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Gene: Itpr3 (inositol 1,4,5-triphosphate receptor 3) Mus musculus
Symbol: Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Description: Exhibits inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in several processes, including calcium ion transport into cytosol; long-term synaptic potentiation; and sensory perception of taste. Localizes to the cytoplasm; endoplasmic reticulum membrane; and nuclear lumen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is expressed in jaw; sensory organ; and skeleton. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; IP3R 3; Ip3r3; Itpr-3; tf; type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
Homo sapiens (human) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itpr3 (inositol 1,4,5-trisphosphate receptor, type 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Canis lupus familiaris (dog) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr3 (inositol 1,4,5-trisphosphate receptor type 3)
Sus scrofa (pig) : ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381727,057,002 - 27,122,223 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371727,194,249 - 27,259,168 (+)NCBIGRCm37mm9NCBIm37
MGSCv361726,785,125 - 26,849,812 (+)NCBImm8
Celera1727,593,736 - 27,658,505 (+)NCBICelera
Cytogenetic Map17 A3.3NCBI
cM Map1713.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itpr3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10822
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.