Gstt1 (glutathione S-transferase theta 1) - Rat Genome Database

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Gene: Gstt1 (glutathione S-transferase theta 1) Rattus norvegicus
Analyze
Symbol: Gstt1
Name: glutathione S-transferase theta 1
RGD ID: 2765
Description: Exhibits alkylhalidase activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in several processes, including dichloromethane metabolic process; response to selenium ion; and response to vitamin E. Localizes to cytosol and nucleus. Biomarker of obesity and type 1 diabetes mellitus; PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-schisandrin B; (E)-1,3-dichloropropene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Glutathione S-transferase 1 (theta); glutathione S-transferase 5; glutathione S-transferase theta-1; glutathione S-transferase, theta 1; GST 5-5; GST class-theta-1; GSTYRS
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,856,613 - 12,873,586 (+)NCBI
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02013,799,102 - 13,816,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02015,989,083 - 16,006,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,604,355 - 13,621,456 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,604,582 - 13,621,683 (-)NCBI
Celera2014,348,088 - 14,365,283 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
Agammaglobulinemia 2, Autosomal Recessive  (ISO)
aggressive periodontitis  (ISO)
alcohol dependence  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
anemia  (ISO)
aplastic anemia  (ISO)
asbestosis  (ISO)
Asthenozoospermia  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
beta thalassemia  (ISO)
breast cancer  (ISO)
Bronchopulmonary Dysplasia  (ISO)
cancer  (ISO)
carcinoma  (ISO)
cardiovascular system disease  (ISO)
cataract  (ISO)
cervical cancer  (ISO)
cervix carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chromosome Aberrations  (ISO)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Congenital Abnormalities  (ISO)
congenital heart disease  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Susceptibility  (ISO)
drug allergy  (ISO)
Drug-induced Anemia  (ISO)
Drug-Induced Immune Thrombocytopenia  (ISO)
Drug-Induced Leukopenia  (ISO)
Drug-induced Neutropenia  (ISO)
end stage renal disease  (ISO)
epilepsy  (ISO)
Epistaxis  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
exfoliation syndrome  (ISO)
Fanconi anemia  (ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
glioblastoma  (ISO)
head and neck cancer  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung's disease  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
hypospadias  (ISO)
infectious mononucleosis  (ISO)
inflammatory bowel disease  (ISO)
Iron Overload  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
leukemia  (ISO)
leukopenia  (ISO)
Leukoplakia  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lymphoid leukemia  (ISO)
Lynch syndrome  (ISO)
medulloblastoma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
motor neuron disease  (ISO)
Mouth Abnormalities  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
Nasal Polyps  (ISO)
neutropenia  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (IEP)
optic neuritis  (ISO)
oral cavity cancer  (ISO)
oral mucosa leukoplakia  (ISO)
oral submucous fibrosis  (ISO)
orofacial cleft  (ISO)
ovary epithelial cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
Parkinson's disease  (ISO)
Perinatal Asphyxia  (ISO)
peripheral nervous system disease  (ISO)
pre-malignant neoplasm  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary tuberculosis  (ISO)
Raynaud disease  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
senile cataract  (ISO)
sickle cell anemia  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
stomach cancer  (ISO)
Therapy-related Acute Myeloid Leukemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Vaso-occlusive Crisis  (ISO)
venous insufficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-schisandrin B  (EXP)
(E)-1,3-dichloropropene  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dibromoethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,2-epoxy-3-(4-nitrophenoxy)propane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-amino-7-methyl-1,7-dihydro-6H-purin-6-one  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphotericin B  (EXP)
angelica lactone  (EXP)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (EXP)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bromodichloromethane  (EXP,ISO)
bromomethane  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroethene  (ISO)
chlorohydrocarbon  (ISO)
chloromethane  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (EXP)
cumene hydroperoxide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibromomethane  (EXP,ISO)
dichloromethane  (EXP,ISO)
diclofenac  (ISO)
diepoxybutane  (EXP,ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
disodium selenite  (ISO)
elemental selenium  (EXP)
ellagic acid  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethoxyquin  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glutathione  (EXP,ISO)
graphite  (EXP)
herbicide  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoniazide  (ISO)
isothiocyanate  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
MeIQx  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methylarsonic acid  (ISO)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
muconic acid  (ISO)
N-ethyl-N-nitrosourea  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
oxirane  (ISO)
ozone  (ISO)
p-nitrobenzyl chloride  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion-methyl  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
potassium chloride  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
propargite  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
rifampicin  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sterigmatocystin  (EXP)
stilbene oxide  (EXP)
styrene  (ISO)
styrene oxide  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
triadimefon  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IDA,ISO)
nucleus  (IDA)

Molecular Function

References

References - curated
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Additional References at PubMed
PMID:1848757   PMID:8670055   PMID:8761485   PMID:8799324   PMID:9307035   PMID:9434735   PMID:9854036   PMID:12038961   PMID:12477932   PMID:15489334   PMID:16496253   PMID:17827337  
PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Gstt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,856,613 - 12,873,586 (+)NCBI
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02013,799,102 - 13,816,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02015,989,083 - 16,006,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,604,355 - 13,621,456 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,604,582 - 13,621,683 (-)NCBI
Celera2014,348,088 - 14,365,283 (+)NCBICelera
Cytogenetic Map20p12NCBI
GSTT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh372224,376,133 - 24,384,311 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,706,141 - 22,714,231 (-)NCBINCBI36hg18NCBI36
Build 342222,700,694 - 22,708,785NCBI
Celera228,176,027 - 8,184,162 (-)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,324,342 - 7,332,477 (-)NCBIHuRef
Gstt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,619,647 - 75,634,418 (-)NCBIGRCm39mm39
GRCm39 Ensembl1075,619,647 - 75,634,418 (-)Ensembl
GRCm381075,783,813 - 75,798,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,783,813 - 75,798,584 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,246,558 - 75,261,329 (-)NCBIGRCm37mm9NCBIm37
MGSCv361075,227,531 - 75,242,300 (-)NCBImm8
Celera1076,828,580 - 76,843,364 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI

Position Markers
RH130749  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02013,816,320 - 13,816,505NCBIRnor6.0
Rnor_5.02016,006,301 - 16,006,486UniSTSRnor5.0
RGSC_v3.42013,604,377 - 13,604,562UniSTSRGSC3.4
Celera2014,365,076 - 14,365,261UniSTS
RH 3.4 Map20154.86UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1581577Pur15Proteinuria QTL 154.380.0002total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20865434118872273Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20965564214411641Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:114
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000001669
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 28 20 10 20 27 34 10
Low 2 43 29 21 9 21 8 11 70 8 7 1 8
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001669   ⟹   ENSRNOP00000001669
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)Ensembl
RefSeq Acc Id: NM_053293   ⟹   NP_445745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,856,680 - 12,873,586 (+)NCBI
Rnor_6.02013,799,102 - 13,816,527 (+)NCBI
Rnor_5.02015,989,083 - 16,006,508 (+)NCBI
RGSC_v3.42013,604,355 - 13,621,456 (-)RGD
Celera2014,348,088 - 14,365,283 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772859   ⟹   XP_008771081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,856,930 - 12,873,580 (+)NCBI
Rnor_6.02013,799,394 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772860   ⟹   XP_008771082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,856,963 - 12,873,580 (+)NCBI
Rnor_6.02013,799,399 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772861   ⟹   XP_008771083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,870,795 - 12,873,580 (+)NCBI
Rnor_6.02013,813,552 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098441   ⟹   XP_038954369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,856,678 - 12,873,580 (+)NCBI
RefSeq Acc Id: XM_039098442   ⟹   XP_038954370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,856,613 - 12,871,278 (+)NCBI
RefSeq Acc Id: XM_039098443   ⟹   XP_038954371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,861,800 - 12,873,580 (+)NCBI
RefSeq Acc Id: XM_039098444   ⟹   XP_038954372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,870,416 - 12,873,580 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445745   ⟸   NM_053293
- UniProtKB: Q01579 (UniProtKB/Swiss-Prot),   B6DYQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771082   ⟸   XM_008772860
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008771081   ⟸   XM_008772859
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771083   ⟸   XM_008772861
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000001669   ⟸   ENSRNOT00000001669
RefSeq Acc Id: XP_038954370   ⟸   XM_039098442
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038954369   ⟸   XM_039098441
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954371   ⟸   XM_039098443
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038954372   ⟸   XM_039098444
- Peptide Label: isoform X5
Protein Domains
GST C-terminal   GST N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701534
Promoter ID:EPDNEW_R12058
Type:multiple initiation site
Name:Gstt1_1
Description:glutathione S-transferase theta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,799,083 - 13,799,143EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2765 AgrOrtholog
Ensembl Genes ENSRNOG00000049771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000001669 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001669 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301492 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105379 IMAGE-MGC_LOAD
NCBI Gene 25260 ENTREZGENE
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTT1 RGD
PhenoGen Gstt1 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206835
UniProt B6DYQ8 ENTREZGENE, UniProtKB/TrEMBL
  GSTT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XTA7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gstt1  glutathione S-transferase theta 1    glutathione S-transferase, theta 1  Name updated 1299863 APPROVED
2002-06-10 Gstt1  Glutathione S-transferase 1 (theta)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 244 amino acid residues 68795
gene_transcript transcript promoter region lacks both TATA and CAAT boxes 68795