CALCIUM TRANSPORT PATHWAY (PW:0001139)

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Description

Calcium permeates almost every aspect of cellular processes and the pathways associated with them - from proliferation to cell death, contraction and gene expression, hormone and neurotransmitter release, metabolism and synaptic plasticity. Movement of calcium ions in and outside of the cell is paramount to the maintenance of a calcium gradient four order of magnitudes between the extracellular environment and the cytoplasmic concentration of resting cells. The steep gradient allows for fast lo

Pathway Diagram:

Elsevier Inc. Stim1 Na+ ---> Na+ in (3) Mcu complex Ca2+ outside ---> Ca2+ Ca2+ Ca2+ ---> Ca2+ stored Ca2+ stored ---> Ca2+ released Na+ ---> Na+ in (4) calcium/calcium-mediated signaling pathway RYRs ITPRs NCKXs NCXs PMCAs ROCs ORAIs CNGs TRPs VOCs NAADP cADPr IP3 Ca2+ outside Ca2+ ---> CA2+ pumped out Ca2+ exchanged CA2+ pumped out Atp2c2 Tpcn2 ---> Ca2+ released Tpcn1 ---> Ca2+ released Ca2+ stored ORAIs ---- Stim2 Ca2+ ---- ITPRs IP3 ---- ITPRs ORAIs ---- Stim1 Na+ Ca2+ ---- RYRs Na+ in (3) Na+ in (4) cADPr ---- RYRs NAADP ---- Tpcn1 NAADP ---- Tpcn2 Mcoln1 ---> Ca2+ released Ca2+ released Atp2c1 Tpcn1 Tpcn2 Mcoln1 Stim2 Slc24a6 Ca2+ ---> Ca2+ exchanged Stim1 --+> ORAIs SERCAs
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Genes in Pathway:

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calcium transport pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 1 197,855,912 197,875,038 RGD:7204695
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 39,553,903 39,603,326 RGD:7204695
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:7204695
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:7204695
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 JBrowse link 4 145,704,779 145,948,997 RGD:7204695
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 JBrowse link X 157,236,400 157,312,028 RGD:7204695
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:7204695
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 JBrowse link 8 113,953,959 114,039,965 RGD:7204695
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 JBrowse link 19 52,347,480 52,404,608 RGD:7204695
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:7204688
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:7204688
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:7204688
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:7204688
G Cacna1e calcium voltage-gated channel subunit alpha1 E JBrowse link 13 71,899,445 72,534,992 RGD:7204688
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:7204688
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:7204688
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:7204688
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:7204688
G Cacna1s calcium voltage-gated channel subunit alpha1 S JBrowse link 13 52,889,570 52,964,558 RGD:7204688
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:7204688
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:7204688
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:7204688
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 JBrowse link 3 37,950,846 38,211,478 RGD:7204688
G Cnga1 cyclic nucleotide gated channel alpha 1 JBrowse link 14 38,155,771 38,171,107 RGD:6893549
G Cnga2 cyclic nucleotide gated channel alpha 2 JBrowse link 16 69,878,513 69,899,075 RGD:6893549
