
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
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Cacna1h
calcium voltage-gated channel subunit alpha1 H
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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Cacna1i
calcium voltage-gated channel subunit alpha1 I
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
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Cacna1s
calcium voltage-gated channel subunit alpha1 S
IEA ISO
KEGG RGD
PMID:21746798
rno:04020, RGD:7204688
NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318
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Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
RGD
PMID:21746798
RGD:7204688
NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
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Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
ISO
RGD
PMID:21746798
RGD:7204688
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
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Cacnb3
calcium voltage-gated channel auxiliary subunit beta 3
ISO
RGD
PMID:21746798
RGD:7204688
NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
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Cacnb4
calcium voltage-gated channel auxiliary subunit beta 4
ISO
RGD
PMID:21746798
RGD:7204688
NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
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Calb1
calbindin 1
ISO
RGD
PMID:20943758
RGD:7204685
NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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Calb2
calbindin 2
ISO
RGD
PMID:20943758
RGD:7204685
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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Calm1
calmodulin 1
IEA ISO
KEGG RGD
PMID:18083096 PMID:10884684
rno:04020, RGD:7204677 , RGD:7204676
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Calm2
calmodulin 2
IEA ISO
KEGG RGD
PMID:18083096 PMID:10884684
rno:04020, RGD:7204677 , RGD:7204676
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
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Calm3
calmodulin 3
IEA ISO
KEGG RGD
PMID:18083096 PMID:10884684
rno:04020, RGD:7204677 , RGD:7204676
NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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Calml3
calmodulin-like 3
IEA
KEGG
rno:04020
NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175
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Calml5
calmodulin-like 5
IEA
KEGG
rno:04020
NCBI chr17:66,394,433...66,395,390
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Calr
calreticulin
ISO
RGD
PMID:20356453
RGD:7204686
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
IEA
KEGG
rno:04020
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
IEA
KEGG
rno:04020
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
IEA
KEGG
rno:04020
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Camk2g
calcium/calmodulin-dependent protein kinase II gamma
IEA
KEGG
rno:04020
NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
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Camk4
calcium/calmodulin-dependent protein kinase IV
IEA
KEGG
rno:04020
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Casq1
calsequestrin 1
ISO
RGD
PMID:20356453
RGD:7204686
NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339
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Casq2
calsequestrin 2
ISO
RGD
PMID:20356453
RGD:7204686
NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267
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Cckar
cholecystokinin A receptor
IEA
KEGG
rno:04020
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
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Cckbr
cholecystokinin B receptor
IEA
KEGG
rno:04020
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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Cd38
CD38 molecule
IEA
KEGG
rno:04020
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Chp1
calcineurin-like EF-hand protein 1
IEA
KEGG
rno:04020
NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251
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Chp2
calcineurin-like EF hand protein 2
IEA
KEGG
rno:04020
NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139
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Chrm1
cholinergic receptor, muscarinic 1
IEA
KEGG
rno:04020
NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm2
cholinergic receptor, muscarinic 2
IEA
KEGG
rno:04020
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrm3
cholinergic receptor, muscarinic 3
IEA
KEGG
rno:04020
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Chrm5
cholinergic receptor, muscarinic 5
IEA
KEGG
rno:04020
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
IEA
KEGG
rno:04020
NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
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Cimip3
ciliary microtubule inner protein 3
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 9:13,560,663...13,582,987
Ensembl chr 9:13,560,876...13,582,814
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Cnga1
cyclic nucleotide gated channel subunit alpha 1
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr14:35,566,947...35,605,065
Ensembl chr14:35,567,125...35,605,065
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Cnga2
cyclic nucleotide gated channel subunit alpha 2
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr X:149,696,999...149,715,051
Ensembl chr X:149,696,997...149,715,051
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Cnga3
cyclic nucleotide gated channel subunit alpha 3
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr 9:39,447,532...39,497,883
Ensembl chr 9:39,448,034...39,493,183
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Cnga4
cyclic nucleotide gated channel subunit alpha 4
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr 1:159,752,357...159,756,369
Ensembl chr 1:159,752,357...159,756,375
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Cngb1
cyclic nucleotide gated channel subunit beta 1
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr19:9,726,595...9,791,111
Ensembl chr19:9,726,595...9,791,173
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Cngb3
cyclic nucleotide gated channel subunit beta 3
ISO
RGD
PMID:22435804
RGD:7204690
NCBI chr 5:32,746,988...32,995,121
Ensembl chr 5:32,746,988...32,995,121
G
Cysltr1
cysteinyl leukotriene receptor 1
IEA
KEGG
rno:04020
NCBI chr X:71,661,415...71,690,158
Ensembl chr X:71,663,821...71,690,121
G
Cysltr2
cysteinyl leukotriene receptor 2
IEA
KEGG
rno:04020
NCBI chr15:48,190,251...48,229,906
Ensembl chr15:48,189,073...48,304,136
G
Drd1
dopamine receptor D1
IEA
KEGG
rno:04020
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
G
Drd5
dopamine receptor D5
IEA
KEGG
rno:04020
NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
G
Ednra
endothelin receptor type A
IEA
KEGG
rno:04020
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
G
Ednrb
endothelin receptor type B
IEA
KEGG
rno:04020
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
G
Egfr
epidermal growth factor receptor
IEA
KEGG
rno:04020
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Erbb2
erb-b2 receptor tyrosine kinase 2
IEA
KEGG
rno:04020
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Erbb3
erb-b2 receptor tyrosine kinase 3
IEA
KEGG
rno:04020
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
G
Erbb4
erb-b2 receptor tyrosine kinase 4
IEA
KEGG
rno:04020
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
G
F2r
coagulation factor II (thrombin) receptor
IEA
KEGG
rno:04020
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
G
Gna11
G protein subunit alpha 11
IEA
KEGG
rno:04020
NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
G
Gna14
G protein subunit alpha 14
IEA
KEGG
rno:04020
NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423
G
Gna15
G protein subunit alpha 15
IEA
KEGG
rno:04020
NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508
G
Gnal
G protein subunit alpha L
IEA
KEGG
rno:04020
NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
G
Gnaq
G protein subunit alpha q
IEA
KEGG
rno:04020
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
G
Gnas
GNAS complex locus
IEA
KEGG
rno:04020
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
IEA
KEGG
rno:04020
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
IEA
KEGG
rno:04020
NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
G
Grin2c
glutamate ionotropic receptor NMDA type subunit 2C
IEA
KEGG
rno:04020
NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
G
Grin2d
glutamate ionotropic receptor NMDA type subunit 2D
IEA
KEGG
rno:04020
NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
G
Grm1
glutamate metabotropic receptor 1
IEA
KEGG
rno:04020
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
G
Grm5
glutamate metabotropic receptor 5
IEA
KEGG
rno:04020
NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
G
Grpr
gastrin releasing peptide receptor
IEA
KEGG
rno:04020
NCBI chr X:30,998,425...31,038,442
Ensembl chr X:30,998,416...31,038,442
G
Guca1a
guanylate cyclase activator 1A
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 9:13,587,695...13,598,566
Ensembl chr 9:13,588,525...13,598,565
G
Guca1b
guanylate cyclase activator 1B
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455
G
Guca2b
guanylate cyclase activator 2B
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966
G
Hrh1
histamine receptor H 1
IEA
KEGG
rno:04020
NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Hrh2
histamine receptor H 2
IEA
KEGG
rno:04020
NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
G
Htr2a
5-hydroxytryptamine receptor 2A
IEA
KEGG
rno:04020
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
G
Htr2b
5-hydroxytryptamine receptor 2B
IEA
KEGG
rno:04020
NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
G
Htr2c
5-hydroxytryptamine receptor 2C
IEA
KEGG
rno:04020
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
G
Htr4
5-hydroxytryptamine receptor 4
IEA
KEGG
rno:04020
NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
G
Htr5a
5-hydroxytryptamine receptor 5A
IEA
KEGG
rno:04020
NCBI chr 4:7,444,968...7,454,651
Ensembl chr 4:7,444,968...7,454,651
G
Htr5b
5-hydroxytryptamine (serotonin) receptor 5B
IEA
KEGG
rno:04020
NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
G
Htr6
5-hydroxytryptamine receptor 6
IEA
KEGG
rno:04020
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
G
Htr7
5-hydroxytryptamine receptor 7
IEA
KEGG
rno:04020
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
G
Itpka
inositol-trisphosphate 3-kinase A
IEA
KEGG
rno:04020
NCBI chr 3:106,726,036...106,734,601
Ensembl chr 3:106,726,036...106,734,600
G
Itpkb
inositol-trisphosphate 3-kinase B
IEA
KEGG
rno:04020
NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
IEA ISO
KEGG RGD
PMID:19133301
rno:04020, RGD:7204693
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Itpr2
inositol 1,4,5-trisphosphate receptor, type 2
IEA ISO
KEGG RGD
PMID:19133301
rno:04020, RGD:7204693
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
G
Itpr3
inositol 1,4,5-trisphosphate receptor, type 3
IEA ISO
KEGG RGD
PMID:19133301
rno:04020, RGD:7204693
NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
G
Kcnip1
potassium voltage-gated channel interacting protein 1
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr10:18,219,519...18,588,833
Ensembl chr10:18,219,519...18,589,045
G
Kcnip2
potassium voltage-gated channel interacting protein 2
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874
G
Kcnip3
potassium voltage-gated channel interacting protein 3
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
G
Kcnip4
potassium voltage-gated channel interacting protein 4
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr14:61,380,699...62,531,399
Ensembl chr14:61,381,076...62,530,144
G
Kcnn1
potassium calcium-activated channel subfamily N member 1
ISO
RGD
PMID:21942705
RGD:7204683
NCBI chr16:18,574,858...18,597,780
Ensembl chr16:18,585,992...18,597,482
G
Kcnn2
potassium calcium-activated channel subfamily N member 2
ISO
RGD
PMID:21942705
RGD:7204683
NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347
G
Kcnn3
potassium calcium-activated channel subfamily N member 3
ISO
RGD
PMID:21942705
RGD:7204683
NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145
G
Kcnn4
potassium calcium-activated channel subfamily N member 4
ISO
RGD
PMID:21942705
RGD:7204683
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
G
Lhcgr
luteinizing hormone/choriogonadotropin receptor
IEA
KEGG
rno:04020
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
G
Ltb4r2
leukotriene B4 receptor 2
IEA
KEGG
rno:04020
NCBI chr15:29,258,427...29,260,340
Ensembl chr15:29,259,240...29,260,316
G
Mcoln1
mucolipin TRP cation channel 1
ISO
RGD
PMID:20716668
RGD:7204689
NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252
G
Mcu
mitochondrial calcium uniporter
ISO
RGD
PMID:22850819
RGD:7204696
NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
G
Mlnr
motilin receptor
IEA
KEGG
rno:04020
NCBI chr19:50,413,570...50,422,842
Ensembl chr19:50,413,580...50,418,770
G
Mylk
myosin light chain kinase
IEA
KEGG
rno:04020
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
G
Mylk2
myosin light chain kinase 2
IEA
KEGG
rno:04020
NCBI chr 3:141,376,450...141,388,357
Ensembl chr 3:141,376,691...141,387,728
G
Mylk3
myosin light chain kinase 3
IEA
KEGG
rno:04020
NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954
G
Ncs1
neuronal calcium sensor 1
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829
G
Nos1
nitric oxide synthase 1
IEA
KEGG
rno:04020
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Nos2
nitric oxide synthase 2
IEA
KEGG
rno:04020
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
IEA
KEGG
rno:04020
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Ntsr1
neurotensin receptor 1
IEA
KEGG
rno:04020
NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
G
Ocm
oncomodulin
ISO
RGD
PMID:20943758
RGD:7204685
NCBI chr12:10,535,619...10,596,705
Ensembl chr12:10,586,897...10,596,707
G
Orai1
ORAI calcium release-activated calcium modulator 1
ISO
RGD
PMID:22914293
RGD:7204692
NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
G
Orai2
ORAI calcium release-activated calcium modulator 2
ISO
RGD
PMID:22914293
RGD:7204692
NCBI chr12:20,500,308...20,520,428
Ensembl chr12:20,497,317...20,520,428
G
Orai3
ORAI calcium release-activated calcium modulator 3
ISO
RGD
PMID:22914293
RGD:7204692
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
G
Oxtr
oxytocin receptor
IEA
KEGG
rno:04020
NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
G
P2rx1
purinergic receptor P2X 1
IEA
KEGG
rno:04020
NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
G
P2rx2
purinergic receptor P2X 2
IEA
KEGG
rno:04020
NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
G
P2rx3
purinergic receptor P2X 3
IEA
KEGG
rno:04020
NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
G
P2rx4
purinergic receptor P2X 4
IEA
KEGG
rno:04020
NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
G
P2rx5
purinergic receptor P2X 5
IEA
KEGG
rno:04020
NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423
G
P2rx6
purinergic receptor P2X 6
IEA
KEGG
rno:04020
NCBI chr11:83,439,922...83,450,449
Ensembl chr11:83,439,924...83,450,481
G
P2rx7
purinergic receptor P2X 7
IEA
KEGG
rno:04020
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
G
Pde1a
phosphodiesterase 1A
IEA
KEGG
rno:04020
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
G
Pde1b
phosphodiesterase 1B
IEA
KEGG
rno:04020
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
G
Pde1c
phosphodiesterase 1C
IEA
KEGG
rno:04020
NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219
G
Pdgfra
platelet derived growth factor receptor alpha
IEA
KEGG
rno:04020
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
G
Pdgfrb
platelet derived growth factor receptor beta
IEA
KEGG
rno:04020
NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
G
Phka1
phosphorylase kinase regulatory subunit alpha 1
IEA
KEGG
rno:04020
NCBI chr X:67,601,302...67,738,504
Ensembl chr X:67,601,302...67,738,455
G
Phka2
phosphorylase kinase regulatory subunit alpha 2
IEA
KEGG
rno:04020
NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466
G
Phkb
phosphorylase kinase regulatory subunit beta
IEA
KEGG
rno:04020
NCBI chr19:21,013,719...21,210,672
Ensembl chr19:21,025,733...21,210,633
G
Phkg1
phosphorylase kinase catalytic subunit gamma 1
IEA
KEGG
rno:04020
NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850
G
Phkg2
phosphorylase kinase catalytic subunit gamma 2
IEA
KEGG
rno:04020
NCBI chr 1:182,184,362...182,197,124
Ensembl chr 1:182,184,650...182,197,124
G
Plcb1
phospholipase C beta 1
IEA
KEGG
rno:04020
NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
G
Plcb2
phospholipase C, beta 2
IEA
KEGG
rno:04020
NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
G
Plcb3
phospholipase C beta 3
IEA
KEGG
rno:04020
NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
G
Plcb4
phospholipase C, beta 4
IEA
KEGG
rno:04020
NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
G
Plcd1
phospholipase C, delta 1
IEA
KEGG
rno:04020
NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
G
Plcd3
phospholipase C, delta 3
IEA
KEGG
rno:04020
NCBI chr10:88,026,707...88,048,080
Ensembl chr10:88,026,740...88,048,296
G
Plcd4
phospholipase C, delta 4
IEA
KEGG
rno:04020
NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
G
Plce1
phospholipase C, epsilon 1
IEA
KEGG
rno:04020
NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
G
Plcg1
phospholipase C, gamma 1
IEA
KEGG
rno:04020
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
G
Plcg2
phospholipase C, gamma 2
IEA
KEGG
rno:04020
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
G
Plcz1
phospholipase C, zeta 1
IEA
KEGG
rno:04020
NCBI chr 4:172,873,110...172,929,191
Ensembl chr 4:172,873,112...172,928,358
G
Pln
phospholamban
IEA
KEGG
rno:04020
NCBI chr20:32,629,537...32,639,559
G
Ppid
peptidylprolyl isomerase D
IEA
KEGG
rno:04020
NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221
G
Ppidl1
peptidylprolyl isomerase D-like 1
IEA
KEGG
rno:04020
NCBI chr 9:112,843,668...112,844,916
Ensembl chr 9:112,843,665...112,844,992
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
IEA
KEGG
rno:04020
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
G
Ppp3cb
protein phosphatase 3 catalytic subunit beta
IEA
KEGG
rno:04020
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
G
Ppp3cc
protein phosphatase 3 catalytic subunit gamma
IEA
KEGG
rno:04020
NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
G
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
IEA
KEGG
rno:04020
NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
G
Ppp3r2
protein phosphatase 3, regulatory subunit B, beta
IEA
KEGG
rno:04020
NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548
G
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
IEA
KEGG
rno:04020
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
G
Prkacb
protein kinase cAMP-activated catalytic subunit beta
IEA
KEGG
rno:04020
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
G
Prkca
protein kinase C, alpha
IEA
KEGG
rno:04020
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Prkcb
protein kinase C, beta
IEA
KEGG
rno:04020
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
G
Prkcg
protein kinase C, gamma
IEA
KEGG
rno:04020
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
G
Prkx
protein kinase cAMP-dependent X-linked catalytic subunit
IEA
KEGG
rno:04020
NCBI chr X:41,823,349...41,866,844
Ensembl chr X:41,823,355...41,866,669
G
Ptafr
platelet-activating factor receptor
IEA
KEGG
rno:04020
NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
G
Ptger1
prostaglandin E receptor 1
IEA
KEGG
rno:04020
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
G
Ptger3
prostaglandin E receptor 3
IEA
KEGG
rno:04020
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
G
Ptgfr
prostaglandin F receptor
IEA
KEGG
rno:04020
NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650
G
Ptk2b
protein tyrosine kinase 2 beta
IEA
KEGG
rno:04020
NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
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Pvalb
parvalbumin
ISO
RGD
PMID:20943758
RGD:7204685
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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Rcvrn
recoverin
ISO
RGD
PMID:20668007
RGD:7204681
NCBI chr10:52,388,706...52,396,454
Ensembl chr10:52,388,706...52,396,453
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RGD1564956
