RT1-Bb (RT1 class II, locus Bb) - Rat Genome Database

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Gene: RT1-Bb (RT1 class II, locus Bb) Rattus norvegicus
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Symbol: RT1-Bb
Name: RT1 class II, locus Bb
RGD ID: 3469
Description: Predicted to enable several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in cellular response to organic cyclic compound; defense response to fungus; and negative regulation of T cell proliferation. Located in cell surface. Used to study uveitis. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bb; MGC94124; MHC class II antigen B beta chain; rano class II histocompatibility antigen, B-1 beta chain; RT1 class II histocompatibility antigen, B-1 beta chain; RT1-B beta; RT1.B; RT1.B-beta(1); RT1.B-BETA1; RT1.Bbeta; RT1.Bbeta 1
RGD Orthologs
Human
Mouse
Bonobo
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,596,558 - 4,602,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0205,193,861 - 5,199,480 (-)NCBIRnor_WKY
Rnor_6.0204,043,726 - 4,049,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,039,413 - 4,049,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,123,272 - 6,128,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,730,559 - 4,736,201 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,730,786 - 4,736,413 (-)NCBI
Celera206,197,565 - 6,203,195 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISO)
acute disseminated encephalomyelitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Addison's disease  (ISO)
agranulocytosis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
alopecia areata  (ISO)
alveolar echinococcosis  (ISO)
Amebic Liver Abscess  (ISO)
angioedema  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
arthritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atrophic gastritis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune pancreatitis  (ISO)
autoimmune polyendocrine syndrome  (ISO)
autoimmune polyendocrine syndrome type 2  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
Cataplexy  (ISO)
celiac disease  (ISO)
cervical cancer  (ISO)
cervical dystonia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chikungunya  (ISO)
choreatic disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
cicatricial pemphigoid  (ISO)
colorectal cancer  (ISO)
common variable immunodeficiency  (ISO)
common wart  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cystic echinococcosis  (ISO)
degenerative myopia  (ISO)
Delayed Hypersensitivity  (IDA)
dental caries  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
Drug Eruptions  (ISO)
Drug-induced Neutropenia  (ISO)
End Stage Liver Disease  (ISO)
erythema multiforme  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA,IMP,ISO)
glaucoma  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Idiopathic Hypersomnolence  (ISO)
IgA glomerulonephritis  (ISO)
immunoglobulin alpha deficiency  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
latex allergy  (ISO)
liver cirrhosis  (ISO)
marginal zone B-cell lymphoma  (ISO)
multidrug-resistant tuberculosis  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
mycosis fungoides  (ISO)
myocarditis  (ISO)
myositis  (ISO)
narcolepsy  (ISO)
Nasal Polyps  (ISO)
neuromyelitis optica  (ISO)
optic neuritis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteomyelitis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pemphigus vulgaris  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumoconiosis  (ISO)
pneumocystosis  (IEP)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (ISO)
primary sclerosing cholangitis  (ISO)
psoriasis  (ISO)
pulmonary tuberculosis  (ISO)
pure red-cell aplasia  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatic fever  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
rhinoscleroma  (ISO)
Rhinosinusitis, Allergic Fungal  (ISO)
sarcoidosis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Small Fiber Neuropathy  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach disease  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
Transplant Rejection  (IDA)
tropical spastic paraparesis  (ISO)
tuberculosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Uterine Cervical Dysplasia  (ISO)
uveitis  (IMP)
Veno-Occlusive Disease  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amoxicillin  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefuroxime  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
choline  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daidzein  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenoprofen  (ISO)
fenthion  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
heme b  (ISO)
hexachlorobenzene  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoprofen  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
menadione  (ISO)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nifedipine  (ISO)
oxaprozin  (ISO)
ozone  (ISO)
palladium  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentamidine  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenacetin  (EXP)
phenobarbital  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
rifampicin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium dichromate  (ISO)
sulfasalazine  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP,ISO)
tolmetin  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Treatment of autoimmune anterior uveitis with recombinant TCR ligands. Adamus G, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2555-61.
2. HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM. Agardh D, etal., Diabetologia. 1996 Nov;39(11):1313-7.
3. Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia. Al-Ola K, etal., Tissue Antigens. 2008 May;71(5):453-7. doi: 10.1111/j.1399-0039.2008.01012.x. Epub 2008 Feb 28.
4. Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. Alves-Leon SV, etal., Arq Neuropsiquiatr. 2009 Sep;67(3A):643-51.
5. [Immunogenetic aspects of the course and treatment of pulmonary tuberculosis]. Archakova LI, etal., Probl Tuberk Bolezn Legk. 2008;(12):34-7.
6. HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica. Asgari N, etal., Mult Scler. 2012 Jan;18(1):23-30. doi: 10.1177/1352458511417480. Epub 2011 Sep 9.
7. Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. Athanasiou MC, etal., J Clin Psychiatry. 2011 Apr;72(4):458-63. doi: 10.4088/JCP.09m05527yel. Epub 2010 Sep 21.
8. Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease. Bajer L, etal., World J Gastroenterol. 2018 Nov 21;24(43):4939-4949. doi: 10.3748/wjg.v24.i43.4939.
9. [Association of the relationship between HLA-DQB1 alleles and major beta-thalassemia in 42 guangdong Chinese]. Bao R, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Feb;10(1):87-8.
10. Systemic morphine administration suppresses genes involved in antigen presentation. Beagles K, etal., Mol Pharmacol. 2004 Feb;65(2):437-42.
11. Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel. Benedek G, etal., Genes Immun. 2010 Jul;11(5):423-31. Epub 2010 May 13.
12. HLA class II distribution in Congolese with hyperthyroidism: preliminary results. Bidingija M, etal., Ann Endocrinol (Paris). 2006 Dec;67(6):596-603.
13. Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population. Blanco C, etal., J Allergy Clin Immunol. 2004 Nov;114(5):1070-6.
14. Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy. Boehncke WH, etal., Clin Exp Allergy. 1998 Apr;28(4):434-41.
15. HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis. Bonagura VR, etal., Hum Immunol. 2004 Aug;65(8):773-82.
16. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Bonagura VR, etal., Hum Immunol. 2010 Feb;71(2):212-9. doi: 10.1016/j.humimm.2009.10.009. Epub 2009 Oct 25.
17. Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study. Book L, etal., Am J Med Genet. 2001 Jan 1;98(1):70-4.
18. HLA-DQ: Celiac disease vs inflammatory bowel disease. Bosca-Watts MM, etal., World J Gastroenterol. 2018 Jan 7;24(1):96-103. doi: 10.3748/wjg.v24.i1.96.
19. Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel. Brill L, etal., J Neuroimmunol. 2016 Apr 15;293:65-70. doi: 10.1016/j.jneuroim.2016.02.006. Epub 2016 Feb 15.
20. Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo. Buc M, etal., Eur J Dermatol. 1998 Jan-Feb;8(1):13-5.
21. Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis. Burrows GG, etal., J Immunol. 1998 Dec 1;161(11):5987-96.
22. HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients. Caliz R, etal., Rheumatology (Oxford). 2001 Jan;40(1):31-6.
23. Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis. Castro F, etal., Ann Rheum Dis. 2001 Aug;60(8):791-5.
24. HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India. Chaaithanya IK, etal., Immunology. 2013 Oct;140(2):202-10. doi: 10.1111/imm.12128.
25. Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. Chan LS, etal., J Invest Dermatol. 1997 Feb;108(2):129-32.
26. The association between HLA-DQB1 polymorphism and antituberculosis drug-induced liver injury: a Case-Control Study. Chen R, etal., J Clin Pharm Ther. 2015 Feb;40(1):110-5. doi: 10.1111/jcpt.12211. Epub 2014 Sep 24.
27. Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages. Cheng BH, etal., BMC Microbiol. 2010 Apr 8;10:103.
28. Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies. Chinoy H, etal., Rheumatology (Oxford). 2007 Sep;46(9):1411-6. Epub 2007 Jun 22.
