RGD Reference Report - Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B. - Rat Genome Database

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Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

Authors: Tanaka, S  Kabayama, H  Enomoto, M  Saito, N  Mikoshiba, K 
Citation: Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
RGD ID: 11535091
Pubmed: PMID:21424589   (View Abstract at PubMed)
DOI: DOI:10.1007/s12576-011-0140-4   (Journal Full-text)

Inositol 1, 4, 5-trisphosphate receptors (IP(3)Rs) are intracellular ligand-gated Ca(2+) channels that mediate Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol and function in diverse cellular processes including fertilization, muscle contraction, apoptosis, secretion, and synaptic plasticity. The Ca(2+) release activity of IP(3)Rs is tightly regulated by many factors including IP(3)R-binding proteins. We show that IP(3)Rs interact with syntaxin 1 (Syx1), a membrane trafficking protein that regulates various plasma-membrane ion channels including N-, P/Q, and L-type voltage-gated Ca(2+) channels, voltage-gated potassium channels, and an epithelial sodium channel. We found that a SNARE-domain of Syx1B, one of the two Syx1 isoforms, directly interacted with the type1 IP(3)R (IP(3)R1) internal coupling domain, a known modulator for channel opening. These results indicate that Syx1B is an IP(3)R-interacting protein and that its interaction may play a crucial role in regulating the channel activity of IP(3)Rs in Syx1B-expressing cells.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding enablesIPIUniProtKB:P6126511535091; 11535091PMID:21424589ParkinsonsUK-UCL 
signaling receptor binding enablesIPIUniProtKB:P2999411535091PMID:21424589ParkinsonsUK-UCL 
signaling receptor binding enablesIPIUniProtKB:Q6326911535091PMID:21424589ParkinsonsUK-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Itpr1  (inositol 1,4,5-trisphosphate receptor, type 1)
Itpr3  (inositol 1,4,5-trisphosphate receptor, type 3)
Stx1b  (syntaxin 1B)


Additional Information