similar to calcium binding protein P22
IEA
KEGG
rno:04020
NCBI chr 5:68,570,894...68,571,875
Ensembl chr 5:68,571,232...68,571,819
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RGD1565588
similar to calcium binding protein P22
IEA
KEGG
rno:04020
G
Ryr1
ryanodine receptor 1
ISO
RGD
PMID:20961976
RGD:7204694
NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
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Ryr2
ryanodine receptor 2
IEA ISO
KEGG RGD
PMID:20961976
rno:04020, RGD:7204694
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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Ryr3
ryanodine receptor 3
IEA ISO
KEGG RGD
PMID:20961976
rno:04020, RGD:7204694
NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961
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S100a1
S100 calcium binding protein A1
ISO
RGD
PMID:16129693 PMID:17964289
RGD:1579960 , RGD:7204682
NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
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S100a4
S100 calcium-binding protein A4
ISO
RGD
PMID:17964289
RGD:7204682
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S100b
S100 calcium binding protein B
ISO
RGD
PMID:17964289
RGD:7204682
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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S100g
S100 calcium binding protein G
ISO
RGD
PMID:20943758
RGD:7204685
NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433
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Slc24a1
solute carrier family 24 member 1
ISO
RGD
PMID:17716241
RGD:7204698
NCBI chr 8:65,440,842...65,466,001
Ensembl chr 8:65,440,730...65,466,001
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Slc24a2
solute carrier family 24 member 2
ISO
RGD
PMID:17716241
RGD:7204698
NCBI chr 5:101,499,536...101,739,337
Ensembl chr 5:101,502,278...101,739,337
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Slc24a3
solute carrier family 24 member 3
ISO
RGD
PMID:17716241
RGD:7204698
NCBI chr 3:132,552,119...133,051,192
Ensembl chr 3:132,551,595...133,051,192
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Slc24a4
solute carrier family 24 member 4
ISO
RGD
PMID:17716241
RGD:7204698
NCBI chr 6:121,278,746...121,419,811
Ensembl chr 6:121,280,031...121,414,949
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Slc24a5
solute carrier family 24 member 5
ISO
RGD
PMID:17716241
RGD:7204698
NCBI chr 3:112,319,305...112,339,231
Ensembl chr 3:112,319,308...112,339,231
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Slc25a31
solute carrier family 25 member 31
IEA
KEGG
rno:04020
NCBI chr 2:123,695,387...123,711,275
Ensembl chr 2:123,695,408...123,710,795
G
Slc25a4
solute carrier family 25 member 4
IEA
KEGG
rno:04020
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
G
Slc25a5
solute carrier family 25 member 5
IEA
KEGG
rno:04020
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
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Slc25a6
solute carrier family 25 member 6
IEA
KEGG
rno:04020
NCBI chr18:68,571,229...68,572,474
Ensembl chr18:68,571,300...68,572,199
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Slc8a1
solute carrier family 8 member A1
IEA ISO
KEGG RGD
PMID:17716241
rno:04020, RGD:7204698
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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Slc8a2
solute carrier family 8 member A2
IEA ISO
KEGG RGD
PMID:17716241
rno:04020, RGD:7204698
NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
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Slc8a3
solute carrier family 8 member A3
IEA ISO
KEGG RGD
PMID:17716241
rno:04020, RGD:7204698
NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508
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Slc8b1
solute carrier family 8 member B1
ISO
RGD
PMID:22850819
RGD:7204696
NCBI chr12:36,029,759...36,053,087
Ensembl chr12:36,029,760...36,053,031
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Sphk1
sphingosine kinase 1
IEA
KEGG
rno:04020
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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Sphk2
sphingosine kinase 2
IEA
KEGG
rno:04020
NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
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Stim1
stromal interaction molecule 1
ISO
RGD
PMID:22914293
RGD:7204692
NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
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Stim2
stromal interaction molecule 2
ISO
RGD
PMID:22914293
RGD:7204692
NCBI chr14:56,878,428...57,004,405
Ensembl chr14:56,878,645...57,004,179
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Syt1
synaptotagmin 1
ISO IMP
RGD
PMID:15534041 PMID:11751925
RGD:7204679 , RGD:2311146
NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
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Syt7
synaptotagmin 7
ISO
RGD
PMID:15534041 PMID:18713958
RGD:7204679 , RGD:2311148
NCBI chr 1:207,031,369...207,093,787
Ensembl chr 1:207,031,592...207,089,026
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Syt9
synaptotagmin 9
ISO IMP
RGD
PMID:18713958 PMID:11751925
RGD:2311148 , RGD:2311146
NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
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Tacr1
tachykinin receptor 1
IEA
KEGG
rno:04020
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
G
Tacr2
tachykinin receptor 2
IEA
KEGG
rno:04020
NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
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Tacr3
tachykinin receptor 3
IEA
KEGG
rno:04020
NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
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Tbxa2r
thromboxane A2 receptor
IEA
KEGG
rno:04020
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
G
Tnnc1
troponin C1, slow skeletal and cardiac type
IEA ISO
KEGG RGD
PMID:17964289
rno:04020, RGD:7204682
NCBI chr16:6,400,801...6,405,419
Ensembl chr16:6,402,171...6,405,634
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Tnnc2
troponin C2, fast skeletal type
IEA ISO
KEGG RGD
PMID:17964289
rno:04020, RGD:7204682
NCBI chr 3:153,513,272...153,516,033
Ensembl chr 3:153,513,271...153,516,029
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Tpcn1
two pore segment channel 1
ISO
RGD
PMID:20018950
RGD:7204697
NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
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Tpcn2
two pore segment channel 2
ISO
RGD
PMID:20018950
RGD:7204697
NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
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Trhr
thyrotropin releasing hormone receptor
IEA
KEGG
rno:04020
NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
G
Trpc1
transient receptor potential cation channel, subfamily C, member 1
IEA
KEGG
rno:04020
NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
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Trpv5
transient receptor potential cation channel, subfamily V, member 5
ISO
RGD
PMID:20716668
RGD:7204689
NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745
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Trpv6
transient receptor potential cation channel, subfamily V, member 6
ISO
RGD
PMID:20716668
RGD:7204689
NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017
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Vdac1
voltage-dependent anion channel 1
IEA
KEGG
rno:04020
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
G
Vdac2
voltage-dependent anion channel 2
IEA
KEGG
rno:04020
NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
G
Vdac3
voltage-dependent anion channel 3
IEA
KEGG
rno:04020
NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471
G
Nfatc2
nuclear factor of activated T-cells 2
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
G
Nfatc3
nuclear factor of activated T-cells 3
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
G
Nfatc4
nuclear factor of activated T-cells 4
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
G
Ppp3cb
protein phosphatase 3 catalytic subunit beta
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
G
Ppp3cc
protein phosphatase 3 catalytic subunit gamma
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
G
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907
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Ppp3r2
protein phosphatase 3, regulatory subunit B, beta
ISO
RGD
PMID:15336966
RGD:1579951
NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548
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Rcan1
regulator of calcineurin 1
ISO
RGD
PMID:16415348
RGD:1581652
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
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Arrb1
arrestin, beta 1
ISO IMP
RGD
PMID:15637145 PMID:22192592
RGD:7207060 , RGD:7207059
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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Arrb2
arrestin, beta 2
ISO IMP
RGD
PMID:15637145 PMID:22192592
RGD:7207060 , RGD:7207059
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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Casr
calcium-sensing receptor
IMP IDA
RGD
PMID:22192592 PMID:12239094 PMID:15637145
RGD:7207059 , RGD:7207227 , RGD:7207060
NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
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Flna
filamin A
ISO
RGD
PMID:12239094
RGD:7207227
NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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Grk2
G protein-coupled receptor kinase 2
ISO
RGD
PMID:15637145
RGD:7207060
NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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Grk3
G protein-coupled receptor kinase 3
ISO
RGD
PMID:15637145
RGD:7207060
NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
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Grk4
G protein-coupled receptor kinase 4
ISO
RGD
PMID:15637145
RGD:7207060
NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
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Rgs12
regulator of G-protein signaling 12
ISO
RGD
PMID:12239094
RGD:7207227
NCBI chr14:75,715,925...75,824,012
Ensembl chr14:75,715,934...75,794,596
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Rgs2
regulator of G-protein signaling 2
ISO
RGD
PMID:12239094
RGD:7207227
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rgs4
regulator of G-protein signaling 4
ISO
RGD
PMID:12239094
RGD:7207227
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Rgs5
regulator of G-protein signaling 5
ISO
RGD
PMID:21393447
RGD:7207228
NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
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Rhoa
ras homolog family member A
ISO
RGD
PMID:12239094
RGD:7207227
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
ISO
RGD
PMID:23091085
RGD:7240708
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
ISO
RGD
PMID:23091085
RGD:7240708
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
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Cacng2
calcium voltage-gated channel auxiliary subunit gamma 2
ISO
RGD
PMID:22334212
RGD:7240704
NCBI chr 7:109,572,838...109,698,516
Ensembl chr 7:109,574,459...109,697,227
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Calm1
calmodulin 1
ISO
RGD
PMID:22717267 PMID:23091085
RGD:7240705 , RGD:7240708
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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Calm2
calmodulin 2
ISO
RGD
PMID:22717267 PMID:23091085
RGD:7240705 , RGD:7240708
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
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Calm3
calmodulin 3
ISO
RGD
PMID:22717267 PMID:23091085
RGD:7240705 , RGD:7240708
NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
ISO
RGD
PMID:22334212 PMID:22717267
RGD:7240704 , RGD:7240705
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
ISO
RGD
PMID:22334212 PMID:22717267
RGD:7240704 , RGD:7240705
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
ISO
RGD
PMID:22717267 PMID:23091085
RGD:7240705 , RGD:7240708
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Camk2g
calcium/calmodulin-dependent protein kinase II gamma
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
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Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
ISO
RGD
PMID:21070840 PMID:21301225
RGD:7240706 , RGD:7240707
NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600
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Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
ISO
RGD
PMID:21070840 PMID:21301225
RGD:7240706 , RGD:7240707
NCBI chr11:80,289,702...80,290,829
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Dlg1
discs large MAGUK scaffold protein 1
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Gria1
glutamate ionotropic receptor AMPA type subunit 1
ISO
RGD
PMID:22334212
RGD:7240704
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
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Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
ISO
RGD
PMID:22334212 PMID:22717267
RGD:7240704 , RGD:7240705
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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Hdac4
histone deacetylase 4
ISO
RGD
PMID:21255680
RGD:7241019
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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Hdac5
histone deacetylase 5
ISO
RGD
PMID:21255680
RGD:7241019
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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Lrrc7
leucine rich repeat containing 7
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr 2:247,147,752...247,533,332
Ensembl chr 2:247,147,752...247,634,547
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Pln
phospholamban
ISO
RGD
PMID:23091085
RGD:7240708
NCBI chr20:32,629,537...32,639,559
G
Ppm1e
protein phosphatase, Mg2+/Mn2+ dependent, 1E
ISO
RGD
PMID:18454172
RGD:7241020
NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282
G
Ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
TAS
RGD
PMID:18454172
RGD:7241020
NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
G
Ppp1cc
protein phosphatase 1 catalytic subunit gamma
ISO
RGD
PMID:18454172
RGD:7241020
NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
G
Ppp2ca
protein phosphatase 2 catalytic subunit alpha
TAS
RGD
PMID:18454172
RGD:7241020
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
G
Ryr2
ryanodine receptor 2
ISO
RGD
PMID:23091085
RGD:7240708
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
G
Scn5a
sodium voltage-gated channel alpha subunit 5
ISO
RGD
PMID:23091085
RGD:7240708
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
G
Syngap1
synaptic Ras GTPase activating protein 1
ISO
RGD
PMID:22717267
RGD:7240705
NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
G
Ednrb
endothelin receptor type B
IMP
RGD
PMID:15245872
RGD:1581866
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
Pathway Gene Annotations
Disease Annotations Associated with Genes in the calcium/calcium-mediated signaling pathway
Adcy1 autosomal recessive nonsyndromic deafness 44 , genetic disease , Hyperkinesis , lung small cell carcinoma , pleomorphic xanthoastrocytoma , withdrawal disorder Adcy2 asthma , bipolar disorder , genetic disease Adcy3 diabetic angiopathy , genetic disease , major depressive disorder , morbid obesity , obesity , Tatton-Brown-Rahman syndrome Adcy4 Brain-Lung-Thyroid Syndrome , genetic disease , lysinuric protein intolerance , Specific Granule Deficiency Adcy7 acute myeloid leukemia , genetic disease , juvenile rheumatoid arthritis , nephronophthisis 14 , schizophrenia , ulcerative colitis Adcy8 diabetic angiopathy , genetic disease , Hyperkinesis , mood disorder , withdrawal disorder Adcy9 congenital heart disease , epilepsy , genetic disease , Greig cephalopolysyndactyly syndrome , idiopathic generalized epilepsy , Kohlschutter-Tonz syndrome , mood disorder , Neurodevelopmental Disorders , Rubinstein-Taybi syndrome , short-rib thoracic dysplasia 9 with or without polydactyly Adora2a amphetamine abuse , anxiety disorder , asthma , bronchiolitis obliterans , cardiomyopathy , chronic obstructive pulmonary disease , depressive disorder , drug allergy , Drug-Related Side Effects and Adverse Reactions , epilepsy , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , genetic disease , Genetic Predisposition to Disease , Hyperkinesis , hypertension , Hypotension , lung disease , movement disease , myopia , panic disorder , pneumonia , primary pulmonary hypertension , pulmonary edema , Reperfusion Injury , rheumatoid arthritis , schizophrenia , Sepsis , Sleep Initiation and Maintenance Disorders , Spinal Cord Injuries , substance-induced psychosis , Tremor , Ventricular Dysfunction , Weight Loss , withdrawal disorder Adora2b Chemical and Drug Induced Liver Injury , genetic disease , Neoplasm Metastasis , Reperfusion Injury , Sepsis Adra1a Alzheimer's disease , bladder neck obstruction , Brain Injuries , depressive disorder , Experimental Diabetes Mellitus , genetic disease , hepatocellular carcinoma , Hyperalgesia , hypertension , Hypotension , liver cirrhosis , Memory Disorders , polycystic ovary syndrome , Spinal Cord Injuries , Urinary Incontinence , Ventricular Remodeling Adra1b Cardiomegaly , Experimental Liver Cirrhosis , genetic disease , hyperinsulinism , hypertension , Hypotension , Insulin Resistance , kidney disease , Nerve Degeneration , polycystic ovary syndrome , toxic encephalopathy Adra1d diastolic heart failure , genetic disease , Huntington's disease-like 1 , pantothenate kinase-associated neurodegeneration , polycystic ovary syndrome Adrb1 Anaphylaxis , Angina Pectoris , aortic valve stenosis , Birth Weight , cardiovascular system disease , chronic obstructive pulmonary disease , congestive heart failure , cystic fibrosis , diabetes mellitus , dilated cardiomyopathy , endomyocardial fibrosis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Familial Natural Short Sleep 2 , genetic disease , Hyperalgesia , Hyperemia , hyperglycemia , hypertension , Left Ventricular Hypertrophy , low tension glaucoma , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , nephrosclerosis , obesity , obstructive sleep apnea , periodontitis , renovascular hypertension , Reperfusion Injury , Stomach Neoplasms , type 1 diabetes mellitus , Ventricular Dysfunction Adrb2 acute kidney failure , AIDS Dementia Complex , Angina Pectoris , asthma , autism spectrum disorder , autistic disorder , Breast Neoplasms , bronchiolitis , cardiomyopathy , cardiovascular system disease , cholangiocarcinoma , chronic obstructive pulmonary disease , congestive heart failure , Coronary Disease , cystic fibrosis , dermatitis , dilated cardiomyopathy , disease of metabolism , end stage renal disease , Experimental Liver Cirrhosis , familial adenomatous polyposis 1 , familial hyperlipidemia , fatty liver disease , Fibrosis , genetic disease , Graves' disease , Hereditary Neoplastic Syndromes , human immunodeficiency virus infectious disease , Hyperlipoproteinemia Type II , hypertension , Hypertriglyceridemia , hypokalemia , hypothyroidism , Insulin Resistance , interstitial cystitis , kidney disease , Left Ventricular Hypertrophy , Liver Injury , lung disease , Metabolic Syndrome , myasthenia gravis , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , myocarditis , Nasal Polyps , nervous system disease , Neurodevelopmental Disorders , obesity , open-angle glaucoma , Paroxysmal Dyspnea , pneumonia , polycystic ovary syndrome , primary open angle glaucoma , Prostatic Neoplasms , psoriasis , pulmonary edema , Reperfusion Injury , sciatic neuropathy , Sepsis , Stomach Neoplasms , toxic shock syndrome , Tremor , type 2 diabetes mellitus , ulcerative colitis , urticaria , Ventricular Dysfunction, Left , Vestibulocochlear Nerve Injuries , viral encephalitis Adrb3 Alzheimer's disease , colitis , congestive heart failure , coronary artery disease , Coronary Disease , cystic fibrosis , Diabetic Nephropathies , diabetic retinopathy , dilated cardiomyopathy 1H , endometrial cancer , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , familial hyperlipidemia , genetic disease , gout , hereditary spastic paraplegia 54 , HIV-Associated Lipodystrophy Syndrome , hyperinsulinism , hypertension , hypogonadotropic hypogonadism 2 with or without anosmia , Insulin Resistance , Left Ventricular Hypertrophy , non-alcoholic fatty liver disease , obesity , paraplegia , polycystic ovary syndrome , retinopathy of prematurity , rheumatoid arthritis , Sepsis , type 2 diabetes