RGD Reference Report - HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus. - Rat Genome Database

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HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus.

Authors: Khazaee, MH  Tavakol Afshari, J  Khazaee, B  Daneshvar, R  Akbarzadeh, J  Khazaee, L  Ganjali, R  Raygan, F 
Citation: Khazaee MH, etal., Eur J Ophthalmol. 2009 Jul-Aug;19(4):638-45.
RGD ID: 7421552
Pubmed: PMID:19551681   (View Abstract at PubMed)

PURPOSE: To investigate if diabetic patients without diabetic retinopathy despite long disease duration have different human leukocyte antigen (HLA) status vs those with an early onset of retinopathy. METHODS: Retrospective, nonrandomized, masked comparative study. Type 1 diabetic patients with a disease onset before age 30 were recruited to the study. The study population consisted of two groups of diabetic patients: those with normal retinopathy course (retinopathy developed during the first 20 years of diabetes onset) (23 patients) and those with postponed retinopathy (no obvious retinopathy in spite of passing 20 years of diabetes) (19 patients). These groups were matched with regard to level of glycemic control, blood pressure, and lipid profile. A group of 23 healthy patients served as controls. HLA-DQB1 typing of blood samples was done using a polymerase chain reaction with sequence-specific primer (PCR-SSP) method. RESULTS: HLA-DQB1*0201/HLA-DQB1*0501 and HLA-DQB1*0201/HLA-DQB1*0504 haplotypes were more common among type 1 diabetic patients with normal retinopathy course than those with postponed retinopathy (26.1% vs 0.0%; p=0.019). HLA-DQB1*0301 and HLA-DQB1*0304 were less common among those diabetic patients with normal retinopathy course than those with a postponed retinopathy (63.2% vs 34.8%; p=0.067). CONCLUSIONS: Some haplotypes seem to predispose diabetic patients to diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis of diabetic retinopathy in younger diabetic patients.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
H2-Ab1Mousediabetic retinopathy susceptibilityISOHLA-DQB1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
HLA-DQB1Humandiabetic retinopathy susceptibilityIAGP associated with Diabetes Mellitus more ...RGD 
RT1-BbRatdiabetic retinopathy susceptibilityISOHLA-DQB1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 


Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)