Egr2 (early growth response 2) - Rat Genome Database
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Gene: Egr2 (early growth response 2) Rattus norvegicus
Analyze
Symbol: Egr2
Name: early growth response 2
RGD ID: 621608
Description: Exhibits HMG box domain binding activity. Involved in learning or memory; regulation of neuronal synaptic plasticity; and response to insulin. Predicted to localize to cytoplasm; nuclear chromatin; and nucleoplasm. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 3alpha-hydroxy-5beta-pregnan-20-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response protein 2; EGR-2; Krox20; zinc finger protein Krox-20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22021,051,270 - 21,056,322 (-)NCBI
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02022,452,170 - 22,461,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02024,551,935 - 24,556,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,883,885 - 21,888,177 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12021,897,685 - 21,901,977 (-)NCBI
Celera2022,412,625 - 22,416,917 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-azacytidine  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aripiprazole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atropine  (EXP)
azathioprine  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
bazedoxifene  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
Calcimycin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirenzepine  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
risperidone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
triadimefon  (EXP)
triazoles  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
cytoplasm  (ISO,ISS)
intracellular membrane-bounded organelle  (ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (ISO,ISS,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bellone E, etal., Hum Mutat 1999 Oct;14(4):353-4.
2. Boerkoel CF, etal., Neurogenetics 2001 Jul;3(3):153-7.
3. De S, etal., J Chem Neuroanat 2003 Mar;25(3):213-26.
4. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hirano S, etal., Am J Respir Cell Mol Biol 2000 Sep;23(3):313-9.
8. Inokuchi K, etal., Biochem Biophys Res Commun 1996 Apr 16;221(2):430-6.
9. Jacquin TD, etal., Neuron 1996 Oct;17(4):747-58.
10. Keeton AB, etal., Endocrinology. 2003 Dec;144(12):5402-10. Epub 2003 Sep 11.
11. Mengozzi M, etal., Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22. doi: 10.1073/pnas.1200554109. Epub 2012 May 29.
12. MGD data from the GO Consortium
13. NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Numakura C, etal., J Neurol Sci 2003 Jun 15;210(1-2):61-4.
15. OMIM Disease Annotation Pipeline
16. Parkinson DB, etal., Mol Cell Neurosci 2003 May;23(1):13-27.
17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Vandenberghe N, etal., J Med Genet 2002 Dec;39(12):e81.
21. Warner LE, etal., Hum Mol Genet. 1999 Jul;8(7):1245-51.
22. Wissmuller S, etal., Nucleic Acids Res. 2006 Mar 31;34(6):1735-44. Print 2006.
Additional References at PubMed
PMID:7903221   PMID:7935840   PMID:8093858   PMID:8565822   PMID:8895582   PMID:9806922   PMID:10068633   PMID:10704452   PMID:11509834   PMID:11823429   PMID:12687019   PMID:14532282  
PMID:15282162   PMID:15927552   PMID:16054051   PMID:16136673   PMID:16675951   PMID:16872830   PMID:17478888   PMID:17717711   PMID:17938205   PMID:18396140   PMID:18456662   PMID:19270309  
PMID:19651900   PMID:19765400   PMID:20427655   PMID:21357543   PMID:21836637   PMID:22147266   PMID:22511272   PMID:23073893   PMID:23307302   PMID:26941017   PMID:27890615   PMID:29580816  
PMID:31852952  


Genomics

Comparative Map Data
Egr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22021,051,270 - 21,056,322 (-)NCBI
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02022,452,170 - 22,461,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02024,551,935 - 24,556,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,883,885 - 21,888,177 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12021,897,685 - 21,901,977 (-)NCBI
Celera2022,412,625 - 22,416,917 (-)NCBICelera
Cytogenetic Map20p11NCBI
EGR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1062,811,996 - 62,919,900 (-)EnsemblGRCh38hg38GRCh38
GRCh381062,811,996 - 62,819,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371064,571,756 - 64,578,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361064,241,763 - 64,246,133 (-)NCBINCBI36hg18NCBI36
Build 341064,241,762 - 64,246,133NCBI
Celera1057,839,025 - 57,846,195 (-)NCBI
Cytogenetic Map10q21.3NCBI
HuRef1058,563,537 - 58,570,711 (-)NCBIHuRef
CHM1_11064,853,748 - 64,860,918 (-)NCBICHM1_1
Egr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391067,370,334 - 67,383,354 (+)NCBIGRCm39mm39
GRCm381067,534,469 - 67,542,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,535,475 - 67,542,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371067,000,617 - 67,004,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv361066,933,235 - 66,937,545 (+)NCBImm8
Celera1068,629,352 - 68,633,671 (+)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
Egr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542516,055,748 - 16,060,048 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542516,055,748 - 16,068,429 (-)NCBIChiLan1.0ChiLan1.0
EGR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11061,648,364 - 61,652,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1061,648,364 - 61,652,846 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01059,320,073 - 59,326,869 (-)NCBIMhudiblu_PPA_v0panPan3
EGR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl414,706,600 - 14,709,497 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1414,705,384 - 14,810,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Egr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367531,958,250 - 1,962,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1466,284,577 - 66,291,306 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11466,280,665 - 66,291,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21471,516,963 - 71,523,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q23-q25NCBI
EGR2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,472,640 - 68,479,612 (+)NCBI
ChlSab1.1 Ensembl968,475,102 - 68,479,595 (+)Ensembl
Egr2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624791953,009 - 959,656 (+)NCBI

Position Markers
X06746  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02022,454,769 - 22,454,959NCBIRnor6.0
Rnor_5.02024,552,243 - 24,552,433UniSTSRnor5.0
RGSC_v3.42021,884,193 - 21,884,383UniSTSRGSC3.4
Celera2022,412,933 - 22,413,123UniSTS
Cytogenetic Map20p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201782709656205956Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201887215049108956Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202085847056205956Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:701
Count of miRNA genes:303
Interacting mature miRNAs:391
Transcripts:ENSRNOT00000000792
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 25 8 19 2 2 30 9 22 10 2
Below cutoff 1 18 40 33 33 6 9 42 26 15 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000792   ⟹   ENSRNOP00000000792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)Ensembl
RefSeq Acc Id: NM_053633   ⟹   NP_446085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22021,051,270 - 21,055,562 (-)NCBI
Rnor_6.02022,454,461 - 22,458,753 (-)NCBI
Rnor_5.02024,551,935 - 24,556,227 (-)NCBI
RGSC_v3.42021,883,885 - 21,888,177 (-)RGD
Celera2022,412,625 - 22,416,917 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772857   ⟹   XP_008771079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02022,452,170 - 22,461,018 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601530   ⟹   XP_017457019
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22021,051,270 - 21,056,322 (-)NCBI
Rnor_6.02022,452,170 - 22,459,564 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601531   ⟹   XP_017457020
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02022,452,170 - 22,458,157 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446085   ⟸   NM_053633
- UniProtKB: P51774 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771079   ⟸   XM_008772857
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457019   ⟸   XM_017601530
- Peptide Label: isoform X1
- UniProtKB: P51774 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457020   ⟸   XM_017601531
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000000792   ⟸   ENSRNOT00000000792
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701562
Promoter ID:EPDNEW_R12085
Type:single initiation site
Name:Egr2_1
Description:early growth response 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02022,458,762 - 22,458,822EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621608 AgrOrtholog
Ensembl Genes ENSRNOG00000000640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000000792 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000792 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114090 UniProtKB/Swiss-Prot
NCBI Gene 114090 ENTREZGENE
Pfam DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EGR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QYG4_RAT UniProtKB/TrEMBL
UniProt Secondary Q54AG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Egr2  early growth response 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Egr2  early growth response 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in the hippocampus increases in response to neural activity 728620