G Cnga3 cyclic nucleotide gated channel alpha 3 JBrowse link 9 43,807,412 43,858,225 RGD:6893549
G Cnga4 cyclic nucleotide gated channel alpha 4 JBrowse link 1 170,238,959 170,246,858 RGD:6893549
G Cngb1 cyclic nucleotide gated channel beta 1 JBrowse link 19 10,142,440 10,206,618 RGD:6893549
G Cngb3 cyclic nucleotide gated channel beta 3 JBrowse link 5 33,097,353 33,507,467 RGD:6893549
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:7204693
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:7204693
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 JBrowse link 20 5,645,894 5,711,702 RGD:7204693
G Mcoln1 mucolipin 1 JBrowse link 12 2,054,629 2,068,682 RGD:7204689
G Mcu mitochondrial calcium uniporter JBrowse link 20 29,037,452 29,199,224 RGD:7204696
G Orai1 ORAI calcium release-activated calcium modulator 1 JBrowse link 12 38,981,903 38,995,570 RGD:7204692
G Orai2 ORAI calcium release-activated calcium modulator 2 JBrowse link 12 23,544,483 23,564,602 RGD:7204692
G Orai3 ORAI calcium release-activated calcium modulator 3 JBrowse link 1 199,217,504 199,222,363 RGD:7204692
G Ryr1 ryanodine receptor 1 JBrowse link 1 87,959,596 88,066,252 RGD:7204694
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:7204694
G Ryr3 ryanodine receptor 3 JBrowse link 3 104,117,307 104,665,151 RGD:7204694
G Slc24a1 solute carrier family 24 member 1 JBrowse link 8 70,409,683 70,438,352 RGD:7204698
G Slc24a2 solute carrier family 24 member 2 JBrowse link 5 105,336,287 105,579,959 RGD:7204698
G Slc24a3 solute carrier family 24 member 3 JBrowse link 3 139,333,942 139,835,728 RGD:7204698
G Slc24a4 solute carrier family 24 member 4 JBrowse link 6 126,015,799 126,158,727 RGD:7204698
G Slc8a1 solute carrier family 8 member A1 JBrowse link 6 4,244,076 4,564,262 RGD:7204698
G Slc8a2 solute carrier family 8 member A2 JBrowse link 1 78,029,555 78,054,042 RGD:7204698
G Slc8a3 solute carrier family 8 member A3 JBrowse link 6 104,889,500 105,099,408 RGD:7204698
G Slc8b1 solute carrier family 8 member B1 JBrowse link 12 41,566,980 41,590,294 RGD:7204696
G Stim1 stromal interaction molecule 1 JBrowse link 1 167,373,894 167,533,412 RGD:7204692
G Stim2 stromal interaction molecule 2 JBrowse link 14 59,198,180 59,323,947 RGD:7204692
G Tpcn1 two pore segment channel 1 JBrowse link 12 41,507,784 41,566,847 RGD:7204697
G Tpcn2 two pore segment channel 2 JBrowse link 1 218,419,182 218,448,902 RGD:7204697
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 JBrowse link 4 70,947,615 70,974,004 RGD:7204689
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 JBrowse link 4 70,918,631 70,934,291 RGD:7204689

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassCNGscyclic nucleotide-gated channels
Functional ClassITPRsinositol 1,4,5-trisphophate receptors
ComplexMcu complexmitochondrial calcium uniporter
Functional ClassPMCAsplasma membrane pumps of the ATP2B family
Functional ClassSERCAsRE/SR pumps of the ATP2A family
Functional ClassROCsreceptor-operated channels
Functional ClassRYRsryanodine receptors
Functional ClassNCXssodium/calcium exchangers of the SLC8 family
Functional ClassNCKXssodium/calcium-potassium excahngers of the SLC24 family
Functional ClassORAIsstore-operated ORAI calcium channels
Functional ClassTRPstransient receptor potential channels
Functional ClassVOCsvoltage-operated calcium channels

Pathway Gene Annotations

Disease Annotations Associated with Genes in the calcium transport pathway
Disease TermsGene Symbols
