LOC101703821 (HLA class II histocompatibility antigen, DQ beta 1 chain) - Rat Genome Database

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Gene: LOC101703821 (HLA class II histocompatibility antigen, DQ beta 1 chain) Heterocephalus glaber
Analyze
Symbol: LOC101703821 (Ensembl: HLA-DQB2)
Name: HLA class II histocompatibility antigen, DQ beta 1 chain
RGD ID: 18931104
Description: ENCODES a protein that exhibits peptide antigen binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN antigen processing and presentation (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); antigen processing and presentation of peptide antigen (ortholog); ASSOCIATED WITH achalasia (ortholog); acute disseminated encephalomyelitis (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell surface (ortholog); early endosome (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HLA-DQB1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (ISO)
acute disseminated encephalomyelitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Addison's disease  (ISO)
agranulocytosis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic disease  (ISO)
alopecia areata  (ISO)
alveolar echinococcosis  (ISO)
Amebic Liver Abscess  (ISO)
angioedema  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
arthritis  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atrophic gastritis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune pancreatitis  (ISO)
autoimmune polyendocrine syndrome  (ISO)
autoimmune polyendocrine syndrome type 2  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
autoimmune thyroiditis  (ISO)
bacterial infectious disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
Cataplexy  (ISO)
celiac disease  (ISO)
cervical cancer  (ISO)
cervical dystonia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chikungunya  (ISO)
choreatic disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
cicatricial pemphigoid  (ISO)
colorectal cancer  (ISO)
common variable immunodeficiency  (ISO)
common wart  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cystic echinococcosis  (ISO)
degenerative myopia  (ISO)
Delayed Hypersensitivity  (ISO)
dental caries  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1H  (ISO)
Drug Eruptions  (ISO)
Drug-induced Neutropenia  (ISO)
End Stage Liver Disease  (ISO)
erythema multiforme  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
glaucoma  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Helicobacter Infections  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
HTLV-1-associated myelopathy/tropical spastic paraparesis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Idiopathic Hypersomnolence  (ISO)
IgA glomerulonephritis  (ISO)
immunoglobulin alpha deficiency  (ISO)
iridocyclitis  (ISO)
juvenile rheumatoid arthritis  (ISO)
latex allergy  (ISO)
liver cirrhosis  (ISO)
marginal zone lymphoma  (ISO)
multidrug-resistant tuberculosis  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
mycosis fungoides  (ISO)
myocarditis  (ISO)
myositis  (ISO)
narcolepsy  (ISO)
Nasal Polyps  (ISO)
neuromyelitis optica  (ISO)
optic neuritis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteomyelitis  (ISO)
paroxysmal nocturnal hemoglobinuria  (ISO)
pemphigus  (ISO)
pemphigus vulgaris  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumoconiosis  (ISO)
pneumocystosis  (ISO)
pre-eclampsia  (ISO)
primary progressive multiple sclerosis  (ISO)
primary sclerosing cholangitis  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
psoriasis  (ISO)
pulmonary tuberculosis  (ISO)
pure red-cell aplasia  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatic fever  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
rhinoscleroma  (ISO)
Rhinosinusitis, Allergic Fungal  (ISO)
sarcoidosis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Small Fiber Neuropathy  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach disease  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombotic thrombocytopenic purpura  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
ulcerative colitis  (ISO)
urticaria  (ISO)
Uterine Cervical Dysplasia  (ISO)
uveitis  (ISO)
Veno-Occlusive Disease  (ISO)
vitiligo  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
vulva cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101703821
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HLA-DQB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,659,467 - 32,666,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,659,467 - 32,668,383 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,627,244 - 32,634,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,735,635 - 32,742,444 (-)NCBINCBI36Build 36hg18NCBI36
Celera634,177,338 - 34,182,264 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,368,943 - 32,376,157 (-)NCBIHuRef
CHM1_1632,629,719 - 32,636,944 (-)NCBICHM1_1
T2T-CHM13v2.0632,482,491 - 32,489,842 (-)NCBIT2T-CHM13v2.0
H2-Ab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,482,201 - 34,488,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,476,663 - 34,488,393 (+)EnsemblGRCm39 Ensembl
GRCm381734,263,227 - 34,269,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,257,689 - 34,269,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,400,172 - 34,406,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,871,432 - 33,877,605 (+)NCBIMGSCv36mm8
Celera1737,017,337 - 37,030,239 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
RT1-Bb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,598,475 - 4,604,118 (-)NCBIGRCr8
mRatBN7.2204,596,558 - 4,602,201 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,596,559 - 4,607,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0205,193,861 - 5,199,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,043,726 - 4,049,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,039,413 - 4,049,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,123,272 - 6,128,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,730,559 - 4,736,201 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,730,786 - 4,736,413 (-)NCBI
Celera206,197,565 - 6,203,195 (-)NCBICelera
Cytogenetic Map20p12NCBI
LOC100972994
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,142,796 - 47,149,644 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,014,552 - 43,021,397 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,237,395 - 32,244,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,353,599 - 33,360,284 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,353,599 - 33,360,272 (-)Ensemblpanpan1.1panPan2
DLA-DQB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,305,307 - 2,307,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0122,520,814 - 2,526,447 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1122,243,878 - 2,249,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,325,185 - 2,330,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,399,342 - 2,404,990 (-)NCBIUU_Cfam_GSD_1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015566   ⟹   ENSHGLP00000015406
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475423,895,607 - 23,906,713 (+)Ensembl
RefSeq Acc Id: XM_004846864   ⟹   XP_004846921
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475423,895,509 - 23,902,487 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004846921 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015406
GenBank Protein JAN98414 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004846921   ⟸   XM_004846864
- UniProtKB: A0AAX6P9W3 (UniProtKB/TrEMBL),   A0A0P6JUN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000015406   ⟸   ENSHGLT00000015566


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011013 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015566 ENTREZGENE
Gene3D-CATH Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1 UniProtKB/TrEMBL
  Immunoglobulins UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC/Immunoglobulin UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_II_a/b_N UniProtKB/TrEMBL
  MHC_II_b_N UniProtKB/TrEMBL
NCBI Gene LOC101703821 ENTREZGENE
PANTHER HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
  MHC_II_beta UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
  MHC antigen-recognition domain UniProtKB/TrEMBL
UniProt A0A0P6JUN1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P9W3 ENTREZGENE, UniProtKB/TrEMBL