P4ha1 (prolyl 4-hydroxylase subunit alpha 1) - Rat Genome Database

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Gene: P4ha1 (prolyl 4-hydroxylase subunit alpha 1) Rattus norvegicus
Analyze
Symbol: P4ha1
Name: prolyl 4-hydroxylase subunit alpha 1
RGD ID: 621000
Description: Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to act upstream of or within collagen fibril organization. Predicted to be located in mitochondrion. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4-PH alpha-1; PHalphaI; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase alpha subunit; prolyl 4-hydroxylase subunit alpha-1; prolyl 4-hydroxylase, alpha polypeptide I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,784,696 - 27,895,785 (+)NCBIGRCr8
mRatBN7.22027,302,046 - 27,352,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,311,476 - 28,361,143 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,697,734 - 27,747,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,442,360 - 28,492,030 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02028,920,616 - 28,972,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,726,604 - 30,776,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,745,570 - 28,795,338 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydrogen sulfide  (ISO)
ifosfamide  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (EXP,ISO)
nitric oxide  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The complete cDNA derived sequence of the rat prolyl 4-hydroxylase alpha subunit. Hopkinson I, etal., Gene 1994 Nov 18;149(2):391-2.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Cloning and characterization of the 5'-flanking region of the rat P4Halpha gene encoding the prolyl 4-hydroxylase alpha(I) subunit. Takahashi S, etal., Biochim Biophys Acta 2002 Apr 12;1574(3):354-8.
Additional References at PubMed
PMID:7753822   PMID:10799490   PMID:15489334   PMID:17135260   PMID:19946888   PMID:24207127   PMID:33450132  


Genomics

Comparative Map Data
P4ha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,784,696 - 27,895,785 (+)NCBIGRCr8
mRatBN7.22027,302,046 - 27,352,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2028,311,476 - 28,361,143 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,697,734 - 27,747,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,442,360 - 28,492,030 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02028,920,616 - 28,972,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,726,604 - 30,776,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,745,570 - 28,795,338 (+)NCBICelera
Cytogenetic Map20q11NCBI
P4HA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,007,217 - 73,096,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,007,217 - 73,096,974 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,766,975 - 74,856,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,436,981 - 74,526,630 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,436,987 - 74,526,614NCBI
Celera1068,052,119 - 68,141,888 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,760,779 - 68,850,247 (-)NCBIHuRef
CHM1_11075,048,716 - 75,138,475 (-)NCBICHM1_1
T2T-CHM13v2.01073,878,593 - 73,968,258 (-)NCBIT2T-CHM13v2.0
P4ha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,159,019 - 59,209,126 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,159,118 - 59,209,126 (+)EnsemblGRCm39 Ensembl
GRCm381059,323,197 - 59,373,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,323,296 - 59,373,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,786,044 - 58,836,052 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,718,730 - 58,767,701 (+)NCBIMGSCv36mm8
Celera1060,423,571 - 60,473,579 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.52NCBI
P4ha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,604,525 - 18,668,800 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,604,525 - 18,668,800 (+)NCBIChiLan1.0ChiLan1.0
P4HA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,183,074 - 85,250,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,188,541 - 85,277,170 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,554,722 - 69,643,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,017,493 - 72,106,083 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,017,500 - 72,106,083 (-)Ensemblpanpan1.1panPan2
P4HA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,600,399 - 23,677,820 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,601,636 - 23,677,762 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,738,890 - 23,816,335 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,886,920 - 23,964,071 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,886,987 - 23,964,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,785,865 - 23,863,342 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,984,840 - 24,062,302 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,339,447 - 24,416,949 (-)NCBIUU_Cfam_GSD_1.0
P4ha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,488,533 - 57,552,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,981,079 - 6,047,499 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,981,205 - 6,045,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P4HA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,825,148 - 75,919,016 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,827,207 - 75,919,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,892,533 - 82,002,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P4HA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,178,350 - 58,259,303 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,178,461 - 58,259,802 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,766,319 - 18,856,093 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P4ha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,705,322 - 6,802,312 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,707,429 - 6,802,333 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P4ha1
192 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000070897
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 43 44 28 19 28 8 11 74 35 40 11 8
Low 2 13 13 13 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070897   ⟹   ENSRNOP00000064405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,148 - 27,351,821 (+)Ensembl
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100609   ⟹   ENSRNOP00000096087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104909   ⟹   ENSRNOP00000088456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106077   ⟹   ENSRNOP00000084000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117090   ⟹   ENSRNOP00000096608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,417 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119688   ⟹   ENSRNOP00000077480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,160 - 27,352,404 (+)Ensembl
RefSeq Acc Id: NM_172062   ⟹   NP_742059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,046 - 27,894,823 (+)NCBI
mRatBN7.22027,302,046 - 27,351,824 (+)NCBI
Rnor_6.02028,920,616 - 28,971,984 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Celera2028,745,570 - 28,795,338 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256424   ⟹   XP_006256486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,099 - 27,895,785 (+)NCBI
mRatBN7.22027,302,109 - 27,352,098 (+)NCBI
Rnor_6.02028,920,631 - 28,972,576 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256425   ⟹   XP_006256487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,032 - 27,895,785 (+)NCBI
mRatBN7.22027,302,052 - 27,351,860 (+)NCBI
Rnor_6.02028,920,622 - 28,972,576 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279493   ⟹   XP_063135563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,096 - 27,895,785 (+)NCBI
RefSeq Acc Id: XM_063279494   ⟹   XP_063135564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,784,696 - 27,895,785 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_742059   ⟸   NM_172062
- Peptide Label: precursor
- UniProtKB: Q6AZ74 (UniProtKB/Swiss-Prot),   P54001 (UniProtKB/Swiss-Prot),   A6K3U6 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256487   ⟸   XM_006256425
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASU1 (UniProtKB/TrEMBL),   A6K3U5 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256486   ⟸   XM_006256424
- Peptide Label: isoform X2
- UniProtKB: Q6AZ74 (UniProtKB/Swiss-Prot),   P54001 (UniProtKB/Swiss-Prot),   A6K3U6 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064405   ⟸   ENSRNOT00000070897
RefSeq Acc Id: ENSRNOP00000096087   ⟸   ENSRNOT00000100609
RefSeq Acc Id: ENSRNOP00000084000   ⟸   ENSRNOT00000106077
RefSeq Acc Id: ENSRNOP00000077480   ⟸   ENSRNOT00000119688
RefSeq Acc Id: ENSRNOP00000088456   ⟸   ENSRNOT00000104909
RefSeq Acc Id: ENSRNOP00000096608   ⟸   ENSRNOT00000117090
RefSeq Acc Id: XP_063135564   ⟸   XM_063279494
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135563   ⟸   XM_063279493
- Peptide Label: isoform X1
Protein Domains
Fe2OG dioxygenase   Prolyl 4-hydroxylase alpha subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54001-F1-model_v2 AlphaFold P54001 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701587
Promoter ID:EPDNEW_R12111
Type:multiple initiation site
Name:P4ha1_1
Description:prolyl 4-hydroxylase subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02028,920,711 - 28,920,771EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621000 AgrOrtholog
BioCyc Gene G2FUF-3769 BioCyc
BioCyc Pathway PWY-7894 [procollagen hydroxylation and glycosylation] BioCyc
BioCyc Pathway Image PWY-7894 BioCyc
Ensembl Genes ENSRNOG00000050655 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009534 UniProtKB/Swiss-Prot
  ENSRNOG00060003130 UniProtKB/Swiss-Prot
  ENSRNOG00065025183 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000070897.2 UniProtKB/TrEMBL
  ENSRNOT00000100609.1 UniProtKB/TrEMBL
  ENSRNOT00000104909.1 UniProtKB/TrEMBL
  ENSRNOT00000106077 ENTREZGENE
  ENSRNOT00000106077.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117090.1 UniProtKB/TrEMBL
  ENSRNOT00000119688.1 UniProtKB/TrEMBL
  ENSRNOT00055016163 UniProtKB/Swiss-Prot
  ENSRNOT00060005174 UniProtKB/Swiss-Prot
  ENSRNOT00065043474 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.1460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115543 IMAGE-MGC_LOAD
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P4HA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64475 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93107 IMAGE-MGC_LOAD
NCBI Gene 64475 ENTREZGENE
PANTHER PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10869 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P4Ha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P4ha1 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050655 RatGTEx
  ENSRNOG00055009534 RatGTEx
  ENSRNOG00060003130 RatGTEx
  ENSRNOG00065025183 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZKB2_RAT UniProtKB/TrEMBL
  A0A8I6A688_RAT UniProtKB/TrEMBL
  A0A8I6AP51_RAT UniProtKB/TrEMBL
  A0A8I6ASU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QWJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6K3U5 ENTREZGENE, UniProtKB/TrEMBL
  A6K3U6 ENTREZGENE, UniProtKB/TrEMBL
  P4HA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AZ74 ENTREZGENE
UniProt Secondary Q6AZ74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 P4ha1  prolyl 4-hydroxylase subunit alpha 1  P4ha1  prolyl 4-hydroxylase, alpha polypeptide I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 P4ha1  prolyl 4-hydroxylase, alpha polypeptide I  P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I  P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide    prolyl 4-hydroxylase alpha subunit  Name updated 1299863 APPROVED
2002-08-07 P4ha1  prolyl 4-hydroxylase alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL