Egr2 (early growth response 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Egr2 (early growth response 2) Rattus norvegicus
Analyze
Symbol: Egr2
Name: early growth response 2
RGD ID: 621608
Description: Enables HMG box domain binding activity. Involved in learning or memory; regulation of neuronal synaptic plasticity; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response protein 2; EGR-2; Krox20; zinc finger protein Krox-20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82021,050,149 - 21,055,201 (-)NCBIGRCr8
mRatBN7.22021,051,270 - 21,056,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2021,051,277 - 21,055,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,775,449 - 21,779,741 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02021,128,510 - 21,132,802 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,605,990 - 21,610,282 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,452,170 - 22,461,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,551,935 - 24,556,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,883,885 - 21,888,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12021,897,685 - 21,901,977 (-)NCBI
Celera2022,412,625 - 22,416,917 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-nitrophenol  (ISO)
5-azacytidine  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
atropine  (EXP)
azathioprine  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
bazedoxifene  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirenzepine  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
risperidone  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
triazoles  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease. Bellone E, etal., Hum Mutat 1999 Oct;14(4):353-4.
2. EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Boerkoel CF, etal., Neurogenetics 2001 Jul;3(3):153-7.
3. The ontogeny of Krox-20 expression in brainstem and cerebellar neurons. De S, etal., J Chem Neuroanat 2003 Mar;25(3):213-26.
4. Primary gene response to mechanical loading in healing rat Achilles tendons. Eliasson P, etal., J Appl Physiol (1985). 2013 Jun;114(11):1519-26. doi: 10.1152/japplphysiol.01500.2012. Epub 2013 Mar 21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages. Hirano S, etal., Am J Respir Cell Mol Biol 2000 Sep;23(3):313-9.
8. mRNA differential display reveals Krox-20 as a neural plasticity-regulated gene in the rat hippocampus. Inokuchi K, etal., Biochem Biophys Res Commun 1996 Apr 16;221(2):430-6.
9. Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. Jacquin TD, etal., Neuron 1996 Oct;17(4):747-58.
10. Insulin-regulated expression of Egr-1 and Krox20: dependence on ERK1/2 and interaction with p38 and PI3-kinase pathways. Keeton AB, etal., Endocrinology. 2003 Dec;144(12):5402-10. Epub 2003 Sep 11.
11. Erythropoietin-induced changes in brain gene expression reveal induction of synaptic plasticity genes in experimental stroke. Mengozzi M, etal., Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9617-22. doi: 10.1073/pnas.1200554109. Epub 2012 May 29.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1. Numakura C, etal., J Neurol Sci 2003 Jun 15;210(1-2):61-4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells. Parkinson DB, etal., Mol Cell Neurosci 2003 May;23(1):13-27.
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies. Vandenberghe N, etal., J Med Genet 2002 Dec;39(12):e81.
21. Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies. Warner LE, etal., Hum Mol Genet. 1999 Jul;8(7):1245-51.
22. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissmuller S, etal., Nucleic Acids Res. 2006 Mar 31;34(6):1735-44. Print 2006.
Additional References at PubMed
PMID:7903221   PMID:7935840   PMID:8093858   PMID:8565822   PMID:8895582   PMID:9806922   PMID:10068633   PMID:10704452   PMID:11509834   PMID:11823429   PMID:12687019   PMID:14532282  
PMID:15282162   PMID:15927552   PMID:16054051   PMID:16136673   PMID:16675951   PMID:16872830   PMID:17478888   PMID:17717711   PMID:17938205   PMID:18396140   PMID:18456662   PMID:19270309  
PMID:19651900   PMID:19765400   PMID:20427655   PMID:21357543   PMID:21836637   PMID:22147266   PMID:22511272   PMID:23073893   PMID:23307302   PMID:26941017   PMID:27890615   PMID:29580816  
PMID:31852952   PMID:36648143  


Genomics

Comparative Map Data
Egr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82021,050,149 - 21,055,201 (-)NCBIGRCr8
mRatBN7.22021,051,270 - 21,056,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2021,051,277 - 21,055,562 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,775,449 - 21,779,741 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02021,128,510 - 21,132,802 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,605,990 - 21,610,282 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,452,170 - 22,461,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,551,935 - 24,556,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,883,885 - 21,888,177 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12021,897,685 - 21,901,977 (-)NCBI
Celera2022,412,625 - 22,416,917 (-)NCBICelera
Cytogenetic Map20p11NCBI
EGR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381062,811,996 - 62,819,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1062,811,996 - 62,819,167 (-)EnsemblGRCh38hg38GRCh38
GRCh371064,571,756 - 64,578,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361064,241,763 - 64,246,133 (-)NCBINCBI36Build 36hg18NCBI36
Build 341064,241,762 - 64,246,133NCBI
Celera1057,839,025 - 57,846,195 (-)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1058,563,537 - 58,570,711 (-)NCBIHuRef
CHM1_11064,853,748 - 64,860,918 (-)NCBICHM1_1
T2T-CHM13v2.01063,670,139 - 63,677,309 (-)NCBIT2T-CHM13v2.0
Egr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391067,370,334 - 67,383,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1067,371,305 - 67,378,018 (+)EnsemblGRCm39 Ensembl
GRCm381067,534,469 - 67,542,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,535,475 - 67,542,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371067,000,617 - 67,004,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361066,933,235 - 66,937,545 (+)NCBIMGSCv36mm8
Celera1068,629,352 - 68,633,671 (+)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1034.96NCBI
Egr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542516,055,748 - 16,060,048 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542516,055,748 - 16,068,429 (-)NCBIChiLan1.0ChiLan1.0
EGR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2874,998,060 - 75,105,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11075,003,383 - 75,111,110 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01059,320,073 - 59,326,869 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11061,648,364 - 61,652,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1061,648,364 - 61,652,846 (-)Ensemblpanpan1.1panPan2
EGR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1414,705,384 - 14,810,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl414,706,600 - 14,709,497 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha414,923,311 - 15,027,362 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0414,969,904 - 15,074,026 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl414,969,462 - 14,976,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1414,952,564 - 15,056,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0415,077,597 - 15,181,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0415,433,193 - 15,537,238 (-)NCBIUU_Cfam_GSD_1.0
Egr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721366,381,281 - 66,388,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367531,958,264 - 1,962,640 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367531,958,250 - 1,962,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1466,284,581 - 66,291,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11466,280,665 - 66,291,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21471,516,963 - 71,523,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q23-q25NCBI
EGR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,472,640 - 68,479,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl968,475,102 - 68,479,595 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604829,356,837 - 29,363,580 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624791955,161 - 959,791 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624791953,009 - 959,656 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egr2
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:701
Count of miRNA genes:303
Interacting mature miRNAs:391
Transcripts:ENSRNOT00000000792
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat

Markers in Region
X06746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22021,051,577 - 21,051,768 (+)MAPPERmRatBN7.2
Rnor_6.02022,454,769 - 22,454,959NCBIRnor6.0
Rnor_5.02024,552,243 - 24,552,433UniSTSRnor5.0
RGSC_v3.42021,884,193 - 21,884,383UniSTSRGSC3.4
Celera2022,412,933 - 22,413,123UniSTS
Cytogenetic Map20p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 25 8 19 2 2 30 9 22 10 2
Below cutoff 1 18 40 33 33 6 9 42 26 15 6

Sequence


RefSeq Acc Id: ENSRNOT00000000792   ⟹   ENSRNOP00000000792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2021,051,277 - 21,055,562 (-)Ensembl
Rnor_6.0 Ensembl2022,454,463 - 22,459,025 (-)Ensembl
RefSeq Acc Id: NM_053633   ⟹   NP_446085
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82021,050,149 - 21,054,441 (-)NCBI
mRatBN7.22021,051,270 - 21,055,562 (-)NCBI
Rnor_6.02022,454,461 - 22,458,753 (-)NCBI
Rnor_5.02024,551,935 - 24,556,227 (-)NCBI
RGSC_v3.42021,883,885 - 21,888,177 (-)RGD
Celera2022,412,625 - 22,416,917 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601530   ⟹   XP_017457019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82021,050,149 - 21,055,201 (-)NCBI
mRatBN7.22021,051,270 - 21,056,322 (-)NCBI
Rnor_6.02022,452,170 - 22,459,564 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446085   ⟸   NM_053633
- UniProtKB: Q54AG4 (UniProtKB/Swiss-Prot),   P51774 (UniProtKB/Swiss-Prot),   A6JKW1 (UniProtKB/TrEMBL),   A6JKW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457019   ⟸   XM_017601530
- Peptide Label: isoform X1
- UniProtKB: A6JKW2 (UniProtKB/TrEMBL),   Q9QYG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000792   ⟸   ENSRNOT00000000792
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51774-F1-model_v2 AlphaFold P51774 1-470 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701562
Promoter ID:EPDNEW_R12085
Type:single initiation site
Name:Egr2_1
Description:early growth response 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02022,458,762 - 22,458,822EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621608 AgrOrtholog
BioCyc Gene G2FUF-3870 BioCyc
Ensembl Genes ENSRNOG00000000640 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055009728 UniProtKB/Swiss-Prot
  ENSRNOG00060003248 UniProtKB/Swiss-Prot
  ENSRNOG00065022825 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000792 ENTREZGENE
  ENSRNOT00000000792.5 UniProtKB/Swiss-Prot
  ENSRNOT00055016488 UniProtKB/Swiss-Prot
  ENSRNOT00060005342 UniProtKB/Swiss-Prot
  ENSRNOT00065038977 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGR_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114090 ENTREZGENE
PANTHER E3 SUMO-PROTEIN LIGASE EGR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3446 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egr2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000640 RatGTEx
  ENSRNOG00055009728 RatGTEx
  ENSRNOG00060003248 RatGTEx
  ENSRNOG00065022825 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JKW0 ENTREZGENE, UniProtKB/TrEMBL
  A6JKW1 ENTREZGENE, UniProtKB/TrEMBL
  A6JKW2 ENTREZGENE, UniProtKB/TrEMBL
  EGR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q54AG4 ENTREZGENE
  Q9QYG4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q54AG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Egr2  early growth response 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Egr2  early growth response 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in the hippocampus increases in response to neural activity 728620