ANHIDROSIS, FAMILIAL GENERALIZED, WITH ABNORMAL OR ABSENT SWEAT GLANDS Itpr2
abdominal obesity-metabolic syndrome 1Atp2a2
achromatopsiaCnga3 , Cngb3
Achromatopsia 1Cnga3 , Cngb3
achromatopsia 2Cnga3
achromatopsia 3Cngb3
acrodermatitisItpr3
acrokeratosis verruciformisAtp2a2
adenoid cystic carcinomaSlc24a3
adenomaAtp2a3 , Atp2b3 , Cacna1d
adrenal cortical adenomaAtp2b3
Aland Island eye diseaseCacna1f
Alcohol MyopathyAtp2a1
Alzheimer's diseaseCacna1c , Itpr1 , Slc8a1 , Slc8a2 , Slc8a3
amelogenesis imperfecta hypomaturation type 2A5Slc24a4
amyotrophic lateral sclerosisCacna1a , Itpr2
Animal Disease ModelsCacna1d
ankyloglossiaRyr1
arrhythmogenic right ventricular cardiomyopathyRyr2
arrhythmogenic right ventricular dysplasia 1Ryr2
arrhythmogenic right ventricular dysplasia 2Ryr2
arrhythmogenic right ventricular dysplasia 9Ryr2
arteriovenous malformations of the brainCacna1h
ArthrogryposisRyr1
arthrogryposis due to muscular dystrophyRyr1
asthmaItpr1
AtaxiaCacna1a , Cacnb4 , Itpr1
autism spectrum disorderCacnb2 , Ryr2
autistic disorderCacna1a , Cacna1c , Cacna1h , Itpr3
autosomal recessive nonsyndromic deafness 12Atp2b2
Axial Myopathy, Late-OnsetRyr1
bipolar disorderCacna1c , Cacna1d
BradycardiaCacna1d
Brain HypoxiaItpr1 , Itpr2
brain ischemiaSlc8a1 , Slc8a2 , Slc8a3
branched-chain keto acid dehydrogenase kinase deficiencyOrai3
breast ductal carcinomaCacna1c , Cacna1h
Brody myopathyAtp2a1
Brugada syndromeCacna1c , Cacnb2
Brugada syndrome 1Ryr2
Brugada syndrome 3Cacna1c
Brugada syndrome 4Cacnb2
CachexiaAtp2a1 , Atp2a2
cardiac arrestCacnb2 , Itpr1 , Ryr2
Cardiac ArrhythmiasCacna1c , Cacnb2 , Ryr2
Cardiac Complexes, PrematureCacna1c , Cacnb2 , Ryr2
Cardiac Conduction DefectRyr2
Cardiac Conduction Defect, NonspecificCacnb2
CardiomegalyAtp2a2 , Itpr2 , Slc8a1
cardiomyopathyRyr2
cataractAtp2b1
catecholaminergic polymorphic ventricular tachycardiaRyr2
catecholaminergic polymorphic ventricular tachycardia 1Ryr2
catecholaminergic polymorphic ventricular tachycardia 2Ryr2
central core myopathyRyr1 , Ryr2
cerebellar ataxiaCacna1a
Cerebral HemorrhageSlc24a1 , Slc8b1
Chemical and Drug Induced Liver InjuryItpr1
childhood absence epilepsyCacna1a , Cacna1h
childhood electroclinical syndromeCacna1a
Childhood SchizophreniaRyr2
clubfootRyr1
color blindnessCnga3 , Cngb3
cone dystrophyCnga3
cone-rod dystrophyCnga3
congenital fiber-type disproportionRyr1
congenital heart diseaseRyr2
Congenital Hip DislocationRyr1
Congenital Limb DeformitiesCacna1c
congenital muscular dystrophyRyr1
congenital myasthenic syndromeCacna1c , Ryr1
congenital myasthenic syndrome 10Cacna1c
congenital myopathyRyr1
Congenital Myopathy, with Fiber-Type DisproportionRyr1
Congenital Neuromuscular Disease, with Uniform Type 1 FiberRyr1
congenital stationary night blindnessCacna1f , Slc24a1
congenital stationary night blindness 1BSlc24a1
congenital stationary night blindness 1CSlc24a1
congenital stationary night blindness 1DSlc24a1
congenital stationary night blindness 1ESlc24a1
congenital stationary night blindness 2ACacna1f
congenital structural myopathyOrai1 , Ryr1 , Stim1
congestive heart failureAtp2a1 , Atp2a2 , Ryr2 , Slc8a1
Corneal OpacityMcoln1
coronary artery diseaseAtp2b1
Creatine Phosphokinase, Elevated SerumRyr1
Darier Disease, Acral Hemorrhagic TypeAtp2a2
Darier Disease, SegmentalAtp2a2
DeafnessCacna1d
Developmental DisabilitiesAtp2b3 , Cacna1a
Developmental Dysplasia of the Hip 1Ryr1
diabetes mellitusItpr1
Diabetes Mellitus, Experimental Atp2a1 , Atp2a2 , Atp2a3 , Ryr2 , Slc8a1
