RT1-Bb (RT1 class II, locus Bb) - Rat Genome Database

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Gene: RT1-Bb (RT1 class II, locus Bb) Rattus norvegicus
Symbol: RT1-Bb
Name: RT1 class II, locus Bb
RGD ID: 3469
Description: Predicted to enable several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in cellular response to organic cyclic compound; defense response to fungus; and negative regulation of T cell proliferation. Located in cell surface. Used to study uveitis. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bb; MGC94124; MHC class II antigen B beta chain; rano class II histocompatibility antigen, B-1 beta chain; RT1 class II histocompatibility antigen, B-1 beta chain; RT1-B beta; RT1.B; RT1.B-beta(1); RT1.B-BETA1; RT1.Bbeta; RT1.Bbeta 1
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8204,598,475 - 4,604,118 (-)NCBIGRCr8
mRatBN7.2204,596,558 - 4,602,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0205,193,861 - 5,199,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,043,726 - 4,049,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,039,413 - 4,049,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,123,272 - 6,128,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,730,559 - 4,736,201 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,730,786 - 4,736,413 (-)NCBI
Celera206,197,565 - 6,203,195 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
achalasia  (ISO)
acute disseminated encephalomyelitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Addison's disease  (ISO)
agranulocytosis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
alopecia areata  (ISO)
alveolar echinococcosis  (ISO)
Amebic Liver Abscess  (ISO)
angioedema  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
arthritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atrophic gastritis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune pancreatitis  (ISO)
autoimmune polyendocrine syndrome  (ISO)
autoimmune polyendocrine syndrome type 2  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
Cataplexy  (ISO)
celiac disease  (ISO)
cervical cancer  (ISO)
cervical dystonia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chikungunya  (ISO)
choreatic disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
cicatricial pemphigoid  (ISO)
colorectal cancer  (ISO)
common variable immunodeficiency  (ISO)
common wart  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cystic echinococcosis  (ISO)
degenerative myopia  (ISO)
Delayed Hypersensitivity  (IDA)
dental caries  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
Drug Eruptions  (ISO)
Drug-induced Neutropenia  (ISO)
End Stage Liver Disease  (ISO)
erythema multiforme  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IMP,ISO)
glaucoma  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Idiopathic Hypersomnolence  (ISO)
IgA glomerulonephritis  (ISO)
immunoglobulin alpha deficiency  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
latex allergy  (ISO)
liver cirrhosis  (ISO)
marginal zone lymphoma  (ISO)
multidrug-resistant tuberculosis  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
mycosis fungoides  (ISO)
myocarditis  (ISO)
myositis  (ISO)
narcolepsy  (ISO)
Nasal Polyps  (ISO)
neuromyelitis optica  (ISO)
optic neuritis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteomyelitis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pemphigus vulgaris  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumoconiosis  (ISO)
pneumocystosis  (IEP)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (ISO)
primary sclerosing cholangitis  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
psoriasis  (ISO)
pulmonary tuberculosis  (ISO)
pure red-cell aplasia  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatic fever  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
rhinoscleroma  (ISO)
Rhinosinusitis, Allergic Fungal  (ISO)
sarcoidosis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Small Fiber Neuropathy  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach disease  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
Transplant Rejection  (IDA)
tropical spastic paraparesis  (ISO)
tuberculosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Uterine Cervical Dysplasia  (ISO)
uveitis  (IMP)
Veno-Occlusive Disease  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amoxicillin  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefuroxime  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenoprofen  (ISO)
fenthion  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
heme b  (ISO)
hexachlorobenzene  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
ketoprofen  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nifedipine  (ISO)
oxaprozin  (ISO)
ozone  (ISO)
palladium  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
rifampicin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfasalazine  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
tolmetin  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Treatment of autoimmune anterior uveitis with recombinant TCR ligands. Adamus G, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2555-61.
2. HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM. Agardh D, etal., Diabetologia. 1996 Nov;39(11):1313-7.
3. Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia. Al-Ola K, etal., Tissue Antigens. 2008 May;71(5):453-7. doi: 10.1111/j.1399-0039.2008.01012.x. Epub 2008 Feb 28.
4. Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. Alves-Leon SV, etal., Arq Neuropsiquiatr. 2009 Sep;67(3A):643-51.
5. [Immunogenetic aspects of the course and treatment of pulmonary tuberculosis]. Archakova LI, etal., Probl Tuberk Bolezn Legk. 2008;(12):34-7.
6. HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica. Asgari N, etal., Mult Scler. 2012 Jan;18(1):23-30. doi: 10.1177/1352458511417480. Epub 2011 Sep 9.
7. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. Athanasiou MC, etal., J Clin Psychiatry. 2011 Apr;72(4):458-63. doi: 10.4088/JCP.09m05527yel. Epub 2010 Sep 21.
8. Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease. Bajer L, etal., World J Gastroenterol. 2018 Nov 21;24(43):4939-4949. doi: 10.3748/wjg.v24.i43.4939.
9. [Association of the relationship between HLA-DQB1 alleles and major beta-thalassemia in 42 guangdong Chinese]. Bao R, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Feb;10(1):87-8.
10. Systemic morphine administration suppresses genes involved in antigen presentation. Beagles K, etal., Mol Pharmacol. 2004 Feb;65(2):437-42.
11. Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel. Benedek G, etal., Genes Immun. 2010 Jul;11(5):423-31. Epub 2010 May 13.
12. HLA class II distribution in Congolese with hyperthyroidism: preliminary results. Bidingija M, etal., Ann Endocrinol (Paris). 2006 Dec;67(6):596-603.
13. Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population. Blanco C, etal., J Allergy Clin Immunol. 2004 Nov;114(5):1070-6.
14. Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy. Boehncke WH, etal., Clin Exp Allergy. 1998 Apr;28(4):434-41.
15. HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis. Bonagura VR, etal., Hum Immunol. 2004 Aug;65(8):773-82.
16. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Bonagura VR, etal., Hum Immunol. 2010 Feb;71(2):212-9. doi: 10.1016/j.humimm.2009.10.009. Epub 2009 Oct 25.
17. Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study. Book L, etal., Am J Med Genet. 2001 Jan 1;98(1):70-4.
18. HLA-DQ: Celiac disease vs inflammatory bowel disease. Bosca-Watts MM, etal., World J Gastroenterol. 2018 Jan 7;24(1):96-103. doi: 10.3748/wjg.v24.i1.96.
19. Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel. Brill L, etal., J Neuroimmunol. 2016 Apr 15;293:65-70. doi: 10.1016/j.jneuroim.2016.02.006. Epub 2016 Feb 15.
20. Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo. Buc M, etal., Eur J Dermatol. 1998 Jan-Feb;8(1):13-5.
21. Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. Burrows GG, etal., J Immunol. 1998 Dec 1;161(11):5987-96.
22. HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients. Caliz R, etal., Rheumatology (Oxford). 2001 Jan;40(1):31-6.
23. Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis. Castro F, etal., Ann Rheum Dis. 2001 Aug;60(8):791-5.
24. HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India. Chaaithanya IK, etal., Immunology. 2013 Oct;140(2):202-10. doi: 10.1111/imm.12128.
25. Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. Chan LS, etal., J Invest Dermatol. 1997 Feb;108(2):129-32.
26. The association between HLA-DQB1 polymorphism and antituberculosis drug-induced liver injury: a Case-Control Study. Chen R, etal., J Clin Pharm Ther. 2015 Feb;40(1):110-5. doi: 10.1111/jcpt.12211. Epub 2014 Sep 24.
27. Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages. Cheng BH, etal., BMC Microbiol. 2010 Apr 8;10:103.
28. Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies. Chinoy H, etal., Rheumatology (Oxford). 2007 Sep;46(9):1411-6. Epub 2007 Jun 22.
29. [Analysis of HLA-DQB1 polymorphism for patients with allergic rhinitis of Uygur and Han people in Xinjiang]. Cui Z, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jul;25(14):645-8.
30. Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation. Dalchau R, etal., Eur J Immunol. 1992 Mar;22(3):669-77.
31. Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Davidson EJ, etal., Cancer Res. 2003 Jan 15;63(2):400-3.
32. Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. de Kauwe AL, etal., J Immunol. 2009 Jun 15;182(12):7440-50.
33. HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). De La Concha EG, etal., Clin Exp Immunol. 1999 Jun;116(3):516-20.
34. Association of HLA Class II alleles and haplotypes with cervical dystonia: HLA DR13-DQ6 (DQB1*0604) homozygotes are at greatly increased risk of cervical dystonia in Caucasian Americans. Deitiker PR, etal., Autoimmunity. 2011 May;44(3):167-76. Epub 2010 Sep 15.
35. HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. Djilali-Saiah I, etal., J Hepatol. 2006 Dec;45(6):844-50. Epub 2006 Sep 28.
36. HLA-DRB1 and HLA-DQB1 genes in susceptibility and resistance to cicatricial pemphigoid in French Caucasians. Drouet M, etal., Eur J Dermatol. 1998 Jul-Aug;8(5):330-3.
37. Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. Dunstan SJ, etal., J Infect Dis. 2001 Jan 15;183(2):261-268. doi: 10.1086/317940. Epub 2000 Dec 21.
38. Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β -511 is associated with development of cervical carcinoma. Dutta S, etal., Cancer Immunol Immunother. 2015 Jul;64(7):843-51. doi: 10.1007/s00262-015-1693-5. Epub 2015 Apr 17.
39. No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population. Dzurilla M, etal., Bratisl Lek Listy. 2013;114(2):93-5.
40. HLA and alveolar echinococcosis. Eiermann TH, etal., Tissue Antigens. 1998 Aug;52(2):124-9. doi: 10.1111/j.1399-0039.1998.tb02275.x.
41. Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study. El-Bendary M, etal., J Viral Hepat. 2016 Dec;23(12):961-970. doi: 10.1111/jvh.12573. Epub 2016 Sep 7.
42. Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity. Eller E, etal., Genes Immun. 2007 Dec;8(8):628-33. Epub 2007 Aug 30.
43. HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease. Esmaeilzadeh H, etal., Am J Rhinol Allergy. 2015 May-Jun;29(3):e63-9. doi: 10.2500/ajra.2015.29.4154.
44. HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset. Fain PR, etal., Pigment Cell Res. 2006 Feb;19(1):51-7.
45. DQA1 and DQB1 association and nasal polyposis. Fajardo-Dolci G, etal., Otolaryngol Head Neck Surg. 2006 Aug;135(2):243-7.
46. [Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. Fan XY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):278-81.
47. Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias. Fernandes TA, etal., Blood Cells Mol Dis. 2010 Mar-Apr;44(2):69-73. doi: 10.1016/j.bcmd.2009.10.006. Epub 2010 Jan 3.
48. High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency. Ferreira RC, etal., PLoS Genet. 2012 Jan;8(1):e1002476. doi: 10.1371/journal.pgen.1002476. Epub 2012 Jan 26.
49. HLA profile in patients with AIDS and tuberculosis. Figueiredo JF, etal., Braz J Infect Dis. 2008 Aug;12(4):278-80. doi: 10.1590/s1413-86702008000400004.
50. HLA typing in acute optic neuritis. Relation to multiple sclerosis and magnetic resonance imaging findings. Frederiksen JL, etal., Arch Neurol. 1997 Jan;54(1):76-80.
51. Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons. Friedl-Hajek R, etal., Clin Exp Allergy. 1999 Apr;29(4):478-87.
52. An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia. Furuzawa-Carballeda J, etal., PLoS One. 2018 Aug 9;13(8):e0201676. doi: 10.1371/journal.pone.0201676. eCollection 2018.
53. Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects. Gao J, etal., Chin Med J (Engl). 2003 Jul;116(7):1078-82.
54. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
55. Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients. Gil JM, etal., Int J Dermatol. 2017 May;56(5):557-562. doi: 10.1111/ijd.13577. Epub 2017 Feb 15.
56. HLA-DRB and HLA-DQB loci in the genetic susceptibility to develop glaucoma in Mexicans. Gil-Carrasco F, etal., Am J Ophthalmol. 1999 Sep;128(3):297-300.
57. Renal vascular sclerosis is associated with inherited thrombophilias. Goforth RL, etal., Kidney Int. 2006 Aug;70(4):743-50. Epub 2006 Jun 7.
58. Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. Gundogdu F, etal., J Heart Valve Dis. 2007 May;16(3):293-9.
59. The major histocompatibility complex of the rat (Rattus norvegicus). Gunther E and Walter L, Immunogenetics 2001 Sep;53(7):520-42.
60. [Association between asthma and the polymorphism of HLA-DQ genes]. Guo X, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2001 Mar;24(3):139-41.
61. Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. Han YN, etal., World J Gastroenterol. 2005 Sep 28;11(36):5721-4. doi: 10.3748/wjg.v11.i36.5721.
62. Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection. Hardie RA, etal., AIDS. 2008 Apr 23;22(7):807-16.
63. Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. Hashimoto K, etal., Horm Res. 2005;64(5):253-60. Epub 2005 Oct 27.
64. Translation in Xenopus laevis oocytes of hybrid selected LEW rat RT1.B alpha- and beta-chain transcripts results in serologically discrete class II polypeptide chain complexes. Henkes W and Reske K, Mol Immunol. 1989 Feb;26(2):171-9.
65. Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess. Hernández EG, etal., PLoS One. 2015 May 4;10(5):e0126195. doi: 10.1371/journal.pone.0126195. eCollection 2015.
66. Familial mycosis fungoides: report of 6 kindreds and a study of the HLA system. Hodak E, etal., J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):393-402.
67. HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia. Honda K, etal., Obstet Gynecol. 2000 Sep;96(3):385-9. doi: 10.1016/s0029-7844(00)00918-2.
68. [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children]. Huang YK, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):137-40.
69. Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease. Hughes T, etal., Nat Genet. 2013 Mar;45(3):319-24. doi: 10.1038/ng.2551. Epub 2013 Feb 10.
70. Does HLA Class II haplotype play a role in adult acute disseminated encephalomyelitis? Preliminary findings from a Southern Italy hospital-based study. Imbesi D, etal., Arch Ital Biol. 2012 Mar;150(1):1-4. doi: 10.4449/aib.v150i1.1384.
71. Profiles of autoimmune hepatitis in Brunei Darussalam. Jalihal A, etal., Hepatobiliary Pancreat Dis Int. 2009 Dec;8(6):602-7.
72. HLA-DQB1 allele and hypocretin in Korean narcoleptics with cataplexy. Jeong JH, etal., J Korean Med Sci. 2007 Feb;22(1):127-31.
73. Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone. Jimenez BD, etal., Life Sci. 2002 Jun 7;71(3):311-23.
74. Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome. Kang HI, etal., J Immunol. 1993 Apr 15;150(8 Pt 1):3615-23.
75. Genetic aspect of venom allergy: association with HLA class I and class II antigens. Karakis GP, etal., Ann Agric Environ Med. 2010 Jun;17(1):119-23.
76. Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population. Katahira M, etal., Hum Immunol. 2010 Aug;71(8):789-94. Epub 2010 May 25.
77. HLA-DQA1*0103-DQB1*0601 haplotype and Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue lymphoma. Kawahara Y, etal., Clin Gastroenterol Hepatol. 2005 Sep;3(9):865-8.
78. HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice. Khare M, etal., J Neuroimmunol. 2005 Dec;169(1-2):1-12. Epub 2005 Sep 27.
79. HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus. Khazaee MH, etal., Eur J Ophthalmol. 2009 Jul-Aug;19(4):638-45.
80. HLA class II allele and haplotype frequencies in Iranian patients with leukemia. Khosravi F, etal., Iran J Allergy Asthma Immunol. 2007 Sep;6(3):137-42.
81. Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma. Knutsen AP, etal., Clin Mol Allergy. 2010 Mar 18;8:5.
82. Major histocompatibility complex class II (DRB1*, DQA1*, and DQB1*) and DRB1*04 subtypes' associations of Hashimoto's thyroiditis in a Greek population. Kokaraki G, etal., Tissue Antigens. 2009 Mar;73(3):199-205.
83. HLA associations with multiple sclerosis in Greece. Kouri I, etal., J Neurol Sci. 2011 Jul 7.
84. The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis. Laki J, etal., Int Immunol. 2006 Nov;18(11):1585-90. Epub 2006 Sep 20.
85. Celiac disease in children with autoimmune thyroid disease. Larizza D, etal., J Pediatr. 2001 Nov;139(5):738-40.
86. HLA class II DRB1 and DQB1 allelic polymorphism and sclerosing lymphocytic lobulitis of the breast. Lee AH, etal., J Clin Pathol. 1999 Jun;52(6):445-9.
87. Effects of smoking on the association of human leukocyte antigen with ulcerative colitis. Lee HS, etal., J Gastroenterol Hepatol. 2019 Apr 30. doi: 10.1111/jgh.14695.
88. Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome-wide association study. Lee MH, etal., Hepatology. 2018 Feb;67(2):651-661. doi: 10.1002/hep.29531. Epub 2018 Jan 1.
89. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Legge SE, etal., Mol Psychiatry. 2017 Oct;22(10):1502-1508. doi: 10.1038/mp.2016.97. Epub 2016 Jul 12.
90. Association between HLA-DQB1 and cervical dysplasia in Vietnamese women. Lema C, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1269-77. doi: 10.1111/j.1525-1438.2006.00459.x.
91. Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Levinson RD, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):653-7.
92. [Study on the association of pathologic myopia with HLA-DQB1 gene]. Li S, etal., Zhonghua Yan Ke Za Zhi. 2001 Jul;37(4):263-6.
93. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. Li X, etal., J Allergy Clin Immunol. 2010 Feb;125(2):328-335.e11. doi: 10.1016/j.jaci.2009.11.018.
94. [HLA-DQ molecules associated with myasthenia gravis in Chinese patients]. Li X, etal., Yi Chuan Xue Bao. 1999;26(4):295-300.
95. [Studies of the association of pathological myopia in Chinese patients with HLA alleles]. Li X, etal., Yi Chuan Xue Bao. 2000;27(3):189-94.
96. HLA-DQA1, -DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of northern China. Liu W, etal., Ann Hum Genet. 2005 Jul;69(Pt 4):382-8.
97. Polymorphisms of HLA-DQB1 predict survival of hepatitis B virus-related hepatocellular carcinoma patients receiving hepatic resection. Liu X, etal., Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):739-747. doi: 10.1016/j.clinre.2016.04.005. Epub 2016 Jun 7.
98. Human leukocyte antigen class II associations in patients with idiopathic dilated cardiomyopathy. Myocarditis Treatment Trial Investigators. Lozano MD, etal., J Card Fail. 1997 Jun;3(2):97-103.
99. [Distribution of HLA specificity frequencies in patients with cystic echinococcosis]. Lukmanova GI, etal., Med Parazitol (Mosk). 2011 Oct-Dec;(4):14-6.
100. The same HLA-DQ alleles determine either susceptibility or resistance to different coxsackievirus-mediated autoimmune diseases. Luppi P, etal., J Biol Regul Homeost Agents. 1999 Jan-Mar;13(1):14-26.
101. HLA-A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 frequencies in German immunoglobulin A-deficient individuals. MacHulla HK, etal., Scand J Immunol. 2000 Aug;52(2):207-11.
102. Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds. Maciel LM, etal., Thyroid. 2001 Jan;11(1):31-5.
103. HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease. Mahdi N, etal., Clin Vaccine Immunol. 2008 Apr;15(4):729-31. doi: 10.1128/CVI.00425-07. Epub 2008 Feb 13.
104. HLA DRB1*130101-DQB1*060101 haplotype is associated with acute chest syndrome in sickle cell anemia patients. Mahdi N, etal., Tissue Antigens. 2009 Mar;73(3):245-9. doi: 10.1111/j.1399-0039.2008.01189.x.
105. Recurrent herpes simplex virus-induced erythema multiforme: different HLA-DQB1 alleles associate with severe mucous membrane versus skin attacks. Malo A, etal., Scand J Immunol. 1998 May;47(5):408-11.
106. Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. Manan H, etal., Hum Immunol. 2010 Dec;71(12):1238-42. Epub 2010 Sep 19.
107. IL28B CC-genotype association with HLA-DQB1*0301 allele increases the prediction of spontaneous HCV RNA clearance in thalassaemic HCV-infected patients. Mangia A, etal., Antivir Ther. 2011;16(8):1309-16. doi: 10.3851/IMP1913.
108. Human leukocyte antigen type and progression from onset of symptoms to development of asthma. Martyn MB, etal., Allergy Asthma Proc. 2010 Mar;31(2):120-5. Epub 2010 Mar 8.
109. A rapid and sensitive assay to identify HLA-DQ2/8 risk alleles for celiac disease using real-time PCR method. Mashayekhi K, etal., Gastroenterol Hepatol Bed Bench. 2018 Summer;11(3):250-258.
110. Association between HLA class II alleles and hepatitis B virus infection in Transylvania, Romania. Matei HV, etal., Immunol Invest. 2018 Oct;47(7):735-744. doi: 10.1080/08820139.2018.1489832. Epub 2018 Jul 6.
111. HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections. May J, etal., J Infect Dis. 2001 Jan 1;183(1):168-72. Epub 2000 Nov 10.
112. HLA class II antigens positively and negatively associated with hepatosplenic schistosomiasis in a Chinese population. McManus DP, etal., Int J Parasitol. 2001 May 15;31(7):674-80. doi: 10.1016/s0020-7519(01)00132-1.
113. Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. Melin-Aldana H, etal., J Pediatr. 1992 Jul;121(1):56-60.
114. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Mignot E, etal., Am J Hum Genet. 2001 Mar;68(3):686-99. Epub 2001 Feb 13.
115. [Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome]. Min HY, etal., Zhonghua Yan Ke Za Zhi. 2007 Apr;43(4):355-60.
116. [Single nucleotide polymorphisms of promoter of human leukocyte antigen-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome]. Min HY, etal., Zhonghua Yan Ke Za Zhi. 2008 Oct;44(10):870-5.
117. Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. Miyagawa T, etal., J Hum Genet. 2010 Jan;55(1):63-5. Epub 2009 Nov 20.
118. HLA-A*11 and novel associations in Malays and Chinese with systemic lupus erythematosus. Mohd-Yusuf Y, etal., Immunol Lett. 2011 Sep 30;139(1-2):68-72. Epub 2011 May 30.
119. HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Molnar-Gabor E, etal., Laryngoscope. 2000 Mar;110(3 Pt 1):422-5.
120. Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. Monsuur AJ, etal., PLoS One. 2008 May 28;3(5):e2270.
121. Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity. Moriguchi M, etal., Metabolism. 2011 Jun;60(6):761-6. Epub 2010 Sep 9.
122. Association of HLA class II alleles with childhood asthma and Total IgE levels. Movahedi M, etal., Iran J Allergy Asthma Immunol. 2008 Dec;7(4):215-20.
123. HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation. Murad H, etal., BMC Gastroenterol. 2018 May 24;18(1):70. doi: 10.1186/s12876-018-0802-2.
124. HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Muro M, etal., Microbiol Immunol. 2013 Mar;57(3):193-7. doi: 10.1111/1348-0421.12020.
125. HLA DQ gene dosage and risk and severity of celiac disease. Murray JA, etal., Clin Gastroenterol Hepatol. 2007 Dec;5(12):1406-12. Epub 2007 Oct 24.
126. Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia. Nakao S, etal., Blood. 1994 Dec 15;84(12):4257-61.
127. HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury. Nicoletti P, etal., Pharmacogenet Genomics. 2016 May;26(5):218-24. doi: 10.1097/FPC.0000000000000209.
128. [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. Nizhevich AA, etal., Eksp Klin Gastroenterol. 2010;(1):58-63.
129. Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin. Nomura S, etal., Autoimmunity. 1999;30(2):99-105.
130. Immunogenetic characteristics of patients with autoimmune gastritis. Oksanen AM, etal., World J Gastroenterol. 2010 Jan 21;16(3):354-8.
131. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
132. Association between HLA-DQB1 gene and patients with acute lymphoblastic leukemia (ALL). Orouji E, etal., Int J Hematol. 2012 May;95(5):551-5. doi: 10.1007/s12185-012-1051-8. Epub 2012 Mar 21.
133. Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease. Pani MA, etal., Clin Endocrinol (Oxf). 2002 Jun;56(6):773-7.
134. Substitution of aspartic acid at position 57 of the DQbeta1 affects relapse of autoimmune pancreatitis. Park do H, etal., Gastroenterology. 2008 Feb;134(2):440-6. Epub 2007 Nov 17.
135. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
136. HLA-DQB1* polymorphism and associations with dilated cardiomyopathy, inflammatory dilated cardiomyopathy and myocarditis. Portig I, etal., Autoimmunity. 2009 Jan;42(1):33-40.
137. HLA typing in patients with ocular manifestations of Stevens-Johnson syndrome. Power WJ, etal., Ophthalmology. 1996 Sep;103(9):1406-9.
138. The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309. Praditpornsilpa K, etal., Nephrol Dial Transplant. 2009 May;24(5):1545-9. doi: 10.1093/ndt/gfn450. Epub 2008 Aug 8.
139. Nationwide collaborative study of HLA class II associations with distinct types of juvenile chronic arthritis (JCA) in Greece. Pratsidou-Gertsi P, etal., Eur J Immunogenet. 1999 Aug;26(4):299-310.
140. HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome. Raguénès O, etal., Tissue Antigens. 1995 Apr;45(4):246-9. doi: 10.1111/j.1399-0039.1995.tb02447.x.
141. Association of HLA DQ B1* and HLA DR B1* alleles with goitrous juvenile autoimmune hypothyroidism--a case control study. Rekha PL, etal., J Clin Immunol. 2007 Sep;27(5):486-9. Epub 2007 Jun 22.
142. Association of HLA-DQB1 allelic sequence variation with susceptibility to systemic lupus erythematosus. Rezaieyazdi Z, etal., Iran J Allergy Asthma Immunol. 2008 Jun;7(2):91-5.
143. GOA pipeline RGD automated data pipeline
144. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
145. Autoimmunity predominates in a large South African cohort with Addison's disease of mainly European descent despite long-standing disease and is associated with HLA DQB*0201. Ross I, etal., Clin Endocrinol (Oxf). 2010 Sep;73(3):291-8. Epub 2010 Apr 23.
146. [Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang]. Ruihan Z, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Feb 1;36(1):4-8. doi: 10.7518/hxkq.2018.01.002.
147. Myenteric antiplexus antibodies and class II HLA in achalasia. Ruiz-de-Leon A, etal., Dig Dis Sci. 2002 Jan;47(1):15-9.
148. HLA-DQB1 locus and the development of atrophic gastritis with Helicobacter pylori infection. Sakai T, etal., J Gastroenterol. 1999;34 Suppl 11:24-7.
149. Association of HLA-DQA1*03011-DQB1*0301 haplotype with the development of respiratory scleroma. Sanchez-Marin LA, etal., Otolaryngol Head Neck Surg. 2007 Mar;136(3):481-3.
150. Association of hypersensitivity to the nematode Anisakis simplex with HLA class II DRB1*1502-DQB1*0601 haplotype. Sanchez-Velasco P, etal., Hum Immunol. 2000 Mar;61(3):314-9.
151. Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients. Sanchez-Velasco P, etal., Hum Immunol. 2005 Jul;66(7):818-25.
152. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. Santamaria P, etal., J Clin Endocrinol Metab. 1994 Apr;78(4):878-83.
153. HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group. Sarafnejad A, etal., Iran J Allergy Asthma Immunol. 2006 Sep;5(3):115-9.
154. HLA-DQB1 *03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders. Schubert MS, etal., J Allergy Clin Immunol. 2004 Dec;114(6):1376-83.
155. HLA-DQB1 and HLA-DPB1 genotypes in familial sarcoidosis. Schürmann M, etal., Respir Med. 1998 Apr;92(4):649-52. doi: 10.1016/s0954-6111(98)90512-1.
156. Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link. Scully M, etal., J Thromb Haemost. 2010 Feb;8(2):257-62. doi: 10.1111/j.1538-7836.2009.03692.x. Epub 2009 Nov 17.
157. HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris. Shams S, etal., J Clin Immunol. 2009 Mar;29(2):175-9. Epub 2008 Sep 9.
158. Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India. Shankarkumar U, etal., Int J Immunogenet. 2010 Jun;37(3):199-204. Epub 2010 Mar 14.
159. Clinical and genetic risk factors for the development of multi-drug resistant tuberculosis in non-HIV infected patients at a tertiary care center in India: a case-control study. Sharma SK, etal., Infect Genet Evol. 2003 Sep;3(3):183-8.
160. HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria. Shichishima T, etal., Blood. 2002 Jul 1;100(1):22-8.
161. Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. Smyth CM, etal., Eur J Gastroenterol Hepatol. 2007 Jun;19(6):493-8. doi: 10.1097/MEG.0b013e328010687d.
162. Human leukocyte antigen class II alleles and natural history of HPV 2/27/57-induced common warts. Spelten B, etal., Arch Dermatol Res. 2004 Aug;296(3):105-11. doi: 10.1007/s00403-004-0485-0. Epub 2004 Jul 15.
163. HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. Stanevicha V, etal., Arthritis Res Ther. 2007;9(3):R58.
164. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
165. HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom. Suzuki K, etal., Tissue Antigens. 2005 May;65(5):459-66.
166. Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province. Tafreshian AR, etal., Iran J Basic Med Sci. 2014 Oct;17(10):798-801.
167. Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney. Takahashi Y, etal., J Toxicol Sci. 2012;37(3):663-6.
168. Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. Taylor GM, etal., Br J Cancer. 1998 Sep;78(5):561-5.
169. Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease. Tillmann HL, etal., Gut. 2001 May;48(5):714-8. doi: 10.1136/gut.48.5.714.
170. Strain-based HLA association analysis identified HLA-DRB1*09:01 associated with modern strain tuberculosis. Toyo-Oka L, etal., HLA. 2017 Sep;90(3):149-156. doi: 10.1111/tan.13070. Epub 2017 Jun 14.
171. Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population. Trinks J, etal., Liver Int. 2017 Oct;37(10):1476-1487. doi: 10.1111/liv.13405. Epub 2017 Mar 30.
172. Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain. Ueki A, etal., Immunobiology. 2001 Dec;204(4):458-65. doi: 10.1078/0171-2985-00055.
173. IL10 GGC haplotype is positively and HLA-DQA1*05-DQB1*02 is negatively associated with radiographic progression in undifferentiated arthritis. Ursum J, etal., J Rheumatol. 2010 Jul;37(7):1431-8. Epub 2010 May 15.
174. First genotype-phenotype study reveals HLA-DQβ1 insertion heterogeneity in high-resolution manometry achalasia subtypes. Vackova Z, etal., United European Gastroenterol J. 2019 Feb;7(1):45-51. doi: 10.1177/2050640618804717. Epub 2018 Oct 3.
175. Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. Vasconcelos CC, etal., J Neuroimmunol. 2009 Sep 29;214(1-2):101-3. Epub 2009 Jul 17.
176. Analysis of B- and T-cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helicobacter pylori infection and response to eradication treatment. Veneri D, etal., Platelets. 2005 Aug;16(5):307-11.
177. HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease. Viken MK, etal., HLA. 2017 May;89(5):278-284. doi: 10.1111/tan.12986. Epub 2017 Feb 28.
178. Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy. Voorter CE, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Jun;22(2):129-32.
179. Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Wagner AM, etal., Diabetes Metab Res Rev. 2011 Jul;27(5):493-498. doi: 10.1002/dmrr.1189.
180. Genetic Variation in the IL-6 and HLA-DQB1 Genes Is Associated with Spontaneous Clearance of Hepatitis C Virus Infection. Waldron PR, etal., J Immunol Res. 2016;2016:6530436. doi: 10.1155/2016/6530436. Epub 2016 Jun 2.
181. Genome-wide expression profiling-based copy number variations and colorectal cancer risk in Chinese. Wang K, etal., Mol Carcinog. 2019 Jul;58(7):1324-1333. doi: 10.1002/mc.23015. Epub 2019 Apr 18.
182. Primary autoimmune neutropenia in children in Taiwan. Wang LY, etal., Transfusion. 2009 May;49(5):1003-6. doi: 10.1111/j.1537-2995.2008.02084.x. Epub 2009 Feb 6.
183. The polymorphisms of human leukocyte antigen loci may contribute to the susceptibility and severity of severe aplastic anemia in Chinese patients. Wang M, etal., Hum Immunol. 2014 Aug;75(8):867-72. doi: 10.1016/j.humimm.2014.06.011. Epub 2014 Jun 27.
184. Association between HLA class II locus and the susceptibility to Artemisia pollen-induced allergic rhinitis in Chinese population. Wang M, etal., Otolaryngol Head Neck Surg. 2004 Feb;130(2):192-6.
185. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. Ward MM, etal., Arthritis Rheum. 2009 Jul 15;61(7):859-66.
186. Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes. Weinstock C, etal., Tissue Antigens. 2011 Apr;77(4):317-24. doi: 10.1111/j.1399-0039.2011.01634.x.
187. The HLA-DQ associations with Graves' disease in Chinese children. Wong GW, etal., Clin Endocrinol (Oxf). 1999 Apr;50(4):493-5.
188. NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study. Wu F, etal., Biomed Res Int. 2013;2013:484535. doi: 10.1155/2013/484535. Epub 2013 Sep 1.
189. Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women. Wu Y, etal., Int J Cancer. 2006 Jun 15;118(12):3006-11. doi: 10.1002/ijc.21746.
190. Analysis of HLA-DQB1 gene polymorphisms in asymptomatic HBV carriers and chronic hepatitis B patients in the Chinese Han population. Xi-Lin Z, etal., Int J Immunogenet. 2006 Aug;33(4):249-54.
191. Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans. Xiao FL, etal., Arch Dermatol Res. 2005 Nov;297(5):201-9. Epub 2005 Nov 11.
192. Association of HLA-DQA1*0101/2 and DQB1*0502 with myasthenia gravis in southern Iranian patients. Yousefipour GA, etal., Iran J Immunol. 2009 Jun;6(2):99-102.
193. Comprehensive investigating of cytokine and receptor related genes variants in patients with chronic hepatitis B virus infection. Yu F, etal., Cytokine. 2018 Mar;103:10-14. doi: 10.1016/j.cyto.2017.12.017. Epub 2017 Dec 26.
194. Genetic Factors of Low-responsiveness to Hepatitis B Virus Vaccine Confirms the Importance of Human Leukocyte Antigen Class II Types in a Japanese Young Adult Population. Yukimasa N, etal., Acta Med Okayama. 2017 Oct;71(5):433-436. doi: 10.18926/AMO/55442.
195. Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602. Zeitzer JM, etal., Psychiatry Res. 2011 May 30;187(3):397-400. Epub 2011 Feb 2.
196. HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han. Zhang X, etal., Int J Dermatol. 2004 Mar;43(3):181-7.
197. [The study on correlativity between HLA-DQ gene polymorphism and primary Sjogren's syndrome of the Han nationality in Shanxi province]. Zhang XY, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Feb;27(2):182-5.
198. Evidence for human leukocyte antigen-related susceptibility in idiopathic childhood ischemic stroke. Zou LP, etal., Eur Neurol. 2002;48(3):153-7.
Additional References at PubMed
PMID:1378867   PMID:1845803   PMID:1859846   PMID:1904838   PMID:1909605   PMID:2159298   PMID:2493384   PMID:2502420   PMID:2784784   PMID:7584146   PMID:7679955   PMID:7691725  
PMID:7985028   PMID:8598040   PMID:8598041   PMID:8611149   PMID:8638109   PMID:8890155   PMID:9244347   PMID:9432982   PMID:9492004   PMID:9610637   PMID:10469380   PMID:11027433  
PMID:11069069   PMID:11148202   PMID:11714799   PMID:11854359   PMID:12082013   PMID:12801066   PMID:14607905   PMID:14643301   PMID:15507239   PMID:15517241   PMID:16785530   PMID:19946888  
PMID:24586191   PMID:25861730  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8204,598,475 - 4,604,118 (-)NCBIGRCr8
mRatBN7.2204,596,558 - 4,602,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0205,193,861 - 5,199,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,043,726 - 4,049,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,039,413 - 4,049,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,123,272 - 6,128,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,730,559 - 4,736,201 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,730,786 - 4,736,413 (-)NCBI
Celera206,197,565 - 6,203,195 (-)NCBICelera
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38632,659,467 - 32,666,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,659,467 - 32,668,383 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,627,244 - 32,634,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,735,635 - 32,742,444 (-)NCBINCBI36Build 36hg18NCBI36
Celera634,177,338 - 34,182,264 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,368,943 - 32,376,157 (-)NCBIHuRef
CHM1_1632,629,719 - 32,636,944 (-)NCBICHM1_1
T2T-CHM13v2.0632,482,491 - 32,489,842 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,482,201 - 34,488,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,476,663 - 34,488,393 (+)EnsemblGRCm39 Ensembl
GRCm381734,263,227 - 34,269,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,257,689 - 34,269,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,400,172 - 34,406,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,871,432 - 33,877,605 (+)NCBIMGSCv36mm8
Celera1737,017,337 - 37,030,239 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2547,142,796 - 47,149,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,014,552 - 43,021,397 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,237,395 - 32,244,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,353,599 - 33,360,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1122,305,307 - 2,307,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0122,520,814 - 2,526,447 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1122,243,878 - 2,249,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,325,185 - 2,330,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,399,342 - 2,404,990 (-)NCBIUU_Cfam_GSD_1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in RT1-Bb
886 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:187
Interacting mature miRNAs:204
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
7175099Tcs2T cell selection QTL 2T cell selectionexpression2045040024693102Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,600,429 - 4,600,624 (-)MAPPERmRatBN7.2
Rnor_6.0204,045,303 - 4,045,497NCBIRnor6.0
Rnor_5.0206,124,849 - 6,125,043UniSTSRnor5.0
RGSC_v3.4204,734,430 - 4,734,624UniSTSRGSC3.4
Celera206,201,424 - 6,201,618UniSTS
Cytogenetic Map20p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,596,602 - 4,596,755 (-)MAPPERmRatBN7.2
Rnor_6.0204,049,170 - 4,049,322NCBIRnor6.0
Rnor_5.0206,128,716 - 6,128,868UniSTSRnor5.0
RGSC_v3.4204,730,604 - 4,730,756UniSTSRGSC3.4
Celera206,197,610 - 6,197,762UniSTS
Cytogenetic Map20p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 3 16 2 19 2 2 20 18 11
Low 36 33 31 31 8 9 70 15 21 8
Below cutoff 2 6 6 6 2 2


Nucleotide Sequences
RefSeq Transcripts NM_001004084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF113922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY701538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB313071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000000525   ⟹   ENSRNOP00000000525
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)Ensembl
Rnor_6.0 Ensembl204,043,741 - 4,049,711 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079126
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,046,237 - 4,047,015 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082136   ⟹   ENSRNOP00000070172
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,604,477 (-)Ensembl
Rnor_6.0 Ensembl204,039,413 - 4,047,093 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083231
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,043,752 - 4,045,789 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084246
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,046,948 - 4,047,705 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086283
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,044,599 - 4,047,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111849   ⟹   ENSRNOP00000094408
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,604,477 (-)Ensembl
RefSeq Acc Id: NM_001004084   ⟹   NP_001004084
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8204,598,475 - 4,604,118 (-)NCBI
mRatBN7.2204,596,558 - 4,602,201 (-)NCBI
Rnor_6.0204,043,726 - 4,049,367 (+)NCBI
Rnor_5.0206,123,272 - 6,128,913 (+)NCBI
RGSC_v3.4204,730,559 - 4,736,201 (-)RGD
Celera206,197,565 - 6,203,195 (-)RGD
RefSeq Acc Id: NP_001004084   ⟸   NM_001004084
- Peptide Label: precursor
- UniProtKB: P29826 (UniProtKB/Swiss-Prot),   A0A023ILS1 (UniProtKB/TrEMBL),   A6JJD7 (UniProtKB/TrEMBL),   Q5UT93 (UniProtKB/TrEMBL),   Q5UT99 (UniProtKB/TrEMBL),   Q6AYB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070172   ⟸   ENSRNOT00000082136
RefSeq Acc Id: ENSRNOP00000000525   ⟸   ENSRNOT00000000525
RefSeq Acc Id: ENSRNOP00000094408   ⟸   ENSRNOT00000111849
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29826-F1-model_v2 AlphaFold P29826 1-263 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701328
Promoter ID:EPDNEW_R11851
Type:initiation region
Description:RT1 class II, locus Bb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,043,722 - 4,043,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3469 AgrOrtholog
BioCyc Gene G2FUF-4561 BioCyc
Ensembl Genes ENSRNOG00000032708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000525.7 UniProtKB/TrEMBL
  ENSRNOT00000082136.2 UniProtKB/TrEMBL
  ENSRNOT00000111849.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309622 UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen RT1-Bb PhenoGen
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032708 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary A6JJD7 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 RT1-Bb  RT1 class II, locus Bb      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 RT1-Bb  RT1 class II, locus Bb      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps to the MHC RT1 complex 1300431
gene_physical_interaction beta chain, with the RT1-Ba alpha chain forms the Rt1-B MHC class II molecule 1300427