RGD Reference Report - [Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang]. - Rat Genome Database

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[Association between the dental caries and the human leucocyte antigen DQB1 allele polymorphisms among the Uygur and Han children in Xinjiang].

Authors: Ruihan, Zhang  Xiaobing, Li  Liping, Wang  Yishan, Liu 
Citation: Ruihan Z, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Feb 1;36(1):4-8. doi: 10.7518/hxkq.2018.01.002.
RGD ID: 14928324
Pubmed: PMID:29594988   (View Abstract at PubMed)
PMCID: PMC7030167   (View Article at PubMed Central)
DOI: DOI:10.7518/hxkq.2018.01.002   (Journal Full-text)


OBJECTIVE: This study aims to investigate the association between human leucocyte antigen (HLA)-DQB1 allele polymorphisms and the presence dental caries among the Uygur and Han children in Xinjiang.
METHODS: HLA-DQB1 allele in the Uygur and Han children with dental caries and healthy control in Xinjiang was tested (n=40) using the polymerase chain reaction-sequence specific primer (PCR-SSP) DNA parting technology.
RESULTS: A total of five specific loci were detected in the HLA-DQB1 locus among the Uygur and Han children. The frequency of the HLA-DQB1*02 allele in the Han group with severe caries (12.5%) was significantly lower than in the control group (32.5%) (P<0.05, OR=0.297). Moreover, the frequency of the HLA-DQB1*05 allele in the Uygur group with severe caries (37.5%) was significantly higher than in the control group (17.5%) (P<0.05, OR=2.829).
CONCLUSIONS: Caries susceptibility among the Uygur and Han children in Xinjiang is related to the HLA-DQB1 allele. The HLA-DQB1*02 allele may protect against caries among the Han children, whereas the HLA-DQB1*05 allele may be responsible for the susceptibility of the Uygur children to caries.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dental caries  ISOHLA-DQB1 (Homo sapiens)14928324; 14928324 RGD 
dental caries  IAGP 14928324 RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information