mellitus Agtr1a abdominal aortic aneurysm , AIDS-Associated Nephropathy , Alzheimer's disease , anti-basement membrane glomerulonephritis , asthma , atrial fibrillation , breast cancer , breast lobular carcinoma , Cardiac Arrhythmias , Cardiomegaly , carotid artery disease , Carotid Artery Injuries , cerebrovascular disease , chronic kidney disease , congestive heart failure , corneal neovascularization , coronary artery disease , Coronary Disease , COVID-19 , Diabetic Nephropathies , diabetic retinopathy , Diaphragmatic Hernia , diffuse cystic renal dysplasia , dilated cardiomyopathy , Ductal Carcinoma , essential hypertension , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Fetal Growth Retardation , Fibrosis , focal segmental glomerulosclerosis , genetic disease , glomerulosclerosis , glucose intolerance , glycogen storage disease XV , Huntington's disease , hyperinsulinism , hypertension , Hypertensive Nephropathy , IgA glomerulonephritis , Inflammation , intermediate coronary syndrome , kidney disease , Left Ventricular Hypertrophy , limb ischemia , lung disease , Metabolic Syndrome , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephritis , pancreatic ductal carcinoma , Parkinson's disease , patent ductus arteriosus , Pituitary Neoplasms , placental insufficiency , Postoperative Cognitive Dysfunction , proteinuria , pulmonary fibrosis , pulmonary hypertension , renal cell carcinoma , renal hypertension , Renal Tubular Dysgenesis , renovascular hypertension , sarcoidosis , Spontaneous Abortions , Vascular System Injuries , Ventricular Remodeling , vesicoureteral reflux Agtr1b Cardiomegaly , Diaphragmatic Hernia , hypertension , Postoperative Cognitive Dysfunction , Prenatal Exposure Delayed Effects , renovascular hypertension Atp2a1 16p11.2 Deletion Syndrome , Alcohol Myopathy , Brody myopathy , Cachexia , chromosome 16p11.2 deletion syndrome , congestive heart failure , Experimental Diabetes Mellitus , genetic disease , Myocardial Reperfusion Injury , neuronal ceroid lipofuscinosis , schizophrenia , Sepsis , Spinal Cord Injuries , type 2 diabetes mellitus Atp2a2 abdominal obesity-metabolic syndrome 1 , acrokeratosis verruciformis , Acute Experimental Pancreatitis , Cachexia , Cardiomegaly , congestive heart failure , Darier Disease, Acral Hemorrhagic Type , Darier Disease, Segmental , Diabetic Cardiomyopathies , essential hypertension , euthyroid sick syndrome , Experimental Diabetes Mellitus , genetic disease , heart disease , hypothyroidism , Iron Overload , keratosis follicularis , Myocardial Reperfusion Injury , myocardial stunning , Neointima , pulmonary hypertension , Spinal Cord Injuries , status epilepticus , type 2 diabetes mellitus , Ventricular Dysfunction, Left , Ventricular Tachycardia Atp2a3 adenoma , Experimental Diabetes Mellitus , genetic disease , hypertension , type 2 diabetes mellitus Atp2b1 Autosomal Dominant Intellectual Developmental Disorder 66 , cataract , clubfoot , coronary artery disease , genetic disease , hypertension , Neurodevelopmental Disorders Atp2b2 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome , agenesis of the corpus callosum with peripheral neuropathy , Atrioventricular Septal Defect 2 , autosomal dominant nonsyndromic deafness , Autosomal Dominant Nonsyndromic Deafness 82 , autosomal recessive nonsyndromic deafness 12 , genetic disease , Hearing Loss , myoclonic-atonic epilepsy , Neurodevelopmental Disorders Atp2b3 adenoma , adrenal cortical adenoma , adrenoleukodystrophy , autistic disorder , Barth syndrome , creatine transporter deficiency , Developmental Disabilities , dyskeratosis congenita , Emery-Dreifuss muscular dystrophy , favism , fetal akinesia deformation sequence syndrome 1 , genetic disease , hypertension , immunodeficiency 33 , Meester-Loeys syndrome , Muscle Hypotonia , paraplegia , periventricular nodular heterotopia , primary hyperaldosteronism , spastic ataxia , Splenomegaly , syndromic X-linked intellectual disability Lubs type , thoracic aortic aneurysm , Tremor , X-linked spinocerebellar ataxia 1 Atp2b4 dystonia , familial adult myoclonic epilepsy 5 , gastrointestinal stromal tumor , genetic disease , Hypokalemic Periodic Paralysis, Type 1 , parathyroid carcinoma , prostate cancer Atp2c1 alkaptonuria , genetic disease , Hailey-Hailey disease , immunodeficiency 21 , Primary Lymphedema with Myelodysplasia Atp2c2 genetic disease , persistent fetal circulation syndrome Avpr1a acute kidney failure , autism spectrum disorder , autistic disorder , brain edema , Brain Injuries , Cardiomegaly , congenital adrenal hyperplasia , genetic disease , Hemorrhage , hypertension , myocardial infarction , portal hypertension , renovascular hypertension , schizophrenia Avpr1b ACTH-secreting pituitary adenoma , alcohol dependence , anxiety disorder , autism spectrum disorder , autistic disorder , bipolar disorder , Cushing Syndrome , depressive disorder , familial adult myoclonic epilepsy 5 , gastrointestinal stromal tumor , genetic disease , Hypokalemic Periodic Paralysis, Type 1 , mood disorder , parathyroid carcinoma , pituitary adenoma Bdkrb1 acute myeloid leukemia , Diabetes Complications , diabetic angiopathy , diabetic neuropathy , diabetic retinopathy , Edema , end stage renal disease , epilepsy , essential thrombocythemia , Experimental Arthritis , Experimental Diabetes Mellitus , Fibrosis , focal segmental glomerulosclerosis , genetic disease , glomerulonephritis , Hyperalgesia , hypertension , Inflammation , Insulin Resistance , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , Microvascular Angina , myelofibrosis , myocardial infarction , nephritis , obesity , overactive bladder syndrome , Pain , pleurisy , pulmonary fibrosis , renal fibrosis , rhinitis , sciatic neuropathy , Splenomegaly , temporal lobe epilepsy , Vascular System Injuries Bdkrb2 acute kidney failure , acute myeloid leukemia , Animal Disease Models , asthma , cardiomyopathy , Chemical and Drug Induced Liver Injury , chronic obstructive pulmonary disease , Cough , Diabetes Complications , Diabetic Nephropathies , Eosinophilia , epilepsy , essential thrombocythemia , Experimental Diabetes Mellitus , Extravasation of Diagnostic and Therapeutic Materials , genetic disease , Hemorrhage , high grade glioma , Hyperalgesia , Hyperemia , hypertension , Hypotension , Inflammation , Left Ventricular Hypertrophy , lung disease , Microvascular Angina , myelofibrosis , myocardial infarction , occupational dermatitis , Pain , pancreatitis , pleurisy , pneumonia , portal hypertension , pulmonary hypertension , rheumatoid arthritis , rhinitis , sciatic neuropathy , temporal lobe epilepsy , thrombosis , Vascular System Injuries Bst1 genetic disease , Joubert syndrome , lung disease , Parkinson's disease Cabp1 Chemical and Drug Induced Liver Injury , genetic disease , schizophrenia , Serotonin Syndrome , temporal lobe epilepsy Cabp2 Aicardi-Goutieres Syndrome 3 , autosomal recessive nonsyndromic deafness , autosomal recessive nonsyndromic deafness 93 , genetic disease , Hearing Loss , intellectual disability , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Cabp4 achromatopsia , Aicardi-Goutieres Syndrome 3 , Aland Island eye disease , cone dystrophy , cone-rod dystrophy , congenital stationary night blindness , Congenital Stationary Night Blindness 2B , COVID-19 , fundus dystrophy , genetic disease , intellectual disability , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Cacna1a alpha-mannosidosis , amyotrophic lateral sclerosis , Ataxia , autism spectrum disorder , autistic disorder , cerebellar ataxia , cerebral palsy , Charcot-Marie-Tooth disease dominant intermediate B , childhood absence epilepsy , childhood electroclinical syndrome , developmental and epileptic encephalopathy 1 , developmental and epileptic encephalopathy 42 , developmental and epileptic encephalopathy 52 , Developmental Disabilities , disorder of sexual development , epilepsy , episodic ataxia , episodic ataxia type 2 , exfoliation syndrome , familial hemiplegic migraine , familial hemiplegic migraine 1 , generalized dystonia , Generalized Epilepsy , genetic disease , glutaric acidemia I , intellectual disability , Lambert-Eaton myasthenic syndrome , Marshall-Smith syndrome , migraine , migraine with aura , Muscle Weakness , Nervous System Malformations , Neurodevelopmental Disorders , progressive bulbar palsy , spastic ataxia , spinocerebellar ataxia type 6 , Spinocerebellar Ataxias , Sporadic Hemiplegic Migraine , subependymal giant cell astrocytoma , sudden infant death syndrome , temporal lobe epilepsy , vascular dementia , visual epilepsy Cacna1b Adams-Oliver Syndrome 5 , autosomal dominant intellectual developmental disorder 8 , developmental and epileptic encephalopathy 14 , Diabetic Nephropathies , dystonia 23 , epilepsy , Experimental Autoimmune Encephalomyelitis , genetic disease , Hyperalgesia , Joubert syndrome , Kleefstra syndrome 1 , Lambert-Eaton myasthenic syndrome , multiple sclerosis , Neurodevelopmental Disorder with Seizures and Nonepileptic Hyperkinetic Movements , peripheral nervous system disease , primary coenzyme Q10 deficiency 7 , Rafiq syndrome Cacna1c acute stress disorder , alcohol dependence , Alzheimer's disease , amyloidosis , anxiety disorder , arrhythmogenic right ventricular cardiomyopathy , autism spectrum disorder , autistic disorder , bipolar disorder , breast cancer , breast ductal carcinoma , Brugada syndrome , Brugada syndrome 3 , Cardiac Arrhythmias , cardiomyopathy , catecholaminergic polymorphic ventricular tachycardia , cerebral palsy , Cognitive Dysfunction , Congenital Limb Deformities , congestive heart failure , dilated cardiomyopathy , epilepsy , esophageal atresia , Familial Ventricular Tachycardia , Fetal Growth Retardation , genetic disease , Genetic Predisposition to Disease , Heart Block , Hyperphosphatemic Familial Tumoral Calcinosis 1 , hypertension , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , hypoglycemia , intellectual disability , invasive ductal carcinoma , Joint Instability , Language Development Disorders , long QT syndrome , long QT syndrome 1 , major depressive disorder , NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, LANGUAGE DELAY, AND SKELETAL DEFECTS WITH OR WITHOUT SEIZURES , Neurodevelopmental Disorders , post-traumatic stress disorder , primary immunodeficiency disease , Psychomotor Agitation , pulmonary valve stenosis , restrictive cardiomyopathy , Romano-Ward Syndrome , schizophrenia , short QT syndrome , Sudden Cardiac Death , Sudden Death , Sudden Unexpected Nocturnal Death Syndrome , Timothy syndrome , Tremor , Ventricular Fibrillation, Paroxysmal Familial, 1 , Ventricular Tachycardia , Wolff-Parkinson-White syndrome Cacna1d adenoma , Alcohol Withdrawal Seizures , Animal Disease Models , autism spectrum disorder , bipolar disorder , Bradycardia , colon adenocarcinoma , colon adenoma , Deafness , Drug-Induced Dyskinesia , epilepsy , Fetal Growth Retardation , genetic disease , Hearing Loss , Heart Block , intellectual disability , Memory Disorders , Presbycusis , Primary Aldosteronism, Seizures, and Neurologic Abnormalities , primary hyperaldosteronism , prostate cancer , sciatic neuropathy , sick sinus syndrome , Sinoatrial Node Dysfunction and Deafness , Supraventricular Tachycardia , type 2 diabetes mellitus Cacna1e 1q24 Deletion Syndrome , autosomal recessive chronic granulomatous disease 2 , Coma , developmental and epileptic encephalopathy , developmental and epileptic encephalopathy 69 , early infantile epileptic encephalopathy , gastrointestinal stromal tumor , genetic disease , hyperglycemia , intellectual disability , Niemann-Pick disease type C1 , parathyroid carcinoma , Van der Woude syndrome , Wolff-Parkinson-White syndrome Cacna1f Aland Island eye disease , autistic disorder , cone-rod dystrophy , congenital disorder of glycosylation type IIm , congenital stationary night blindness , congenital stationary night blindness 2A , Eye Abnormalities , fundus dystrophy , genetic disease , immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome , macular degeneration , myopia , neurodegeneration with brain iron accumulation 5 , retinitis pigmentosa , syndromic X-linked intellectual disability Lubs type , X-linked cone-rod dystrophy 3 , X-linked epilepsy with variable learning disabilities and behavior disorders , X-linked severe congenital neutropenia Cacna1g brain disease , cerebellar ataxia , cerebellar ataxia type 42 , cerebrotendinous xanthomatosis , Developmental Disease , epilepsy , genetic disease , intellectual disability , juvenile myoclonic epilepsy , Left Ventricular Hypertrophy , Neurodevelopmental Disorders , spastic ataxia , Spinocerebellar Ataxia 42, Early-Onset, Severe, with Neurodevelopmental Deficits , Spinocerebellar Ataxias Cacna1h arteriovenous malformations of the brain , autistic disorder , beta thalassemia , breast ductal carcinoma , childhood absence epilepsy , Childhood Absence Epilepsy 6 , Drug-Related Side Effects and Adverse Reactions , epilepsy , Familial Hyperaldosteronism, Type IV , focal epilepsy , genetic disease , Hyperalgesia , idiopathic generalized epilepsy , peripheral nervous system disease , primary hyperaldosteronism , sciatic neuropathy , short-rib thoracic dysplasia 9 with or without polydactyly , tuberous sclerosis 2 Cacna1i adenylosuccinase lyase deficiency , Coffin-Siris syndrome 6 , Developmental Disabilities , genetic disease , hydrocephalus , Hyperalgesia , Neurodevelopmental Disorder with Speech Impairment and with or without Seizures , schizophrenia , sciatic neuropathy , Ventriculomegaly , withdrawal disorder Cacna1s CONGENITAL MYOPATHY 18 , familial adult myoclonic epilepsy 5 , gastrointestinal stromal tumor , genetic disease , hereditary neuropathy with liability to pressure palsies , hypokalemic periodic paralysis , Hypokalemic Periodic Paralysis, Type 1 , malignant hyperthermia , muscular atrophy , parathyroid carcinoma , respiratory failure , Rhabdomyolysis , Thyrotoxic Periodic Paralysis Cacnb1 genetic disease Cacnb2 arrhythmogenic right ventricular cardiomyopathy , autism spectrum disorder , Brugada syndrome , Brugada syndrome 4 , cardiac arrest , Cardiac Arrhythmias , cardiomyopathy , dilated cardiomyopathy , genetic disease , heart conduction disease , hypertension , hypertrophic cardiomyopathy , hypoparathyroidism-deafness-renal disease syndrome , Imerslund-Grasbeck Syndrome , long QT syndrome , Nerve Injuries , Paroxysmal Ventricular Fibrillation , short QT syndrome , Sudden Death , Sudden Unexpected Nocturnal Death Syndrome , Supraventricular Tachycardia , Ventricular Fibrillation , Ventricular Tachycardia Cacnb3 genetic disease , Nerve Injuries , ovarian cyst Cacnb4 Ataxia , dilated cardiomyopathy , episodic ataxia , episodic ataxia type 5 , Generalized Epilepsy , genetic disease , idiopathic generalized epilepsy , idiopathic generalized epilepsy 9 , juvenile myoclonic epilepsy , nemaline myopathy 2 , spastic ataxia Calb1 bilirubin metabolic disorder , genetic disease , kidney disease Calb2 amyotrophic lateral sclerosis type 1 , autosomal dominant dyskeratosis congenita 6 , Endometrial Neoplasms , genetic disease , malignant mesothelioma , Peritoneal Neoplasms , uveitis Calm1 achondrogenesis type IA , Alzheimer's disease , cannabis abuse , catecholaminergic polymorphic ventricular tachycardia , catecholaminergic polymorphic ventricular tachycardia 1 , catecholaminergic polymorphic ventricular tachycardia 4 , Cocaine-Related Disorders , Familial Ventricular Tachycardia , long QT syndrome 14 , phencyclidine abuse , type 2 diabetes mellitus , Weight Gain Calm2 cannabis abuse , Cocaine-Related Disorders , COVID-19 , genetic disease , long QT syndrome , long QT syndrome 1 , long QT syndrome 15 , Lynch syndrome , major depressive disorder , multiple intestinal atresia , phencyclidine abuse , sudden infant death syndrome Calm3 familial hypertrophic cardiomyopathy , long QT syndrome 1 , Long QT Syndrome 16 , Walker-Warburg syndrome Calml3 genetic disease , hepatocellular carcinoma , hypoparathyroidism-deafness-renal disease syndrome , Lung Neoplasms , Neoplasm Metastasis , schizophrenia Calml5 Alzheimer's disease , genetic disease , hypoparathyroidism-deafness-renal disease syndrome , schizophrenia Calr acute myeloid leukemia , alpha-mannosidosis , Burkitt lymphoma , Charcot-Marie-Tooth disease dominant intermediate B , colon adenocarcinoma , colon cancer , colon carcinoma , colorectal cancer , Colorectal Neoplasms , congestive heart failure , episodic ataxia type 2 , esophagus squamous cell carcinoma , essential thrombocythemia , Experimental Melanoma , Fibrosis , gallbladder cancer , gastric adenocarcinoma , genetic disease , glutaric acidemia I , hepatocellular carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , myelofibrosis , myeloid neoplasm , Myeloperoxidase Deficiency , Myocardial Ischemia , nasopharynx carcinoma , Neoplasm Invasiveness , neuroendocrine tumor , oral squamous cell carcinoma , ovarian cancer , pancreatic ductal adenocarcinoma , pancreatic ductal carcinoma , Prostatic Neoplasms , pulmonary fibrosis , sideroblastic anemia , stomach cancer , thrombocytosis , vitamin B12 deficiency Camk2a Alzheimer's disease , autism spectrum disorder , autosomal dominant intellectual developmental disorder 53 , autosomal recessive intellectual developmental disorder 63 , bipolar disorder , Cocaine-Related Disorders , Developmental Disabilities , familial adenomatous polyposis 1 , genetic disease , Hearing Loss, Cisplatin-Induced , Hepatomegaly , Hereditary Neoplastic Syndromes , high grade glioma , Hyperalgesia , Inflammation , intellectual disability , Larsen syndrome , middle cerebral artery infarction , mitochondrial metabolism disease , transient cerebral ischemia , Wilson disease Camk2b Apnea , autism spectrum disorder , autosomal dominant intellectual developmental disorder 54 , cannabis abuse , Cocaine-Related Disorders , Developmental Disabilities , Developmental Disease , dystonia , genetic disease , Hearing Loss, Cisplatin-Induced , high grade glioma , Hyperventilation , intellectual disability , microcephaly , Nervous System Malformations , Neurodevelopmental Disorders , oligodendroglioma , phencyclidine abuse , pleomorphic xanthoastrocytoma , schizophrenia , substance-induced psychosis Camk2d aniridia , atrial fibrillation , epilepsy , Experimental Liver Cirrhosis , genetic disease , Myocardial Ischemia , Neurodevelopmental Disorders , polycystic ovary syndrome Camk2g autistic disorder , Autosomal Dominant Intellectual Developmental Disorder 59 , genetic disease , intellectual disability , malignant astrocytoma Camk4 Cocaine-Related Disorders , familial adenomatous polyposis 1 , genetic disease , Hereditary Neoplastic Syndromes , intellectual disability , male infertility , Neurodevelopmental Disorders Casq1 autoimmune interstitial lung, joint, and kidney disease , Experimental Diabetes Mellitus , familial hemiplegic migraine , gastrointestinal stromal tumor , genetic disease , myopathy , parathyroid carcinoma , peroxisome biogenesis disorder 12A , type 2 diabetes mellitus , Vacuolar Myopathy Casq2 atrial fibrillation , Cardiac Arrhythmias , Cardiac Conduction Defect , cardiomyopathy , catecholaminergic polymorphic ventricular tachycardia , catecholaminergic polymorphic ventricular tachycardia 1 , catecholaminergic polymorphic ventricular tachycardia 2 , caudal regression syndrome , congestive heart failure , Diabetic Cardiomyopathies , dilated cardiomyopathy , Familial Ventricular Tachycardia , genetic disease , Heart Block , neural tube defect , progressive familial heart block , RASopathy , Sudden Death , supravalvular aortic stenosis , Ventricular Tachycardia , Wolff-Parkinson-White syndrome Cckar alcohol use disorder , cholelithiasis , Gallbladder Neoplasms , genetic disease , Hallucinations , obesity , pancreatic cancer , pancreatic ductal carcinoma , type 2 diabetes mellitus Cckbr Cocaine-Related Disorders , colitis , Experimental Diabetes Mellitus , genetic disease , Hyperalgesia , neuronal ceroid lipofuscinosis , obsessive-compulsive disorder , Pain , pancreatic cancer , pancreatic ductal carcinoma , panic disorder , toxic shock syndrome , withdrawal disorder Cd38 Albuminuria , Cardiomegaly , Diabetic Nephropathies , Experimental Liver Cirrhosis , genetic disease , Joubert syndrome , Myocardial Ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus Chp1 Bloom syndrome , colorectal cancer , Spastic Ataxia 9, Autosomal Recessive Chp2 genetic disease Chrm1 asthma , brain ischemia , Contracture , epilepsy , genetic disease , intellectual disability , Lambert-Eaton myasthenic syndrome , leukocyte adhesion deficiency 3 , Memory Disorders , myasthenia gravis Chrm2 asthma , bipolar disorder , Bradycardia , Brain Injuries , candidiasis , cardiomyopathy , Chagas disease , depressive disorder , diabetic neuropathy , dilated cardiomyopathy , epilepsy , Experimental Diabetes Mellitus , genetic disease , heroin dependence , major depressive disorder , neurogenic bladder , pleomorphic xanthoastrocytoma , schizophrenia , substance-related disorder , type 1 diabetes mellitus Chrm3 Ascites , asthma , bladder disease , Chemical and Drug Induced Liver Injury , chronic obstructive pulmonary disease , cryptorchidism , gastrointestinal stromal tumor , genetic disease , Hereditary Leiomyomatosis and Renal Cell Cancer , liver cirrhosis , megacystis-microcolon-intestinal hypoperistalsis syndrome , Neurodevelopmental Disorders , parathyroid carcinoma , prune belly syndrome , pulmonary fibrosis , small cell carcinoma Chrm5 Bloom syndrome , Cocaine-Related Disorders , colorectal cancer , genetic disease , withdrawal disorder Chrna7 Alzheimer's disease , attention deficit hyperactivity disorder , Auditory Perceptual Disorders , autism spectrum disorder , autistic disorder , Brain Injuries , chromosome 15q11.2 deletion syndrome , chromosome 15q13.3 microdeletion syndrome , chronic obstructive pulmonary disease , cognitive disorder , colorectal cancer , COVID-19 , Crohn's disease , esophagus squamous cell carcinoma , Experimental Colitis , Generalized Epilepsy , genetic disease , Hyperalgesia , idiopathic generalized epilepsy 7 , Lewy body dementia , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , malignant pleural mesothelioma , Memory Disorders , Neoplasm Invasiveness , Nerve Degeneration , Neurobehavioral Manifestations , Neurodevelopmental Disorders , rheumatoid arthritis , schizophrenia , Spina Bifida Cystica , sudden infant death syndrome , Tobacco Use Disorder , ulcerative colitis , umbilical hernia , withdrawal disorder Cimip3 cone-rod dystrophy 14 , Hereditary Eye Diseases Cnga1 cone-rod dystrophy , fundus dystrophy , genetic disease , macular degeneration , prostate cancer , retinitis pigmentosa , retinitis pigmentosa 49 Cnga2 autistic disorder , genetic disease , syndromic X-linked intellectual disability Lubs type Cnga3 achromatopsia , Achromatopsia 1 , achromatopsia 2 , color blindness , cone dystrophy , cone-rod dystrophy , Eye Abnormalities , fundus dystrophy , genetic disease , macular degeneration Cnga4 genetic disease , neuronal ceroid lipofuscinosis Cngb1 Bardet-Biedl syndrome , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , fundus dystrophy , genetic disease , retinitis pigmentosa , retinitis pigmentosa 45 , retinitis pigmentosa 49 Cngb3 achromatopsia , Achromatopsia 1 , achromatopsia 3 , color blindness , cone-rod dystrophy , Eye Abnormalities , fundus dystrophy , genetic disease , globe disease , Leber congenital amaurosis , macular degeneration , pathologic nystagmus , retinitis pigmentosa , Stargardt disease , Stargardt Disease 1 Cysltr1 Acute Lung Injury , allergic asthma , allergic disease , aspirin-induced respiratory disease , asthma , autistic disorder , Bronchial Hyperreactivity , bronchiolitis , Closed Fractures , colon cancer , drug allergy , Dyspnea , genetic disease , Helicobacter Infections , Inflammation , lung disease , Multiple Organ Failure , Nasal Polyps , obstructive sleep apnea , Pneumococcal Meningitis , prostate cancer , pulmonary fibrosis , pulmonary hypertension , Reperfusion Injury , rhinitis , syndromic X-linked intellectual disability Lubs type Cysltr2 aspirin-induced respiratory disease , asthma , chromosome 13q14 deletion syndrome , drug allergy , genetic disease , intellectual disability , obstructive sleep apnea , otitis media , Pneumococcal Meningitis , pulmonary fibrosis , Reperfusion Injury , rhinitis , uveal melanoma Drd1 Albuminuria , Alzheimer's disease , amphetamine abuse , autistic disorder , Binge-Eating Disorder , bipolar disorder , Catalepsy , Cocaine-Related Disorders , depressive disorder , Drug-Induced Dyskinesia , end stage renal disease , Experimental Arthritis , Experimental Diabetes Mellitus , Fever , genetic disease , heroin dependence , Huntington's disease , hyperglycemia , Hyperkinesis , hypertension , Hypotension , Insulin Resistance , kidney failure , movement disease , Neuralgia , obesity , Parkinson's disease , schizophrenia , Sleep Deprivation , tracheal stenosis , traumatic brain injury , ureteral obstruction , withdrawal disorder Drd5 Alzheimer's disease , attention deficit hyperactivity disorder , Benign Essential Blepharospasm , bipolar disorder , blepharospasm , cervical dystonia , depressive disorder , genetic disease , Huntington's disease , hypertension , Parkinson's disease , pervasive developmental disorder , psychotic disorder Ednra Acute Experimental Pancreatitis , asthma , Cardiovascular Abnormalities , congenital heart disease , congestive heart failure , Craniofacial Abnormalities , Diabetic Nephropathies , Diaphragmatic Hernia , Disease Progression , Experimental Diabetes Mellitus , genetic disease , hyperhomocysteinemia , hypertension , impotence , Inflammation , lung disease , mandibulofacial dysostosis with alopecia , methylmalonic acidemia cblA type , migraine , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Nasopharyngeal Neoplasms , Neoplasm Metastasis , nephrotic syndrome , obstructive sleep apnea , Optic Nerve Injuries , Ovarian Neoplasms , pleurisy , portal hypertension , pulmonary emphysema , pulmonary hypertension , renal fibrosis , Stroke , type 2 diabetes mellitus , velocardiofacial syndrome Ednrb ABCD syndrome , asthma , autosomal recessive nonsyndromic deafness , Breast Neoplasms , chromosome 13q14 deletion syndrome , congestive heart failure , Diaphragmatic Hernia , genetic disease , Hearing Loss , hepatopulmonary syndrome , Hirschsprung's disease , hypertension , Hypopigmentation , lymphopenia , megacolon , mitochondrial DNA depletion syndrome 12a , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Neoplasm Invasiveness , nephrosis , neuronal ceroid lipofuscinosis , Optic Nerve Injuries , Perinatal Death , portal hypertension , pulmonary hypertension , Reperfusion Injury , sensorineural hearing loss , Subarachnoid Hemorrhage , Total Intestinal Aganglionosis , type 2 diabetes mellitus , Waardenburg syndrome type 2A , Waardenburg Syndrome Type 4 , Waardenburg syndrome type 4A , Waardenburg's syndrome Egfr acute kidney failure , Acute Lung Injury , adenocarcinoma , adrenocortical carcinoma , Alcoholic Liver Diseases , Alzheimer's disease , Animal Mammary Neoplasms , aortic valve disease , aortic valve stenosis , arteriovenous malformations of the brain , asthma , autistic disorder , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , Bile Duct Neoplasms , Brain Neoplasms , breast cancer , breast carcinoma , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , carcinoma , Cardiomegaly , cerebral palsy , Chloracne , cholangiocarcinoma , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Coronavirus infectious disease , Craniofacial Abnormalities , dementia , dermatitis , diabetes mellitus , diabetic retinopathy , dilated cardiomyopathy , Disease Progression , endometrial carcinoma , Endometrioid Carcinomas , endometriosis , esophageal carcinoma , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , familial adenomatous polyposis , Gallbladder Neoplasms , genetic disease , glioblastoma , head and neck cancer , Head and Neck Neoplasms , head and neck squamous cell carcinoma , Helicobacter Infections , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , high grade glioma , Huntington's disease , Hyperplasia , hypertension , Immediate Hypersensitivity , Inflammation , Insulin Resistance , Laryngeal Neoplasms , laryngeal squamous cell carcinoma , Left Ventricular Hypertrophy , leiomyoma , liver cirrhosis , lung adenocarcinoma , lung cancer , lung carcinoma , lung disease , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , malignant mesothelioma , median neuropathy , Mesothelioma , Nasopharyngeal Neoplasms , Neonatal Inflammatory Skin and Bowel Disease 2 , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Recurrence, Local , obesity , oral squamous cell carcinoma , osteosarcoma , ovarian cancer , Ovarian Neoplasms , pancreatic cancer , papilloma , papillomavirus infectious disease , Parkinson's disease , Parkinsonism , peptic esophagitis , Phyllodes Tumor , pleomorphic xanthoastrocytoma , prostate cancer , Prostatic Neoplasms , pulmonary fibrosis , pulmonary hypertension , Pulmonary Hypertension, Hypoxia-Induced , pulmonary tuberculosis , rectal benign neoplasm , renal cell carcinoma , Right Ventricular Hypertrophy , schizophrenia , severe acute respiratory syndrome , Spinal Cord Injuries , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Tobacco Use Disorder , tongue squamous cell carcinoma , transitional cell carcinoma , type 1 diabetes mellitus , type 2 diabetes mellitus , urinary bladder cancer , Uterine Cervical Neoplasms , Vascular Remodeling , Ventricular Fibrillation Erbb2 adenocarcinoma , Animal Disease Models , Animal Mammary Neoplasms , basal cell carcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , calcinosis , Carcinogenesis , cholangiocarcinoma , Circulating Neoplastic Cells , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congestive heart failure , Diabetic Cardiomyopathies , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , esophageal carcinoma , Esophageal Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Familial Visceral Neuropathy 2, Autosomal Recessive , gallbladder carcinoma , Gallbladder Neoplasms , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , Germ Cell and Embryonal Neoplasms , head and neck squamous cell carcinoma , Helicobacter Infections , HELLP syndrome , high grade glioma , Hirschsprung's disease , hypertrophic cardiomyopathy 25 , invasive ductal carcinoma , invasive lobular carcinoma , Kidney Neoplasms , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , mammary Paget's disease , median neuropathy , medulloblastoma , melanoma , Mouth Neoplasms , Myocardial Ischemia , Neoplasm Metastasis , Neoplasm Recurrence, Local , nephroblastoma , oral squamous cell carcinoma , ovarian cancer , ovarian carcinoma , Ovarian Neoplasms , ovarian serous cystadenocarcinoma , ovary adenocarcinoma , pancreatic adenocarcinoma , papillary renal cell carcinoma , papilloma , Parkinson's disease , pre-eclampsia , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Recurrence , renal cell carcinoma , skin melanoma , Sporadic Papillary Renal Cell Carcinoma , stomach cancer , stomach carcinoma , Stomach Neoplasms , transitional cell carcinoma , urinary bladder cancer , Urologic Neoplasms , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Wallerian Degeneration Erbb3 Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , Colorectal Neoplasms , disease of cellular proliferation , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , Experimental Mammary Neoplasms , Familial Erythroleukemia , Familial Visceral Neuropathy , gallbladder carcinoma , Gallbladder Neoplasms , gastric adenocarcinoma , genetic disease , hepatocellular carcinoma , intestinal pseudo-obstruction , laryngeal squamous cell carcinoma , lethal congenital contracture syndrome 2 , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lymphatic Metastasis , median neuropathy , Mouth Neoplasms , nasopharynx carcinoma , Neoplasm Metastasis , neuronal intestinal dysplasia type A , Ovarian Neoplasms , Phyllodes Tumor , prostate cancer , Prostatic Neoplasms , Recurrence , Spinal Cord Injuries , stomach carcinoma , Stomach Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , urinary bladder cancer , uterine cancer , uterine carcinosarcoma , Uterine Cervical Neoplasms , Wallerian Degeneration Erbb4 amyotrophic lateral sclerosis , amyotrophic lateral sclerosis type 10 , amyotrophic lateral sclerosis type 19 , atrial fibrillation , Breast Neoplasms , cervical cancer , colorectal cancer , congestive heart failure , Diabetic Cardiomyopathies , ductal carcinoma in situ , Endometrial Neoplasms , Endometrioid Carcinomas , esophagus squamous cell carcinoma , Experimental Mammary Neoplasms , frontotemporal dementia , Gallbladder Neoplasms , genetic disease , head and neck squamous cell carcinoma , hepatocellular carcinoma , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , Lymphatic Metastasis , median neuropathy , melanoma , NATURAL KILLER CELL ENTEROPATHY , Neointima , Neoplasm Metastasis , Neurodevelopmental Disorders , oral squamous cell carcinoma , Ovarian Neoplasms , peripheral nervous system disease , Phyllodes Tumor , prostate cancer , radiculopathy , renal cell carcinoma , schizophrenia , Skin Neoplasms , stomach carcinoma , Stroke , Subarachnoid Hemorrhage , teratoma , tibial muscular dystrophy , tongue squamous cell carcinoma , transitional cell carcinoma , trichorhinophalangeal syndrome type I , urinary bladder cancer , Uterine Cervical Neoplasms , visual epilepsy F2r brain edema , brain ischemia , coronary restenosis , Experimental Arthritis , Experimental Liver Cirrhosis , Experimental Neoplasms , fatty liver disease , genetic disease , Helicobacter Infections , hepatitis , Hyperalgesia , hypertension , Inflammation , liver cirrhosis , Neurodevelopmental Disorders , pre-eclampsia , Stomach Neoplasms , thrombosis Gna11 autosomal dominant hypocalcemia 2 , CLOVES syndrome , congenital heart disease , Craniofacial Abnormalities , familial hypocalciuric hypercalcemia 2 , familial multiple nevi flammei , genetic disease , melanoma , Neurodevelopmental Disorders , skin melanoma , uveal melanoma Gna14 choreaacanthocytosis , Experimental Liver Cirrhosis , genetic disease , High Myopia , Kaposiform Hemangioendothelioma , Neu-Laxova syndrome 2 Gna15 genetic disease , Neurodevelopmental Disorders Gnal chromosome 18p deletion syndrome , Dysarthria , dystonia , dystonia 25 , genetic disease , intellectual disability , Parkinsonism , traumatic brain injury Gnaq Albuminuria , blood coagulation disease , Cardiomegaly , Cardiovascular Abnormalities , congenital heart disease , congestive heart failure , Craniofacial Abnormalities , dilated cardiomyopathy , familial multiple nevi flammei , focal segmental glomerulosclerosis , genetic disease , Klippel-Trenaunay syndrome , lung cancer , lung non-small cell carcinoma , melanoma , Neu-Laxova syndrome 2 , Port-Wine Stain , Sturge-Weber syndrome , uveal melanoma Gnas acromegaly , ACTH-independent macronodular adrenal hyperplasia , ACTH-independent macronodular adrenal hyperplasia 1 , adrenal gland hyperfunction , Adrenal Gland Neoplasms , adrenocortical carcinoma , Albright's hereditary osteodystrophy , Alzheimer's disease , B-Cell Chronic Lymphocytic Leukemia , brachydactyly , Breast Neoplasms , Cafe-au-Lait Spots , cholangiocarcinoma , Colorectal Neoplasms , Cushing Syndrome , disease of cellular proliferation , endocrine system disease , Gallstones , gastric adenocarcinoma , genetic disease , growth hormone secreting pituitary adenoma , head and neck squamous cell carcinoma , hemorrhagic disease , hepatocellular carcinoma , hereditary spastic paraplegia 4 , Heterotopic Ossification , hypertension , Hypoxia , Insulin Resistance , intellectual disability , lung adenocarcinoma , McCune Albright syndrome , melanoma , Metabolic Bone Diseases , neuroblastoma , obesity , Orthostatic Hypotension , pancreatic adenocarcinoma , pancreatic cancer , Parasitic Liver Diseases , pituitary adenoma 3 , Pituitary Neoplasms , polycystic kidney disease , polycystic ovary syndrome , Precocious Puberty , primary hyperaldosteronism , Primary Pigmented Nodular Adrenocortical Disease, 1 , progressive osseous heteroplasia , pseudohypoaldosteronism , pseudohypoparathyroidism , pseudohypoparathyroidism type IB , Pseudohypoparathyroidism Type IC , pseudopseudohypoparathyroidism , Respiration Disorders , schizophrenia , sex cord-gonadal stromal tumor , skin melanoma , Tachycardia , Uterine Cervical Neoplasms , withdrawal disorder Grin1 Adams-Oliver Syndrome 5 , alcohol use disorder , Alzheimer's disease , Animal Disease Models , autism spectrum disorder , autistic disorder , autosomal dominant intellectual developmental disorder 8 , autosomal dominant nocturnal frontal lobe epilepsy 5 , benign epilepsy with centrotemporal spikes , Brain Hypoxia-Ischemia , cerebral infarction , Cocaine-Related Disorders , cognitive disorder , developmental and epileptic encephalopathy 1 , Developmental and Epileptic Encephalopathy 101 , developmental and epileptic encephalopathy 14 , Developmental Disabilities , epilepsy , Febrile Seizures , genetic disease , Hemimegalencephaly , Hyperalgesia , intellectual disability , Joubert syndrome , Kleefstra syndrome 1 , Language Development Disorders , Leigh disease , Macrocephaly , Macrocephaly, Dysmorphic Facies, and Psychomotor Retardation , middle cerebral artery infarction , Neurodevelopmental Disorder with or without Hyperkinetic Movements and Seizures, Autosomal Recessive , Neurodevelopmental Disorders , Pain , placental insufficiency , primary coenzyme Q10 deficiency 7 , prostate cancer , psychotic disorder , Rafiq syndrome , schizophrenia , sciatic neuropathy , status epilepticus , trigeminal neuralgia , tuberous sclerosis 1 , vascular dementia Grin2a Alzheimer's disease , autistic disorder , autosomal dominant intellectual developmental disorder 21 , benign epilepsy with centrotemporal spikes , bipolar disorder , Brain Hypoxia-Ischemia , Central Nervous System Viral Diseases , Charcot-Marie-Tooth disease type 1C , cognitive disorder , colorectal cancer , Colorectal Neoplasms , Developmental Disabilities , epilepsy , Episodic Ataxia Type 9 , familial temporal lobe epilepsy 1 , Fetal Growth Retardation , focal epilepsy , Focal Epilepsy with Speech Disorder and with or without Mental Retardation , GABA aminotransferase deficiency , Generalized Epilepsy , genetic disease , Huntington's disease , Hyperalgesia , hyperhomocysteinemia , intellectual disability , Landau-Kleffner syndrome , Language Development Disorders , melanoma , MHC class II deficiency , microcephaly , morphine dependence , nasopharynx carcinoma , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES , Neurodevelopmental Disorders , placental insufficiency , pyridoxine-dependent epilepsy , Reperfusion Injury , schizophrenia , Sepsis , speech disorder , status epilepticus , vascular dementia , withdrawal disorder Grin2c genetic disease Grin2d brain disease , developmental and epileptic encephalopathy 46 , epilepsy , genetic disease , intellectual disability , Nerve Degeneration , schizophrenia Grm1 attention deficit hyperactivity disorder , autosomal recessive spinocerebellar ataxia 13 , Bone Tissue Neoplasms , cerebellar ataxia , Developmental Disabilities , epilepsy , fibroma , fragile X syndrome , genetic disease , skin melanoma , spinocerebellar ataxia 44 , Spinocerebellar Ataxias , status epilepticus , temporal lobe epilepsy , uveal melanoma Grm5 attention deficit hyperactivity disorder , autism spectrum disorder , Cocaine-Related Disorders , diabetic neuropathy , genetic disease , Huntington's disease , intellectual disability , Keratosis Palmoplantaris with Periodontopathia and Onychogryposis , Neuralgia , schizophrenia , status epilepticus , substance-related disorder , temporal lobe epilepsy Grpr autistic disorder , genetic disease , Memory Disorders , Neurodevelopmental Disorders , Prostatic Neoplasms , syndromic X-linked intellectual disability Lubs type Guca1a cone dystrophy , cone-rod dystrophy , cone-rod dystrophy 14 , fundus dystrophy , genetic disease , Hereditary Eye Diseases , infantile Refsum disease , macular degeneration , retinitis pigmentosa , Usher syndrome , Zellweger syndrome Guca1b cone dystrophy , cone-rod dystrophy 14 , genetic disease , infantile Refsum disease , Leber congenital amaurosis , retinitis pigmentosa , retinitis pigmentosa 48 , Zellweger syndrome Guca2b Charcot-Marie-Tooth disease dominant intermediate C , end stage renal disease , genetic disease , nephrotic syndrome Hrh1 allergic rhinitis , atherosclerosis , Extravasation of Diagnostic and Therapeutic Materials , genetic disease , Hypotension , Neurodevelopmental Disorders , Pain , Pruritus , respiratory allergy , rhinitis , schizophrenia , telangiectasis , withdrawal disorder Hrh2 Chemical and Drug Induced Liver Injury , congestive heart failure , coronary stenosis , Experimental Neoplasms , genetic disease , hypertension , Left Ventricular Hypertrophy , Myocardial Reperfusion Injury , myoepithelioma , Neoplasm Metastasis , transient cerebral ischemia , transitional cell carcinoma , withdrawal disorder Htr2a alcohol use disorder , anorexia nervosa , asthma , autistic disorder , Back Pain , basal ganglia disease , bipolar disorder , bladder neck obstruction , chronic obstructive pulmonary disease , Cocaine-Related Disorders , cognitive disorder , congestive heart failure , depressive disorder , Diabetic Nephropathies , disease of metabolism , Dyskinesias , Experimental Diabetes Mellitus , Fever , genetic disease , Hallucinations , Hyperalgesia , hyperglycemia , Hyperkinesis , Hyperphagia , hypertension , Hypoxia , Insulin Resistance , major depressive disorder , Memory Disorders , migraine , obesity , obsessive-compulsive disorder , pancreatitis , psychotic disorder , schizophrenia Htr2b Bardet-Biedl syndrome , Cardiomegaly , congestive heart failure , Drug-Related Side Effects and Adverse Reactions , Experimental Liver Cirrhosis , genetic disease , heart valve disease , hypertension , hypertrophic cardiomyopathy , Joubert syndrome 22 , Perlman syndrome , pulmonary hypertension Htr2c anxiety disorder , autistic disorder , bipolar disorder , Experimental Liver Neoplasms , genetic disease , Hyperkinesis , major depressive disorder , Metabolic Syndrome , Neuralgia , obesity , osteoporosis , Pain , Prader-Willi syndrome , prostate cancer , schizophrenia , substance-related disorder , syndromic X-linked intellectual disability Lubs type , type 2 diabetes mellitus , Weight Gain , withdrawal disorder Htr4 Anorexia , anorexia nervosa , atrial fibrillation , Cardiac Arrhythmias , congenital adrenal hyperplasia , familial adenomatous polyposis 1 , genetic disease , Hereditary Neoplastic Syndromes , lung adenocarcinoma , Neurodevelopmental Disorders , squamous cell carcinoma , Stroke , Tachycardia Htr5a autistic disorder , genetic disease , holoprosencephaly 3 , prostate cancer Htr6 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency , Alzheimer's disease , amphetamine abuse , chromosome 1p36 deletion syndrome , congenital disorder of glycosylation Ir , genetic disease , hyperprolinemia type 2 , Memory Disorders , Parkinson's disease 6 , schizophrenia , substance-induced psychosis Htr7 alcohol use disorder , amnestic disorder , anxiety disorder , Brain Injuries , childhood absence epilepsy , cognitive disorder , depressive disorder , epilepsy , genetic disease , Hyperalgesia , Hyperkinesis , irritable bowel syndrome , learning disability , Memory Disorders , migraine , muscular disease , obsessive-compulsive disorder , Pain , Peripheral Nerve Injuries , schizophrenia , sleep disorder Itpka Bloom syndrome , colorectal cancer , genetic disease Itpkb gastrointestinal stromal tumor , genetic disease , myeloproliferative neoplasm , parathyroid carcinoma Itpr1 Alzheimer's disease , anterior segment dysgenesis , asthma , Ataxia , autosomal dominant cerebellar ataxia , Brain Hypoxia , cardiac arrest , cerebellar ataxia , Chemical and Drug Induced Liver Injury , Congenital Mydriasis , diabetes mellitus , dilated cardiomyopathy , epilepsy , genetic disease , Gillespie syndrome , Huntington's disease , Hyperalgesia , Hypoxia , intellectual disability , movement disease , mucosulfatidosis , neurodegenerative disease , Neurodevelopmental Disorders , Niemann-Pick disease type A , Prostatic Neoplasms , spastic ataxia , spinocerebellar ataxia type 15 , spinocerebellar ataxia type 29 , transient cerebral ischemia Itpr2 amyotrophic lateral sclerosis , Brain Hypoxia , Cardiomegaly , genetic disease , intellectual disability , isolated anhidrosis with normal sweat glands Itpr3 acrodermatitis , autism spectrum disorder , autistic disorder , autosomal dominant intellectual developmental disorder 5 , Charcot-Marie-Tooth Disease Type 1J , genetic disease , JMP syndrome , type 1 diabetes mellitus Kcnip1 Diastolic Hypertension, Resistance to , genetic disease , idiopathic generalized epilepsy Kcnip2 Cardiac Arrhythmias , genetic disease Kcnip3 genetic disease Kcnip4 genetic disease Kcnn1 genetic disease , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 Kcnn2 atrial fibrillation , autistic disorder , cerebellar ataxia , Developmental Disabilities , essential tremor , familial adenomatous polyposis 1 , genetic disease , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , Myoclonic Dystonia 34 , NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT VARIABLE MOVEMENT OR BEHAVIORAL ABNORMALITIES , Neurodevelopmental Disorders , Parkinson's disease Kcnn3 atrial fibrillation , Charcot-Marie-Tooth disease type 2 , gastrointestinal stromal tumor , genetic disease , immunodeficiency 42 , MHC class II deficiency , paranoid schizophrenia , parathyroid carcinoma , prostate cancer , schizophrenia , severe congenital neutropenia 3 , severe congenital neutropenia 5 , Zimmermann-Laband Syndrome 3 Kcnn4 dehydrated hereditary stomatocytosis , dehydrated hereditary stomatocytosis 1 , dehydrated hereditary stomatocytosis 2 , ethylmalonic encephalopathy , Experimental Arthritis , Experimental Diabetes Mellitus , genetic disease , schizophrenia , Stomatocytosis II Lhcgr 46, XY Disorders of Sex Development , Anorchia , breast cancer , disorder of sexual development , Experimental Mammary Neoplasms , familial male-limited precocious puberty , genetic disease , gonadal disease , granulosa cell tumor , hypogonadism , Leydig cell hypoplasia , Leydig cell hypoplasia type I , Leydig cell hypoplasia type II , Leydig cell tumor , male infertility , mucinous cystadenocarcinoma , Ovarian Neoplasms , Pitt-Hopkins-like syndrome 2 , pseudohermaphroditism , serous cystadenocarcinoma , Somatic Leydig Cell Adenoma, with Male-Limited Precocious Puberty , syndromic X-linked intellectual disability Siderius type Ltb4r2 Acute Lung Injury , Brain-Lung-Thyroid Syndrome , genetic disease , lysinuric protein intolerance , Specific Granule Deficiency Mcoln1 Boucher-Neuhauser syndrome , Corneal Opacity , familial hemophagocytic lymphohistiocytosis 5 , genetic disease , glycoproteinosis , Growth Disorders , hereditary spastic paraplegia , hereditary spastic paraplegia 39 , hereditary spastic paraplegia 5A , intellectual disability , mucolipidosis , mucolipidosis type IV , Nervous System Malformations , periventricular leukomalacia Mcu genetic disease Mylk Acute Lung Injury , adult respiratory distress syndrome , alkaptonuria , allergic disease , aortic aneurysm , Aortic Aneurysm, Familial Abdominal 1 , aortic dissection , asthma , atrial heart septal defect , autosomal dominant familial visceral neuropathy , brain edema , carotid artery dissection , Carotid Artery Dissection, Internal , carotid artery occlusion , connective tissue disease , Disproportionate Tall Stature , familial hypocalciuric hypercalcemia , Familial Thoracic Aortic Aneurysm 1 , Familial Thoracic Aortic Aneurysm 6 , Familial Thoracic Aortic Aneurysm 7 , gastrointestinal system disease , genetic disease , glaucoma , high grade glioma , Hypercholesterolemia , intestinal pseudo-obstruction , Loeys-Dietz syndrome , Marfan syndrome , Marfanoid Hypermobility Syndrome , megacystis-microcolon-intestinal hypoperistalsis syndrome , Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1 , Neoplasm Invasiveness , Neoplasm Metastasis , pneumonia , Primary Lymphedema with Myelodysplasia , prostate cancer , Sepsis , Stroke , thoracic aortic aneurysm , vascular disease , Ventricular Dysfunction, Right Mylk2 cardiomyopathy , Diabetic Cardiomyopathies , dilated cardiomyopathy 1G , Dilated Cardiomyopathy with Left Ventricular Noncompaction , Fabry disease , familial hypertrophic cardiomyopathy , genetic disease , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , Stroke , Sudden Death , Ventricular Tachycardia Mylk3 genetic disease , glycogen storage disease IXb , Parkinson's disease 17 Ncs1 genetic disease , primary coenzyme Q10 deficiency 7 Nos1 achalasia , acute kidney failure , acute necrotizing pancreatitis , alcoholic cardiomyopathy , Alzheimer's disease , amphetamine abuse , arteriosclerosis , asthma , autism spectrum disorder , brain ischemia , Bronchial Hyperreactivity , Carbon Monoxide Poisoning , Cardiomegaly , cardiomyopathy , cerebellar disease , chronic obstructive pulmonary disease , congestive heart failure , cystic fibrosis , Dehydration , depressive disorder , Diabetic Nephropathies , diabetic retinopathy , disease of mental health , Duchenne muscular dystrophy , End Stage Liver Disease , end stage renal disease , Experimental Diabetes Mellitus , Experimental Radiation Injuries , fetal alcohol spectrum disorder , Fetal Growth Retardation , Fetal Hypoxia , Fever , genetic disease , Heat Stroke , hepatic encephalopathy , Human Influenza , Hyperalgesia , hypertension , hypertrophic pyloric stenosis , Hypoxia , impotence , Infantile Hypertrophic Pyloric Stenosis 1 , intestinal perforation , intracranial aneurysm , major depressive disorder , Memory Disorders , morphine dependence , motor neuron disease , nephrotic syndrome , Nerve Degeneration , nervous system disease , Nervous System Trauma , Neuralgia , Neurobehavioral Manifestations , obesity , Parkinson's disease , Parkinsonism , portal hypertension , Prehypertension , renovascular hypertension , Reperfusion Injury , retinopathy of prematurity , Right Ventricular Hypertrophy , schizophrenia , Sepsis , Spinal Cord Injuries , status epilepticus , Stroke , temporal lobe epilepsy , transient cerebral ischemia , type 1 diabetes mellitus , type 2 diabetes mellitus , urethral obstruction , Urination Disorders , Ventricular Remodeling Nos2 abdominal aortic aneurysm , Acute Hepatitis , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute necrotizing pancreatitis , Alzheimer's disease , amyotrophic lateral sclerosis , anterior uveitis , anti-basement membrane glomerulonephritis , asbestosis , aspiration pneumonia , asthma , atherosclerosis , autism spectrum disorder , autistic disorder , brain edema , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , Breast Neoplasms , bronchial disease , Bronchial Hyperreactivity , bronchiolitis obliterans , Burns , Cardiovascular Abnormalities , cholangiocarcinoma , cholestasis , Chronic Bronchitis , Chronic Hepatitis , chronic obstructive pulmonary disease , colitis , colon adenocarcinoma , Colonic Neoplasms , congestive heart failure , coronary artery disease , cystic fibrosis , dementia , diabetic angiopathy , diabetic neuropathy , duodenal ulcer , Edema , Emphysema , Endotoxemia , Esophageal Neoplasms , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Neuritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , extrahepatic cholestasis , extrinsic allergic alveolitis , Fetal Diseases , Fetal Growth Retardation , focal segmental glomerulosclerosis , Fungal Lung Diseases , Gallbladder Neoplasms , gastric ulcer , gastroschisis , genetic disease , Hemorrhagic Shock , hepatic encephalopathy , Hepatic Insufficiency , hepatitis , hepatocellular carcinoma , Hepatomegaly , Human Influenza , Hyperalgesia , Hyperemia , hypertension , Hypothermia , hypothyroidism , impotence , Inflammation , inflammatory bowel disease , Insulin Resistance , interstitial cystitis , interstitial lung disease , intestinal disease , kidney disease , Lewy body dementia , liver disease , lung disease , Lung Neoplasms , malaria , Manganese Poisoning , Marfan syndrome , middle cerebral artery infarction , mitochondrial metabolism disease , mucositis , Mycoplasma Infections , myocardial infarction , Myocardial Reperfusion Injury , myocardial stunning , Nasal Polyps , Necrosis , Neoplasm Metastasis , Neoplastic Cell Transformation , non-alcoholic fatty liver disease , obesity , obstructive sleep apnea , otitis media , pancreatic cancer , pancreatic ductal carcinoma , paraplegia , Parkinson's disease , Perennial Allergic Rhinitis , perinatal necrotizing enterocolitis , pleurisy , Pneumococcal Pneumonia , pneumocystosis , primary biliary cholangitis , psoriasis , psoriatic arthritis , pulmonary edema , pulmonary emphysema , pulmonary eosinophilia , pulmonary fibrosis , pulmonary hypertension , pulmonary sarcoidosis , pulmonary tuberculosis , renal hypertension , Reperfusion Injury , respiratory allergy , retinal disease , retinopathy of prematurity , rhinitis , Schistosomiasis Mansoni , sclerosing cholangitis , secondary Parkinson disease , Sepsis , silicosis , sleeping sickness , Spinal Cord Injuries , status epilepticus , Stevens-Johnson syndrome , Stroke , Subarachnoid Hemorrhage , Systemic Inflammatory Response Syndrome , systemic lupus erythematosus , Takayasu's arteritis , Thrombotic Microangiopathies , toxic shock syndrome , traumatic brain injury , Turner syndrome , type 1 diabetes mellitus , type 2 diabetes mellitus , uremia , ureteral obstruction , urinary tract infection , uveitis , Viral Bronchiolitis , withdrawal disorder Nos3 acute chest syndrome , acute kidney failure , Acute Liver Failure , acute lymphoblastic leukemia , acute myeloid leukemia , adenocarcinoma , Alzheimer's disease , angle-closure glaucoma , anterior ischemic optic neuropathy , aortic valve disease , arteriosclerosis , Arteriovenous Fistula , asthma , atherosclerosis , atrial fibrillation , autism spectrum disorder , Behcet's disease , bladder neck obstruction , Brain Hypoxia , brain ischemia , breast cancer , Breast Neoplasms , Bronchial Hyperreactivity , bronchiolitis obliterans , Cardiomegaly , cardiomyopathy , Cardiotoxicity , cardiovascular system disease , Carotid Artery Injuries , central sleep apnea , cerebral infarction , Child Behavior Disorders , cholestasis , Chronic Cerebral Hypoperfusion , chronic kidney disease , chronic obstructive pulmonary disease , cleft lip , cleft palate , colitis , congenital diaphragmatic hernia , congestive heart failure , coronary artery disease , coronary artery vasospasm , cystic fibrosis , diabetic angiopathy , Diabetic Cardiomyopathies , Diabetic Gastroparesis , Diabetic Nephropathies , diabetic retinopathy , Diaphragmatic Hernia , disease of cellular proliferation , Drug-Induced Enteropathy , end stage renal disease , endometrial carcinoma , Endotoxemia , Esophageal Neoplasms , esophagus adenocarcinoma , essential hypertension , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , extrahepatic cholestasis , familial hyperlipidemia , Fetal Growth Retardation , gastric ulcer , genetic disease , Graft Occlusion, Vascular , Hemorrhagic Shock , Hepatic Insufficiency , Hepatomegaly , hepatopulmonary syndrome , high grade glioma , Huntington's disease , Hyperemia , hyperglycemia , hyperinsulinism , Hyperoxia , hypertension , Hypertension Resistant to Conventional Therapy , Hypertriglyceridemia , hypothyroidism , Hypoxia , ileus , impotence , Insulin Resistance , intestinal perforation , Intestinal Reperfusion Injury , Intimal Hyperplasia , intracranial aneurysm , Intracranial Hemorrhages , irritable bowel syndrome , ischemia , Kidney Reperfusion Injury , Kuhnt-Junius degeneration , Left Ventricular Hypertrophy , leiomyoma , lethal congenital glycogen storage disease of heart , limb ischemia , liver cirrhosis , Liver Reperfusion Injury , long QT syndrome , lung disease , Lung Reperfusion Injury , lymphangioleiomyomatosis , Lymphatic Metastasis , macular retinal edema , male infertility , Metabolic Syndrome , migraine , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Nasal Polyps , Neoplasm Metastasis , nephritis , obesity , obstructive sleep apnea , oligospermia , ovarian cancer , overnutrition , Pain , Perennial Allergic Rhinitis , perinatal necrotizing enterocolitis , persistent fetal circulation syndrome , Phyllodes Tumor , placental abruption , polycystic kidney disease , portal hypertension , pre-eclampsia , Pregnancy-Induced Hypertension , primary biliary cholangitis , primary open angle glaucoma , primary ovarian insufficiency , prostate cancer , Prostatic Neoplasms , pulmonary edema , pulmonary embolism , pulmonary emphysema , pulmonary eosinophilia , pulmonary hypertension , Pulmonary Hypertension, Hypoxia-Induced , Radiation Pneumonitis , renal hypertension , renovascular hypertension , Reperfusion Injury , respiratory allergy , Retina Reperfusion Injury , retinal degeneration , retinopathy of prematurity , Right Ventricular Hypertrophy , Sepsis , sickle cell anemia , Spinal Cord Compression , Spinal Cord Injuries , Stomach Neoplasms , Stroke , Subarachnoid Hemorrhage , Sudden Hearing Loss , telangiectasis , Teratozoospermia , Testis Reperfusion Injury , Thromboembolism , Thrombotic Microangiopathies , transient cerebral ischemia , Transplant Rejection , type 1 diabetes mellitus , type 2 diabetes mellitus , uremia , ureteral obstruction , urinary bladder cancer , vasculitis , Vaso-occlusive Crisis , Venous Thrombosis , Ventricular Dysfunction, Right , Ventricular Premature Complexes , Ventricular Tachycardia , vestibular disease , vulva cancer Ntsr1 autism spectrum disorder , COVID-19 , developmental and epileptic encephalopathy , developmental and epileptic encephalopathy 33 , early infantile epileptic encephalopathy , epilepsy , genetic disease , Hyperalgesia , neuronal ceroid lipofuscinosis , Pain , Parkinson's disease , schizophrenia Ocm genetic disease , Lynch syndrome , Lynch syndrome 1 Orai1 congenital structural myopathy , genetic disease , hypertension , immunodeficiency 9 , Neoplasm Metastasis , tubular aggregate myopathy 1 , tubular aggregate myopathy 2 Orai2 genetic disease , pleomorphic xanthoastrocytoma Orai3 branched-chain keto acid dehydrogenase kinase deficiency , generalized epilepsy with febrile seizures plus 9 , genetic disease Oxtr Atrioventricular Septal Defect 2 , autism spectrum disorder , autistic disorder , cardiomyopathy , Chromosome 3, Monosomy 3p25 , cognitive disorder , distal muscular dystrophy Tateyama type , familial hypertrophic cardiomyopathy , gastric ulcer , genetic disease , hypertension , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , Hypoxia , isolated elevated serum creatine phosphokinase levels , Joubert syndrome 9 , limb-girdle muscular dystrophy , long QT syndrome , long QT syndrome 1 , long QT syndrome 9 , lung non-small cell carcinoma , Neurodevelopmental Disorders , rippling muscle disease 2 , Romano-Ward Syndrome , schizophrenia , sudden infant death syndrome P2rx1 Canavan disease , genetic disease , toxic encephalopathy P2rx2 autosomal dominant nonsyndromic deafness 41 , colorectal cancer , epilepsy , genetic disease , Hyperalgesia , sensorineural hearing loss P2rx3 genetic disease , Hyperalgesia , intellectual disability , Nervous System Trauma P2rx4 congestive heart failure , COVID-19 , epilepsy , genetic disease , Hyperalgesia , Peripheral Nerve Injuries , temporal lobe epilepsy P2rx5 Canavan disease , genetic disease P2rx6 autistic disorder , chromosome 22q11.2 deletion syndrome, distal , chromosome 22q11.2 microduplication syndrome , DiGeorge syndrome , Dwarfism , epilepsy , genetic disease , intellectual disability , megacolon , Neurodevelopmental Disorders , primary immunodeficiency disease , schizophrenia , velocardiofacial syndrome P2rx7 Animal Disease Models , B-Cell Chronic Lymphocytic Leukemia , genetic disease , hypophosphatasia , liver cirrhosis , multiple sclerosis , Spinal Cord Injuries , temporal lobe epilepsy Pde1a genetic disease , Left Ventricular Hypertrophy Pde1b genetic disease , learning disability , Parkinsonism Pde1c autosomal dominant nonsyndromic deafness , autosomal dominant nonsyndromic deafness 74 , genetic disease , pleomorphic xanthoastrocytoma , prostate cancer , substance-related disorder Pdgfra B-lymphoblastic leukemia/lymphoma , Brain Injuries , brain stem glioma , breast carcinoma , Chronic Allograft Nephropathy , chronic ulcer of skin , cleft palate , colon carcinoma , congenital diaphragmatic hernia , congenital disorder of glycosylation type IIk , congestive heart failure , Craniofacial Abnormalities , craniopharyngioma , Endometrioid Carcinomas , Eosinophilia , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Liver Cirrhosis , Fetal Death , gastrointestinal stromal tumor , genetic disease , Germ Cell and Embryonal Neoplasms , Hereditary Neoplastic Syndromes , hypereosinophilic syndrome , Hyperoxia , hypertension , in situ carcinoma , isolated cleft palate , Kidney Reperfusion Injury , leukemia , Leydig cell tumor , lung disease , lung squamous cell carcinoma , medulloblastoma , melanoma , mesenchymal