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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr3
Name: inositol 1,4,5-trisphosphate receptor, type 3
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr3decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of ITPR3 mRNAPMID:29427782
Itpr3increases expressionEXP 6480464CTDValproic Acid results in increased expression of ITPR3 mRNAPMID:32428529
Itpr3affects expressionISOITPR3 (Homo sapiens)6480464CTDValproic Acid affects the expression of ITPR3 mRNAPMID:25979313
Itpr3increases expressionISOITPR3 (Homo sapiens)6480464CTDValproic Acid results in increased expression of ITPR3 mRNAPMID:19101580 PMID:23179753 PMID:26272509 PMID:28001369
Itpr3multiple interactionsISOITPR3 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPR3 mRNAPMID:27188386
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