RGD Reference Report - HLA associations with multiple sclerosis in Greece. - Rat Genome Database

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HLA associations with multiple sclerosis in Greece.

Authors: Kouri, I  Papakonstantinou, S  Bempes, V  Vasiliadis, HS  Kyritsis, AP  Pelidou, SH 
Citation: Kouri I, etal., J Neurol Sci. 2011 Jul 7.
RGD ID: 5147555
Pubmed: PMID:21741664   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jns.2011.06.037   (Journal Full-text)

BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system originated by a complex interplay of environmental and genetic factors. The association of MS with the human leukocyte antigen (HLA) class II alleles was investigated in MS patients in northwest Greece, in the geographical region of Epirus. OBJECTIVE: Our aim was to estimate the prevalence of the HLA-DRB1*1501, HLA-DQB1*0602 and HLA-DQA1*0102 alleles, consisting the most common susceptibility haplotype in North European and North American Caucasians. METHODS: We studied 126 MS patients and 93 age and sex matched healthy controls. HLA typing was performed by a polymerase chain reaction (PCR) amplification with sequence-specific primers (PCR-SSP) method. RESULTS: We found that HLA-DRB1*1501, HLA-DQB1*0602 and HLA-DQA1*0102 alleles were significantly more frequent among patients (34% versus 11%, p=0.00015; 69% versus 51%, p=0.01; 76% versus 55%, p=0.002, respectively). HLA-DRB1*1501, HLA-DQB1*0602, HLA-DQA1*0102 haplotype was significantly more common among patients (p=0.00067). HLA-DRB1*1501 and HLA-DQB1*0602 alleles were more frequently detected in patients with initial symptoms from the brainstem or the cerebellum (p=0.024). No significant correlation was observed among these alleles with sex, disease clinical course, or age at onset. CONCLUSION: This is the first study to investigate genetic susceptibility to MS in Greece. Our results are in line with previous reports in North European and North American patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
multiple sclerosis susceptibilityISOHLA-DQA1 (Homo sapiens)5147555; 5147555DNA:polymorphism (human)RGD 
multiple sclerosis susceptibilityISOHLA-DQB1 (Homo sapiens)5147555; 5147555DNA:polymorphism (human)RGD 
multiple sclerosis susceptibilityISOHLA-DRB1 (Homo sapiens)5147555; 5147555DNA:polymorphism: :HLA-DRB*1501 (human)RGD 
multiple sclerosis susceptibilityIAGP 5147555; 5147555DNA:polymorphism (human)RGD 
multiple sclerosis susceptibilityIAGP 5147555DNA:polymorphism: :HLA-DRB*1501 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information