RGD Reference Report - [Immunogenetic aspects of the course and treatment of pulmonary tuberculosis]. - Rat Genome Database

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[Immunogenetic aspects of the course and treatment of pulmonary tuberculosis].

Authors: Archakova, L I  Skvortsova, L A  Knoring, B E  Pavlova, M V 
Citation: Archakova LI, etal., Probl Tuberk Bolezn Legk. 2008;(12):34-7.
RGD ID: 5147614
Pubmed: PMID:19230186   (View Abstract at PubMed)

The paper presents the clinical, X-ray, and laboratory characteristics of patients with pulmonary tuberculosis. Both general regularities and differences in the frequency of alleles of the HLA-DQB1* locus have been revealed in the groups of patients with pulmonary tuberculosis as compared with healthy individuals. There are specificities associated with the risk of pulmonary tuberculosis and the variants of the course of infection; thus, allele 05 of the HLA-DQB1* locus is positively associated with the incidence of tuberculosis. Specificity 03 of the HLA-DQB1* locus has been ascertained to be associated with the poor course of the disease. The most pronounced immunological changes have been observed in patients with the poor course of the disease, who are the carriers of specificity 05 of the HLA-DQB1* locus. The totality of immunological parameters and the data of genetic studies provide a basis for using the selective immunomodulator rIL-2 (roncoleukin) in the most seriously ill patients who are carriers of specificity 05.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary tuberculosis disease_progressionISOHLA-DQB1 (Homo sapiens)5147614; 5147614DNA:polymorphisms (human)RGD 
pulmonary tuberculosis disease_progressionIAGP 5147614DNA:polymorphisms (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information