RGD Reference Report - No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population. - Rat Genome Database

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No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population.

Authors: Dzurilla, M  Vrlík, M  Homolová, M  Buc, M 
Citation: Dzurilla M, etal., Bratisl Lek Listy. 2013;114(2):93-5.
RGD ID: 13506906
Pubmed: PMID:23331206   (View Abstract at PubMed)

109 patients (62 boys/men and 47 girls/women) suffering from bronchial asthma induced by pollen allergens were typed for HLA-DRB1 and -DQBl alleles, respectively, by a low resolution SSP technique. Frequencies of DRB1 alleles varied from 0.5 % to 16.1 %. The most frequent was HLA-DRB1*11 (16.1 %), the least frequent HLA-DRB1*09 (0.4 %). Occurrence rates of HLA-DQB1 alleles ranged from 2.3 % to 37.2 %, HLA-DQB1*03 being the most frequent (37.2 %) and DQB1*04 stood on the opposite pole (2.3 %). By comparing to occurrence rates in the healthy population, no statistically significant differences were disclosed (Tab. 2, Ref. 16).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma no_associationISOHLA-DQB1 (Homo sapiens)13506906; 13506906 RGD 
asthma no_associationISOHLA-DRB1 (Homo sapiens)13506906; 13506906 RGD 
asthma no_associationIAGP 13506906; 13506906 RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information