29. [Analysis of HLA-DQB1 polymorphism for patients with allergic rhinitis of Uygur and Han people in Xinjiang]. Cui Z, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jul;25(14):645-8.
30. Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation. Dalchau R, etal., Eur J Immunol. 1992 Mar;22(3):669-77.
31. Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Davidson EJ, etal., Cancer Res. 2003 Jan 15;63(2):400-3.
32. Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells. de Kauwe AL, etal., J Immunol. 2009 Jun 15;182(12):7440-50.
33. HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). De La Concha EG, etal., Clin Exp Immunol. 1999 Jun;116(3):516-20.
34. Association of HLA Class II alleles and haplotypes with cervical dystonia: HLA DR13-DQ6 (DQB1*0604) homozygotes are at greatly increased risk of cervical dystonia in Caucasian Americans. Deitiker PR, etal., Autoimmunity. 2011 May;44(3):167-76. Epub 2010 Sep 15.
35. HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. Djilali-Saiah I, etal., J Hepatol. 2006 Dec;45(6):844-50. Epub 2006 Sep 28.
36. HLA-DRB1 and HLA-DQB1 genes in susceptibility and resistance to cicatricial pemphigoid in French Caucasians. Drouet M, etal., Eur J Dermatol. 1998 Jul-Aug;8(5):330-3.
37. Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam. Dunstan SJ, etal., J Infect Dis. 2001 Jan 15;183(2):261-268. doi: 10.1086/317940. Epub 2000 Dec 21.
38. Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β -511 is associated with development of cervical carcinoma. Dutta S, etal., Cancer Immunol Immunother. 2015 Jul;64(7):843-51. doi: 10.1007/s00262-015-1693-5. Epub 2015 Apr 17.
39. No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population. Dzurilla M, etal., Bratisl Lek Listy. 2013;114(2):93-5.
40. HLA and alveolar echinococcosis. Eiermann TH, etal., Tissue Antigens. 1998 Aug;52(2):124-9. doi: 10.1111/j.1399-0039.1998.tb02275.x.
41. Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study. El-Bendary M, etal., J Viral Hepat. 2016 Dec;23(12):961-970. doi: 10.1111/jvh.12573. Epub 2016 Sep 7.
42. Differential effects of DRB1*0301 and DQA1*0501-DQB1*0201 on the activation and progression of islet cell autoimmunity. Eller E, etal., Genes Immun. 2007 Dec;8(8):628-33. Epub 2007 Aug 30.
43. HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease. Esmaeilzadeh H, etal., Am J Rhinol Allergy. 2015 May-Jun;29(3):e63-9. doi: 10.2500/ajra.2015.29.4154.
44. HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset. Fain PR, etal., Pigment Cell Res. 2006 Feb;19(1):51-7.
45. DQA1 and DQB1 association and nasal polyposis. Fajardo-Dolci G, etal., Otolaryngol Head Neck Surg. 2006 Aug;135(2):243-7.
46. [Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. Fan XY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):278-81.
47. Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias. Fernandes TA, etal., Blood Cells Mol Dis. 2010 Mar-Apr;44(2):69-73. doi: 10.1016/j.bcmd.2009.10.006. Epub 2010 Jan 3.
48. High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency. Ferreira RC, etal., PLoS Genet. 2012 Jan;8(1):e1002476. doi: 10.1371/journal.pgen.1002476. Epub 2012 Jan 26.
49. HLA profile in patients with AIDS and tuberculosis. Figueiredo JF, etal., Braz J Infect Dis. 2008 Aug;12(4):278-80. doi: 10.1590/s1413-86702008000400004.
50. HLA typing in acute optic neuritis. Relation to multiple sclerosis and magnetic resonance imaging findings. Frederiksen JL, etal., Arch Neurol. 1997 Jan;54(1):76-80.
51. Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons. Friedl-Hajek R, etal., Clin Exp Allergy. 1999 Apr;29(4):478-87.
52. An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia. Furuzawa-Carballeda J, etal., PLoS One. 2018 Aug 9;13(8):e0201676. doi: 10.1371/journal.pone.0201676. eCollection 2018.
53. Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects. Gao J, etal., Chin Med J (Engl). 2003 Jul;116(7):1078-82.
54. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
55. Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients. Gil JM, etal., Int J Dermatol. 2017 May;56(5):557-562. doi: 10.1111/ijd.13577. Epub 2017 Feb 15.
56. HLA-DRB and HLA-DQB loci in the genetic susceptibility to develop glaucoma in Mexicans. Gil-Carrasco F, etal., Am J Ophthalmol. 1999 Sep;128(3):297-300.
57. Renal vascular sclerosis is associated with inherited thrombophilias. Goforth RL, etal., Kidney Int. 2006 Aug;70(4):743-50. Epub 2006 Jun 7.
58. Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. Gundogdu F, etal., J Heart Valve Dis. 2007 May;16(3):293-9.
59. The major histocompatibility complex of the rat (Rattus norvegicus). Gunther E and Walter L, Immunogenetics 2001 Sep;53(7):520-42.
60. [Association between asthma and the polymorphism of HLA-DQ genes]. Guo X, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2001 Mar;24(3):139-41.
61. Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. Han YN, etal., World J Gastroenterol. 2005 Sep 28;11(36):5721-4. doi: 10.3748/wjg.v11.i36.5721.
62. Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection. Hardie RA, etal., AIDS. 2008 Apr 23;22(7):807-16.
63. Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. Hashimoto K, etal., Horm Res. 2005;64(5):253-60. Epub 2005 Oct 27.
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Additional References at PubMed
PMID:1378867   PMID:1845803   PMID:1859846   PMID:1904838   PMID:1909605   PMID:2159298   PMID:2493384   PMID:2502420   PMID:2784784   PMID:7584146   PMID:7679955   PMID:7691725  
PMID:7985028   PMID:8598040   PMID:8598041   PMID:8611149   PMID:8638109   PMID:8890155   PMID:9244347   PMID:9432982   PMID:9492004   PMID:9610637   PMID:10469380   PMID:11027433  
PMID:11069069   PMID:11148202   PMID:11714799   PMID:11854359   PMID:12082013   PMID:12801066   PMID:14607905   PMID:14643301   PMID:15507239   PMID:15517241   PMID:16785530   PMID:19946888  
PMID:24586191   PMID:25861730  


Genomics

Comparative Map Data
RT1-Bb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,596,558 - 4,602,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0205,193,861 - 5,199,480 (-)NCBIRnor_WKY
Rnor_6.0204,043,726 - 4,049,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,039,413 - 4,049,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,123,272 - 6,128,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,730,559 - 4,736,201 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,730,786 - 4,736,413 (-)NCBI
Celera206,197,565 - 6,203,195 (-)NCBICelera
Cytogenetic Map20p12NCBI
HLA-DQB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,659,467 - 32,666,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl632,659,467 - 32,668,383 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,627,244 - 32,634,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,735,635 - 32,742,444 (-)NCBINCBI36Build 36hg18NCBI36
Celera634,177,338 - 34,182,264 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,368,943 - 32,376,157 (-)NCBIHuRef
CHM1_1632,629,719 - 32,636,944 (-)NCBICHM1_1
T2T-CHM13v2.0632,482,491 - 32,489,842 (-)NCBIT2T-CHM13v2.0
H2-Ab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,482,201 - 34,488,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,476,663 - 34,488,393 (+)EnsemblGRCm39 Ensembl
GRCm381734,263,227 - 34,269,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,257,689 - 34,269,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,400,172 - 34,406,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,871,432 - 33,877,605 (+)NCBIMGSCv36mm8
Celera1737,017,337 - 37,030,239 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
LOC100972994
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1633,353,599 - 33,360,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0632,237,395 - 32,244,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC101703821
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RT1-Bb
698 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:187
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000000525
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
7175099Tcs2T cell selection QTL 2T cell selectionexpression2045025574693102Rat

Markers in Region
D17Dgm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,600,429 - 4,600,624 (-)MAPPERmRatBN7.2
Rnor_6.0204,045,303 - 4,045,497NCBIRnor6.0
Rnor_5.0206,124,849 - 6,125,043UniSTSRnor5.0
RGSC_v3.4204,734,430 - 4,734,624UniSTSRGSC3.4
Celera206,201,424 - 6,201,618UniSTS
Cytogenetic Map20p12UniSTS
RH133529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,596,602 - 4,596,755 (-)MAPPERmRatBN7.2
Rnor_6.0204,049,170 - 4,049,322NCBIRnor6.0
Rnor_5.0206,128,716 - 6,128,868UniSTSRnor5.0
RGSC_v3.4204,730,604 - 4,730,756UniSTSRGSC3.4
Celera206,197,610 - 6,197,762UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 3 16 2 19 2 2 20 18 11
Low 36 33 31 31 8 9 70 15 21 8
Below cutoff 2 6 6 6 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC098547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF113922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY626187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY701538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB313071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC222940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000525   ⟹   ENSRNOP00000000525
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)Ensembl
Rnor_6.0 Ensembl204,043,741 - 4,049,711 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,046,237 - 4,047,015 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082136   ⟹   ENSRNOP00000070172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,604,477 (-)Ensembl
Rnor_6.0 Ensembl204,039,413 - 4,047,093 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083231
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,043,752 - 4,045,789 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,046,948 - 4,047,705 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086283
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,044,599 - 4,047,752 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111849   ⟹   ENSRNOP00000094408
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,596,559 - 4,604,477 (-)Ensembl
RefSeq Acc Id: NM_001004084   ⟹   NP_001004084
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,596,558 - 4,602,201 (-)NCBI
Rnor_6.0204,043,726 - 4,049,367 (+)NCBI
Rnor_5.0206,123,272 - 6,128,913 (+)NCBI
RGSC_v3.4204,730,559 - 4,736,201 (-)RGD
Celera206,197,565 - 6,203,195 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001004084   ⟸   NM_001004084
- Peptide Label: precursor
- UniProtKB: Q6AYB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070172   ⟸   ENSRNOT00000082136
RefSeq Acc Id: ENSRNOP00000000525   ⟸   ENSRNOT00000000525
RefSeq Acc Id: ENSRNOP00000094408   ⟸   ENSRNOT00000111849
Protein Domains
Ig-like   Ig-like C1-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29826-F1-model_v2 AlphaFold P29826 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701328
Promoter ID:EPDNEW_R11851
Type:initiation region
Name:RT1-Bb_1
Description:RT1 class II, locus Bb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,043,722 - 4,043,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3469 AgrOrtholog
BioCyc Gene G2FUF-4561 BioCyc
Ensembl Genes ENSRNOG00000032708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000525.5 UniProtKB/TrEMBL
  ENSRNOP00000070172 ENTREZGENE
  ENSRNOP00000070172.2 UniProtKB/TrEMBL
  ENSRNOP00000094408.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000525.7 UniProtKB/TrEMBL
  ENSRNOT00000082136 ENTREZGENE
  ENSRNOT00000082136.2 UniProtKB/TrEMBL
  ENSRNOT00000111849.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.320.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126686 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_b_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309622 UniProtKB/TrEMBL
MGC_CLONE MGC:94124 IMAGE-MGC_LOAD
NCBI Gene 309622 ENTREZGENE
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HLA-DQB1 RGD
PhenoGen RT1-Bb PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX83_RAT UniProtKB/TrEMBL
  A0A8I6AKW6_RAT UniProtKB/TrEMBL
  F7EQR2_RAT UniProtKB/TrEMBL
  HB2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5UT90_RAT UniProtKB/TrEMBL
  Q5UT96_RAT UniProtKB/TrEMBL
  Q5UT97_RAT UniProtKB/TrEMBL
  Q6AYB1 ENTREZGENE, UniProtKB/TrEMBL
  Q6MGA1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 RT1-Bb  RT1 class II, locus Bb      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 RT1-Bb  RT1 class II, locus Bb      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps to the MHC RT1 complex 1300431
gene_physical_interaction beta chain, with the RT1-Ba alpha chain forms the Rt1-B MHC class II molecule 1300427