Diabetic CardiomyopathiesAtp2a2 , Ryr2 , Slc8a1
Diabetic NephropathiesCacna1b
Diastolic DysfunctionRyr2
dilated cardiomyopathyCacna1c , Cacnb2 , Cacnb4 , Itpr1 , Ryr2 , Slc8a1
dilated cardiomyopathy 1AARyr2
Dilated Cardiomyopathy with Left Ventricular NoncompactionRyr2
distal arthrogryposisRyr1
Drug-Induced DyskinesiaCacna1d
DysarthriaCacna1a
dystoniaAtp2b4 , Cacna1b
dystonia 23Cacna1b
Early Infantile Epileptic Encephalopathy 1Cacna1a
Early Infantile Epileptic Encephalopathy, 42Cacna1a
epilepsyCacna1c , Itpr1
episodic ataxiaCacna1a , Cacnb4
episodic ataxia type 2Cacna1a
episodic ataxia type 5Cacnb4
essential hypertensionAtp2a2
euthyroid sick syndromeAtp2a2
exfoliation syndromeCacna1a
Experimental Autoimmune EncephalomyelitisCacna1b
Experimental NeoplasmsStim1
eye diseaseCacna1f , Cnga3 , Cngb3
familial hemiplegic migraineCacna1a
Familial Hemiplegic Migraine, Type 1Cacna1a
Familial Hyperaldosteronism, Type IVCacna1h
familial hypertrophic cardiomyopathyRyr2
Familial Ventricular TachycardiaRyr2
focal epilepsyCacna1h
fundus dystrophyCacna1f , Cnga1 , Cnga3 , Cngb1 , Cngb3
gangliosidosisMcoln1
generalized dystoniaCacna1a
Generalized EpilepsyCacna1a , Cacnb4 , Ryr3
genetic diseaseAtp2b3 , Cacna1a , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cngb3 , Itpr1 , Mcoln1 , Ryr1 , Ryr2 , Ryr3
Gillespie SyndromeItpr1
glycoproteinosisMcoln1
Gonadal Dysgenesis, XX Type, with DeafnessRyr1
Hailey-Hailey diseaseAtp2c1
Heart BlockCacna1d
heart diseaseAtp2a2 , Ryr2
hereditary spastic paraplegiaMcoln1
hereditary spastic paraplegia 39Mcoln1
hereditary spastic paraplegia 7Ryr1
HirsutismCacna1g
Huntington's diseaseItpr1
HyperalgesiaCacna1b , Cacna1h , Itpr1
hyperglycemiaCacna1e
hyperkalemic periodic paralysisCacna1s
hypertensionAtp2a3 , Atp2b1 , Atp2b3 , Cacna1c , Cacnb2 , Orai1 , Slc8a1 , Stim1
hypertrophic cardiomyopathyCacnb2 , Ryr2
hypertrophic cardiomyopathy 1Cacna1c
hypertrophic cardiomyopathy 4Ryr2
hypoglycemiaCacna1c
hypokalemic periodic paralysisCacna1s
Hypokalemic Periodic Paralysis, Type 1Cacna1s
hypothyroidismAtp2a2
HypoxiaItpr1
idiopathic generalized epilepsyCacna1h , Cacnb4
Immune Dysfunction with T-Cell Inactivation due to Calcium Entry Defect 1Orai1
Immune Dysfunction with T-Cell Inactivation due to Calcium Entry Defect 2Stim1
Infant DeathRyr2
intellectual disabilityCacna1g , Mcoln1
Iron OverloadAtp2a2
isolated anhidrosis with normal sweat glandsItpr2
juvenile myoclonic epilepsyCacna1g , Cacnb4
juvenile rheumatoid arthritisStim1
keratosis follicularisAtp2a2
King Denborough SyndromeRyr1
Lambert-Eaton myasthenic syndromeCacna1a , Cacna1b
Language Development DisordersMcoln1
Leber congenital amaurosisCngb3
Left Ventricular HypertrophyCacna1g
left ventricular noncompactionRyr2
long QT syndromeCacna1c , Cacnb2 , Ryr2
Lung NeoplasmsStim1
macular degenerationCnga3 , Cngb3
Macular Dystrophy, Concentric AnnularRyr1 , Ryr2
Malformations of Cortical Development, Group IICacna1f
malignant hyperthermiaCacna1s , Ryr1
Malignant Hyperthermia Susceptibility Type 1Cacna1s , Ryr1
Malignant Hyperthermia Susceptibility Type 5Cacna1s
Malignant HypothermiaRyr1
malignant mesotheliomaRyr2
Marshall-Smith syndromeCacna1a
megacolonSlc8a1
melanomaCacna1a , Cacna1c , Cacna1s , Cnga3 , Ryr1 , Ryr2
Memory DisordersCacna1d
methylmalonic aciduria and homocystinuria type cblCRyr1 , Ryr2
microcephalyAtp2b3
migraineCacna1a , Stim1
migraine with auraCacna1a
Migraine, Sporadic HemiplegicCacna1a
Minicore Myopathy with External OphthalmoplegiaRyr1
Mitochondrial Progressive Myopathy with Congenital Cataract, Hearing Loss, and Developmental DelayRyr1
movement diseaseItpr1
Multiple AbnormalitiesCacna1c , Cacna1g , Itpr1
multiple sclerosisCacna1b
Muscle HypotoniaRyr1
muscle tissue diseaseRyr1
Muscle WeaknessCacna1a , Ryr1
muscular diseaseRyr1
MyalgiaRyr1
Myocardial IschemiaRyr2 , Slc8a1
Myocardial Reperfusion InjuryAtp2a1 , Atp2a2 , Slc8a1
myocardial stunningAtp2a2
myopathyRyr1
myopiaCacna1f
MyotoniaRyr1
nemaline myopathy 6Slc24a1
NeointimaAtp2a2
Nerve InjuriesCacnb2 , Cacnb3
neurodegenerative diseaseItpr1
Neurodevelopmental DisordersItpr1
Niemann-Pick disease type AItpr1
nonsyndromic deafnessMcoln1
obstructive sleep apneaRyr1
oligospermiaTpcn1
osteoporosisRyr1
ovarian cystCacnb3
Pancreatitis, Experimental, Acute Atp2a2
Paroxysmal Ventricular FibrillationCacna1c , Cacnb2 , Ryr2
pathologic nystagmusCngb3
peripheral nervous system diseaseCacna1b
periventricular leukomalaciaMcoln1
PhotophobiaCnga3
pleomorphic xanthoastrocytomaOrai2
polycystic ovary syndromeTrpv6
PresbycusisCacna1d
Primary Aldosteronism, Seizures, and Neurologic AbnormalitiesCacna1d
primary hyperaldosteronismAtp2b3 , Cacna1d , Cacna1h
primary immunodeficiency diseaseCacna1c
Progressive Myoclonic Epilepsy 6Ryr1
prostate cancerAtp2b4 , Cacna1d , Cnga1 , Slc8a3
Prostatic NeoplasmsItpr1
ptosisRyr1
pulmonary hypertensionAtp2a2 , Slc8a1
renal cell carcinomaRyr1
Reperfusion InjurySlc8a1 , Slc8a2 , Slc8a3
respiratory failureCacna1s , Ryr1
restrictive cardiomyopathyCacna1c
retinitis pigmentosaCacna1f , Cnga1 , Cnga3 , Cngb1 , Cngb3 , Slc24a1
retinitis pigmentosa 45Cngb1
retinitis pigmentosa 49Cnga1 , Cngb1
RhabdomyolysisCacna1s , Ryr1
rigid spine muscular dystrophy 1Ryr1
Sacral Defect and Anterior Sacral MeningoceleRyr1
Salivary Gland NeoplasmsSlc24a3
schizophreniaAtp2a1 , Cacna1c , Cacna1h
sciatic neuropathyCacna1d
scoliosisRyr1
sensorineural hearing lossRyr1
SepsisAtp2a1
short QT syndromeCacna1c , Cacnb2
sick sinus syndromeCacna1d
Sinoatrial Node Dysfunction and DeafnessCacna1d
Skin/Hair/Eye Pigmentation, Variation In, 10Tpcn2
Skin/Hair/Eye Pigmentation, Variation In, 6Slc24a4
Smith-Magenis syndromeCacna1g , Cacnb1
Spastic Paraplegia Type 7Ryr1
Spinal Cord InjuriesAtp2a1 , Atp2a2
Spinocerebellar Ataxia 42Cacna1g
Spinocerebellar Ataxia 42, Early-Onset, Severe, with Neurodevelopmental DeficitsCacna1g
spinocerebellar ataxia type 15Itpr1
spinocerebellar ataxia type 29Itpr1
spinocerebellar ataxia type 6Cacna1a
Spinocerebellar Ataxia, X-Linked 1Atp2b3
Spinocerebellar AtaxiasCacna1a , Cacna1g , Itpr1
Stargardt diseaseCngb3
Stargardt Disease 1Cngb3
status epilepticusAtp2a2 , Slc8a1 , Slc8a2 , Slc8a3
Stormorken syndromeStim1
strabismusCacna1a
subependymal giant cell astrocytomaCacna1a
Sudden DeathRyr2
Sudden Death, CardiacCacna1c , Ryr2
TachycardiaRyr2
Tachycardia, SupraventricularCacna1d
temporal lobe epilepsyCacna1a
thoracic aortic aneurysmAtp2b3
Thyrotoxic Periodic ParalysisCacna1s
Thyrotoxic Periodic Paralysis, Susceptibility To, 1Cacna1s
Timothy syndromeCacna1c
transient cerebral ischemiaItpr1
TremorAtp2b3
tubular aggregate myopathyOrai1 , Stim1
type 1 diabetes mellitusItpr3
type 2 diabetes mellitusAtp2a1 , Atp2a2 , Atp2a3 , Cacna1d
Ventricular Dysfunction, LeftAtp2a2
Ventricular FibrillationCacnb2 , Ryr2
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c , Ryr2
Ventricular TachycardiaAtp2a2 , Cacna1c , Ryr2
visual epilepsyCacna1a , Slc8a1 , Slc8a3
Weight GainStim2
