RGD Reference Report - Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia. - Rat Genome Database

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Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia.

Authors: Al-Ola, K  Mahdi, N  Al-Subaie, AM  Ali, ME  Al-Absi, IK  Almawi, WY 
Citation: Al-Ola K, etal., Tissue Antigens. 2008 May;71(5):453-7. doi: 10.1111/j.1399-0039.2008.01012.x. Epub 2008 Feb 28.
RGD ID: 11041747
Pubmed: PMID:18312480   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1399-0039.2008.01012.x   (Journal Full-text)

We investigated the association of human leukocyte antigen (HLA) class II alleles and haplotypes with the pathogenesis of sickle cell anemia (SCA) osteomyelitis. SCA patients comprised 42 patients with osteomyelitis and 150 patients without osteomyelitis; HLA-DRB1* and HLA-DQB1* genotyping was performed by polymerase chain reaction-sequence-specific priming (SSP). DRB1*100101 (P value corrected for the number of different alleles tested, Pc=0.003) was positively associated with osteomyelitis. At the haplotype level, DRB1*100101-DQB1*050101 (Pc=0.001) was more prevalent among patients, while DRB1*030101-DQB1*0201 (Pc=0.020) and DRB1*040101-DQB1*0302 (Pc=0.039) were more prevalent among SCA controls, thereby conferring disease susceptibility or protection to these haplotypes, respectively. These results show that specific HLA haplotypes influence SCA osteomyelitis risk and that specific HLA types may serve as markers for identifying SCA patients at high risk for osteomyelitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
osteomyelitis susceptibilityISOHLA-DQB1 (Homo sapiens)11041747; 11041747associated with Anemia more ...RGD 
osteomyelitis susceptibilityIAGP 11041747associated with Anemia more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Osteomyelitis susceptibilityIAGP 11041747associated with Anemia more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information