chondrosarcoma , middle cerebral artery infarction , Multiple Polyps and Recurrent Inflammatory Fibroid, Gastrointestinal , myeloid leukemia , myeloid sarcoma , myeloproliferative neoplasm , Neointima , oligohydramnios , ovarian cancer , Ovarian Neoplasms , pancreatic cancer , Pdgfra-Associated Chronic Eosinophilic Leukemia , prostate adenocarcinoma , pulmonary fibrosis , renal cell carcinoma , Respiratory System Abnormalities , sciatic neuropathy , seminoma , spina bifida , Stroke , T-cell acute lymphoblastic leukemia , Uterine Neoplasms Pdgfrb atherosclerosis , autism spectrum disorder , basal ganglia calcification , basal ganglia disease , Brain Injuries , breast cancer , breast carcinoma , Breast Neoplasms , calcinosis , Cardiomegaly , cerebral palsy , choriocarcinoma , Chronic Allograft Nephropathy , Colonic Neoplasms , Dandy-Walker syndrome , Diabetic Nephropathies , Endometrioid Carcinomas , Experimental Autoimmune Encephalomyelitis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , extrahepatic cholestasis , familial adenomatous polyposis 1 , genetic disease , glioblastoma , Hereditary Neoplastic Syndromes , Hydatidiform Mole , hydrocephalus , Hyperoxia , hypertension , Idiopathic Basal Ganglia Calcification 1 , Idiopathic Basal Ganglia Calcification 4 , infantile myofibromatosis , Infantile Myofibromatosis 1 , Intimal Hyperplasia , Kidney Reperfusion Injury , Kosaki Overgrowth Syndrome , Kuhnt-Junius degeneration , Leydig cell tumor , Lung Neoplasms , microcephaly , middle cerebral artery infarction , myeloproliferative disorder with eosinophilia , myeloproliferative neoplasm , Neointima , Neoplasm Metastasis , Neurodevelopmental Disorders , oligohydramnios , Ovarian Neoplasms , Parkinsonism , Penttinen-Aula Syndrome , prostate cancer , renal cell carcinoma , schizophrenia , sciatic neuropathy , severe nonproliferative diabetic retinopathy , Subarachnoid Hemorrhage , Transplant Rejection , Wounds and Injuries Phka1 autistic disorder , Cornelia de Lange syndrome 5 , Experimental Diabetes Mellitus , genetic disease , glycogen storage disease , glycogen storage disease IXd , hypothyroidism , intestinal volvulus , neuropathy , peripheral nervous system disease , syndromic X-linked intellectual disability Lubs type , Volvulus Of Midgut , X-linked spinocerebellar ataxia 1 Phka2 autistic disorder , Coffin-Lowry syndrome , developmental and epileptic encephalopathy 2 , genetic disease , glycogen storage disease , glycogen storage disease IXa , glycogen storage disease VIII , Nance-Horan syndrome , Neurodevelopmental Disorders , Pyruvate Dehydrogenase E1 Alpha Deficiency , syndromic X-linked intellectual disability Lubs type Phkb genetic disease , glycogen storage disease IXb Phkg1 autistic disorder , genetic disease , pleomorphic xanthoastrocytoma , PSPH deficiency Phkg2 branched-chain keto acid dehydrogenase kinase deficiency , Fibrosis , generalized epilepsy with febrile seizures plus 9 , genetic disease , glycogen storage disease , glycogen storage disease IXc , liver cirrhosis , Mauriac Syndrome Plcb1 acute myeloid leukemia , Alagille syndrome , Alzheimer's disease , benign epilepsy with centrotemporal spikes , Colonic Neoplasms , congenital myasthenic syndrome 18 , developmental and epileptic encephalopathy 1 , developmental and epileptic encephalopathy 12 , epilepsy , genetic disease , myelodysplastic syndrome , myocardial infarction , Pain , schizophrenia , visual epilepsy , West syndrome Plcb2 Bloom syndrome , colorectal cancer , genetic disease , Moebius syndrome Plcb3 chronic ulcer of skin , Experimental Diabetes Mellitus , genetic disease , high grade glioma , Huntington's disease , intellectual disability , leukocyte adhesion deficiency 3 , myocardial infarction , spondylometaphyseal dysplasia with corneal dystrophy Plcb4 Alagille syndrome , Auriculocondylar Syndrome , Auriculocondylar Syndrome 1 , Auriculocondylar Syndrome 2 , congenital myasthenic syndrome 18 , developmental and epileptic encephalopathy 12 , genetic disease , long QT syndrome , melanoma , prostate cancer , uveal melanoma Plcd1 alopecia , Alzheimer's disease , Brugada syndrome , congestive heart failure , genetic disease , Hyperoxia , hypertension , Hypotension , Myocardial Ischemia , Myocardial Reperfusion Injury , nonsyndromic congenital nail disorder 3 , osteoarthritis , Skin Neoplasms , Visceral Heterotaxy 4, Autosomal Plcd3 genetic disease Plcd4 alacrima, achalasia, and impaired intellectual development syndrome , cerebrotendinous xanthomatosis , genetic disease , myofibrillar myopathy 1 , Neurodevelopmental Disorders , paroxysmal nonkinesigenic dyskinesia 1 Plce1 adenocarcinoma , benign familial hematuria , dengue hemorrhagic fever , Diffuse Mesangial Sclerosis , esophagus squamous cell carcinoma , focal segmental glomerulosclerosis , focal segmental glomerulosclerosis 1 , gastric adenocarcinoma , genetic disease , glomerulonephritis , kidney disease , nephrotic syndrome , nephrotic syndrome type 2 , nephrotic syndrome type 3 , polycystic kidney disease , polycystic kidney disease 4 , proteinuria , Stomach Neoplasms Plcg1 acute myocardial infarction , adult T-cell leukemia/lymphoma , Alzheimer's disease , angiosarcoma , breast cancer , breast carcinoma , colon cancer , colorectal cancer , Experimental Diabetes Mellitus , familial adenomatous polyposis , focal epilepsy , genetic disease , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , oral squamous cell carcinoma , polycystic kidney disease , primary cutaneous T-cell non-Hodgkin lymphoma , Sezary's disease Plcg2 Alzheimer's disease , Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated , B-Cell Chronic Lymphocytic Leukemia , Cryopyrin-Associated Periodic Syndromes , familial cold autoinflammatory syndrome , familial cold autoinflammatory syndrome 3 , Fever , genetic disease , inflammatory bowel disease Plcz1 genetic disease , spermatogenic failure 17 Pln atrial fibrillation , autistic disorder , cardiac arrest , cardiomyopathy , centronuclear myopathy , congenital disorder of glycosylation Iaa , congestive heart failure , Diabetes Complications , Diabetic Cardiomyopathies , dilated cardiomyopathy , dilated cardiomyopathy 1P , Ebstein anomaly , epilepsy , heart disease , hereditary spastic paraplegia 35 , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 18 , intellectual disability , lissencephaly 10 , microcephaly , myocardial infarction , Myocardial Reperfusion Injury , myocardial stunning , Prehypertension , Sudden Cardiac Death , Tremor , type 2 diabetes mellitus , Ventricular Dysfunction, Left Ppid brain ischemia , genetic disease , megacolon Ppp3ca Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development , autism spectrum disorder , beta-mannosidosis , Brain Injuries , Cardiomegaly , cholangiocarcinoma , developmental and epileptic encephalopathy 91 , Developmental Disease , dilated cardiomyopathy , epilepsy , focal segmental glomerulosclerosis , genetic disease , Huntington's disease , kidney disease , Left Ventricular Hypertrophy , lung adenocarcinoma , ovarian carcinoma , pancreatitis , Prostatic Neoplasms , Reperfusion Injury , Right Ventricular Hypertrophy , schizophrenia , testicular disease , Ventricular Tachycardia , Wilson disease Ppp3cb aortic valve stenosis , focal segmental glomerulosclerosis , genetic disease , Left Ventricular Hypertrophy , Reperfusion Injury , Right Ventricular Hypertrophy , schizophrenia , Wilson disease Ppp3cc Conotruncal Cardiac Defects , genetic disease , Genetic Predisposition to Disease , keratoconus , schizophrenia , urinary bladder cancer Ppp3r1 Alzheimer's disease , dilated cardiomyopathy , Left Ventricular Hypertrophy , Myocardial Ischemia , schizophrenia , traumatic brain injury Ppp3r2 fructose-1,6-bisphosphatase deficiency , genetic disease , hereditary fructose intolerance syndrome , intellectual disability , traumatic brain injury Prkaca ACTH-independent macronodular adrenal hyperplasia 1 , adrenal cortical adenoma , Adrenal Gland Neoplasms , brain ischemia , Cardioacrofacial Dysplasia 1 , cholangiocarcinoma , congestive heart failure , fibrolamellar carcinoma , genetic disease , Hypoglossal Nerve Injuries , mixed fibrolamellar hepatocellular carcinoma , Neurodevelopmental Disorders , non-alcoholic fatty liver disease , Primary Pigmented Nodular Adrenocortical Disease, 4 Prkacb adrenal cortical adenoma , biliary tract benign neoplasm , brain ischemia , Cardioacrofacial Dysplasia 2 , cholangiocarcinoma , Cushing Syndrome , genetic disease , Hypoglossal Nerve Injuries , Prostatic Neoplasms Prkca brain ischemia , Breast Neoplasms , Cardiomegaly , chordoid glioma , congestive heart failure , dilated cardiomyopathy , ductal carcinoma in situ , endometrial carcinoma , Experimental Diabetes Mellitus , genetic disease , high grade glioma , hypertension , Intestinal Neoplasms , ischemia , large cell carcinoma , Left Ventricular Hypertrophy , nephrogenic diabetes insipidus , non-alcoholic fatty liver disease , occupational asthma , ovarian cancer , ovarian carcinoma , Pituitary Neoplasms , Polyuria , prostate carcinoma , Reperfusion Injury , Right Ventricular Hypertrophy , urinary bladder cancer Prkcb adult T-cell leukemia/lymphoma , Alzheimer's disease , autistic disorder , Cardiomegaly , Colorectal Neoplasms , congestive heart failure , Diabetic Nephropathies , dilated cardiomyopathy , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Fetal Diseases , genetic disease , Hyperalgesia , hyperglycemia , hypertension , immune system disease , Insulin Resistance , Left Ventricular Hypertrophy , lung non-small cell carcinoma , Myocardial Reperfusion Injury , obesity , sensorineural hearing loss , silicosis , status epilepticus , Stomach Neoplasms , type 2 diabetes mellitus Prkcg Animal Disease Models , autosomal dominant cerebellar ataxia , cerebellar ataxia , familial cold autoinflammatory syndrome 2 , genetic disease , hereditary ataxia , Hyperalgesia , intellectual disability , middle cerebral artery infarction , primary cerebellar degeneration , retinitis pigmentosa , Spinal Cord Injuries , spinocerebellar ataxia type 14 , Spinocerebellar Ataxias , trigeminal neuralgia Prkx autistic disorder , genetic disease , Neurodevelopmental Disorders Ptafr Acute Experimental Pancreatitis , acute kidney failure , Acute Liver Failure , conjunctivitis , Crohn's disease , Endotoxemia , Experimental Liver Cirrhosis , genetic disease , glomerulonephritis , Hyperalgesia , Hypotension , Multiple Organ Failure , neutropenia , Neutrophilia , Otitis Media with Effusion , Oxygen-Induced Retinopathy , perinatal necrotizing enterocolitis , pleurisy , polycystic ovary syndrome , Reperfusion Injury , sciatic neuropathy , transient cerebral ischemia , Traumatic Shock Ptger1 adenocarcinoma , Animal Mammary Neoplasms , Experimental Mammary Neoplasms , gastric ulcer , genetic disease , hydronephrosis , Hyperalgesia , invasive ductal carcinoma , sexual dysfunction , squamous cell carcinoma Ptger3 asthma , Brain Injuries , cicatricial pemphigoid , colon cancer , Colonic Neoplasms , drug allergy , Edema , Fetal Growth Retardation , Fever , genetic disease , Hyperalgesia , intellectual disability , leiomyoma , membranous glomerulonephritis , Myocardial Reperfusion Injury , NSAID-Enteropathy , Oxygen-Induced Retinopathy , polycystic ovary syndrome , renovascular hypertension , Stevens-Johnson syndrome , thrombosis , withdrawal disorder Ptgfr Airway Obstruction , endometriosis , genetic disease , myoepithelioma Ptk2b Alzheimer's disease , anti-basement membrane glomerulonephritis , brain ischemia , breast cancer , diabetic angiopathy , genetic disease , glomerulonephritis , hypertension , Insulin Resistance , Left Ventricular Hypertrophy , melanoma , Neointima , nephritis , Postmenopausal Osteoporosis , prostate cancer , Reperfusion Injury , Skin Neoplasms , status epilepticus Pvalb adenylosuccinase lyase deficiency , bipolar disorder , Emery-Dreifuss muscular dystrophy , genetic disease , myoclonic dystonia 26 , neurodegeneration with brain iron accumulation 2A , oxyphilic adenoma , psychotic disorder , renal cell carcinoma , schizophrenia Rcvrn genetic disease , proximal myopathy and ophthalmoplegia Ryr1 ankyloglossia , Aortic Coarctation , arthrogryposis multiplex congenita , atrial heart septal defect , Axial Myopathy, Late-Onset , Bronchomalacia , cardiomyopathy , caudal regression syndrome , central core disease , centronuclear myopathy , clubfoot , congenital fiber-type disproportion , Congenital Hip Dislocation , congenital muscular dystrophy , congenital myasthenic syndrome , congenital myasthenic syndrome 12 , congenital myopathy , Congenital Neuromuscular Disease, with Uniform Type 1 Fiber , congenital structural myopathy , Developmental Disabilities , distal arthrogryposis , Dwarfism , Dyskinesias , dystonia , fetal akinesia deformation sequence syndrome , fetal akinesia deformation sequence syndrome 1 , gastroesophageal reflux disease , genetic disease , glaucoma , GNE myopathy , Heart Block , Heat Stroke , Hereditary Motor Neuropathy with Myopathic Features , Hydrops Fetalis , intracranial vasospasm , isolated elevated serum creatine phosphokinase levels , King Denborough syndrome , learning disability , Malignant Fever , malignant hyperthermia , Malignant Hypothermia , Mitochondrial Progressive Myopathy with Congenital Cataract, Hearing Loss, and Developmental Delay , multiminicore disease , Muscle Hypotonia , Muscle Weakness , muscular disease , Myalgia , myopathy , Myotonia , neuromuscular disease , obesity , obstructive sleep apnea , osteoporosis , panhypopituitarism , primary pulmonary hypertension , ptosis , renal cell carcinoma , Rhabdomyolysis , rigid spine muscular dystrophy 1 , scoliosis , Ullrich congenital muscular dystrophy , ventricular septal defect Ryr2 arrhythmogenic right ventricular cardiomyopathy , arrhythmogenic right ventricular dysplasia 1 , arrhythmogenic right ventricular dysplasia 9 , autism spectrum disorder , Brugada syndrome , cardiac arrest , Cardiac Arrhythmias , Cardiac Conduction Defect , cardiomyopathy , catecholaminergic polymorphic ventricular tachycardia , catecholaminergic polymorphic ventricular tachycardia 1 , catecholaminergic polymorphic ventricular tachycardia 2 , Childhood Schizophrenia , congenital heart disease , congestive heart failure , Diabetic Cardiomyopathies , Diastolic Dysfunction , dilated cardiomyopathy , dilated cardiomyopathy 1AA , dilated cardiomyopathy 1B , Dilated Cardiomyopathy with Left Ventricular Noncompaction , Experimental Diabetes Mellitus , familial hypertrophic cardiomyopathy , Familial Sudden Death , Familial Ventricular Tachycardia , gastrointestinal stromal tumor , genetic disease , Heart Block , heart disease , Hereditary Leiomyomatosis and Renal Cell Cancer , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , hypertrophic cardiomyopathy 4 , Infant Death , left ventricular noncompaction , long QT syndrome , long QT syndrome 1 , malignant mesothelioma , Myocardial Ischemia , parathyroid carcinoma , Sudden Cardiac Death , Sudden Death , Syncope , Tachycardia , Ventricular Fibrillation , Ventricular Fibrillation, Paroxysmal Familial, 1 , Ventricular Tachycardia , Wolff-Parkinson-White syndrome Ryr3 amenorrhea , arthrogryposis multiplex congenita , Bloom syndrome , colorectal cancer , Congenital Myopathy 20 , Contracture , developmental and epileptic encephalopathy , epilepsy , fetal akinesia deformation sequence syndrome 1 , Generalized Epilepsy , genetic disease , hepatocellular carcinoma , Hydrops Fetalis , primary ovarian insufficiency S100a1 Cardiomegaly , gastrointestinal stromal tumor , genetic disease , immunodeficiency 42 , intracranial vasospasm , MHC class II deficiency , Myocardial Ischemia , parathyroid carcinoma , severe congenital neutropenia 3 , severe congenital neutropenia 5 S100a4 adult respiratory distress syndrome , Breast Neoplasms , Colonic Neoplasms , gastrointestinal stromal tumor , genetic disease , immunodeficiency 42 , intracranial vasospasm , ischemia , Keloid , medulloblastoma , melanoma , MHC class II deficiency , Neoplasm Invasiveness , Neoplasm Metastasis , nephrosclerosis , osteoarthritis , parathyroid carcinoma , severe congenital neutropenia 3 , severe congenital neutropenia 5 S100b Acute Coronary Syndrome , Alzheimer's disease , Animal Disease Models , aspergillosis , asphyxia neonatorum , Attention Deficit and Disruptive Behavior Disorders , autistic disorder , Axenfeld-Rieger syndrome type 3 , bacterial meningitis , bipolar disorder , borna disease , brain disease , brain edema , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , Brain Neoplasms , Cerebral Hemorrhage , Creutzfeldt-Jakob disease , demyelinating disease , Dental Pulp Exposure , depressive disorder , Diffuse Brain Injuries , dilated cardiomyopathy , Down syndrome , epilepsy , Experimental Diabetes Mellitus , Femoral Fractures , genetic disease , Hematoma , hepatic encephalopathy , hypertension , Hypotension , Inflammation , intracranial vasospasm , intrahepatic cholangiocarcinoma , invasive aspergillosis , Machado-Joseph disease , malignant mesothelioma , Mercury Poisoning, Nervous System , migraine without aura , myocardial infarction , Myocardial Reperfusion Injury , neuromyelitis optica , Parkinson's disease , relapsing-remitting multiple sclerosis , Reperfusion Injury , schizophrenia , Sepsis , sleep apnea , Spinal Fractures , Sporadic Creutzfeldt-Jakob Disease , Stroke , urinary bladder cancer , visual epilepsy , West Nile fever S100g autistic disorder , Neurodevelopmental Disorders , syndromic X-linked intellectual disability Lubs type Slc24a1 Bloom syndrome , Cerebral Hemorrhage , colorectal cancer , congenital stationary night blindness , congenital stationary night blindness 1D , fundus dystrophy , genetic disease , nemaline myopathy 6 , retinitis pigmentosa Slc24a2 genetic disease Slc24a3 adenoid cystic carcinoma , genetic disease , Salivary Gland Neoplasms Slc24a4 achondrogenesis type IA , amelogenesis imperfecta , amelogenesis imperfecta hypomaturation type 2A5 , genetic disease , Skin/Hair/Eye Pigmentation, Variation In, 6 Slc24a5 Bloom syndrome , colorectal cancer , genetic disease , Marfan syndrome , ocular albinism , oculocutaneous albinism , oculocutaneous albinism type VI , Skin/Hair/Eye Pigmentation, Variation In, 4 Slc25a31 genetic disease , neuronal ceroid lipofuscinosis 7 Slc25a4 alcoholic cardiomyopathy , Alzheimer's disease , autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 , Cachexia , Cardiomegaly , chronic progressive external ophthalmoplegia , Diabetic Cardiomyopathies , dilated cardiomyopathy , dilated cardiomyopathy 1H , Experimental Liver Cirrhosis , facioscapulohumeral muscular dystrophy , genetic disease , Herpes Simplex Encephalitis 1 , hypertrophic cardiomyopathy , Left Ventricular Hypertrophy , mitochondrial DNA depletion syndrome 12a , mitochondrial DNA depletion syndrome 12b , mitochondrial metabolism disease , mitochondrial myopathy , Myocardial Reperfusion Injury , myopia , restrictive cardiomyopathy , sensorineural hearing loss , Sudden Cardiac Death , Vertigo Slc25a5 autistic disorder , genetic disease , lung cancer , lung small cell carcinoma , syndromic X-linked intellectual disability Cabezas type , syndromic X-linked intellectual disability Lubs type Slc25a6 autistic disorder Slc8a1 Alzheimer's disease , brain ischemia , Cardiomegaly , congestive heart failure , Diabetic Cardiomyopathies , dilated cardiomyopathy , Experimental Diabetes Mellitus , genetic disease , hypertension , Lynch syndrome , megacolon , Myocardial Ischemia , Myocardial Reperfusion Injury , Neurodevelopmental Disorders , pulmonary hypertension , Reperfusion Injury , status epilepticus Slc8a2 Alzheimer's disease , brain ischemia , genetic disease , Reperfusion Injury , status epilepticus Slc8a3 Alzheimer's disease , brain ischemia , genetic disease , prostate cancer , Reperfusion Injury , status epilepticus Slc8b1 Cerebral Hemorrhage , genetic disease Sphk1 adenocarcinoma , Fibrosis , genetic disease , high grade glioma , leukemia , myelodysplastic syndrome , type 2 diabetes mellitus , ulcerative colitis Sphk2 genetic disease , Memory Disorders , middle cerebral artery infarction Stim1 colorectal cancer , congenital structural myopathy , delta beta-thalassemia , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , esophagus squamous cell carcinoma , Experimental Neoplasms , gastrointestinal stromal tumor , genetic disease , hepatocellular carcinoma , hypertension , immunodeficiency 10 , immunodeficiency with hyper-IgM type 2 , juvenile rheumatoid arthritis , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , migraine , Neointima , Neoplasm Metastasis , nephrogenic diabetes insipidus , stomach cancer , Stormorken syndrome , tubular aggregate myopathy 1 Stim2 genetic disease , Weight Gain Syt1 Baker-Gordon Syndrome , genetic disease , Neurodevelopmental Disorders , syndromic intellectual disability , visual epilepsy Syt7 genetic disease , Hereditary Paraganglioma-Pheochromocytoma Syndromes , intellectual disability , leukocyte adhesion deficiency 3 , myoepithelioma , paraganglioma Syt9 genetic disease Tacr1 Acute Lung Injury , acute necrotizing pancreatitis , alcohol use disorder , allergic rhinitis , asthma , attention deficit hyperactivity disorder , bipolar disorder , Bradycardia , bronchial disease , Bronchial Hyperreactivity , Burns , central sleep apnea , colitis , cystitis , exercise-induced bronchoconstriction , genetic disease , Hyperalgesia , Hyperoxia , hypertension , Hypotension , Inflammation , Lung Injury , Neurogenic Inflammation , Pain , pancreatitis , pulmonary edema , pulmonary emphysema , pulmonary hypertension , respiratory syncytial virus infectious disease , Spinal Cord Injuries , Subarachnoid Hemorrhage , Ventilator-Induced Lung Injury , Vomiting , Weight Gain , withdrawal disorder Tacr2 Abnormal Reflexes , asthma , bronchial disease , colitis , Cough , genetic disease , pulmonary hypertension Tacr3 alcohol use disorder , amenorrhea , beta-mannosidosis , Cocaine-Related Disorders , Delayed Puberty , genetic disease , hypertension , hypogonadism , hypogonadotropic hypogonadism , hypogonadotropic hypogonadism 11 with or without anosmia , hypogonadotropic hypogonadism 12 with or without anosmia , hypogonadotropic hypogonadism 7 with or without anosmia , Hypotension , Inflammation , Klinefelter syndrome , Pain , visual epilepsy Tbxa2r adult respiratory distress syndrome , aspirin-induced respiratory disease , asthma , blood platelet disease , Chemical and Drug Induced Liver Injury , Endotoxemia , Experimental Pancreatitis , genetic disease , hemorrhagic disease , kidney failure , Necrosis , Neurodevelopmental Disorders , obesity , Perennial Allergic Rhinitis , Platelet-Type Bleeding Disorder 13 , pulmonary embolism , pulmonary eosinophilia , rhinitis , thrombocytopenia , toxic shock syndrome , Transplant Rejection , Venous Thrombosis Tnnc1 cardiomyopathy , congenital disorder of glycosylation In , dilated cardiomyopathy , dilated cardiomyopathy 1S , dilated cardiomyopathy 1Z , Dilated Cardiomyopathy with Left Ventricular Noncompaction , genetic disease , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 13 Tnnc2 Congenital Myopathy 15 , focal epilepsy , genetic disease , T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations Tpcn1 genetic disease , oligospermia Tpcn2 Aicardi-Goutieres Syndrome 3 , genetic disease , intellectual disability , Marfanoid Mental Retardation Syndrome, Autosomal , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations , Skin/Hair/Eye Pigmentation, Variation In, 10 Trhr congenital hypothyroidism , congenital nongoitrous hypothyroidism 7 , genetic disease , hypertension , hypothyroidism , thyroid hormone resistance syndrome Trpc1 Cardiomegaly , Diabetic Nephropathies , Experimental Diabetes Mellitus , genetic disease , Hyperalgesia , prostate cancer , stomach cancer , type 2 diabetes mellitus Trpv5 genetic disease Trpv6 genetic disease , hyperparathyroidism , polycystic ovary syndrome , Transient Neonatal Hyperparathyroidism Vdac1 COVID-19 , Diabetic Nephropathies , epilepsy , Experimental Diabetes Mellitus , familial adenomatous polyposis 1 , genetic disease , Hereditary Neoplastic Syndromes , mitochondrial myopathy , myocardial infarction , Myocardial Reperfusion Injury , Neurodevelopmental Disorders , Parkinson's disease , Parkinsonism , prostate cancer , Psychomotor Disorders , Ventricular Dysfunction, Left , visual epilepsy Vdac2 Burns , Diabetic Nephropathies , epilepsy , genetic disease , Genitopatellar Syndrome , Mouth Neoplasms , myocardial infarction , osteoarthritis , squamous cell carcinoma , temporal lobe epilepsy , visual epilepsy Vdac3 genetic disease , IMMUNODEFICIENCY 15 , immunodeficiency 15B , torsion dystonia 6
16p11.2 Deletion Syndrome Atp2a1 1q24 Deletion Syndrome Cacna1e 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency Htr6 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome Atp2b2 46, XY Disorders of Sex Development Lhcgr ABCD syndrome Ednrb abdominal aortic aneurysm Agtr1a , Nos2 abdominal obesity-metabolic syndrome 1 Atp2a2 Abnormal Reflexes Tacr2 achalasia Nos1 achondrogenesis type IA Calm1 , Slc24a4 achromatopsia Cabp4 , Cnga3 , Cngb3 Achromatopsia 1 Cnga3 , Cngb3 achromatopsia 2 Cnga3 achromatopsia 3 Cngb3 acrodermatitis Itpr3 acrokeratosis verruciformis Atp2a2 acromegaly Gnas ACTH-independent macronodular adrenal hyperplasia Gnas ACTH-independent macronodular adrenal hyperplasia 1 Gnas , Prkaca ACTH-secreting pituitary adenoma Avpr1b acute chest syndrome Nos3 Acute Coronary Syndrome S100b Acute Experimental Pancreatitis Atp2a2 , Ednra , Ptafr Acute Hepatitis Nos2 acute kidney failure Adrb2 , Avpr1a , Bdkrb2 , Egfr , Nos1 , Nos2 , Nos3 , Ptafr Acute Liver Failure Nos2 , Nos3 , Ptafr Acute Lung Injury Cysltr1 , Egfr , Ltb4r2 , Mylk , Nos2 , Tacr1 acute lymphoblastic leukemia Nos3 acute myeloid leukemia Adcy7 , Bdkrb1 , Bdkrb2 , Calr , Nos3 , Plcb1 acute myocardial infarction Plcg1 acute necrotizing pancreatitis Nos1 , Nos2 , Tacr1 acute stress disorder Cacna1c Adams-Oliver Syndrome 5 Cacna1b , Grin1 adenocarcinoma Egfr , Erbb2 , Nos3 , Plce1 , Ptger1 , Sphk1 adenoid cystic carcinoma Slc24a3 adenoma Atp2a3 , Atp2b3 , Cacna1d adenylosuccinase lyase deficiency Cacna1i , Pvalb adrenal cortical adenoma Atp2b3 , Prkaca , Prkacb adrenal gland hyperfunction Gnas Adrenal Gland Neoplasms Gnas , Prkaca adrenocortical carcinoma Egfr , Gnas adrenoleukodystrophy Atp2b3 adult respiratory distress syndrome Mylk , S100a4 , Tbxa2r adult T-cell leukemia/lymphoma Plcg1 , Prkcb agenesis of the corpus callosum with peripheral neuropathy Atp2b2 Aicardi-Goutieres Syndrome 3 Cabp2 , Cabp4 , Tpcn2 AIDS Dementia Complex Adrb2 AIDS-Associated Nephropathy Agtr1a Airway Obstruction Ptgfr alacrima, achalasia, and impaired intellectual development syndrome Plcd4 Alagille syndrome Plcb1 , Plcb4 Aland Island eye disease Cabp4 , Cacna1f Albright's hereditary osteodystrophy Gnas Albuminuria Cd38 , Drd1 , Gnaq alcohol dependence Avpr1b , Cacna1c Alcohol Myopathy Atp2a1 alcohol use disorder Cckar , Grin1 , Htr2a , Htr7 , Tacr1 , Tacr3 Alcohol Withdrawal Seizures Cacna1d alcoholic cardiomyopathy Nos1 , Slc25a4 Alcoholic Liver Diseases Egfr alkaptonuria Atp2c1 , Mylk allergic asthma Cysltr1 allergic disease Cysltr1 , Mylk allergic rhinitis Hrh1 , Tacr1 alopecia Plcd1 alpha-mannosidosis Cacna1a , Calr Alzheimer's disease Adra1a , Adrb3 , Agtr1a , Cacna1c , Calm1 , Calml5 , Camk2a , Chrna7 , Drd1 , Drd5 , Egfr , Gnas , Grin1 , Grin2a , Htr6 , Itpr1 , Nos1 , Nos2 , Nos3 , Plcb1 , Plcd1 , Plcg1 , Plcg2 , Ppp3r1 , Prkcb , Ptk2b , S100b , Slc25a4 , Slc8a1 , Slc8a2 , Slc8a3 amelogenesis imperfecta Slc24a4 amelogenesis imperfecta hypomaturation type 2A5 Slc24a4 amenorrhea Ryr3 , Tacr3 amnestic disorder Htr7 amphetamine abuse Adora2a , Drd1 , Htr6 , Nos1 amyloidosis Cacna1c amyotrophic lateral sclerosis Cacna1a , Erbb4 , Itpr2 , Nos2 amyotrophic lateral sclerosis type 1 Calb2 amyotrophic lateral sclerosis type 10 Erbb4 amyotrophic lateral sclerosis type 19 Erbb4 Anaphylaxis Adrb1 Angina Pectoris Adrb1 , Adrb2 angiosarcoma Plcg1 angle-closure glaucoma Nos3 Animal Disease Models Bdkrb2 , Cacna1d , Erbb2 , Grin1 , P2rx7 , Prkcg , S100b Animal Mammary Neoplasms Egfr , Erbb2 , Ptger1 aniridia Camk2d ankyloglossia Ryr1 Anorchia Lhcgr Anorexia Htr4 anorexia nervosa Htr2a , Htr4 anterior ischemic optic neuropathy Nos3 anterior segment dysgenesis Itpr1 anterior uveitis Nos2 anti-basement membrane glomerulonephritis Agtr1a , Nos2 , Ptk2b anxiety disorder Adora2a , Avpr1b , Cacna1c , Htr2c , Htr7 aortic aneurysm Mylk Aortic Aneurysm, Familial Abdominal 1 Mylk Aortic Coarctation Ryr1 aortic dissection Mylk aortic valve disease Egfr , Nos3 aortic valve stenosis Adrb1 , Egfr , Ppp3cb Apnea Camk2b arrhythmogenic right ventricular cardiomyopathy Cacna1c , Cacnb2 , Ryr2 arrhythmogenic right ventricular dysplasia 1 Ryr2 arrhythmogenic right ventricular dysplasia 9 Ryr2 arteriosclerosis Nos1 , Nos3 Arteriovenous Fistula Nos3 arteriovenous malformations of the brain Cacna1h , Egfr arthrogryposis multiplex congenita Ryr1 , Ryr3 Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development Ppp3ca asbestosis Nos2 Ascites Chrm3 aspergillosis S100b asphyxia neonatorum S100b aspiration pneumonia Nos2 aspirin-induced respiratory disease Cysltr1 , Cysltr2 , Tbxa2r asthma Adcy2 , Adora2a , Adrb2 , Agtr1a , Bdkrb2 , Chrm1 , Chrm2 , Chrm3 , Cysltr1 , Cysltr2 , Ednra , Ednrb , Egfr , Htr2a , Itpr1 , Mylk , Nos1 , Nos2 , Nos3 , Ptger3 , Tacr1 , Tacr2 , Tbxa2r Ataxia Cacna1a , Cacnb4 , Itpr1 atherosclerosis Hrh1 , Nos2 , Nos3 , Pdgfrb atrial fibrillation Agtr1a , Camk2d , Casq2 , Erbb4 , Htr4 , Kcnn2 , Kcnn3 , Nos3 , Pln atrial heart septal defect Mylk , Ryr1 Atrioventricular Septal Defect 2 Atp2b2 , Oxtr Attention Deficit and Disruptive Behavior Disorders S100b attention deficit hyperactivity disorder Chrna7 , Drd5 , Grm1 , Grm5 , Tacr1 Auditory Perceptual Disorders Chrna7 Auriculocondylar Syndrome Plcb4 Auriculocondylar Syndrome 1 Plcb4 Auriculocondylar Syndrome 2 Plcb4 autism spectrum disorder Adrb2 , Avpr1a , Avpr1b , Cacna1a , Cacna1c , Cacna1d , Cacnb2 , Camk2a , Camk2b , Chrna7 , Grin1 , Grm5 , Itpr3 , Nos1 , Nos2 , Nos3 , Ntsr1 , Oxtr , Pdgfrb , Ppp3ca , Ryr2 autistic disorder Adrb2 , Atp2b3 , Avpr1a , Avpr1b , Cacna1a , Cacna1c , Cacna1f , Cacna1h , Camk2g , Chrna7 , Cnga2 , Cysltr1 , Drd1 , Egfr , Grin1 , Grin2a , Grpr , Htr2a , Htr2c , Htr5a , Itpr3 , Kcnn2 , Nos2 , Oxtr , P2rx6 , Phka1 , Phka2 , Phkg1 , Pln , Prkcb , Prkx , S100b , S100g , Slc25a5 , Slc25a6 autoimmune interstitial lung, joint, and kidney disease Casq1 Autoinflammation, Antibody Deficiency, and Immune Dysregulation, PLCG2-Associated Plcg2 autosomal dominant cerebellar ataxia Itpr1 , Prkcg autosomal dominant dyskeratosis congenita 6 Calb2 autosomal dominant familial visceral neuropathy Mylk autosomal dominant hypocalcemia 2 Gna11 autosomal dominant intellectual developmental disorder 21 Grin2a autosomal dominant intellectual developmental disorder 5 Itpr3 autosomal dominant intellectual developmental disorder 53 Camk2a autosomal dominant intellectual developmental disorder 54 Camk2b Autosomal Dominant Intellectual Developmental Disorder 59 Camk2g Autosomal Dominant Intellectual Developmental Disorder 66 Atp2b1 autosomal dominant intellectual developmental disorder 8 Cacna1b , Grin1 autosomal dominant nocturnal frontal lobe epilepsy 5 Grin1 autosomal dominant nonsyndromic deafness Atp2b2 , Pde1c autosomal dominant nonsyndromic deafness 41 P2rx2 autosomal dominant nonsyndromic deafness 74 Pde1c Autosomal Dominant Nonsyndromic Deafness 82 Atp2b2 autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 Slc25a4 autosomal recessive chronic granulomatous disease 2 Cacna1e autosomal recessive intellectual developmental disorder 63 Camk2a autosomal recessive nonsyndromic deafness Cabp2 , Ednrb autosomal recessive nonsyndromic deafness 12 Atp2b2 autosomal recessive nonsyndromic deafness 44 Adcy1 autosomal recessive nonsyndromic deafness 93 Cabp2 autosomal recessive polycystic kidney disease Egfr autosomal recessive spinocerebellar ataxia 13 Grm1 Axenfeld-Rieger syndrome type 3 S100b Axial Myopathy, Late-Onset Ryr1 B-Cell Chronic Lymphocytic Leukemia Gnas , P2rx7 , Plcg2 B-lymphoblastic leukemia/lymphoma Pdgfra Back Pain Htr2a bacterial meningitis S100b Baker-Gordon Syndrome Syt1 Bannayan-Riley-Ruvalcaba syndrome Egfr Bardet-Biedl syndrome Cngb1 , Htr2b Barth syndrome Atp2b3 basal cell carcinoma Erbb2 basal ganglia calcification Pdgfrb basal ganglia disease Htr2a , Pdgfrb Behcet's disease Nos3 benign epilepsy with centrotemporal spikes Grin1 , Grin2a , Plcb1 Benign Essential Blepharospasm Drd5 benign familial hematuria Plce1 beta thalassemia Cacna1h beta-mannosidosis Ppp3ca , Tacr3 Bile Duct Neoplasms Egfr biliary tract benign neoplasm Prkacb bilirubin metabolic disorder Calb1 Binge-Eating Disorder Drd1 bipolar disorder Adcy2 , Avpr1b , Cacna1c , Cacna1d , Camk2a , Chrm2 , Drd1 , Drd5 , Grin2a , Htr2a , Htr2c , Pvalb , S100b , Tacr1 Birth Weight Adrb1 bladder disease Chrm3 bladder neck obstruction Adra1a , Htr2a , Nos3 blepharospasm Drd5 blood coagulation disease Gnaq blood platelet disease Tbxa2r Bloom syndrome Chp1 , Chrm5 , Itpka , Plcb2 , Ryr3 , Slc24a1 , Slc24a5 Bone Tissue Neoplasms Grm1 borna disease S100b Boucher-Neuhauser syndrome Mcoln1 brachydactyly Gnas Bradycardia Cacna1d , Chrm2 , Tacr1 brain disease Cacna1g , Grin2d , S100b brain edema Avpr1a , F2r , Mylk , Nos2 , S100b Brain Hypoxia Itpr1 , Itpr2 , Nos3 Brain Hypoxia-Ischemia Grin1 , Grin2a , Nos2 , S100b Brain Injuries Adra1a , Avpr1a , Chrm2 , Chrna7 , Htr7 , Nos2 , Pdgfra , Pdgfrb , Ppp3ca , Ptger3 , S100b brain ischemia Chrm1 , F2r , Nos1 , Nos2 , Nos3 , Ppid , Prkaca , Prkacb , Prkca , Ptk2b , S100b , Slc8a1 , Slc8a2 , Slc8a3 Brain Neoplasms Egfr , S100b brain stem glioma Pdgfra Brain-Lung-Thyroid Syndrome Adcy4 , Ltb4r2 branched-chain keto acid dehydrogenase kinase deficiency Orai3 , Phkg2 breast cancer Agtr1a , Cacna1c , Egfr , Erbb2 , Lhcgr , Nos3 , Pdgfrb , Plcg1 , Ptk2b Breast Cancer, Familial Erbb2 breast carcinoma Egfr , Pdgfra , Pdgfrb , Plcg1 breast ductal carcinoma Cacna1c , Cacna1h breast lobular carcinoma Agtr1a Breast Neoplasms Adrb2 , Ednrb , Egfr , Erbb2 , Erbb3 , Erbb4 , Gnas , Nos2 , Nos3 , Pdgfrb , Prkca , S100a4 Brody myopathy Atp2a1 bronchial disease Nos2 , Tacr1 , Tacr2 Bronchial Hyperreactivity Cysltr1 , Nos1 , Nos2 , Nos3 , Tacr1 bronchiolitis Adrb2 , Cysltr1 bronchiolitis obliterans Adora2a , Nos2 , Nos3 bronchiolo-alveolar adenocarcinoma Egfr Bronchomalacia Ryr1 Brugada syndrome Cacna1c , Cacnb2 , Plcd1 , Ryr2 Brugada syndrome 3 Cacna1c Brugada syndrome 4 Cacnb2 Burkitt lymphoma Calr Burns Nos2 , Tacr1 , Vdac2 Cachexia Atp2a1 , Atp2a2 , Slc25a4 Cafe-au-Lait Spots Gnas calcinosis Erbb2 , Pdgfrb Canavan disease P2rx1 , P2rx5 candidiasis Chrm2 cannabis abuse Calm1 , Calm2 , Camk2b Carbon Monoxide Poisoning Nos1 Carcinogenesis Erbb2 carcinoma Egfr cardiac arrest Cacnb2 , Itpr1 , Pln , Ryr2 Cardiac Arrhythmias Agtr1a , Cacna1c , Cacnb2 , Casq2 , Htr4 , Kcnip2 , Ryr2 Cardiac Conduction Defect Casq2 , Ryr2 Cardioacrofacial Dysplasia 1 Prkaca Cardioacrofacial Dysplasia 2 Prkacb Cardiomegaly Adra1b , Agtr1a , Agtr1b , Atp2a2 , Avpr1a , Cd38 , Egfr , Gnaq , Htr2b , Itpr2 , Nos1 , Nos3 , Pdgfrb , Ppp3ca , Prkca , Prkcb , S100a1 , Slc25a4 , Slc8a1 , Trpc1 cardiomyopathy Adora2a , Adrb2 , Bdkrb2 , Cacna1c , Cacnb2 , Casq2 , Chrm2 , Mylk2 , Nos1 , Nos3 , Oxtr , Pln , Ryr1 , Ryr2 , Tnnc1 Cardiotoxicity Nos3 Cardiovascular Abnormalities Ednra , Gnaq , Nos2 cardiovascular system disease Adrb1 , Adrb2 , Nos3 carotid artery disease Agtr1a carotid artery dissection Mylk Carotid Artery Dissection, Internal Mylk Carotid Artery Injuries Agtr1a , Nos3 carotid artery occlusion Mylk Catalepsy Drd1 cataract Atp2b1 catecholaminergic polymorphic ventricular tachycardia Cacna1c , Calm1 , Casq2 , Ryr2 catecholaminergic polymorphic ventricular tachycardia 1 Calm1 , Casq2 , Ryr2 catecholaminergic polymorphic ventricular tachycardia 2 Casq2 , Ryr2 catecholaminergic polymorphic ventricular tachycardia 4 Calm1 caudal regression syndrome Casq2 , Ryr1 central core disease Ryr1 Central Nervous System Viral Diseases Grin2a central sleep apnea Nos3 , Tacr1 centronuclear myopathy Pln , Ryr1 cerebellar ataxia Cacna1a , Cacna1g , Grm1 , Itpr1 , Kcnn2 , Prkcg cerebellar ataxia type 42 Cacna1g cerebellar disease Nos1 Cerebral Hemorrhage S100b , Slc24a1 , Slc8b1 cerebral infarction Grin1 , Nos3 cerebral palsy Cacna1a , Cacna1c , Egfr , Pdgfrb cerebrotendinous xanthomatosis Cacna1g , Plcd4 cerebrovascular disease Agtr1a cervical cancer Erbb4 cervical dystonia Drd5 Chagas disease Chrm2 Charcot-Marie-Tooth disease dominant intermediate B Cacna1a , Calr Charcot-Marie-Tooth disease dominant intermediate C Guca2b Charcot-Marie-Tooth disease type 1C Grin2a Charcot-Marie-Tooth Disease Type 1J Itpr3 Charcot-Marie-Tooth disease type 2 Kcnn3 Chemical and Drug Induced Liver Injury Adora2b , Bdkrb2 , Cabp1 , Chrm3 , Hrh2 , Itpr1 , Tbxa2r Child Behavior Disorders Nos3 childhood absence epilepsy Cacna1a , Cacna1h , Htr7 Childhood Absence Epilepsy 6 Cacna1h childhood electroclinical syndrome Cacna1a Childhood Schizophrenia Ryr2 Chloracne Egfr cholangiocarcinoma Adrb2 , Egfr , Erbb2 , Gnas , Nos2 , Ppp3ca , Prkaca , Prkacb cholelithiasis Cckar cholestasis Nos2 , Nos3 chordoid glioma Prkca choreaacanthocytosis Gna14 choriocarcinoma Pdgfrb chromosome 13q14 deletion syndrome Cysltr2 , Ednrb chromosome 15q11.2 deletion syndrome Chrna7 chromosome 15q13.3 microdeletion syndrome Chrna7 chromosome 16p11.2 deletion syndrome Atp2a1 chromosome 18p deletion syndrome Gnal chromosome 1p36 deletion syndrome Htr6 chromosome 22q11.2 deletion syndrome, distal P2rx6 chromosome 22q11.2 microduplication syndrome P2rx6 Chromosome 3, Monosomy 3p25 Oxtr Chronic Allograft Nephropathy Pdgfra , Pdgfrb Chronic Bronchitis Nos2 Chronic Cerebral Hypoperfusion Nos3 Chronic Hepatitis Nos2 chronic kidney disease Agtr1a , Nos3 chronic obstructive pulmonary disease Adora2a , Adrb1 , Adrb2 , Bdkrb2 , Chrm3 , Chrna7 , Egfr , Erbb3 , Htr2a , Nos1 , Nos2 , Nos3 chronic progressive external ophthalmoplegia Slc25a4 chronic ulcer of skin Pdgfra , Plcb3 cicatricial pemphigoid Ptger3 Circulating Neoplastic Cells Erbb2 cleft lip Nos3 cleft palate Nos3 , Pdgfra Closed Fractures Cysltr1 CLOVES syndrome Gna11 clubfoot Atp2b1 , Ryr1 Cocaine-Related Disorders Calm1 , Calm2 , Camk2a , Camk2b , Camk4 , Cckbr , Chrm5 , Drd1 , Grin1 , Grm5 , Htr2a , Tacr3 Coffin-Lowry syndrome Phka2 Coffin-Siris syndrome 6 Cacna1i cognitive disorder Chrna7 , Grin1 , Grin2a , Htr2a , Htr7 , Oxtr Cognitive Dysfunction Cacna1c colitis Adrb3 , Cckbr , Nos2 , Nos3 , Tacr1 , Tacr2 colon adenocarcinoma Cacna1d , Calr , Nos2 colon adenoma Cacna1d colon cancer Calr , Cysltr1 , Plcg1 , Ptger3 colon carcinoma Calr , Pdgfra Colonic Neoplasms Egfr , Erbb2 , Erbb3 , Nos2 , Pdgfrb , Plcb1 , Ptger3 , S100a4 color blindness Cnga3 , Cngb3 colorectal adenocarcinoma Erbb3 colorectal cancer Calr , Chp1 , Chrm5 , Chrna7 , Egfr , Erbb2 , Erbb4 , Grin2a , Itpka , P2rx2 , Plcb2 , Plcg1 , Ryr3 , Slc24a1 , Slc24a5 , Stim1 Colorectal Neoplasms Calr , Egfr , Erbb2 , Erbb3 , Gnas , Grin2a , Prkcb Coma Cacna1e cone dystrophy Cabp4 , Cnga3 , Guca1a , Guca1b cone-rod dystrophy Cabp4 , Cacna1f , Cnga1 , Cnga3 , Cngb3 , Guca1a cone-rod dystrophy 14 Cimip3 , Guca1a , Guca1b congenital adrenal hyperplasia Avpr1a , Htr4 congenital diaphragmatic hernia Nos3 , Pdgfra congenital disorder of glycosylation Iaa Pln congenital disorder of glycosylation In Tnnc1 congenital disorder of glycosylation Ir Htr6 congenital disorder of glycosylation type IIk Pdgfra congenital disorder of glycosylation type IIm Cacna1f congenital fiber-type disproportion Ryr1 congenital heart disease Adcy9 , Ednra , Gna11 , Gnaq , Ryr2 Congenital Hip Dislocation Ryr1 congenital hypothyroidism Trhr Congenital Limb Deformities Cacna1c congenital muscular dystrophy Ryr1 congenital myasthenic syndrome Ryr1 congenital myasthenic syndrome 12 Ryr1 congenital myasthenic syndrome 18 Plcb1 , Plcb4 Congenital Mydriasis Itpr1 congenital myopathy Ryr1 Congenital Myopathy 15 Tnnc2 CONGENITAL MYOPATHY 18 Cacna1s Congenital Myopathy 20 Ryr3 Congenital Neuromuscular Disease, with Uniform Type 1 Fiber Ryr1 congenital nongoitrous hypothyroidism 7 Trhr congenital stationary night blindness Cabp4 , Cacna1f , Slc24a1 congenital stationary night blindness 1D Slc24a1 congenital stationary night blindness 2A Cacna1f Congenital Stationary Night Blindness 2B Cabp4 congenital structural myopathy Orai1 , Ryr1 , Stim1 congestive heart failure Adrb1 , Adrb2 , Adrb3 , Agtr1a , Atp2a1 , Atp2a2 , Cacna1c , Calr , Casq2 , Ednra , Ednrb , Erbb2 , Erbb4 , Gnaq , Hrh2 , Htr2a , Htr2b , Nos1 , Nos2 , Nos3 , P2rx4 , Pdgfra , Plcd1 , Pln , Prkaca , Prkca , Prkcb , Ryr2 , Slc8a1 conjunctivitis Ptafr connective tissue disease Mylk Conotruncal Cardiac Defects Ppp3cc Contracture Chrm1 , Ryr3 corneal neovascularization