RGD Reference Report - Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population. - Rat Genome Database

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Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.

Authors: Trinks, Julieta  Nishida, Nao  Hulaniuk, María Laura  Caputo, Mariela  Tsuchiura, Takayo  Marciano, Sebastián  Haddad, Leila  Blejer, Jorgelina  Bartoli, Sonia  Ameigeiras, Beatriz  Frías, Silvia E  Vistarini, Cecilia  Heinrich, Fabiana  Remondegui, Carlos  Ceballos, Susana  Echenique, Gustavo  Charre Samman, Miguel  D'Amico, Claudia  Rojas, Amalia  Martínez, Alfredo  Ridruejo, Ezequiel  Fernández, Roberto J  Burgos Pratx, Leandro  Salamone, Horacio  Nuñez, Félix  Galdame, Omar  Gadano, Adrián  Corach, Daniel  Sugiyama, Masaya  Flichman, Diego  Tokunaga, Katsushi  Mizokami, Masashi 
Citation: Trinks J, etal., Liver Int. 2017 Oct;37(10):1476-1487. doi: 10.1111/liv.13405. Epub 2017 Mar 30.
RGD ID: 14974232
Pubmed: PMID:28267888   (View Abstract at PubMed)
DOI: DOI:10.1111/liv.13405   (Journal Full-text)


BACKGROUND & AIMS: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown.
METHODS: A total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients.
RESULTS: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542.
CONCLUSIONS: This is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Hepatitis B no_associationISOHLA-DQB1 (Homo sapiens)14974232; 14974232DNA:SNP: :rs2856718 (human)RGD 
Chronic Hepatitis B susceptibilityIAGP 14974232DNA:SNP:exon and 3' utr: (rs9277542) (human)RGD 
Chronic Hepatitis B no_associationIAGP 14974232DNA:SNP: :rs2856718 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic hepatitis susceptibilityIAGP 14974232DNA:SNP:exon and 3' utr: (rs9277542) RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DPB1  (major histocompatibility complex, class II, DP beta 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information