RGD Reference Report - [Distribution of HLA specificity frequencies in patients with cystic echinococcosis]. - Rat Genome Database

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[Distribution of HLA specificity frequencies in patients with cystic echinococcosis].

Authors: Lukmanova, G I  Gumerov, A A  Elicheva, Z M  Lukmanova, L I 
Citation: Lukmanova GI, etal., Med Parazitol (Mosk). 2011 Oct-Dec;(4):14-6.
RGD ID: 36174019
Pubmed: PMID:22308705   (View Abstract at PubMed)

This investigation was undertaken to study the associations of the polymorphic variants of the HLA-DRBI and HLA-DQB1 loci with the development of cystic echinococcosis in children. The material for the investigation was collected from 57 children admitted for surgery to the clinic of the Department of Pediatric Surgery, Orthopedics, and Anesthesiology, Bashkir State Medical University (Ufa). The PROTRANS kit (Germany) was used to isolate DNA samples from peripheral venous blood served as an object of the investigations. HLA specificities were typed by polymerase chain reaction. Molecular genetic studies established the association of DRB1*07, DQB1*0.9, DQB1*02 specificities with the increased risk of cystic echinococcosis in children. The echinococcosis cyst suppuration-complicated course of the disease was found to be more frequently encountered in DQB1*02 and DRB1*03 allele carriers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cystic echinococcosis  ISOHLA-DQB1 (Homo sapiens)36174019; 36174019DNA:polymorphisms: :HLA- DQB1*0.9 and DQB1*02(human)RGD 
cystic echinococcosis  ISOHLA-DRB1 (Homo sapiens)36174019; 36174019DNA:polymorphism: :HLA-DRB1*03 and DRB1*07(human)RGD 
cystic echinococcosis  IAGP 36174019DNA:polymorphisms: :HLA-DQB1*0.9 and DQB1*02(human)RGD 
cystic echinococcosis  IAGP 36174019DNA:polymorphism: :HLA-DRB1*03 and DRB1*07(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information