Agtr1a Corneal Opacity Mcoln1 Cornelia de Lange syndrome 5 Phka1 coronary artery disease Adrb3 , Agtr1a , Atp2b1 , Nos2 , Nos3 coronary artery vasospasm Nos3 Coronary Disease Adrb2 , Adrb3 , Agtr1a coronary restenosis F2r coronary stenosis Hrh2 Coronavirus infectious disease Egfr Cough Bdkrb2 , Tacr2 COVID-19 Agtr1a , Cabp4 , Calm2 , Chrna7 , Ntsr1 , P2rx4 , Vdac1 Craniofacial Abnormalities Ednra , Egfr , Gna11 , Gnaq , Pdgfra craniopharyngioma Pdgfra creatine transporter deficiency Atp2b3 Creutzfeldt-Jakob disease S100b Crohn's disease Chrna7 , Ptafr Cryopyrin-Associated Periodic Syndromes Plcg2 cryptorchidism Chrm3 Cushing Syndrome Avpr1b , Gnas , Prkacb cystic fibrosis Adrb1 , Adrb2 , Adrb3 , Nos1 , Nos2 , Nos3 cystitis Tacr1 Dandy-Walker syndrome Pdgfrb Darier Disease, Acral Hemorrhagic Type Atp2a2 Darier Disease, Segmental Atp2a2 Deafness Cacna1d dehydrated hereditary stomatocytosis Kcnn4 dehydrated hereditary stomatocytosis 1 Kcnn4 dehydrated hereditary stomatocytosis 2 Kcnn4 Dehydration Nos1 Delayed Puberty Tacr3 delta beta-thalassemia Stim1 dementia Egfr , Nos2 demyelinating disease S100b dengue hemorrhagic fever Plce1 Dental Pulp Exposure S100b depressive disorder Adora2a , Adra1a , Avpr1b , Chrm2 , Drd1 , Drd5 , Htr2a , Htr7 , Nos1 , S100b dermatitis Adrb2 , Egfr developmental and epileptic encephalopathy Cacna1e , Cngb1 , Ntsr1 , Ryr3 , Stim1 developmental and epileptic encephalopathy 1 Cacna1a , Grin1 , Plcb1 Developmental and Epileptic Encephalopathy 101 Grin1 developmental and epileptic encephalopathy 12 Plcb1 , Plcb4 developmental and epileptic encephalopathy 14 Cacna1b , Grin1 developmental and epileptic encephalopathy 2 Phka2 developmental and epileptic encephalopathy 33 Ntsr1 developmental and epileptic encephalopathy 42 Cacna1a developmental and epileptic encephalopathy 46 Grin2d developmental and epileptic encephalopathy 52 Cacna1a developmental and epileptic encephalopathy 69 Cacna1e developmental and epileptic encephalopathy 91 Ppp3ca Developmental Disabilities Atp2b3 , Cacna1a , Cacna1i , Camk2a , Camk2b , Grin1 , Grin2a , Grm1 , Kcnn2 , Ryr1 Developmental Disease Cacna1g , Camk2b , Ppp3ca Diabetes Complications Bdkrb1 , Bdkrb2 , Pln diabetes mellitus Adrb1 , Egfr , Itpr1 diabetic angiopathy Adcy3 , Adcy8 , Bdkrb1 , Nos2 , Nos3 , Ptk2b Diabetic Cardiomyopathies Atp2a2 , Casq2 , Erbb2 , Erbb4 , Mylk2 , Nos3 , Pln , Ryr2 , Slc25a4 , Slc8a1 Diabetic Gastroparesis Nos3 Diabetic Nephropathies Adrb3 , Agtr1a , Bdkrb2 , Cacna1b , Cd38 , Ednra , Htr2a , Nos1 , Nos3 , Pdgfrb , Prkcb , Trpc1 , Vdac1 , Vdac2 diabetic neuropathy Bdkrb1 , Chrm2 , Grm5 , Nos2 diabetic retinopathy Adrb3 , Agtr1a , Bdkrb1 , Egfr , Nos1 , Nos3 Diaphragmatic Hernia Agtr1a , Agtr1b , Ednra , Ednrb , Nos3 Diastolic Dysfunction Ryr2 diastolic heart failure Adra1d Diastolic Hypertension, Resistance to Kcnip1 Diffuse Brain Injuries S100b diffuse cystic renal dysplasia Agtr1a Diffuse Mesangial Sclerosis Plce1 DiGeorge syndrome P2rx6 dilated cardiomyopathy Adrb1 , Adrb2 , Agtr1a , Cacna1c , Cacnb2 , Cacnb4 , Casq2 , Chrm2 , Egfr , Erbb2 , Gnaq , Itpr1 , Pln , Ppp3ca , Ppp3r1 , Prkca , Prkcb , Ryr2 , S100b , Slc25a4 , Slc8a1 , Tnnc1 dilated cardiomyopathy 1AA Ryr2 dilated cardiomyopathy 1B Ryr2 dilated cardiomyopathy 1G Mylk2 dilated cardiomyopathy 1H Adrb3 , Slc25a4 dilated cardiomyopathy 1P Pln dilated cardiomyopathy 1S Tnnc1 dilated cardiomyopathy 1Z Tnnc1 Dilated Cardiomyopathy with Left Ventricular Noncompaction Mylk2 , Ryr2 , Tnnc1 disease of cellular proliferation Erbb2 , Erbb3 , Gnas , Nos3 disease of mental health Nos1 disease of metabolism Adrb2 , Htr2a Disease Progression Ednra , Egfr , Erbb2 , Erbb3 disorder of sexual development Cacna1a , Lhcgr Disproportionate Tall Stature Mylk distal arthrogryposis Ryr1 distal muscular dystrophy Tateyama type Oxtr Down syndrome S100b drug allergy Adora2a , Cysltr1 , Cysltr2 , Ptger3 Drug-Induced Dyskinesia Cacna1d , Drd1 Drug-Induced Enteropathy Nos3 Drug-Related Side Effects and Adverse Reactions Adora2a , Cacna1h , Htr2b Duchenne muscular dystrophy Nos1 Ductal Carcinoma Agtr1a ductal carcinoma in situ Erbb2 , Erbb3 , Erbb4 , Prkca duodenal ulcer Nos2 Dwarfism P2rx6 , Ryr1 Dysarthria Gnal dyskeratosis congenita Atp2b3 Dyskinesias Htr2a , Ryr1 Dyspnea Cysltr1 dystonia Atp2b4 , Camk2b , Gnal , Ryr1 dystonia 23 Cacna1b dystonia 25 Gnal early infantile epileptic encephalopathy Cacna1e , Cngb1 , Ntsr1 , Stim1 Ebstein anomaly Pln Edema Bdkrb1 , Nos2 , Ptger3 Emery-Dreifuss muscular dystrophy Atp2b3 , Pvalb Emphysema Nos2 End Stage Liver Disease Nos1 end stage renal disease Adrb2 , Bdkrb1 , Drd1 , Guca2b , Nos1 , Nos3 endocrine system disease Gnas endometrial cancer Adrb3 endometrial carcinoma Egfr , Nos3 , Prkca Endometrial Neoplasms Calb2 , Erbb2 , Erbb3 , Erbb4 Endometrioid Carcinomas Egfr , Erbb2 , Erbb3 , Erbb4 , Pdgfra , Pdgfrb endometriosis Egfr , Ptgfr endomyocardial fibrosis Adrb1 Endotoxemia Nos2 , Nos3 , Ptafr , Tbxa2r Eosinophilia Bdkrb2 , Pdgfra epilepsy Adcy9 , Adora2a , Bdkrb1 , Bdkrb2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1g , Cacna1h , Camk2d , Chrm1 , Chrm2 , Grin1 , Grin2a , Grin2d , Grm1 , Htr7 , Itpr1 , Ntsr1 , P2rx2 , P2rx4 , P2rx6 , Plcb1 , Pln , Ppp3ca , Ryr3 , S100b , Vdac1 , Vdac2 episodic ataxia Cacna1a , Cacnb4 episodic ataxia type 2 Cacna1a , Calr episodic ataxia type 5 Cacnb4 Episodic Ataxia Type 9 Grin2a esophageal atresia Cacna1c esophageal carcinoma Egfr , Erbb2 Esophageal Neoplasms Egfr , Erbb2 , Nos2 , Nos3 esophagus adenocarcinoma Nos3 esophagus squamous cell carcinoma Calr , Chrna7 , Egfr , Erbb4 , Plce1 , Stim1 essential hypertension Agtr1a , Atp2a2 , Nos3 essential thrombocythemia Bdkrb1 , Bdkrb2 , Calr essential tremor Kcnn2 ethylmalonic encephalopathy Kcnn4 euthyroid sick syndrome Atp2a2 exercise-induced bronchoconstriction Tacr1 exfoliation syndrome Cacna1a Experimental Arthritis Bdkrb1 , Drd1 , Egfr , F2r , Kcnn4 , Nos2 , Nos3 Experimental Autoimmune Encephalomyelitis Cacna1b , Nos2 , Pdgfra , Pdgfrb Experimental Autoimmune Neuritis Nos2 Experimental Colitis Adrb3 , Chrna7 , Pdgfra , Pdgfrb Experimental Diabetes Mellitus Adora2a , Adra1a , Adrb1 , Adrb3 , Atp2a1 , Atp2a2 , Atp2a3 , Bdkrb1 , Bdkrb2 , Casq1 , Cckbr , Chrm2 , Drd1 , Ednra , Egfr , Htr2a , Kcnn4 , Nos1 , Nos2 , Nos3 , Pdgfrb , Phka1 , Plcb3 , Plcg1 , Prkca , Prkcb , Ryr2 , S100b , Slc8a1 , Trpc1 , Vdac1 Experimental Liver Cirrhosis Adora2a , Adra1b , Adrb1 , Adrb2 , Adrb3 , Agtr1a , Camk2d , Cd38 , F2r , Gna14 , Htr2b , Nos2 , Nos3 , Pdgfra , Pdgfrb , Prkcb , Ptafr , Slc25a4 Experimental Liver Neoplasms Htr2c , Nos2 Experimental Mammary Neoplasms Agtr1a , Egfr , Erbb2 , Erbb3 , Erbb4 , Lhcgr , Ptger1 Experimental Melanoma Calr Experimental Neoplasms Erbb2 , F2r , Hrh2 , Stim1 Experimental Pancreatitis Tbxa2r Experimental Radiation Injuries Agtr1a , Nos1 extrahepatic cholestasis Nos2 , Nos3 , Pdgfrb Extravasation of Diagnostic and Therapeutic Materials Bdkrb2 , Hrh1 extrinsic allergic alveolitis Nos2 Eye Abnormalities Cacna1f , Cnga3 , Cngb3 Fabry disease Mylk2 facioscapulohumeral muscular dystrophy Slc25a4 familial adenomatous polyposis Egfr , Plcg1 familial adenomatous polyposis 1 Adrb2 , Camk2a , Camk4 , Htr4 , Kcnn2 , Pdgfrb , Vdac1 familial adult myoclonic epilepsy 5 Atp2b4 , Avpr1b , Cacna1s familial cold autoinflammatory syndrome Plcg2 familial cold autoinflammatory syndrome 2 Prkcg familial cold autoinflammatory syndrome 3 Plcg2 Familial Erythroleukemia Erbb3 familial hemiplegic migraine Cacna1a , Casq1 familial hemiplegic migraine 1 Cacna1a familial hemophagocytic lymphohistiocytosis 5 Mcoln1 Familial Hyperaldosteronism, Type IV Cacna1h familial hyperlipidemia Adrb2 , Adrb3 , Nos3 familial hypertrophic cardiomyopathy Calm3 , Mylk2 , Oxtr , Ryr2 familial hypocalciuric hypercalcemia Mylk familial hypocalciuric hypercalcemia 2 Gna11 familial male-limited precocious puberty Lhcgr familial multiple nevi flammei Gna11 , Gnaq Familial Natural Short Sleep 2 Adrb1 Familial Sudden Death Ryr2 familial temporal lobe epilepsy 1 Grin2a Familial Thoracic Aortic Aneurysm 1 Mylk Familial Thoracic Aortic Aneurysm 6 Mylk Familial Thoracic Aortic Aneurysm 7 Mylk Familial Ventricular Tachycardia Cacna1c , Calm1 , Casq2 , Ryr2 Familial Visceral Neuropathy Erbb3 Familial Visceral Neuropathy 2, Autosomal Recessive Erbb2 fatty liver disease Adrb2 , F2r favism Atp2b3 Febrile Seizures Grin1 Femoral Fractures S100b fetal akinesia deformation sequence syndrome Ryr1 fetal akinesia deformation sequence syndrome 1 Atp2b3 , Ryr1 , Ryr3 fetal alcohol spectrum disorder Nos1 Fetal Death Pdgfra Fetal Diseases Nos2 , Prkcb Fetal Growth Retardation Agtr1a , Cacna1c , Cacna1d , Grin2a , Nos1 , Nos2 , Nos3 , Ptger3 Fetal Hypoxia Nos1 Fever Drd1 , Htr2a , Nos1 , Plcg2 , Ptger3 fibrolamellar carcinoma Prkaca fibroma Grm1 Fibrosis Adrb2 , Agtr1a , Bdkrb1 , Calr , Phkg2 , Sphk1 focal epilepsy Cacna1h , Grin2a , Plcg1 , Tnnc2 Focal Epilepsy with Speech Disorder and with or without Mental Retardation Grin2a focal segmental glomerulosclerosis Agtr1a , Bdkrb1 , Gnaq , Nos2 , Plce1 , Ppp3ca , Ppp3cb focal segmental glomerulosclerosis 1 Plce1 fragile X syndrome Grm1 frontotemporal dementia Erbb4 fructose-1,6-bisphosphatase deficiency Ppp3r2 fundus dystrophy Cabp4 , Cacna1f , Cnga1 , Cnga3 , Cngb1 , Cngb3 , Guca1a , Slc24a1 Fungal Lung Diseases Nos2 GABA aminotransferase deficiency Grin2a gallbladder cancer Calr gallbladder carcinoma Erbb2 , Erbb3 Gallbladder Neoplasms Cckar , Egfr , Erbb2 , Erbb3 , Erbb4 , Nos2 Gallstones Gnas gastric adenocarcinoma Calr , Erbb2 , Erbb3 , Gnas , Plce1 gastric ulcer Nos2 , Nos3 , Oxtr , Ptger1 gastroesophageal reflux disease Ryr1 Gastrointestinal Neoplasms Erbb2 gastrointestinal stromal tumor Atp2b4 , Avpr1b , Cacna1e , Cacna1s , Casq1 , Chrm3 , Itpkb , Kcnn3 , Pdgfra , Ryr2 , S100a1 , S100a4 , Stim1 gastrointestinal system disease Mylk gastroschisis Nos2 generalized dystonia Cacna1a Generalized Epilepsy Cacna1a , Cacnb4 , Chrna7 , Grin2a , Ryr3 generalized epilepsy with febrile seizures plus 9 Orai3 , Phkg2 genetic disease Adcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Adora2a , Adora2b , Adra1a , Adra1b , Adra1d , Adrb1 , Adrb2 , Adrb3 , Agtr1a , Atp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Avpr1a , Avpr1b , Bdkrb1 , Bdkrb2 , Bst1 , Cabp1 , Cabp2 , Cabp4 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Calb1 , Calb2 , Calm2 , Calml3 , Calml5 , Calr , Camk2a , Camk2b , Camk2d , Camk2g , Camk4 , Casq1 , Casq2 , Cckar , Cckbr , Cd38 , Chp2 , Chrm1 , Chrm2 , Chrm3 , Chrm5 , Chrna7 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Cysltr1 , Cysltr2 , Drd1 , Drd5 , Ednra , Ednrb , Egfr , Erbb2 , Erbb3 , Erbb4 , F2r , Gna11 , Gna14 , Gna15 , Gnal , Gnaq , Gnas , Grin1 , Grin2a , Grin2c , Grin2d , Grm1 , Grm5 , Grpr , Guca1a , Guca1b , Guca2b , Hrh1 , Hrh2 , Htr2a , Htr2b , Htr2c , Htr4 , Htr5a , Htr6 , Htr7 , Itpka , Itpkb , Itpr1 , Itpr2 , Itpr3 , Kcnip1 , Kcnip2 , Kcnip3 , Kcnip4 , Kcnn1 , Kcnn2 , Kcnn3 , Kcnn4 , Lhcgr , Ltb4r2 , Mcoln1 , Mcu , Mylk , Mylk2 , Mylk3 , Ncs1 , Nos1 , Nos2 , Nos3 , Ntsr1 , Ocm , Orai1 , Orai2 , Orai3 , Oxtr , P2rx1 , P2rx2 , P2rx3 , P2rx4 , P2rx5 , P2rx6 , P2rx7 , Pde1a , Pde1b , Pde1c , Pdgfra , Pdgfrb , Phka1 , Phka2 , Phkb , Phkg1 , Phkg2 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Plcd1 , Plcd3 , Plcd4 , Plce1 , Plcg1 , Plcg2 , Plcz1 , Ppid , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r2 , Prkaca , Prkacb , Prkca , Prkcb , Prkcg , Prkx , Ptafr , Ptger1 , Ptger3 , Ptgfr , Ptk2b , Pvalb , Rcvrn , Ryr1 , Ryr2 , Ryr3 , S100a1 , S100a4 , S100b , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc24a5 , Slc25a31 , Slc25a4 , Slc25a5 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Sphk1 , Sphk2 , Stim1 , Stim2 , Syt1 , Syt7 , Syt9 , Tacr1 , Tacr2 , Tacr3 , Tbxa2r , Tnnc1 , Tnnc2 , Tpcn1 , Tpcn2 , Trhr , Trpc1 , Trpv5 , Trpv6 , Vdac1 , Vdac2 , Vdac3 Genetic Predisposition to Disease Adora2a , Cacna1c , Ppp3cc Genitopatellar Syndrome Vdac2 Germ Cell and Embryonal Neoplasms Erbb2 , Pdgfra Gillespie syndrome Itpr1 glaucoma Mylk , Ryr1 glioblastoma Egfr , Pdgfrb globe disease Cngb3 glomerulonephritis Bdkrb1 , Plce1 , Ptafr , Ptk2b glomerulosclerosis Agtr1a glucose intolerance Agtr1a glutaric acidemia I Cacna1a , Calr glycogen storage disease Phka1 , Phka2 , Phkg2 glycogen storage disease IXa Phka2 glycogen storage disease IXb Mylk3 , Phkb glycogen storage disease IXc Phkg2 glycogen storage disease IXd Phka1 glycogen storage disease VIII Phka2 glycogen storage disease XV Agtr1a glycoproteinosis Mcoln1 GNE myopathy Ryr1 gonadal disease Lhcgr gout Adrb3 Graft Occlusion, Vascular Nos3 granulosa cell tumor Lhcgr Graves' disease Adrb2 Greig cephalopolysyndactyly syndrome Adcy9 Growth Disorders Mcoln1 growth hormone secreting pituitary adenoma Gnas Hailey-Hailey disease Atp2c1 Hallucinations Cckar , Htr2a head and neck cancer Egfr Head and Neck Neoplasms Egfr head and neck squamous cell carcinoma Egfr , Erbb2 , Erbb4 , Gnas Hearing Loss Atp2b2 , Cabp2 , Cacna1d , Ednrb Hearing Loss, Cisplatin-Induced Camk2a , Camk2b Heart Block Cacna1c , Cacna1d , Casq2 , Ryr1 , Ryr2 heart conduction disease Cacnb2 heart disease Atp2a2 , Pln , Ryr2 heart valve disease Htr2b Heat Stroke Nos1 , Ryr1 Helicobacter Infections Cysltr1 , Egfr , Erbb2 , F2r HELLP syndrome Erbb2 Hematoma S100b Hemimegalencephaly Grin1 Hemorrhage Avpr1a , Bdkrb2 hemorrhagic disease Gnas , Tbxa2r Hemorrhagic Shock Nos2 , Nos3 hepatic encephalopathy Nos1 , Nos2 , S100b Hepatic Insufficiency Nos2 , Nos3 hepatitis F2r , Nos2 hepatocellular carcinoma Adra1a , Calml3 , Calr , Egfr , Erbb3 , Erbb4 , Gnas , Kcnn2 , Nos2 , Plcg1 , Ryr3 , Stim1 Hepatomegaly Camk2a , Nos2 , Nos3 hepatopulmonary syndrome Ednrb , Nos3 hereditary ataxia Prkcg hereditary breast ovarian cancer syndrome Egfr , Plcg1 Hereditary Eye Diseases Cimip3 , Guca1a hereditary fructose intolerance syndrome Ppp3r2 Hereditary Leiomyomatosis and Renal Cell Cancer Chrm3 , Ryr2 Hereditary Motor Neuropathy with Myopathic Features Ryr1 Hereditary Neoplastic Syndromes Adrb2 , Camk2a , Camk4 , Egfr , Htr4 , Kcnn2 , Pdgfra , Pdgfrb , Vdac1 hereditary neuropathy with liability to pressure palsies Cacna1s Hereditary Paraganglioma-Pheochromocytoma Syndromes Syt7 hereditary spastic paraplegia Mcoln1 hereditary spastic paraplegia 35 Pln hereditary spastic paraplegia 39 Mcoln1 hereditary spastic paraplegia 4 Gnas hereditary spastic paraplegia 54 Adrb3 hereditary spastic paraplegia 5A Mcoln1 heroin dependence Chrm2 , Drd1 Herpes Simplex Encephalitis 1 Slc25a4 Heterotopic Ossification Gnas high grade glioma Bdkrb2 , Camk2a , Camk2b , Egfr , Erbb2 , Mylk , Nos3 , Plcb3 , Prkca , Sphk1 High Myopia Gna14 Hirschsprung's disease Ednrb , Erbb2 HIV-Associated Lipodystrophy Syndrome Adrb3 holoprosencephaly 3 Htr5a human immunodeficiency virus infectious disease Adrb2 Human Influenza Nos1 , Nos2 Huntington's disease Agtr1a , Drd1 , Drd5 , Egfr , Grin2a , Grm5 , Itpr1 , Nos3 , Plcb3 , Ppp3ca Huntington's disease-like 1 Adra1d Hydatidiform Mole Pdgfrb hydrocephalus Cacna1i , Pdgfrb hydronephrosis Ptger1 Hydrops Fetalis Ryr1 , Ryr3 Hyperalgesia Adra1a , Adrb1 , Bdkrb1 , Bdkrb2 , Cacna1b , Cacna1h , Cacna1i , Camk2a , Cckbr , Chrna7 , F2r , Grin1 , Grin2a , Htr2a , Htr7 , Itpr1 , Nos1 , Nos2 , Ntsr1 , P2rx2 , P2rx3 , P2rx4 , Prkcb , Prkcg , Ptafr , Ptger1 , Ptger3 , Tacr1 , Trpc1 Hypercholesterolemia Mylk Hyperemia Adrb1 , Bdkrb2 , Nos2 , Nos3 hypereosinophilic syndrome Pdgfra hyperglycemia Adrb1 , Cacna1e , Drd1 , Htr2a , Nos3 , Prkcb hyperhomocysteinemia Ednra , Grin2a hyperinsulinism Adra1b , Adrb3 , Agtr1a , Nos3 Hyperkinesis Adcy1 , Adcy8 , Adora2a , Drd1 , Htr2a , Htr2c , Htr7 Hyperlipoproteinemia Type II Adrb2 Hyperoxia Nos3 , Pdgfra , Pdgfrb , Plcd1 , Tacr1 hyperparathyroidism Trpv6 Hyperphagia Htr2a Hyperphosphatemic Familial Tumoral Calcinosis 1 Cacna1c Hyperplasia Egfr hyperprolinemia type 2 Htr6 hypertension Adora2a , Adra1a , Adra1b , Adrb1 , Adrb2 , Adrb3 , Agtr1a , Agtr1b , Atp2a3 , Atp2b1 , Atp2b3 , Avpr1a , Bdkrb1 , Bdkrb2 , Cacna1c , Cacnb2 , Drd1 , Drd5 , Ednra , Ednrb , Egfr , F2r , Gnas , Hrh2 , Htr2a , Htr2b , Nos1 , Nos2 , Nos3 , Orai1 , Oxtr , Pdgfra , Pdgfrb , Plcd1 , Prkca , Prkcb , Ptk2b , S100b , Slc8a1 , Stim1 , Tacr1 , Tacr3 , Trhr Hypertension Resistant to Conventional Therapy Nos3 Hypertensive Nephropathy Agtr1a Hypertriglyceridemia Adrb2 , Nos3 hypertrophic cardiomyopathy Cacna1c , Cacnb2 , Htr2b , Mylk2 , Oxtr , Pln , Ryr2 , Slc25a4 , Tnnc1 hypertrophic cardiomyopathy 1 Cacna1c , Mylk2 , Oxtr , Ryr2 hypertrophic cardiomyopathy 13 Tnnc1 hypertrophic cardiomyopathy 18 Pln hypertrophic cardiomyopathy 25 Erbb2 hypertrophic cardiomyopathy 4 Ryr2 hypertrophic pyloric stenosis Nos1 Hyperventilation Camk2b Hypoglossal Nerve Injuries Prkaca , Prkacb hypoglycemia Cacna1c hypogonadism Lhcgr , Tacr3 hypogonadotropic hypogonadism Tacr3 hypogonadotropic hypogonadism 11 with or without anosmia Tacr3 hypogonadotropic hypogonadism 12 with or without anosmia Tacr3 hypogonadotropic hypogonadism 2 with or without anosmia Adrb3 hypogonadotropic hypogonadism 7 with or without anosmia Tacr3 hypokalemia Adrb2 hypokalemic periodic paralysis Cacna1s Hypokalemic Periodic Paralysis, Type 1 Atp2b4 , Avpr1b , Cacna1s hypoparathyroidism-deafness-renal disease syndrome Cacnb2 , Calml3 , Calml5 hypophosphatasia P2rx7 Hypopigmentation Ednrb Hypotension Adora2a , Adra1a , Adra1b , Bdkrb2 , Drd1 , Hrh1 , Plcd1 , Ptafr , S100b , Tacr1 , Tacr3 Hypothermia Nos2 hypothyroidism Adrb2 , Atp2a2 , Nos2 , Nos3 , Phka1 , Trhr Hypoxia Gnas , Htr2a , Itpr1 , Nos1 , Nos3 , Oxtr Idiopathic Basal Ganglia Calcification 1 Pdgfrb Idiopathic Basal Ganglia Calcification 4 Pdgfrb idiopathic generalized epilepsy Adcy9 , Cacna1h , Cacnb4 , Kcnip1 idiopathic generalized epilepsy 7 Chrna7 idiopathic generalized epilepsy 9 Cacnb4 IgA glomerulonephritis Agtr1a ileus Nos3 Imerslund-Grasbeck Syndrome Cacnb2 Immediate Hypersensitivity Egfr immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome Cacna1f immune system disease Prkcb immunodeficiency 10 Stim1 IMMUNODEFICIENCY 15 Vdac3 immunodeficiency 15B Vdac3 immunodeficiency 21 Atp2c1 immunodeficiency 33 Atp2b3 immunodeficiency 42 Kcnn3 , S100a1 , S100a4 immunodeficiency 9 Orai1 immunodeficiency with hyper-IgM type 2 Stim1 impotence Ednra , Nos1 , Nos2 , Nos3 in situ carcinoma Pdgfra Infant Death Ryr2 Infantile Hypertrophic Pyloric Stenosis 1 Nos1 infantile myofibromatosis Pdgfrb Infantile Myofibromatosis 1 Pdgfrb infantile Refsum disease Guca1a , Guca1b Inflammation Agtr1a , Bdkrb1 , Bdkrb2 , Camk2a , Cysltr1 , Ednra , Egfr , F2r , Nos2 , S100b , Tacr1 , Tacr3 inflammatory bowel disease Nos2 , Plcg2 Insulin Resistance Adra1b , Adrb2 , Adrb3 , Bdkrb1 , Drd1 , Egfr , Gnas , Htr2a , Nos2 , Nos3 , Prkcb , Ptk2b intellectual disability Cabp2 , Cabp4 , Cacna1a , Cacna1c , Cacna1d , Cacna1e , Cacna1g , Camk2a , Camk2b , Camk2g , Camk4 , Chrm1 , Cysltr2 , Gnal , Gnas , Grin1 , Grin2a , Grin2d , Grm5 , Itpr1 , Itpr2 , Mcoln1 , P2rx3 , P2rx6 , Plcb3 , Pln , Ppp3r2 , Prkcg , Ptger3 , Syt7 , Tpcn2 intermediate coronary syndrome Agtr1a interstitial cystitis Adrb2 , Nos2 interstitial lung disease Nos2 intestinal disease Nos2 Intestinal Neoplasms Prkca intestinal perforation Nos1 , Nos3 intestinal pseudo-obstruction Erbb3 , Mylk Intestinal Reperfusion Injury Nos3 intestinal volvulus Phka1 Intimal Hyperplasia Nos3 , Pdgfrb intracranial aneurysm Nos1 , Nos3 Intracranial Hemorrhages Nos3 intracranial vasospasm Ryr1 , S100a1 , S100a4 , S100b intrahepatic cholangiocarcinoma S100b invasive aspergillosis S100b invasive ductal carcinoma Cacna1c , Erbb2 , Ptger1 invasive lobular carcinoma Erbb2 Iron Overload Atp2a2 irritable bowel syndrome Htr7 , Nos3 ischemia Nos3 , Prkca , S100a4 isolated anhidrosis with normal sweat glands Itpr2 isolated cleft palate Pdgfra isolated elevated serum creatine phosphokinase levels Oxtr , Ryr1 JMP syndrome Itpr3 Joint Instability Cacna1c Joubert syndrome Bst1 , Cacna1b , Cd38 , Grin1 Joubert syndrome 22 Htr2b Joubert syndrome 9 Oxtr juvenile myoclonic epilepsy Cacna1g , Cacnb4 juvenile rheumatoid arthritis Adcy7 , Stim1 Kaposiform Hemangioendothelioma Gna14 Keloid S100a4 keratoconus Ppp3cc keratosis follicularis Atp2a2 Keratosis Palmoplantaris with Periodontopathia and Onychogryposis Grm5 kidney disease Adra1b , Adrb2 , Agtr1a , Calb1 , Nos2 , Plce1 , Ppp3ca kidney failure Drd1 , Tbxa2r Kidney Neoplasms Erbb2 Kidney Reperfusion Injury Bdkrb1 , Nos3 , Pdgfra , Pdgfrb King Denborough syndrome Ryr1 Kleefstra syndrome 1 Cacna1b , Grin1 Klinefelter syndrome