RGD Reference Report - Immunogenetic characteristics of patients with autoimmune gastritis. - Rat Genome Database

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Immunogenetic characteristics of patients with autoimmune gastritis.

Authors: Oksanen, AM  Haimila, KE  Rautelin, HI  Partanen, JA 
Citation: Oksanen AM, etal., World J Gastroenterol. 2010 Jan 21;16(3):354-8.
RGD ID: 5147582
Pubmed: PMID:20082482   (View Abstract at PubMed)
PMCID: PMC2807957   (View Article at PubMed Central)

AIM: To explore whether predisposition to autoimmune gastritis (AIG) is found in human leukocyte antigen (HLA), cytokine or killer cell immunoglobulin-like receptor (KIR) gene variations. METHODS: Twelve Finnish patients with autoimmune-type severe atrophy of the gastric corpus were included. The patients' serum was analyzed for pepsinogen I and Helicobacter pylori (H. pylori) antibodies. DNA was separated and the patients were genotyped for HLA-A, B, Cw, DRB1 and DQB1 antigens, and studied for single nucleotide polymorphisms for the following cytokines: interleukin (IL)-1 gene cluster, IL-2, IL-4, IL-6, IL-10, IL-12, interferon gamma, transforming growth factor beta, and tumor necrosis factor alpha. Variation in KIR genes was also explored. The results were compared with prevalence of the polymorphisms in Finnish or European populations. RESULTS: All patients had pepsinogen I levels below normal (mean: 11 microg/L, range: < 5 to 25 microg/L). Three patients had elevated H. pylori IgG antibodies, while H. pylori serology was negative in the rest of the patients. AIG patients carried significantly more often HLA-DRB1*04 (58%) and DQB1*03 (83%) than the general Finnish population did (28% and 51%, respectively; P = 0.045 and 0.034 by the Fisher's exact test). No patient was positive for HLA-B8-DRB1*03, a well-established autoimmune marker. Neither cytokine polymorphisms nor KIR gene variation showed association with AIG. CONCLUSION: As explored with modern DNA-based methods, HLA-DRB1*04 and DQB1*03 alleles, but not HLA-B8-DRB1*03, may predispose to AIG.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
H2-Ab1Mouseatrophic gastritis  ISOHLA-DQB1 (Homo sapiens)DNA:polymorphism (human)RGD 
H2-Eb1Mouseatrophic gastritis  ISOHLA-DRB1 (Homo sapiens)DNA:polymorphism (human)RGD 
HLA-DQB1Humanatrophic gastritis  IAGP DNA:polymorphism (human)RGD 
HLA-DRB1Humanatrophic gastritis  IAGP DNA:polymorphism (human)RGD 
RT1-BbRatatrophic gastritis  ISOHLA-DQB1 (Homo sapiens)DNA:polymorphism (human)RGD 
RT1-Db1Ratatrophic gastritis  ISOHLA-DRB1 (Homo sapiens)DNA:polymorphism (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information