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HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group.

Authors: Sarafnejad, A  Khosravi, F  Alimoghadam, K  Dianat, S  Ansaripour, B  Moradi, B  Dorkhosh, S  Amirzargar, A 
Citation: Sarafnejad A, etal., Iran J Allergy Asthma Immunol. 2006 Sep;5(3):115-9.
Pubmed: (View Article at PubMed) PMID:17237562
DOI: Full-text: DOI:05.03/ijaai.115119

Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. We have analyzed HLA class II alleles and haplotypes in 60 Iranian patients with acute myelogenous leukemia (AML) and 180 unrelated normal subjects. Blood samples were collected after obtaining informed consents. From the patients and control DNA extraction and HLA typing were performed using PCR-SSP method. Significant positive association with the disease was found for HLA-DRB1*11 allele (35% vs. 24.7%, p=0.033). Two alleles including HLA-DRB4 and -DQB1*0303 were found to be significantly decreased in patients compared to controls. Regarding haplotype analysis, no significant association was found between case and control groups. It is suggested that HLA-DRB1*11 allele plays as a presumptive predisposing factor while the HLA-DRB4 and -DQB1*0303 alleles are suggested as protective genetic factors against acute myelogenous leukemia. Larger studies are needed to confirm and establish the role of these associations with acute myelogenous leukemia.


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RGD Object Information
RGD ID: 11041776
Created: 2016-03-29
Species: All species
Last Modified: 2016-03-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.