Wilson diseaseRyr1
Wolff-Parkinson-White syndromeCacna1c , Cacna1e , Ryr2
X-linked cone-rod dystrophy 3Cacna1f
Pathway Annotations Associated with Genes in the calcium transport pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
alfentanil pharmacodynamics pathwayCacna1a , Cacnb1
altered visual phototransduction pathwayCnga1 , Cngb1
Alzheimer's disease pathwayAtp2a1 , Atp2a2 , Atp2a3 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Itpr1 , Itpr2 , Itpr3 , Ryr3
amiodarone pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
amlodipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
arrhythmogenic right ventricular cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
atenolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
betaxolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bisoprolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bupivacaine pharmacodynamics pathwayCacna1a , Cacnb1
bupranolol drug pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
bupranolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
buprenorphine pharmacodynamics pathwayCacna1a , Cacnb1
calcium transport pathwayAtp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Itpr1 , Itpr2 , Itpr3 , Mcoln1 , Mcu , Orai1 , Orai2 , Orai3 , Ryr1 , Ryr2 , Ryr3 , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Stim1 , Stim2 , Tpcn1 , Tpcn2 , Trpv5 , Trpv6
calcium/calcium-mediated signaling pathwayAtp2a1 , Atp2a2 , Atp2a3 , Atp2b1 , Atp2b2 , Atp2b3 , Atp2b4 , Atp2c1 , Atp2c2 , Cacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Cnga1 , Cnga2 , Cnga3 , Cnga4 , Cngb1 , Cngb3 , Itpr1 , Itpr2 , Itpr3 , Mcoln1 , Mcu , Orai1 , Orai2 , Orai3 , Ryr1 , Ryr2 , Ryr3 , Slc24a1 , Slc24a2 , Slc24a3 , Slc24a4 , Slc8a1 , Slc8a2 , Slc8a3 , Slc8b1 , Stim1 , Stim2 , Tpcn1 , Tpcn2 , Trpv5 , Trpv6
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c , Cacnb2 , Ryr2
carvedilol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
chloroprocaine pharmacodynamics pathwayCacna1a , Cacnb1
citalopram pharmacodynamics pathwayCacna1a , Cacnb1
cocaine pharmacodynamics pathwayCacna1a , Cacnb1
codeine and morphine pharmacodynamics pathwayCacna1a , Cacnb1
desipramine pharmacodynamics pathwayCacna1a , Cacnb1
dilated cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
diltiazem pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
diphenoxylate pharmacodynamics pathwayCacna1a , Cacnb1
disopyramide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
dobutamine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
escitalopram pharmacodynamics pathwayCacna1a , Cacnb1
esmolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
ethylmorphine pharmacodynamics pathwayCacna1a , Cacnb1
felodipine pharmacokinetics pathwayCacna1c , Cacnb1
fentanyl pharmacodynamics pathwayCacna1a , Cacnb1
flecainde pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
fluoxetine pharmacodynamics pathwayCacna1a , Cacnb1
fosphenytoin pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
gliclazide pharmacodynamics pathwayCacna1a , Cacnb1
glutamate signaling pathwayCacna1a , Cacna1c , Cacna1d , Itpr1 , Itpr2 , Itpr3
glyburide pharmacodynamics pathwayCacna1a , Cacnb1
gonadotropin-releasing hormone signaling pathwayCacna1c , Cacna1d , Cacna1f , Cacna1s , Itpr1 , Itpr2 , Itpr3
heroin pharmacodynamics pathwayCacna1a , Cacnb1
Huntington's disease pathwayItpr1
hydrocodone pharmacodynamics pathwayCacna1a , Cacnb1
hydromorphone pharmacodynamics pathwayCacna1a , Cacnb1
hypertrophic cardiomyopathy pathwayAtp2a2 , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4 , Ryr2 , Slc8a1
ibutilide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
imipramine pharmacodynamics pathwayCacna1a , Cacnb1
insulin secretion pathwayCacna1a , Cacna1c , Cacna1d
isoprenaline pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
isradipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
levacetylmethadol pharmacodynamics pathwayCacna1a , Cacnb1
levobunolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
levobupivacaine phgarmacodynamics pathwayCacna1a , Cacnb1
levorphanol pharmacodynamics pathwayCacna1a , Cacnb1
lidocaine pharmacodynamics pathwayAtp2a2 , Cacna1a , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
long term depressionCacna1a , Itpr1 , Itpr2 , Itpr3
long term potentiationCacna1c , Itpr1 , Itpr2 , Itpr3
mepivacaine pharmacodynamics pathwayCacna1a , Cacnb1
methadone pharmacodynamics pathwayCacna1a , Cacnb1
metoprolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
mexiletine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
mitogen activated protein kinase signaling pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1f , Cacna1g , Cacna1h , Cacna1i , Cacna1s , Cacnb1 , Cacnb2 , Cacnb3 , Cacnb4
nadolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nalbuphine pharmacodynamics pathwayCacna1a , Cacnb1
naloxone pharmacodynamics pathwayCacna1a , Cacnb1
naltrexone pharmacodynamics pathwayCacna1a , Cacnb1
nebivolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nicotine pharmacodynamics pathwayCacna1a , Cacnb1
nifedipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nimodipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nisoldipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
nitrendipine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
oxybuprocaine pharmacodynamics pathwayCacna1a , Cacnb1
oxycodone pharmacodynamics pathwayCacna1a , Cacnb1
oxymorphone pharmacodynamics pathwayCacna1a , Cacnb1
penbutolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
pentazocine pharmacodynamics pathwayCacna1a , Cacnb1
phenytoin pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
phosphatidylinositol 3-kinase signaling pathwayItpr1 , Itpr2 , Itpr3
pindolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
potassium channel inhibitors pharmacodynamics pathwayCacna1a , Cacnb1
prilocaine pharmacodynamics pathwayCacna1a , Cacnb1
procainamide pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
procaine pharmacodynamics pathwayCacna1a , Cacnb1
propranolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
quinidine pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
remifentanil pharmacodynamics pathwayCacna1a , Cacnb1
retinitis pigmentosa pathwayCnga1 , Cngb1
ropivacaine pharmacodynamics pathwayCacna1a , Cacnb1
sotalol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
timolol pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
tramadol pharmacodynamics pathwayCacna1a , Cacnb1
type 2 diabetes mellitus pathwayCacna1a , Cacna1b , Cacna1c , Cacna1d , Cacna1e , Cacna1g
verapamil pharmacodynamics pathwayAtp2a2 , Cacna1c , Cacna1g , Cacna1h , Cacnb1 , Itpr1 , Ryr2 , Slc8a1
visual phototransduction pathwayCnga1 , Cnga3 , Cngb1 , Cngb3 , Slc24a1 , Slc24a2
Phenotype Annotations Associated with Genes in the calcium transport pathway

References Associated with the calcium transport pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: